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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTCFL-MAPKAPK5 (FusionGDB2 ID:20104)

Fusion Gene Summary for CTCFL-MAPKAPK5

check button Fusion gene summary
Fusion gene informationFusion gene name: CTCFL-MAPKAPK5
Fusion gene ID: 20104
HgeneTgene
Gene symbol

CTCFL

MAPKAPK5

Gene ID

140690

8550

Gene nameCCCTC-binding factor likeMAPK activated protein kinase 5
SynonymsBORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2MAPKAP-K5|MK-5|MK5|PRAK
Cytomap

20q13.31

12q24.12-q24.13

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor CTCFLBORIS-like proteinbrother of the regulator of imprinted sitescancer/testis antigen 27MAP kinase-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5mitogen-activated protein kinase-activated protein kinase 5p38-regulated/activated protein kinase
Modification date2020031320200313
UniProtAcc

Q8NI51

Q8IW41

Ensembl transtripts involved in fusion geneENST00000243914, ENST00000371196, 
ENST00000422869, ENST00000423479, 
ENST00000429804, ENST00000432255, 
ENST00000433949, ENST00000481655, 
ENST00000502686, ENST00000539382, 
ENST00000608158, ENST00000608263, 
ENST00000608425, ENST00000608440, 
ENST00000608858, ENST00000608903, 
ENST00000609232, 		ENST00000546394, 
ENST00000547305, ENST00000550735, 
ENST00000551404, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 10 X 3=240
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTCFL [Title/Abstract] AND MAPKAPK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTCFL(56085863)-MAPKAPK5(112297103), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTCFL

GO:0010628

positive regulation of gene expression

18413740

HgeneCTCFL

GO:0045893

positive regulation of transcription, DNA-templated

18413740

HgeneCTCFL

GO:0045944

positive regulation of transcription by RNA polymerase II

16140944

TgeneMAPKAPK5

GO:0006417

regulation of translation

21329882

TgeneMAPKAPK5

GO:0007265

Ras protein signal transduction

17254968

TgeneMAPKAPK5

GO:0046777

protein autophosphorylation

21329882

TgeneMAPKAPK5

GO:0090400

stress-induced premature senescence

17254968


check buttonFusion gene breakpoints across CTCFL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAPKAPK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC576418CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+


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Fusion Gene ORF analysis for CTCFL-MAPKAPK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000243914ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000243914ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000243914ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000243914ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000371196ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000371196ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000371196ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000371196ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000422869ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000422869ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000422869ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000422869ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000423479ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000423479ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000423479ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000423479ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000429804ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000429804ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000429804ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000429804ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000432255ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000432255ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000432255ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000432255ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000433949ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000433949ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000433949ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000433949ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000481655ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000481655ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000481655ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000481655ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000502686ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000502686ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000502686ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000502686ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000539382ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000539382ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000539382ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000539382ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608158ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608158ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608158ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608158ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608263ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608263ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608263ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608263ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608425ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608425ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608425ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608425ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608440ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608440ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608440ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608440ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608858ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608858ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608858ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608858ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608903ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608903ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608903ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000608903ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000609232ENST00000546394CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000609232ENST00000547305CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000609232ENST00000550735CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+
intron-intronENST00000609232ENST00000551404CTCFLchr20

56085863

-MAPKAPK5chr12

112297103

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CTCFL-MAPKAPK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTCFL-MAPKAPK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56085863/:112297103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTCFL

Q8NI51

MAPKAPK5

Q8IW41

FUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}.FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CTCFL-MAPKAPK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CTCFL-MAPKAPK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTCFL-MAPKAPK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTCFL-MAPKAPK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource