|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CSNK2A1-CDKN2A (FusionGDB2 ID:19872) |
Fusion Gene Summary for CSNK2A1-CDKN2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSNK2A1-CDKN2A | Fusion gene ID: 19872 | Hgene | Tgene | Gene symbol | CSNK2A1 | CDKN2A | Gene ID | 1459 | 1029 |
| Gene name | casein kinase 2 alpha 2 | cyclin dependent kinase inhibitor 2A | |
| Synonyms | CK2A2|CK2alpha'|CSNK2A1 | ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16 | |
| Cytomap | 16q21 | 9p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | casein kinase II subunit alpha'CK II alpha'casein kinase 2 alpha'casein kinase 2, alpha prime polypeptide | cyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1 | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | P68400 | Q96HQ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000217244, ENST00000349736, ENST00000400217, ENST00000400227, | ENST00000304494, ENST00000361570, ENST00000579122, ENST00000579755, ENST00000446177, ENST00000479692, ENST00000494262, ENST00000497750, ENST00000498124, ENST00000498628, ENST00000530628, ENST00000578845, ENST00000470819, | |
| Fusion gene scores | * DoF score | 12 X 7 X 7=588 | 13 X 5 X 10=650 |
| # samples | 15 | 16 | |
| ** MAII score | log2(15/588*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/650*10)=-2.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CSNK2A1 [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CSNK2A1(524315)-CDKN2A(21971207), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSNK2A1 | GO:0018105 | peptidyl-serine phosphorylation | 28031292 |
| Tgene | CDKN2A | GO:0000082 | G1/S transition of mitotic cell cycle | 10208428 |
| Tgene | CDKN2A | GO:0007050 | cell cycle arrest | 15149599 |
| Tgene | CDKN2A | GO:0008285 | negative regulation of cell proliferation | 15149599 |
| Tgene | CDKN2A | GO:0030308 | negative regulation of cell growth | 10208428 |
| Tgene | CDKN2A | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 10353611 |
| Tgene | CDKN2A | GO:0042326 | negative regulation of phosphorylation | 8259215|10208428 |
| Tgene | CDKN2A | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 7739547|8259215 |
| Fusion gene breakpoints across CSNK2A1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CDKN2A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-13-1492 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
Top |
Fusion Gene ORF analysis for CSNK2A1-CDKN2A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000217244 | ENST00000304494 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000217244 | ENST00000361570 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000217244 | ENST00000579122 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000217244 | ENST00000579755 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000349736 | ENST00000304494 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000349736 | ENST00000361570 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000349736 | ENST00000579122 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000349736 | ENST00000579755 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400217 | ENST00000304494 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400217 | ENST00000361570 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400217 | ENST00000579122 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400217 | ENST00000579755 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400227 | ENST00000304494 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400227 | ENST00000361570 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400227 | ENST00000579122 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-3CDS | ENST00000400227 | ENST00000579755 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000446177 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000479692 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000494262 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000497750 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000498124 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000498628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000530628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000217244 | ENST00000578845 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000446177 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000479692 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000494262 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000497750 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000498124 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000498628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000530628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000349736 | ENST00000578845 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000446177 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000479692 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000494262 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000497750 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000498124 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000498628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000530628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400217 | ENST00000578845 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000446177 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000479692 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000494262 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000497750 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000498124 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000498628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000530628 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-5UTR | ENST00000400227 | ENST00000578845 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-intron | ENST00000217244 | ENST00000470819 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-intron | ENST00000349736 | ENST00000470819 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-intron | ENST00000400217 | ENST00000470819 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| 5UTR-intron | ENST00000400227 | ENST00000470819 | CSNK2A1 | chr20 | 524315 | - | CDKN2A | chr9 | 21971207 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for CSNK2A1-CDKN2A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for CSNK2A1-CDKN2A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:524315/:21971207) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSNK2A1 | CDKN2A |
| FUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:30699359, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for CSNK2A1-CDKN2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for CSNK2A1-CDKN2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CSNK2A1-CDKN2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for CSNK2A1-CDKN2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies