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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTBP2-FGFR2 (FusionGDB2 ID:20054)

Fusion Gene Summary for CTBP2-FGFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTBP2-FGFR2
Fusion gene ID: 20054
HgeneTgene
Gene symbol

CTBP2

FGFR2

Gene ID

1488

2263

Gene nameC-terminal binding protein 2fibroblast growth factor receptor 2
Synonyms-BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25
Cytomap

10q26.13

10q26.13

Type of geneprotein-codingprotein-coding
DescriptionC-terminal-binding protein 2ribeyefibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14
Modification date2020031320200322
UniProtAcc.

P21802

Ensembl transtripts involved in fusion geneENST00000337195, ENST00000476817, 
ENST00000494626, ENST00000309035, 
ENST00000334808, ENST00000411419, 
ENST00000531469, 		ENST00000369061, 
ENST00000351936, ENST00000356226, 
ENST00000357555, ENST00000358487, 
ENST00000359354, ENST00000360144, 
ENST00000369059, ENST00000369060, 
ENST00000457416, ENST00000490349, 
ENST00000346997, ENST00000369056, 
ENST00000478859, 
Fusion gene scores* DoF score20 X 14 X 8=224011 X 11 X 8=968
# samples 2516
** MAII scorelog2(25/2240*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/968*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTBP2 [Title/Abstract] AND FGFR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTBP2(126848888)-FGFR2(123353481), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

TgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

TgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across CTBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FGFR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5772CTBP2chr10

126848888

-FGFR2chr10

123353481

-


Top

Fusion Gene ORF analysis for CTBP2-FGFR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337195ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-3CDSENST00000476817ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-3CDSENST00000494626ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000337195ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000476817ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-5UTRENST00000494626ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000337195ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000337195ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000337195ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000476817ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000476817ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000476817ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000494626ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000494626ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
5UTR-intronENST00000494626ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-3CDSENST00000309035ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-3CDSENST00000334808ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-3CDSENST00000411419ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-3CDSENST00000531469ENST00000369061CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000309035ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000334808ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000411419ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000351936CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000356226CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000357555CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000358487CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000359354CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000360144CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000369059CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000369060CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000457416CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-5UTRENST00000531469ENST00000490349CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000309035ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000309035ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000309035ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000334808ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000334808ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000334808ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000411419ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000411419ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000411419ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000531469ENST00000346997CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000531469ENST00000369056CTBP2chr10

126848888

-FGFR2chr10

123353481

-
intron-intronENST00000531469ENST00000478859CTBP2chr10

126848888

-FGFR2chr10

123353481

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CTBP2-FGFR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTBP2-FGFR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:126848888/:123353481)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGFR2

P21802

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CTBP2-FGFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CTBP2-FGFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTBP2-FGFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTBP2-FGFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource