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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK2B-LY6G5B (FusionGDB2 ID:19889)

Fusion Gene Summary for CSNK2B-LY6G5B

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK2B-LY6G5B
Fusion gene ID: 19889
HgeneTgene
Gene symbol

CSNK2B

LY6G5B

Gene ID

1460

58496

Gene namecasein kinase 2 betalymphocyte antigen 6 family member G5B
SynonymsCK2B|CK2N|CSK2B|Ckb1|Ckb2|G5A|POBINDSC6orf19|G5b
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase II subunit betaCK II betaCSNK2B-LY6G5B-1072CSNK2B-LY6G5B-1103CSNK2B-LY6G5B-532CSNK2B-LY6G5B-560CSNK2B-LY6G5B-562Casein kinase II beta subunitalternative name: G5a, phosvitincasein kinase 2, beta polypeptidecasein kinase II b subunilymphocyte antigen 6 complex locus protein G5blymphocyte antigen 6 complex, locus G5Blymphocyte antigen-6 G5B splicing isoform 288lymphocyte antigen-6 G5B splicing isoform 452lymphocyte antigen-6 G5B splicing isoform 690lymphocyte antigen-6 G5B splic
Modification date2020032720200313
UniProtAcc

P67870

Q8NDX9

Ensembl transtripts involved in fusion geneENST00000375865, ENST00000375866, 
ENST00000375882, ENST00000375885, 
ENST00000383427, ENST00000383431, 
ENST00000383433, ENST00000400110, 
ENST00000400116, ENST00000412802, 
ENST00000413083, ENST00000416194, 
ENST00000418230, ENST00000422261, 
ENST00000422567, ENST00000424502, 
ENST00000428483, ENST00000429633, 
ENST00000431476, ENST00000432290, 
ENST00000436169, ENST00000437010, 
ENST00000439572, ENST00000443673, 
ENST00000448596, ENST00000451917, 
ENST00000452985, ENST00000453234, 
ENST00000454382, ENST00000454511, 
ENST00000455161, ENST00000458330, 
ENST00000464220, ENST00000468132, 
ENST00000476022, ENST00000480866, 
ENST00000485003, ENST00000488020, 
ENST00000409525, ENST00000383429, 
ENST00000437674, ENST00000456439, 
ENST00000471088, ENST00000480515, 
ENST00000480530, ENST00000484964, 
ENST00000556456, ENST00000375864, 
Fusion gene scores* DoF score6 X 6 X 4=1444 X 4 X 3=48
# samples 64
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK2B [Title/Abstract] AND LY6G5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK2B(31636949)-LY6G5B(31638750), # samples:1
Anticipated loss of major functional domain due to fusion event.CSNK2B-LY6G5B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CSNK2B-LY6G5B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK2B

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

19592636

HgeneCSNK2B

GO:0018107

peptidyl-threonine phosphorylation

15723517

HgeneCSNK2B

GO:0033211

adiponectin-activated signaling pathway

19233263

HgeneCSNK2B

GO:0043537

negative regulation of blood vessel endothelial cell migration

19592636


check buttonFusion gene breakpoints across CSNK2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LY6G5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACF264683CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+


Top

Fusion Gene ORF analysis for CSNK2B-LY6G5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000375865ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-5UTRENST00000375866ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-5UTRENST00000375882ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-5UTRENST00000375885ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375865ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375866ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375882ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
5CDS-intronENST00000375885ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
Frame-shiftENST00000375865ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
Frame-shiftENST00000375866ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
Frame-shiftENST00000375882ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
Frame-shiftENST00000375885ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000383427ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000383431ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000383433ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000400110ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000400116ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000412802ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000413083ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000416194ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000418230ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000422261ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000422567ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000424502ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000428483ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000429633ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000431476ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000432290ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000436169ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000437010ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000439572ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000443673ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000448596ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000451917ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000452985ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000453234ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000454382ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000454511ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000455161ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000458330ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000464220ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000468132ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000476022ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000480866ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000485003ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-3CDSENST00000488020ENST00000375864CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000383427ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000383431ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000383433ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000400110ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000400116ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000412802ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000413083ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000416194ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000418230ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000422261ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000422567ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000424502ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000428483ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000429633ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000431476ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000432290ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000436169ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000437010ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000439572ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000443673ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000448596ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000451917ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000452985ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000453234ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000454382ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000454511ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000455161ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000458330ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000464220ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000468132ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000476022ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000480866ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000485003ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-5UTRENST00000488020ENST00000409525CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383427ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383431ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000471088CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000480515CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000480530CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000484964CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000383433ENST00000556456CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000400110ENST00000383429CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000400110ENST00000437674CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000400110ENST00000456439CSNK2Bchr6

31636949

+LY6G5Bchr6

31638750

+
intron-intronENST00000400110ENST00000471088CSNK2Bchr6

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intron-intronENST00000400110ENST00000480515CSNK2Bchr6

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intron-intronENST00000400110ENST00000480530CSNK2Bchr6

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intron-intronENST00000400110ENST00000484964CSNK2Bchr6

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intron-intronENST00000400110ENST00000556456CSNK2Bchr6

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intron-intronENST00000400116ENST00000383429CSNK2Bchr6

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intron-intronENST00000400116ENST00000437674CSNK2Bchr6

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intron-intronENST00000400116ENST00000456439CSNK2Bchr6

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intron-intronENST00000400116ENST00000471088CSNK2Bchr6

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intron-intronENST00000400116ENST00000480515CSNK2Bchr6

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intron-intronENST00000400116ENST00000480530CSNK2Bchr6

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intron-intronENST00000400116ENST00000484964CSNK2Bchr6

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intron-intronENST00000400116ENST00000556456CSNK2Bchr6

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intron-intronENST00000412802ENST00000383429CSNK2Bchr6

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intron-intronENST00000412802ENST00000437674CSNK2Bchr6

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intron-intronENST00000412802ENST00000456439CSNK2Bchr6

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intron-intronENST00000412802ENST00000471088CSNK2Bchr6

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intron-intronENST00000412802ENST00000480515CSNK2Bchr6

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intron-intronENST00000412802ENST00000480530CSNK2Bchr6

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intron-intronENST00000412802ENST00000484964CSNK2Bchr6

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intron-intronENST00000412802ENST00000556456CSNK2Bchr6

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intron-intronENST00000413083ENST00000383429CSNK2Bchr6

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intron-intronENST00000413083ENST00000437674CSNK2Bchr6

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intron-intronENST00000413083ENST00000456439CSNK2Bchr6

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intron-intronENST00000413083ENST00000471088CSNK2Bchr6

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intron-intronENST00000413083ENST00000480515CSNK2Bchr6

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intron-intronENST00000413083ENST00000480530CSNK2Bchr6

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intron-intronENST00000413083ENST00000484964CSNK2Bchr6

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intron-intronENST00000413083ENST00000556456CSNK2Bchr6

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intron-intronENST00000416194ENST00000383429CSNK2Bchr6

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intron-intronENST00000416194ENST00000437674CSNK2Bchr6

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intron-intronENST00000416194ENST00000456439CSNK2Bchr6

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intron-intronENST00000416194ENST00000471088CSNK2Bchr6

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intron-intronENST00000416194ENST00000480515CSNK2Bchr6

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intron-intronENST00000416194ENST00000480530CSNK2Bchr6

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intron-intronENST00000416194ENST00000484964CSNK2Bchr6

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intron-intronENST00000416194ENST00000556456CSNK2Bchr6

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intron-intronENST00000418230ENST00000383429CSNK2Bchr6

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intron-intronENST00000418230ENST00000437674CSNK2Bchr6

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intron-intronENST00000418230ENST00000456439CSNK2Bchr6

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intron-intronENST00000418230ENST00000471088CSNK2Bchr6

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intron-intronENST00000418230ENST00000480515CSNK2Bchr6

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intron-intronENST00000418230ENST00000480530CSNK2Bchr6

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intron-intronENST00000418230ENST00000484964CSNK2Bchr6

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intron-intronENST00000418230ENST00000556456CSNK2Bchr6

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intron-intronENST00000422261ENST00000383429CSNK2Bchr6

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intron-intronENST00000422261ENST00000437674CSNK2Bchr6

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intron-intronENST00000422261ENST00000456439CSNK2Bchr6

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intron-intronENST00000422261ENST00000471088CSNK2Bchr6

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intron-intronENST00000422261ENST00000480515CSNK2Bchr6

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intron-intronENST00000422261ENST00000480530CSNK2Bchr6

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intron-intronENST00000422261ENST00000484964CSNK2Bchr6

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intron-intronENST00000422261ENST00000556456CSNK2Bchr6

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intron-intronENST00000422567ENST00000383429CSNK2Bchr6

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intron-intronENST00000422567ENST00000437674CSNK2Bchr6

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intron-intronENST00000422567ENST00000456439CSNK2Bchr6

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intron-intronENST00000422567ENST00000471088CSNK2Bchr6

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intron-intronENST00000422567ENST00000480515CSNK2Bchr6

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intron-intronENST00000422567ENST00000480530CSNK2Bchr6

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intron-intronENST00000422567ENST00000484964CSNK2Bchr6

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intron-intronENST00000422567ENST00000556456CSNK2Bchr6

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intron-intronENST00000424502ENST00000383429CSNK2Bchr6

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intron-intronENST00000424502ENST00000437674CSNK2Bchr6

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intron-intronENST00000424502ENST00000456439CSNK2Bchr6

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intron-intronENST00000424502ENST00000471088CSNK2Bchr6

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intron-intronENST00000424502ENST00000480515CSNK2Bchr6

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intron-intronENST00000424502ENST00000480530CSNK2Bchr6

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intron-intronENST00000424502ENST00000484964CSNK2Bchr6

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intron-intronENST00000424502ENST00000556456CSNK2Bchr6

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intron-intronENST00000428483ENST00000383429CSNK2Bchr6

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intron-intronENST00000428483ENST00000437674CSNK2Bchr6

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intron-intronENST00000428483ENST00000456439CSNK2Bchr6

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intron-intronENST00000428483ENST00000471088CSNK2Bchr6

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intron-intronENST00000428483ENST00000480515CSNK2Bchr6

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intron-intronENST00000428483ENST00000484964CSNK2Bchr6

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intron-intronENST00000428483ENST00000556456CSNK2Bchr6

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intron-intronENST00000429633ENST00000383429CSNK2Bchr6

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intron-intronENST00000429633ENST00000437674CSNK2Bchr6

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intron-intronENST00000429633ENST00000456439CSNK2Bchr6

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intron-intronENST00000429633ENST00000471088CSNK2Bchr6

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intron-intronENST00000429633ENST00000480515CSNK2Bchr6

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intron-intronENST00000429633ENST00000480530CSNK2Bchr6

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intron-intronENST00000429633ENST00000484964CSNK2Bchr6

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intron-intronENST00000429633ENST00000556456CSNK2Bchr6

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intron-intronENST00000431476ENST00000383429CSNK2Bchr6

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intron-intronENST00000431476ENST00000437674CSNK2Bchr6

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intron-intronENST00000431476ENST00000456439CSNK2Bchr6

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intron-intronENST00000431476ENST00000471088CSNK2Bchr6

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intron-intronENST00000431476ENST00000480515CSNK2Bchr6

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intron-intronENST00000431476ENST00000480530CSNK2Bchr6

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intron-intronENST00000431476ENST00000484964CSNK2Bchr6

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intron-intronENST00000431476ENST00000556456CSNK2Bchr6

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intron-intronENST00000432290ENST00000383429CSNK2Bchr6

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intron-intronENST00000432290ENST00000437674CSNK2Bchr6

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intron-intronENST00000432290ENST00000456439CSNK2Bchr6

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intron-intronENST00000432290ENST00000471088CSNK2Bchr6

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intron-intronENST00000432290ENST00000480515CSNK2Bchr6

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intron-intronENST00000432290ENST00000480530CSNK2Bchr6

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intron-intronENST00000432290ENST00000484964CSNK2Bchr6

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intron-intronENST00000432290ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000436169ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000436169ENST00000437674CSNK2Bchr6

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intron-intronENST00000436169ENST00000456439CSNK2Bchr6

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intron-intronENST00000436169ENST00000471088CSNK2Bchr6

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intron-intronENST00000436169ENST00000480515CSNK2Bchr6

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intron-intronENST00000436169ENST00000480530CSNK2Bchr6

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intron-intronENST00000436169ENST00000484964CSNK2Bchr6

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intron-intronENST00000436169ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000437010ENST00000383429CSNK2Bchr6

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intron-intronENST00000437010ENST00000437674CSNK2Bchr6

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intron-intronENST00000437010ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000437010ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000437010ENST00000480515CSNK2Bchr6

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intron-intronENST00000437010ENST00000480530CSNK2Bchr6

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intron-intronENST00000437010ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000437010ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000439572ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000439572ENST00000437674CSNK2Bchr6

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intron-intronENST00000439572ENST00000456439CSNK2Bchr6

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intron-intronENST00000439572ENST00000471088CSNK2Bchr6

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intron-intronENST00000439572ENST00000480515CSNK2Bchr6

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intron-intronENST00000439572ENST00000480530CSNK2Bchr6

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intron-intronENST00000439572ENST00000484964CSNK2Bchr6

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intron-intronENST00000439572ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000437674CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000443673ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000437674CSNK2Bchr6

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intron-intronENST00000448596ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000448596ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000437674CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000451917ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000437674CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000452985ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000437674CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000453234ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000437674CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000456439CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000471088CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000484964CSNK2Bchr6

31636949

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intron-intronENST00000454382ENST00000556456CSNK2Bchr6

31636949

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intron-intronENST00000454511ENST00000383429CSNK2Bchr6

31636949

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intron-intronENST00000454511ENST00000471088CSNK2Bchr6

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intron-intronENST00000454511ENST00000480515CSNK2Bchr6

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intron-intronENST00000455161ENST00000383429CSNK2Bchr6

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intron-intronENST00000455161ENST00000437674CSNK2Bchr6

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intron-intronENST00000455161ENST00000456439CSNK2Bchr6

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intron-intronENST00000455161ENST00000471088CSNK2Bchr6

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intron-intronENST00000455161ENST00000480515CSNK2Bchr6

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intron-intronENST00000455161ENST00000480530CSNK2Bchr6

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intron-intronENST00000455161ENST00000484964CSNK2Bchr6

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intron-intronENST00000455161ENST00000556456CSNK2Bchr6

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intron-intronENST00000458330ENST00000383429CSNK2Bchr6

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intron-intronENST00000458330ENST00000437674CSNK2Bchr6

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intron-intronENST00000458330ENST00000456439CSNK2Bchr6

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intron-intronENST00000458330ENST00000471088CSNK2Bchr6

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intron-intronENST00000458330ENST00000480515CSNK2Bchr6

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intron-intronENST00000458330ENST00000480530CSNK2Bchr6

31636949

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intron-intronENST00000458330ENST00000484964CSNK2Bchr6

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intron-intronENST00000458330ENST00000556456CSNK2Bchr6

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intron-intronENST00000464220ENST00000383429CSNK2Bchr6

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intron-intronENST00000464220ENST00000437674CSNK2Bchr6

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intron-intronENST00000464220ENST00000456439CSNK2Bchr6

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intron-intronENST00000464220ENST00000471088CSNK2Bchr6

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intron-intronENST00000464220ENST00000480515CSNK2Bchr6

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intron-intronENST00000464220ENST00000480530CSNK2Bchr6

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intron-intronENST00000464220ENST00000484964CSNK2Bchr6

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intron-intronENST00000464220ENST00000556456CSNK2Bchr6

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intron-intronENST00000468132ENST00000383429CSNK2Bchr6

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intron-intronENST00000468132ENST00000437674CSNK2Bchr6

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intron-intronENST00000468132ENST00000456439CSNK2Bchr6

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intron-intronENST00000468132ENST00000471088CSNK2Bchr6

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intron-intronENST00000468132ENST00000480515CSNK2Bchr6

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intron-intronENST00000468132ENST00000480530CSNK2Bchr6

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intron-intronENST00000468132ENST00000484964CSNK2Bchr6

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intron-intronENST00000468132ENST00000556456CSNK2Bchr6

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intron-intronENST00000476022ENST00000383429CSNK2Bchr6

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intron-intronENST00000476022ENST00000437674CSNK2Bchr6

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intron-intronENST00000476022ENST00000456439CSNK2Bchr6

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intron-intronENST00000476022ENST00000471088CSNK2Bchr6

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intron-intronENST00000476022ENST00000480515CSNK2Bchr6

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intron-intronENST00000476022ENST00000480530CSNK2Bchr6

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intron-intronENST00000476022ENST00000556456CSNK2Bchr6

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intron-intronENST00000480866ENST00000383429CSNK2Bchr6

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intron-intronENST00000480866ENST00000437674CSNK2Bchr6

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intron-intronENST00000485003ENST00000456439CSNK2Bchr6

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intron-intronENST00000485003ENST00000471088CSNK2Bchr6

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intron-intronENST00000485003ENST00000480515CSNK2Bchr6

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intron-intronENST00000485003ENST00000480530CSNK2Bchr6

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intron-intronENST00000485003ENST00000484964CSNK2Bchr6

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intron-intronENST00000488020ENST00000383429CSNK2Bchr6

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intron-intronENST00000488020ENST00000437674CSNK2Bchr6

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intron-intronENST00000488020ENST00000456439CSNK2Bchr6

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intron-intronENST00000488020ENST00000471088CSNK2Bchr6

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intron-intronENST00000488020ENST00000480515CSNK2Bchr6

31636949

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intron-intronENST00000488020ENST00000480530CSNK2Bchr6

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intron-intronENST00000488020ENST00000484964CSNK2Bchr6

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check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CSNK2B-LY6G5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CSNK2B-LY6G5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31636949/:31638750)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK2B

P67870

LY6G5B

Q8NDX9

FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CSNK2B-LY6G5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CSNK2B-LY6G5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK2B-LY6G5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSNK2B-LY6G5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource