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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK1E-DYNLRB1 (FusionGDB2 ID:19833)

Fusion Gene Summary for CSNK1E-DYNLRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1E-DYNLRB1
Fusion gene ID: 19833
HgeneTgene
Gene symbol

CSNK1E

DYNLRB1

Gene ID

1454

83658

Gene namecasein kinase 1 epsilondynein light chain roadblock-type 1
SynonymsCKIe|CKIepsilon|HCKIEBITH|BLP|DNCL2A|DNLC2A|ROBLD1
Cytomap

22q13.1

20q11.22

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform epsilondynein light chain roadblock-type 1ROBL/LC7-like 1bithoraxoid-like proteindynein, cytoplasmic, light polypeptide 2Adynein-associated protein Km23roadblock domain-containing protein 1
Modification date2020032920200320
UniProtAcc.

Q9NP97

Ensembl transtripts involved in fusion geneENST00000400206, ENST00000359867, 
ENST00000396832, ENST00000403904, 
ENST00000405675, ENST00000413574, 
ENST00000498529, 		ENST00000357156, 
ENST00000300469, ENST00000374846, 
ENST00000417166, ENST00000480759, 
Fusion gene scores* DoF score13 X 9 X 10=117017 X 12 X 12=2448
# samples 1723
** MAII scorelog2(17/1170*10)=-2.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2448*10)=-3.41189779174828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK1E [Title/Abstract] AND DYNLRB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1E(38794443)-DYNLRB1(33114073), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1E

GO:0006468

protein phosphorylation

15917222|17244647

HgeneCSNK1E

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1E

GO:0032091

negative regulation of protein binding

23109420

HgeneCSNK1E

GO:0060070

canonical Wnt signaling pathway

14722104

HgeneCSNK1E

GO:1903827

regulation of cellular protein localization

17244647


check buttonFusion gene breakpoints across CSNK1E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYNLRB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-A5-A0R6-01ACSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+


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Fusion Gene ORF analysis for CSNK1E-DYNLRB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000400206ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000400206ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000400206ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000400206ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000400206ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000359867ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000396832ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000403904ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000405675ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000413574ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000498529ENST00000357156CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359867ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359867ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359867ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359867ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000396832ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000396832ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000396832ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000396832ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000403904ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000403904ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000403904ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000403904ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000405675ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000405675ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000405675ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000405675ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000413574ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000413574ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000413574ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000413574ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000498529ENST00000300469CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000498529ENST00000374846CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000498529ENST00000417166CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000498529ENST00000480759CSNK1Echr22

38794443

-DYNLRB1chr20

33114073

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CSNK1E-DYNLRB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK1Echr2238794442-DYNLRB1chr2033114072+0.0001610770.99983895
CSNK1Echr2238794442-DYNLRB1chr2033114072+0.0001610770.99983895

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CSNK1E-DYNLRB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38794443/:33114073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYNLRB1

Q9NP97

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CSNK1E-DYNLRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CSNK1E-DYNLRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK1E-DYNLRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSNK1E-DYNLRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource