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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CRTC3-MESP2 (FusionGDB2 ID:19574)

Fusion Gene Summary for CRTC3-MESP2

Fusion gene summary

Fusion gene information	Fusion gene name: CRTC3-MESP2
	Fusion gene ID: 19574
		Hgene	Tgene
	Gene symbol	CRTC3	MESP2
	Gene ID	64784	145873
	Gene name	CREB regulated transcription coactivator 3	mesoderm posterior bHLH transcription factor 2
	Synonyms	TORC-3\|TORC3	SCDO2\|bHLHc6
	Cytomap	15q26.1	15q26.1
	Type of gene	protein-coding	protein-coding
	Description	CREB-regulated transcription coactivator 3transducer of regulated CREB protein 3transducer of regulated cAMP response element-binding protein (CREB) 3	mesoderm posterior protein 2class C basic helix-loop-helix protein 6mesoderm posterior 2 homologmesoderm posterior basic helix-loop-helix transcription factor 2
	Modification date	20200313	20200313
	UniProtAcc	Q6UUV7	Q0VG99
	Ensembl transtripts involved in fusion gene	ENST00000268184, ENST00000420329, ENST00000558619, ENST00000560098,	ENST00000341735, ENST00000558723, ENST00000560219,
Fusion gene scores	* DoF score	7 X 6 X 7=294	5 X 4 X 4=80
	# samples	9	5
	** MAII score	log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CRTC3 [Title/Abstract] AND MESP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CRTC3(91182047)-MESP2(90321296), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CRTC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MESP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NA-A4R1-01A	CRTC3	chr15	91182047	-	MESP2	chr15	90321296	+
ChimerDB4	UCS	TCGA-NA-A4R1-01A	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
ChimerDB4	UCS	TCGA-NA-A4R1	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+

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Fusion Gene ORF analysis for CRTC3-MESP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000268184	ENST00000341735	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
5CDS-3UTR	ENST00000268184	ENST00000558723	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
5CDS-3UTR	ENST00000420329	ENST00000341735	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
5CDS-3UTR	ENST00000420329	ENST00000558723	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
In-frame	ENST00000268184	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
In-frame	ENST00000420329	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3CDS	ENST00000558619	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3CDS	ENST00000560098	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3UTR	ENST00000558619	ENST00000341735	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3UTR	ENST00000558619	ENST00000558723	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3UTR	ENST00000560098	ENST00000341735	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+
intron-3UTR	ENST00000560098	ENST00000558723	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000420329

CRTC3

chr15

91182047

ENST00000560219

MESP2

chr15

90321296

2382

1695

147

1964

605

ENST00000268184

CRTC3

chr15

91182047

ENST00000560219

MESP2

chr15

90321296

2239

1552

1821

605

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000420329	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+	0.061630234	0.93836975
ENST00000268184	ENST00000560219	CRTC3	chr15	91182047	+	MESP2	chr15	90321296	+	0.06718763	0.93281233

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Fusion Genomic Features for CRTC3-MESP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CRTC3	chr15	91182047	+	MESP2	chr15	90321295	+	0.25680444	0.74319553
CRTC3	chr15	91182047	+	MESP2	chr15	90321295	+	0.25680444	0.74319553
CRTC3	chr15	91182047	+	MESP2	chr15	90321295	+	0.25680444	0.74319553
CRTC3	chr15	91182047	+	MESP2	chr15	90321295	+	0.25680444	0.74319553

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRTC3-MESP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:91182047/chr15:90321296)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CRTC3 Q6UUV7	MESP2 Q0VG99
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.	FUNCTION: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRTC3

chr15:91182047

chr15:90321296

ENST00000268184

180_183

516

620.0

Compositional bias

Note=Poly-Gly

Hgene

CRTC3

chr15:91182047

chr15:90321296

ENST00000268184

444_451

516

620.0

Compositional bias

Note=Poly-Pro

Hgene

CRTC3

chr15:91182047

chr15:90321296

ENST00000420329

180_183

516

619.0

Compositional bias

Note=Poly-Gly

Hgene

CRTC3

chr15:91182047

chr15:90321296

ENST00000420329

444_451

516

619.0

Compositional bias

Note=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

81_135

308

398.0

Domain

bHLH

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

179_204

308

398.0

Region

Note=13 X 2 AA tandem repeats of G-Q

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

179_180

308

398.0

Repeat

Note=1

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

181_182

308

398.0

Repeat

Note=2

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

183_184

308

398.0

Repeat

Note=3

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

185_186

308

398.0

Repeat

Note=4

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

187_188

308

398.0

Repeat

Note=5

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

189_190

308

398.0

Repeat

Note=6

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

191_192

308

398.0

Repeat

Note=7

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

193_194

308

398.0

Repeat

Note=8

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

195_196

308

398.0

Repeat

Note=9

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

197_198

308

398.0

Repeat

Note=10

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

199_200

308

398.0

Repeat

Note=11

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

201_202

308

398.0

Repeat

Note=12

Tgene

MESP2

chr15:91182047

chr15:90321296

ENST00000341735

203_204

308

398.0

Repeat

Note=13

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Fusion Gene Sequence for CRTC3-MESP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19574_19574_1_CRTC3-MESP2_CRTC3_chr15_91182047_ENST00000268184_MESP2_chr15_90321296_ENST00000560219_length(transcript)=2239nt_BP=1552nt
CGCCATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGA
GACGCGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGGTTCAATTTCAGAAGCTTCAGCAACTGCGCCTTACACAGTACCA
TGGAGGATCCTTACCAAATGTGAGCCAGCTGCGGAGCAGTGCGTCAGAGTTTCAGCCGTCATTTCACCAAGCTGATAATGTTCGGGGAAC
CCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAACCGCTTCCACCCCCTCCACCGAAGGTCTGGGGACAAGCCAGGGCGACAATTTGA
TGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCTCTGGATGAGAGTTGGCCAAGGCAGCAGCCTCCTTGGAAAGACGAAAAGCATCC
TGGGTTCAGGCTGACATCTGCACTTAACAGGACCAATTCTGATTCTGCTCTTCACACGAGTGCTCTGAGTACCAAGCCCCAGGACCCCTA
TGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATACATGGGTTTCTGTGATGGTGAGAATAATGGACATGGGGAAGTAGCATCTTTCCC
TGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCGAAGCCACTGCCAAAACAACTGTGGGAGACCAAGGAGATTCAGTCCCTGTCAGG
ACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCTTTTCCACATAATGGTCAAAACCTAGGCCTCTCACCCTTCTTGGGGACCTTGAA
CACTGGAGGGTCATTGCCAGATCTAACCAACCTCCACTACTCGACACCCCTGCCAGCCTCCCTGGACACCACCGACCACCACTTTGGCAG
TATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCTGCTATGACCCACCTGGGTATAAGAAGCTCCTCTGGTCTCCAGAGTTCTCGGAG
TAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTGCTTTCCTCTTCCTTAAATAACCACCCACAGACATCTGTTCCCAACGCATCTGC
TCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAACCCATCTCTTTCCACCACAAACCTGAGCGGCCCGTCTCGGCGTCGGCAGCCTCC
CGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCACATCAAGGTTTCAGCAGACAGCTGTCTTCAACCAGCCCACTGGCCCCATATCC
TACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTTTCCTTTCTGCCCACAGAAGCTCAAGCCCAGGTGTCGCCGCCACCCCCTTACCC
TGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAGCCCCGCGCCCCTGAGGCCCCTGCCCAGCAGCCCCAGGCAGCCTCCTCACTGCC
ACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCATCTTTGACCAACTTCTTCCCAGATGTGGGTTTTGACCAGCAGTCCATGAGGCC
AGGCCCTGCCTTTCCTCAACAGGGTCTCTCTGTGTCTCCAGAGCCCTGTCTGTCGCTGGGAGCTCCATCTCTCCTGCCCCACCCATCATG
CCAGAGACTGCAGCCTCAGACCCCCGGGAGGTGCTGGAGCCACAGTGCAGAGGTGGTGCCCAACTCAGAGGACCAGGGACCGGGCGCCGC
CTTCCAGCTCAGTGAAGCAAGCCCTCCCCAGAGCTCAGGCCTGCGGTTCAGTGGCTGCCCTGAACTTTGGCAAGAAGATCTGGAGGGGGC
CCGCCTGGGCATCTTCTACTAAATGGCCTCGGCTTCCCTCTTTCCATCCAGGAATCAGTCCTGTAGCTTGGGTGCCTCCTTATTTGTTAA
TTAGTGGCTTTTCATGTTCTCCTTTAGCCAAGGCTCCCTTTTTCCAAGTGATGTCTTTCAGGGAAGCAGTGTTTGAAATAGATAGCGGGT
ACCTTCCCTGGATGGAGTCAGGGCGGGGGCACTGTCCTCCACTGCTAGACACCCCCAGAATGCCTGGCGCTCTGCAGAGCACAGTCTGAG
CTGCTCTAAGAAGGGGTCTCCTTTACCCTAAAGGCAGCTGGGCAGGGACAGGTGGGAGAATGGGTGTAGGAGGCAGGCCCCAGGCTCTGC

>19574_19574_1_CRTC3-MESP2_CRTC3_chr15_91182047_ENST00000268184_MESP2_chr15_90321296_ENST00000560219_length(amino acids)=605AA_BP=509
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTR
HHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYG
GGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNT
GGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASAL
HPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPA
PQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQGLSVSPEPCLSLGAPSLLPHPSCQ

--------------------------------------------------------------
>19574_19574_2_CRTC3-MESP2_CRTC3_chr15_91182047_ENST00000420329_MESP2_chr15_90321296_ENST00000560219_length(transcript)=2382nt_BP=1695nt
CTCCGGGGCCGCGGCGGCTCCTCTGCCGGGTCGCGCCGGACGACTGGCTTCGGGCGGCGGCCCCGGCGGCCTGTGGACGGACGGGTGGGC
CGAGGTACAGGCCCCACGGCCGCCGTCTCCCGCTTCTGCCCGCGCAGAGTCCGCGCCATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAAC
CCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGAGACGCGGGCCTTCGAGCAGCTCATGACCGACCTCACC
CTGTCGCGGGTTCAATTTCAGAAGCTTCAGCAACTGCGCCTTACACAGTACCATGGAGGATCCTTACCAAATGTGAGCCAGCTGCGGAGC
AGTGCGTCAGAGTTTCAGCCGTCATTTCACCAAGCTGATAATGTTCGGGGAACCCGCCATCACGGGCTGGTGGAGAGGCCATCCAGGAAC
CGCTTCCACCCCCTCCACCGAAGGTCTGGGGACAAGCCAGGGCGACAATTTGATGGTAGTGCTTTTGGAGCCAATTATTCCTCACAGCCT
CTGGATGAGAGTTGGCCAAGGCAGCAGCCTCCTTGGAAAGACGAAAAGCATCCTGGGTTCAGGCTGACATCTGCACTTAACAGGACCAAT
TCTGATTCTGCTCTTCACACGAGTGCTCTGAGTACCAAGCCCCAGGACCCCTATGGAGGAGGGGGCCAGTCGGCCTGGCCTGCCCCATAC
ATGGGTTTCTGTGATGGTGAGAATAATGGACATGGGGAAGTAGCATCTTTCCCTGGCCCATTGAAAGAAGAGAATCTGTTAAATGTTCCG
AAGCCACTGCCAAAACAACTGTGGGAGACCAAGGAGATTCAGTCCCTGTCAGGACGCCCTCGATCCTGTGATGTTGGAGGTGGCAATGCT
TTTCCACATAATGGTCAAAACCTAGGCCTCTCACCCTTCTTGGGGACCTTGAACACTGGAGGGTCATTGCCAGATCTAACCAACCTCCAC
TACTCGACACCCCTGCCAGCCTCCCTGGACACCACCGACCACCACTTTGGCAGTATGAGTGTGGGGAATAGTGTGAACAACATCCCAGCT
GCTATGACCCACCTGGGTATAAGAAGCTCCTCTGGTCTCCAGAGTTCTCGGAGTAACCCCTCCATCCAAGCCACGCTCAATAAGACTGTG
CTTTCCTCTTCCTTAAATAACCACCCACAGACATCTGTTCCCAACGCATCTGCTCTTCACCCTTCGCTCCGTCTGTTTTCCCTTAGCAAC
CCATCTCTTTCCACCACAAACCTGAGCGGCCCGTCTCGGCGTCGGCAGCCTCCCGTCAGCCCTCTCACGCTTTCTCCTGGCCCTGAAGCA
CATCAAGGTTTCAGCAGACAGCTGTCTTCAACCAGCCCACTGGCCCCATATCCTACCTCCCAGATGGTGTCCTCAGACCGAAGCCAACTT
TCCTTTCTGCCCACAGAAGCTCAAGCCCAGGTGTCGCCGCCACCCCCTTACCCTGCACCCCAGGAGCTCACCCAGCCCCTCCTGCAGCAG
CCCCGCGCCCCTGAGGCCCCTGCCCAGCAGCCCCAGGCAGCCTCCTCACTGCCACAGTCAGACTTTCAGCTTCTCCCGGCCCAGGGCTCA
TCTTTGACCAACTTCTTCCCAGATGTGGGTTTTGACCAGCAGTCCATGAGGCCAGGCCCTGCCTTTCCTCAACAGGGTCTCTCTGTGTCT
CCAGAGCCCTGTCTGTCGCTGGGAGCTCCATCTCTCCTGCCCCACCCATCATGCCAGAGACTGCAGCCTCAGACCCCCGGGAGGTGCTGG
AGCCACAGTGCAGAGGTGGTGCCCAACTCAGAGGACCAGGGACCGGGCGCCGCCTTCCAGCTCAGTGAAGCAAGCCCTCCCCAGAGCTCA
GGCCTGCGGTTCAGTGGCTGCCCTGAACTTTGGCAAGAAGATCTGGAGGGGGCCCGCCTGGGCATCTTCTACTAAATGGCCTCGGCTTCC
CTCTTTCCATCCAGGAATCAGTCCTGTAGCTTGGGTGCCTCCTTATTTGTTAATTAGTGGCTTTTCATGTTCTCCTTTAGCCAAGGCTCC
CTTTTTCCAAGTGATGTCTTTCAGGGAAGCAGTGTTTGAAATAGATAGCGGGTACCTTCCCTGGATGGAGTCAGGGCGGGGGCACTGTCC
TCCACTGCTAGACACCCCCAGAATGCCTGGCGCTCTGCAGAGCACAGTCTGAGCTGCTCTAAGAAGGGGTCTCCTTTACCCTAAAGGCAG
CTGGGCAGGGACAGGTGGGAGAATGGGTGTAGGAGGCAGGCCCCAGGCTCTGCTTCTTGGTGACAGTTGGCCAGAGCCCTGTATGCTTTG

>19574_19574_2_CRTC3-MESP2_CRTC3_chr15_91182047_ENST00000420329_MESP2_chr15_90321296_ENST00000560219_length(amino acids)=605AA_BP=509
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTR
HHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYG
GGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNT
GGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASAL
HPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPA
PQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQGLSVSPEPCLSLGAPSLLPHPSCQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CRTC3-MESP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CRTC3-MESP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CRTC3-MESP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source