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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM23-CERKL (FusionGDB2 ID:1996)

Fusion Gene Summary for ADAM23-CERKL

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM23-CERKL
Fusion gene ID: 1996
HgeneTgene
Gene symbol

ADAM23

CERKL

Gene ID

8745

375298

Gene nameADAM metallopeptidase domain 23ceramide kinase like
SynonymsMDC-3|MDC3RP26
Cytomap

2q33.3

2q31.3

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 23metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3ceramide kinase-like protein
Modification date2020031320200313
UniProtAcc

O75077

Q49MI3

Ensembl transtripts involved in fusion geneENST00000264377, ENST00000374415, 
ENST00000374416, 		ENST00000479558, 
ENST00000339098, ENST00000374969, 
ENST00000374970, ENST00000409440, 
ENST00000410087, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 5 X 3=45
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM23 [Title/Abstract] AND CERKL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM23(207424842)-CERKL(182468806), # samples:3
Anticipated loss of major functional domain due to fusion event.ADAM23-CERKL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADAM23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CERKL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-33-4538-01AADAM23chr2

207424842

-CERKLchr2

182468806

-
ChimerDB4LUSCTCGA-33-4538-01AADAM23chr2

207424842

+CERKLchr2

182482148

-
ChimerDB4LUSCTCGA-33-4538ADAM23chr2

207424842

+CERKLchr2

182468806

-
ChimerDB4LUSCTCGA-33-4538ADAM23chr2

207424842

+CERKLchr2

182482148

-


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Fusion Gene ORF analysis for ADAM23-CERKL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264377ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182468806

-
5CDS-5UTRENST00000374415ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182468806

-
5CDS-5UTRENST00000374416ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182468806

-
5CDS-intronENST00000264377ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000264377ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000264377ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000264377ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000264377ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000264377ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374415ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182482148

-
5CDS-intronENST00000374416ENST00000479558ADAM23chr2

207424842

+CERKLchr2

182482148

-
Frame-shiftENST00000264377ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000264377ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000264377ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000264377ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000264377ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374415ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374415ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374415ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374415ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374415ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374416ENST00000339098ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374416ENST00000374969ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374416ENST00000374970ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374416ENST00000409440ADAM23chr2

207424842

+CERKLchr2

182468806

-
Frame-shiftENST00000374416ENST00000410087ADAM23chr2

207424842

+CERKLchr2

182468806

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADAM23-CERKL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM23-CERKL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:207424842/:182468806)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM23

O75077

CERKL

Q49MI3

FUNCTION: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.FUNCTION: Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. {ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADAM23-CERKL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADAM23-CERKL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM23-CERKL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAM23-CERKL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource