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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRYM-ANKS1B (FusionGDB2 ID:19620)

Fusion Gene Summary for CRYM-ANKS1B

check button Fusion gene summary
Fusion gene informationFusion gene name: CRYM-ANKS1B
Fusion gene ID: 19620
HgeneTgene
Gene symbol

CRYM

ANKS1B

Gene ID

1428

56899

Gene namecrystallin muankyrin repeat and sterile alpha motif domain containing 1B
SynonymsDFNA40|THBPAIDA|AIDA-1|ANKS2|EB-1|EB1|cajalin-2
Cytomap

16p12.2

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionketimine reductase mu-crystallinNADP-regulated thyroid-hormone binding proteinmu-crystallin homologthiomorpholine-carboxylate dehydrogenaseankyrin repeat and sterile alpha motif domain-containing protein 1BE2a-Pbx1-associated proteinamyloid-beta precursor protein intracellular domain associated protein 1cajalin 2
Modification date2020031320200313
UniProtAcc

Q14894

Q7Z6G8

Ensembl transtripts involved in fusion geneENST00000219599, ENST00000396023, 
ENST00000415987, ENST00000543948, 
ENST00000574787, 		ENST00000329257, 
ENST00000332712, ENST00000333732, 
ENST00000341752, ENST00000546568, 
ENST00000546960, ENST00000547010, 
ENST00000547446, ENST00000547776, 
ENST00000549025, ENST00000549493, 
ENST00000549558, ENST00000550693, 
ENST00000550833, 
Fusion gene scores* DoF score2 X 2 X 2=827 X 22 X 9=5346
# samples 228
** MAII scorelog2(2/8*10)=1.32192809488736log2(28/5346*10)=-4.25496110529811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRYM [Title/Abstract] AND ANKS1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRYM(21273435)-ANKS1B(99374657), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CRYM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKS1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACA489005CRYMchr16

21273435

-ANKS1Bchr12

99374657

+


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Fusion Gene ORF analysis for CRYM-ANKS1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000219599ENST00000329257CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000332712CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000333732CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000341752CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000546568CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000546960CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000547010CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000547446CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000547776CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000549025CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000549493CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000549558CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000550693CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000219599ENST00000550833CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000329257CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000332712CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000333732CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000341752CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000546568CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000546960CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000547010CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000547446CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000547776CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000549025CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000549493CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000549558CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000550693CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000396023ENST00000550833CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000329257CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000332712CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000333732CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000341752CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000546568CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000546960CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000547010CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000547446CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000547776CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000549025CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000549493CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000549558CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000550693CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000415987ENST00000550833CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000329257CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000332712CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000333732CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000341752CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000546568CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000546960CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000547010CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000547446CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000547776CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000549025CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000549493CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000549558CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000550693CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000543948ENST00000550833CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000329257CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000332712CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000333732CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000341752CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000546568CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000546960CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000547010CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000547446CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000547776CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000549025CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000549493CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000549558CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000550693CRYMchr16

21273435

-ANKS1Bchr12

99374657

+
intron-intronENST00000574787ENST00000550833CRYMchr16

21273435

-ANKS1Bchr12

99374657

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CRYM-ANKS1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRYM-ANKS1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21273435/:99374657)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRYM

Q14894

ANKS1B

Q7Z6G8

FUNCTION: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269|PubMed:21332720}.FUNCTION: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CRYM-ANKS1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CRYM-ANKS1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRYM-ANKS1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRYM-ANKS1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource