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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTDSP2-HMGA2 (FusionGDB2 ID:20174)

Fusion Gene Summary for CTDSP2-HMGA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDSP2-HMGA2
Fusion gene ID: 20174
HgeneTgene
Gene symbol

CTDSP2

HMGA2

Gene ID

10106

8091

Gene nameCTD small phosphatase 2high mobility group AT-hook 2
SynonymsOS4|PSR2|SCP2BABL|HMGI-C|HMGIC|LIPO|STQTL9
Cytomap

12q14.1

12q14.3

Type of geneprotein-codingprotein-coding
Descriptioncarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-interahigh mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
Modification date2020031320200329
UniProtAcc

O14595

P52926

Ensembl transtripts involved in fusion geneENST00000398073, ENST00000548823, 
ENST00000547701, 		ENST00000354636, 
ENST00000393578, ENST00000425208, 
ENST00000536545, ENST00000541363, 
ENST00000393577, ENST00000403681, 
Fusion gene scores* DoF score32 X 8 X 10=256016 X 12 X 5=960
# samples 3715
** MAII scorelog2(37/2560*10)=-2.79054663437105
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/960*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTDSP2 [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTDSP2(58240155)-HMGA2(66345163), # samples:1
CTDSP2(58240154)-HMGA2(66345162), # samples:1
Anticipated loss of major functional domain due to fusion event.CTDSP2-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CTDSP2-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CTDSP2-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTDSP2

GO:0006470

protein dephosphorylation

12721286

TgeneHMGA2

GO:0000122

negative regulation of transcription by RNA polymerase II

14627817

TgeneHMGA2

GO:0002062

chondrocyte differentiation

21484705

TgeneHMGA2

GO:0006284

base-excision repair

19465398

TgeneHMGA2

GO:0007095

mitotic G2 DNA damage checkpoint

16061642

TgeneHMGA2

GO:0010564

regulation of cell cycle process

14645522

TgeneHMGA2

GO:0010628

positive regulation of gene expression

18832382

TgeneHMGA2

GO:0031052

chromosome breakage

19549901

TgeneHMGA2

GO:0031507

heterochromatin assembly

16901784

TgeneHMGA2

GO:0035978

histone H2A-S139 phosphorylation

16061642

TgeneHMGA2

GO:0035986

senescence-associated heterochromatin focus assembly

16901784

TgeneHMGA2

GO:0035988

chondrocyte proliferation

21484705

TgeneHMGA2

GO:0042769

DNA damage response, detection of DNA damage

19465398

TgeneHMGA2

GO:0043065

positive regulation of apoptotic process

16061642

TgeneHMGA2

GO:0043066

negative regulation of apoptotic process

19465398

TgeneHMGA2

GO:0043392

negative regulation of DNA binding

14645522

TgeneHMGA2

GO:0043922

negative regulation by host of viral transcription

17005673

TgeneHMGA2

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

17005673

TgeneHMGA2

GO:0045892

negative regulation of transcription, DNA-templated

18832382

TgeneHMGA2

GO:0045893

positive regulation of transcription, DNA-templated

15225648|15755872|17005673|17324944|17426251

TgeneHMGA2

GO:0045944

positive regulation of transcription by RNA polymerase II

14645522|18832382

TgeneHMGA2

GO:0071158

positive regulation of cell cycle arrest

16061642

TgeneHMGA2

GO:0071902

positive regulation of protein serine/threonine kinase activity

19549901

TgeneHMGA2

GO:0090402

oncogene-induced cell senescence

16901784

TgeneHMGA2

GO:2000648

positive regulation of stem cell proliferation

21484705

TgeneHMGA2

GO:2000679

positive regulation of transcription regulatory region DNA binding

18832382

TgeneHMGA2

GO:2000685

positive regulation of cellular response to X-ray

16061642

TgeneHMGA2

GO:2001022

positive regulation of response to DNA damage stimulus

16061642|19465398

TgeneHMGA2

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

19549901

TgeneHMGA2

GO:2001038

regulation of cellular response to drug

16061642


check buttonFusion gene breakpoints across CTDSP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HMGA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IF-A3RQ-01ACTDSP2chr12

58240155

-HMGA2chr12

66345163

+
ChimerDB4SARCTCGA-IF-A3RQCTDSP2chr12

58240154

-HMGA2chr12

66345162

+


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Fusion Gene ORF analysis for CTDSP2-HMGA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398073ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000354636CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000398073ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000393578CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000398073ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000425208CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000398073ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000536545CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000548823ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000354636CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000548823ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000393578CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000548823ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000425208CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
5CDS-intronENST00000548823ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000536545CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
Frame-shiftENST00000398073ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
Frame-shiftENST00000398073ENST00000541363CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
Frame-shiftENST00000548823ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
Frame-shiftENST00000548823ENST00000541363CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
In-frameENST00000398073ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000398073ENST00000393577CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
In-frameENST00000398073ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000398073ENST00000403681CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
In-frameENST00000548823ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000548823ENST00000393577CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
In-frameENST00000548823ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000548823ENST00000403681CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-3CDSENST00000547701ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000393577CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-3CDSENST00000547701ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000403681CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-3CDSENST00000547701ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000541363CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-intronENST00000547701ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000354636CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-intronENST00000547701ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000393578CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-intronENST00000547701ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000425208CTDSP2chr12

58240154

-HMGA2chr12

66345162

+
intron-intronENST00000547701ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000536545CTDSP2chr12

58240154

-HMGA2chr12

66345162

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398073CTDSP2chr1258240155-ENST00000403681HMGA2chr1266345163+3452368126614162
ENST00000398073CTDSP2chr1258240155-ENST00000393577HMGA2chr1266345163+582368126503125
ENST00000548823CTDSP2chr1258240155-ENST00000403681HMGA2chr1266345163+341733391579162
ENST00000548823CTDSP2chr1258240155-ENST00000393577HMGA2chr1266345163+54733391468125
ENST00000398073CTDSP2chr1258240154-ENST00000403681HMGA2chr1266345162+3452368126614162
ENST00000398073CTDSP2chr1258240154-ENST00000393577HMGA2chr1266345162+582368126503125
ENST00000548823CTDSP2chr1258240154-ENST00000403681HMGA2chr1266345162+341733391579162
ENST00000548823CTDSP2chr1258240154-ENST00000393577HMGA2chr1266345162+54733391468125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398073ENST00000403681CTDSP2chr1258240155-HMGA2chr1266345163+0.42277640.5772236
ENST00000398073ENST00000393577CTDSP2chr1258240155-HMGA2chr1266345163+0.74695870.2530413
ENST00000548823ENST00000403681CTDSP2chr1258240155-HMGA2chr1266345163+0.4490180.550982
ENST00000548823ENST00000393577CTDSP2chr1258240155-HMGA2chr1266345163+0.836703540.16329645
ENST00000398073ENST00000403681CTDSP2chr1258240154-HMGA2chr1266345162+0.42277640.5772236
ENST00000398073ENST00000393577CTDSP2chr1258240154-HMGA2chr1266345162+0.74695870.2530413
ENST00000548823ENST00000403681CTDSP2chr1258240154-HMGA2chr1266345162+0.4490180.550982
ENST00000548823ENST00000393577CTDSP2chr1258240154-HMGA2chr1266345162+0.836703540.16329645

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Fusion Genomic Features for CTDSP2-HMGA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTDSP2chr1258240154-HMGA2chr1266345162+1.26E-060.9999987
CTDSP2chr1258240154-HMGA2chr1266345162+1.26E-060.9999987
CTDSP2chr1258240154-HMGA2chr1266345162+1.26E-060.9999987
CTDSP2chr1258240154-HMGA2chr1266345162+1.26E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTDSP2-HMGA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58240155/chr12:66345163)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDSP2

O14595

HMGA2

P52926

FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHMGA2chr12:58240154chr12:66345162ENST000003546360424_340107.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240154chr12:66345162ENST000003546360444_540107.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240154chr12:66345162ENST000003546360471_820107.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240154chr12:66345162ENST000003935780424_34091.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240154chr12:66345162ENST000003935780444_54091.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240154chr12:66345162ENST000003935780471_82091.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240154chr12:66345162ENST000004252080424_34093.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240154chr12:66345162ENST000004252080444_54093.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240154chr12:66345162ENST000004252080471_82093.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST000003546360424_340107.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST000003546360444_540107.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST000003546360471_820107.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST000003935780424_34091.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST000003935780444_54091.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST000003935780471_82091.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST000004252080424_34093.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST000004252080444_54093.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST000004252080471_82093.0DNA bindingNote=A.T hook 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTDSP2chr12:58240154chr12:66345162ENST00000398073-1897_25521272.0DomainFCP1 homology
HgeneCTDSP2chr12:58240155chr12:66345163ENST00000398073-1897_25521272.0DomainFCP1 homology
TgeneHMGA2chr12:58240154chr12:66345162ENST000004036812524_3483110.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240154chr12:66345162ENST000004036812544_5483110.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240154chr12:66345162ENST000004036812571_8283110.0DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST000004036812524_3483110.0DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST000004036812544_5483110.0DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST000004036812571_8283110.0DNA bindingNote=A.T hook 3


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Fusion Gene Sequence for CTDSP2-HMGA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20174_20174_1_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000398073_HMGA2_chr12_66345162_ENST00000393577_length(transcript)=582nt_BP=368nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATC
TACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATA

>20174_20174_1_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000398073_HMGA2_chr12_66345162_ENST00000393577_length(amino acids)=125AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_2_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000398073_HMGA2_chr12_66345162_ENST00000403681_length(transcript)=3452nt_BP=368nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGG
GGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATG
GTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTA
TATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACT
TTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTT
TAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTG
TGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTT
TTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCT
AACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATA
TCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCC
ATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTA
CAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAA
AAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGT
TTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGG
TGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCT
CTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATT
CTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTAT
GTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTC
CTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTAC
CTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCAT
TCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAAC
ACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGC
AACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGT
ATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAG
TGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTG
AAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCG
CTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTG
GCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCA
TGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTAC
TACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTAT
ATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTT
TTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTG
TCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTG
TATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTTCCATTAA

>20174_20174_2_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000398073_HMGA2_chr12_66345162_ENST00000403681_length(amino acids)=162AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_3_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000548823_HMGA2_chr12_66345162_ENST00000393577_length(transcript)=547nt_BP=333nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATT
GAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATG

>20174_20174_3_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000548823_HMGA2_chr12_66345162_ENST00000393577_length(amino acids)=125AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_4_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000548823_HMGA2_chr12_66345162_ENST00000403681_length(transcript)=3417nt_BP=333nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGT
TGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGG
GGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCC
CAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAA
TAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACG
TGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTG
TAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATT
TTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAA
AGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGT
TTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGC
ATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTAT
GAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCT
CTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAAT
TAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCAT
TCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTA
TTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTA
CAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTT
CAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACT
ACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGA
CTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAAC
TGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAA
TAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAAT
ATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCA
ACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAAC
TGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAG
CTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGA
GAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTG
GATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCAT
CTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATA
CTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTAT
AGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGG
AGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAAT
TGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAAC

>20174_20174_4_CTDSP2-HMGA2_CTDSP2_chr12_58240154_ENST00000548823_HMGA2_chr12_66345162_ENST00000403681_length(amino acids)=162AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_5_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000398073_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=582nt_BP=368nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATC
TACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATA

>20174_20174_5_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000398073_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=125AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_6_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000398073_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3452nt_BP=368nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGG
GGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATG
GTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTA
TATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACT
TTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTT
TAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTG
TGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTT
TTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCT
AACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATA
TCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCC
ATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTA
CAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAA
AAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGT
TTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGG
TGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCT
CTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATT
CTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTAT
GTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTC
CTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTAC
CTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCAT
TCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAAC
ACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGC
AACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGT
ATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAG
TGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTG
AAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCG
CTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTG
GCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCA
TGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTAC
TACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTAT
ATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTT
TTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTG
TCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTG
TATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTTCCATTAA

>20174_20174_6_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000398073_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=162AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_7_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000548823_HMGA2_chr12_66345163_ENST00000393577_length(transcript)=547nt_BP=333nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATT
GAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATG

>20174_20174_7_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000548823_HMGA2_chr12_66345163_ENST00000393577_length(amino acids)=125AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

--------------------------------------------------------------
>20174_20174_8_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000548823_HMGA2_chr12_66345163_ENST00000403681_length(transcript)=3417nt_BP=333nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGT
TGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGG
GGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCC
CAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAA
TAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACG
TGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTG
TAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATT
TTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAA
AGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGT
TTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGC
ATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTAT
GAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCT
CTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAAT
TAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCAT
TCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTA
TTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTA
CAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTT
CAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACT
ACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGA
CTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAAC
TGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAA
TAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAAT
ATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCA
ACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAAC
TGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAG
CTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGA
GAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTG
GATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCAT
CTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATA
CTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTAT
AGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGG
AGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAAT
TGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAAC

>20174_20174_8_CTDSP2-HMGA2_CTDSP2_chr12_58240155_ENST00000548823_HMGA2_chr12_66345163_ENST00000403681_length(amino acids)=162AA_BP=80
MYRPPPFPVRGGNERGDVNSCGSRSLGSRSGPPPRPPSPAQPARPPVLPPSQPGPAGLLDGTRLHHHPGAEGRRPGAHQASHNKLFRRSL

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Fusion Gene PPI Analysis for CTDSP2-HMGA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHMGA2chr12:58240154chr12:66345162ENST000003546360444_630107.0E4F1
TgeneHMGA2chr12:58240154chr12:66345162ENST000003935780444_63091.0E4F1
TgeneHMGA2chr12:58240154chr12:66345162ENST000004252080444_63093.0E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST000003546360444_630107.0E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST000003935780444_63091.0E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST000004252080444_63093.0E4F1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHMGA2chr12:58240154chr12:66345162ENST000004036812544_6383.0110.0E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST000004036812544_6383.0110.0E4F1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTDSP2-HMGA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTDSP2-HMGA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource