FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CSTA-CASR (FusionGDB2 ID:19983)

Fusion Gene Summary for CSTA-CASR

check button Fusion gene summary
Fusion gene informationFusion gene name: CSTA-CASR
Fusion gene ID: 19983
HgeneTgene
Gene symbol

CSTA

CASR

Gene ID

1475

846

Gene namecystatin Acalcium sensing receptor
SynonymsAREI|PSS4|STF1|STFACAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1|hCasR
Cytomap

3q21.1

3q13.33-q21.1

Type of geneprotein-codingprotein-coding
Descriptioncystatin-Acystatin A (stefin A)cystatin ASextracellular calcium-sensing receptorparathyroid Ca(2+)-sensing receptor 1parathyroid cell calcium-sensing receptor 1
Modification date2020031320200313
UniProtAcc

P01040

P41180

Ensembl transtripts involved in fusion geneENST00000479204, ENST00000264474, 
ENST00000296154, ENST00000490131, 
ENST00000498619, 
Fusion gene scores* DoF score6 X 7 X 3=1268 X 9 X 7=504
# samples 815
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSTA [Title/Abstract] AND CASR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSTA(122056495)-CASR(121994659), # samples:4
Anticipated loss of major functional domain due to fusion event.CSTA-CASR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSTA

GO:0010466

negative regulation of peptidase activity

6203523

HgeneCSTA

GO:0018149

peptide cross-linking

10908733

HgeneCSTA

GO:0030216

keratinocyte differentiation

10908733

HgeneCSTA

GO:0045861

negative regulation of proteolysis

3488317

TgeneCASR

GO:0005513

detection of calcium ion

27434672

TgeneCASR

GO:0006874

cellular calcium ion homeostasis

27434672

TgeneCASR

GO:0007186

G protein-coupled receptor signaling pathway

27434672

TgeneCASR

GO:0070509

calcium ion import

20846291


check buttonFusion gene breakpoints across CSTA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8082-01ACSTAchr3

122056495

+CASRchr3

121994659

+
ChimerDB4LUSCTCGA-92-8065-01ACSTAchr3

122056494

+CASRchr3

121994658

+
ChimerDB4LUSCTCGA-92-8065-01ACSTAchr3

122056495

-CASRchr3

121994659

+
ChimerDB4LUSCTCGA-92-8065-01ACSTAchr3

122056495

+CASRchr3

121994659

+
ChimerDB4LUSCTCGA-92-8065CSTAchr3

122056495

+CASRchr3

121994658

+
ChimerDB4LUSCTCGA-92-8065CSTAchr3

122056495

+CASRchr3

121994659

+


Top

Fusion Gene ORF analysis for CSTA-CASR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000479204ENST00000296154CSTAchr3

122056495

+CASRchr3

121994659

+
Frame-shiftENST00000479204ENST00000296154CSTAchr3

122056494

+CASRchr3

121994658

+
Frame-shiftENST00000479204ENST00000296154CSTAchr3

122056495

+CASRchr3

121994658

+
Frame-shiftENST00000479204ENST00000490131CSTAchr3

122056495

+CASRchr3

121994659

+
Frame-shiftENST00000479204ENST00000490131CSTAchr3

122056494

+CASRchr3

121994658

+
Frame-shiftENST00000479204ENST00000490131CSTAchr3

122056495

+CASRchr3

121994658

+
Frame-shiftENST00000479204ENST00000498619CSTAchr3

122056495

+CASRchr3

121994659

+
Frame-shiftENST00000479204ENST00000498619CSTAchr3

122056494

+CASRchr3

121994658

+
Frame-shiftENST00000479204ENST00000498619CSTAchr3

122056495

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000296154CSTAchr3

122056495

+CASRchr3

121994659

+
In-frameENST00000264474ENST00000296154CSTAchr3

122056494

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000296154CSTAchr3

122056495

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000490131CSTAchr3

122056495

+CASRchr3

121994659

+
In-frameENST00000264474ENST00000490131CSTAchr3

122056494

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000490131CSTAchr3

122056495

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000498619CSTAchr3

122056495

+CASRchr3

121994659

+
In-frameENST00000264474ENST00000498619CSTAchr3

122056494

+CASRchr3

121994658

+
In-frameENST00000264474ENST00000498619CSTAchr3

122056495

+CASRchr3

121994658

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CSTA-CASR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSTAchr3122056495+CASRchr3121994658+5.78E-091
CSTAchr3122056495+CASRchr3121994658+5.78E-091
CSTAchr3122056495+CASRchr3121994658+5.78E-091
CSTAchr3122056495+CASRchr3121994658+5.78E-091
CSTAchr3122056495+CASRchr3121994658+5.78E-091
CSTAchr3122056495+CASRchr3121994658+5.78E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CSTA-CASR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:122056495/chr3:121994659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSTA

P01040

CASR

P41180

FUNCTION: This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. {ECO:0000269|PubMed:21944047}.FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). {ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSTAchr3:122056494chr3:121994658ENST00000264474+2346_505699.0MotifNote=Secondary area of contact
HgeneCSTAchr3:122056495chr3:121994658ENST00000264474+2346_505699.0MotifNote=Secondary area of contact
HgeneCSTAchr3:122056495chr3:121994659ENST00000264474+2346_505699.0MotifNote=Secondary area of contact
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137542_6124591079.0RegionCysteine-rich (CR)
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137636_6494591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137671_6814591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137701_7244591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137746_7694591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137793_8054591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137829_8364591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137863_10784591079.0Topological domainCytoplasmic
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426837_8624591079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137837_8624591079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426837_8624591079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137837_8624591079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426837_8624591079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137613_6354591079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137650_6704591079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137682_7004591079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137725_7454591079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137770_7924591079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137806_8284591079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137837_8624591079.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056494chr3:121994658ENST000002961542622_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056494chr3:121994658ENST000002961542666_704591079.0RegionAnion binding
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056494chr3:121994658ENST000004901313722_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056494chr3:121994658ENST000004901313766_704591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056495chr3:121994658ENST000002961542622_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994658ENST000002961542666_704591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056495chr3:121994658ENST000004901313722_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994658ENST000004901313766_704591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056495chr3:121994659ENST000002961542622_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994659ENST000002961542666_704591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137189_3244591079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:122056495chr3:121994659ENST000004901313722_1884591079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137415_4174591079.0RegionAnion binding
TgeneCASRchr3:122056495chr3:121994659ENST000004901313766_704591079.0RegionAnion binding
TgeneCASRchr3:122056494chr3:121994658ENST000002961542620_6124591079.0Topological domainExtracellular
TgeneCASRchr3:122056494chr3:121994658ENST000004901313720_6124591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST000002961542620_6124591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994658ENST000004901313720_6124591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST000002961542620_6124591079.0Topological domainExtracellular
TgeneCASRchr3:122056495chr3:121994659ENST000004901313720_6124591079.0Topological domainExtracellular


Top

Fusion Gene Sequence for CSTA-CASR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CSTA-CASR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCASRchr3:122056494chr3:121994658ENST0000029615426880_900459.01079.0RNF19A
TgeneCASRchr3:122056494chr3:121994658ENST0000049013137880_900459.01079.0RNF19A
TgeneCASRchr3:122056495chr3:121994658ENST0000029615426880_900459.01079.0RNF19A
TgeneCASRchr3:122056495chr3:121994658ENST0000049013137880_900459.01079.0RNF19A
TgeneCASRchr3:122056495chr3:121994659ENST0000029615426880_900459.01079.0RNF19A
TgeneCASRchr3:122056495chr3:121994659ENST0000049013137880_900459.01079.0RNF19A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CSTA-CASR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CSTA-CASR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource