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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTDSPL-PMEPA1 (FusionGDB2 ID:20209)

Fusion Gene Summary for CTDSPL-PMEPA1

Fusion gene summary

Fusion gene information	Fusion gene name: CTDSPL-PMEPA1
	Fusion gene ID: 20209
		Hgene	Tgene
	Gene symbol	CTDSPL	PMEPA1
	Gene ID	10217	56937
	Gene name	CTD small phosphatase like	prostate transmembrane protein, androgen induced 1
	Synonyms	C3orf8\|HYA22\|PSR1\|RBSP3\|SCP3	STAG1\|TMEPAI
	Cytomap	3p22.2	20q13.31
	Type of gene	protein-coding	protein-coding
	Description	CTD small phosphatase-like proteinCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-likeCTDSP-likeNIF-like proteinNLI-interacting factor 1RB protein serine phosphatase from chromosome 3carboxy-terminal domain RNA poly	protein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
	Modification date	20200313	20200313
	UniProtAcc	O15194	.
	Ensembl transtripts involved in fusion gene	ENST00000273179, ENST00000443503, ENST00000310189,	ENST00000265626, ENST00000347215, ENST00000395814, ENST00000395816, ENST00000472841, ENST00000341744,
Fusion gene scores	* DoF score	8 X 6 X 6=288	8 X 5 X 5=200
	# samples	8	8
	** MAII score	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTDSPL [Title/Abstract] AND PMEPA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTDSPL(37903769)-PMEPA1(56234753), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PMEPA1	GO:0010991	negative regulation of SMAD protein complex assembly	20129061
Tgene	PMEPA1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	24627487
Tgene	PMEPA1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	24627487

Fusion gene breakpoints across CTDSPL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PMEPA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8687	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-

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Fusion Gene ORF analysis for CTDSPL-PMEPA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000273179	ENST00000265626	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000273179	ENST00000347215	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000273179	ENST00000395814	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000273179	ENST00000395816	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000273179	ENST00000472841	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000443503	ENST00000265626	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000443503	ENST00000347215	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000443503	ENST00000395814	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000443503	ENST00000395816	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
5CDS-5UTR	ENST00000443503	ENST00000472841	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
In-frame	ENST00000273179	ENST00000341744	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
In-frame	ENST00000443503	ENST00000341744	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-3CDS	ENST00000310189	ENST00000341744	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-5UTR	ENST00000310189	ENST00000265626	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-5UTR	ENST00000310189	ENST00000347215	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-5UTR	ENST00000310189	ENST00000395814	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-5UTR	ENST00000310189	ENST00000395816	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-
intron-5UTR	ENST00000310189	ENST00000472841	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000443503

CTDSPL

chr3

37903769

ENST00000341744

PMEPA1

chr20

56234753

4735

319

1073

335

ENST00000273179

CTDSPL

chr3

37903769

ENST00000341744

PMEPA1

chr20

56234753

4521

105

859

277

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000443503	ENST00000341744	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-	0.011964994	0.988035
ENST00000273179	ENST00000341744	CTDSPL	chr3	37903769	+	PMEPA1	chr20	56234753	-	0.010699435	0.98930055

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Fusion Genomic Features for CTDSPL-PMEPA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTDSPL-PMEPA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:37903769/chr20:56234753)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTDSPL O15194	.
FUNCTION: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269\|PubMed:12721286}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000265626

158_161

238.0

Motif

Note=PPxY motif 1

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000265626

229_232

238.0

Motif

Note=PPxY motif 2

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000341744

158_161

288.0

Motif

Note=PPxY motif 1

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000341744

229_232

288.0

Motif

Note=PPxY motif 2

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000347215

158_161

253.0

Motif

Note=PPxY motif 1

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000347215

229_232

253.0

Motif

Note=PPxY motif 2

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395814

158_161

238.0

Motif

Note=PPxY motif 1

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395814

229_232

238.0

Motif

Note=PPxY motif 2

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395816

158_161

238.0

Motif

Note=PPxY motif 1

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395816

229_232

238.0

Motif

Note=PPxY motif 2

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000265626

1_40

238.0

Topological domain

Lumenal

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000265626

64_287

238.0

Topological domain

Cytoplasmic

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000341744

64_287

288.0

Topological domain

Cytoplasmic

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000347215

1_40

253.0

Topological domain

Lumenal

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000347215

64_287

253.0

Topological domain

Cytoplasmic

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395814

1_40

238.0

Topological domain

Lumenal

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395814

64_287

238.0

Topological domain

Cytoplasmic

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395816

1_40

238.0

Topological domain

Lumenal

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395816

64_287

238.0

Topological domain

Cytoplasmic

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000265626

41_63

238.0

Transmembrane

Helical

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000341744

41_63

288.0

Transmembrane

Helical

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000347215

41_63

253.0

Transmembrane

Helical

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395814

41_63

238.0

Transmembrane

Helical

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000395816

41_63

238.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTDSPL

chr3:37903769

chr20:56234753

ENST00000273179

102_260

277.0

Domain

FCP1 homology

Hgene

CTDSPL

chr3:37903769

chr20:56234753

ENST00000443503

102_260

266.0

Domain

FCP1 homology

Tgene

PMEPA1

chr3:37903769

chr20:56234753

ENST00000341744

1_40

288.0

Topological domain

Lumenal

Top

Fusion Gene Sequence for CTDSPL-PMEPA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20209_20209_1_CTDSPL-PMEPA1_CTDSPL_chr3_37903769_ENST00000273179_PMEPA1_chr20_56234753_ENST00000341744_length(transcript)=4521nt_BP=105nt
GCGGGCGGCCGCCGCGCCGCGCACCCATGGACGGCCCGGCCATCATCACCCAGGTGACCAACCCCAAGGAGGACGAGGGCCGGTTGCCGG
GCGCGGGCGAGAAAGCGGAGCTGGAGTTTGTTCAGATCATCATCATCGTGGTGGTGATGATGGTGATGGTGGTGGTGATCACGTGCCTGC
TGAGCCACTACAAGCTGTCTGCACGGTCCTTCATCAGCCGGCACAGCCAGGGGCGGAGGAGAGAAGATGCCCTGTCCTCAGAAGGATGCC
TGTGGCCCTCGGAGAGCACAGTGTCAGGCAACGGAATCCCAGAGCCGCAGGTCTACGCCCCGCCTCGGCCCACCGACCGCCTGGCCGTGC
CGCCCTTCGCCCAGCGGGAGCGCTTCCACCGCTTCCAGCCCACCTATCCGTACCTGCAGCACGAGATCGACCTGCCACCCACCATCTCGC
TGTCAGACGGGGAGGAGCCCCCACCCTACCAGGGCCCCTGCACCCTCCAGCTTCGGGACCCCGAGCAGCAGCTGGAACTGAACCGGGAGT
CGGTGCGCGCACCCCCAAACAGAACCATCTTCGACAGTGACCTGATGGATAGTGCCAGGCTGGGCGGCCCCTGCCCCCCCAGCAGTAACT
CGGGCATCAGCGCCACGTGCTACGGCAGCGGCGGGCGCATGGAGGGGCCGCCGCCCACCTACAGCGAGGTCATCGGCCACTACCCGGGGT
CCTCCTTCCAGCACCAGCAGAGCAGTGGGCCGCCCTCCTTGCTGGAGGGGACCCGGCTCCACCACACACACATCGCGCCCCTAGAGAGCG
CAGCCATCTGGAGCAAAGAGAAGGATAAACAGAAAGGACACCCTCTCTAGGGTCCCCAGGGGGGCCGGGCTGGGGCTGCGTAGGTGAAAA
GGCAGAACACTCCGCGCTTCTTAGAAGAGGAGTGAGAGGAAGGCGGGGGGCGCAGCAACGCATCGTGTGGCCCTCCCCTCCCACCTCCCT
GTGTATAAATATTTACATGTGATGTCTGGTCTGAATGCACAAGCTAAGAGAGCTTGCAAAAAAAAAAAGAAAAAAGAAAAAAAAAAACCA
CGTTTCTTTGTTGAGCTGTGTCTTGAAGGCAAAAGAAAAAAAATTTCTACAGTAGTCTTTCTTGTTTCTAGTTGAGCTGCGTGCGTGAAT
GCTTATTTTCTTTTGTTTATGATAATTTCACTTAACTTTAAAGACATATTTGCACAAAACCTTTGTTTAAAGATCTGCAATATTATATAT
ATAAATATATATAAGATAAGAGAAACTGTATGTGCGAGGGCAGGAGTATTTTTGTATTAGAAGAGGCCTATTAAAAAAAAAAGTTGTTTT
CTGAACTAGAAGAGGAAAAAAATGGCAATTTTTGAGTGCCAAGTCAGAAAGTGTGTATTACCTTGTAAAGAAAAAAATTACAAAGCAGGG
GTTTAGAGTTATTTATATAAATGTTGAGATTTTGCACTATTTTTTAATATAAATATGTCAGTGCTTGCTTGATGGAAACTTCTCTTGTGT
CTGTTGAGACTTTAAGGGAGAAATGTCGGAATTTCAGAGTCGCCTGACGGCAGAGGGTGAGCCCCCGTGGAGTCTGCAGAGAGGCCTTGG
CCAGGAGCGGCGGGCTTTCCCGAGGGGCCACTGTCCCTGCAGAGTGGATGCTTCTGCCTAGTGACAGGTTATCACCACGTTATATATTCC
CTACCGAAGGAGACACCTTTTCCCCCCTGACCCAGAACAGCCTTTAAATCACAAGCAAAATAGGAAAGTTAACCACGGAGGCACCGAGTT
CCAGGTAGTGGTTTTGCCTTTCCCAAAAATGAAAATAAACTGTTACCGAAGGAATTAGTTTTTCCTCTTCTTTTTTCCAACTGTGAAGGT
CCCCGTGGGGTGGAGCATGGTGCCCCTCACAAGCCGCAGCGGCTGGTGCCCGGGCTACCAGGGACATGCCAGAGGGCTCGATGACTTGTC
TCTGCAGGGCGCTTTGGTGGTTGTTCAGCTGGCTAAAGGTTCACCGGTGAAGGCAGGTGCGGTAACTGCCGCACTGGACCCTAGGAAGCC
CCAGGTATTCGCAATCTGACCTCCTCCTGTCTGTTTCCCTTCACGGATCAATTCTCACTTAAGAGGCCAATAAACAACCCAACATGAAAA
GGTGACAAGCCTGGGTTTCTCCCAGGATAGGTGAAAGGGTTAAAATGAGTAAAGCAGTTGAGCAAACACCAACCCGAGCTTCGGGCGCAG
AATTCTTCACCTTCTCTTCCCCTTTCCATCTCCTTTCCCCGCGGAAACAACGCTTCCCTTCTGGTGTGTCTGTTGATCTGTGTTTTCATT
TACATCTCTCTTAGACTCCGCTCTTGTTCTCCAGGTTTTCACCAGATAGATTTGGGGTTGGCGGGACCTGCTGGTGACGTGCAGGTGAAG
GACAGGAAGGGGCATGTGAGCGTAAATAGAGGTGACCAGAGGAGAGCATGAGGGGTGGGGCTTTGGGACCCACCGGGGCCAGTGGCTGGA
GCTTGACGTCTTTCCTCCCCATGGGGGTGGGAGGGCCCCCAGCTGGAAGAGCAGACTCCCAGCTGCTACCCCCTCCCTTCCCATGGGAGT
GGCTTTCCATTTTGGGCAGAATGCTGACTAGTAGACTAACATAAAAGATATAAAAGGCAATAACTATTGTTTGTGAGCAACTTTTTTATA
ACTTCCAAAACAAAAACCTGAGCACAGTTTTGAAGTTCTAGCCACTCGAGCTCATGCATGTGAAACGTGTGCTTTACGAAGGTGGCAGCT
GACAGACGTGGGCTCTGCATGCCGCCAGCCTAGTAGAAAGTTCTCGTTCATTGGCAACAGCAGAACCTGCCTCTCCGTGAAGTCGTCAGC
CTAAAATTTGTTTCTCTCTTGAAGAGGATTCTTTGAAAAGGTCCTGCAGAGAAATCAGTACAGGTTATCCCGAAAGGTACAAGGACGCAC
TTGTAAAGATGATTAAAACGTATCTTTCCTTTATGTGACGCGTCTCTAGTGCCTTACTGAAGAAGCAGTGACACTCCCGTCGCTCGGTGA
GGACGTTCCCGGACAGTGCCTCACTCACCTGGGACTGGTATCCCCTCCCAGGGTCCACCAAGGGCTCCTGCTTTTCAGACACCCCATCAT
CCTCGCGCGTCCTCACCCTGTCTCTACCAGGGAGGTGCCTAGCTTGGTGAGGTTACTCCTGCTCCTCCAACCTTTTTTTGCCAAGGTTTG
TACACGACTCCCATCTAGGCTGAAAACCTAGAAGTGGACCTTGTGTGTGTGCATGGTGTCAGCCCAAAGCCAGGCTGAGACAGTCCTCAT
ATCCTCTTGAGCCAAACTGTTTGGGTCTCGTTGCTTCATGGTATGGTCTGGATTTGTGGGAATGGCTTTGCGTGAGAAAGGGGAGGAGAG
TGGTTGCTGCCCTCAGCCGGCTTGAGGACAGAGCCTGTCCCTCTCATGACAACTCAGTGTTGAAGCCCAGTGTCCTCAGCTTCATGTCCA
GTGGATGGCAGAAGTTCATGGGGTAGTGGCCTCTCAAAGGCTGGGCGCATCCCAAGACAGCCAGCAGGTTGTCTCTGGAAACGACCAGAG
TTAAGCTCTCGGCTTCTCTGCTGAGGGTGCACCCTTTCCTCTAGATGGTAGTTGTCACGTTATCTTTGAAAACTCTTGGACTGCTCCTGA
GGAGGCCCTCTTTTCCAGTAGGAAGTTAGATGGGGGTTCTCAGAAGTGGCTGATTGGAAGGGGACAAGCTTCGTTTCAGGGGTCTGCCGT
TCCATCCTGGTTCAGAGAAGGCCGAGCGTGGCTTTCTCTAGCCTTGTCACTGTCTCCCTGCCTGTCAATCACCACCTTTCCTCCAGAGGA
GGAAAATTATCTCCCCTGCAAAGCCCGGTTCTACACAGATTTCACAAATTGTGCTAAGAACCGTCCGTGTTCTCAGAAAGCCCAGTGTTT
TTGCAAAGAATGAAAAGGGACCCCATATGTAGCAAAAATCAGGGCTGGGGGAGAGCCGGGTTCATTCCCTGTCCTCATTGGTCGTCCCTA
TGAATTGTACGTTTCAGAGAAATTTTTTTTCCTATGTGCAACACGAAGCTTCCAGAACCATAAAATATCCCGTCGATAAGGAAAGAAAAT
GTCGTTGTTGTTGTTTTTCTGGAAACTGCTTGAAATCTTGCTGTACTATAGAGCTCAGAAGGACACAGCCCGTCCTCCCCTGCCTGCCTG
ATTCCATGGCTGTTGTGCTGATTCCAATGCTTTCACGTTGGTTCCTGGCGTGGGAACTGCTCTCCTTTGCAGCCCCATTTCCCAAGCTCT
GTTCAAGTTAAACTTATGTAAGCTTTCCGTGGCATGCGGGGCGCGCACCCACGTCCCCGCTGCGTAAGACTCTGTATTTGGATGCCAATC
CACAGGCCTGAAGAAACTGCTTGTTGTGTATCAGTAATCATTAGTGGCAATGATGACATTCTGAAAAGCTGCAATACTTATACAATAAAT

>20209_20209_1_CTDSPL-PMEPA1_CTDSPL_chr3_37903769_ENST00000273179_PMEPA1_chr20_56234753_ENST00000341744_length(amino acids)=277AA_BP=26
MDGPAIITQVTNPKEDEGRLPGAGEKAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVS
GNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRT
IFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKD

--------------------------------------------------------------
>20209_20209_2_CTDSPL-PMEPA1_CTDSPL_chr3_37903769_ENST00000443503_PMEPA1_chr20_56234753_ENST00000341744_length(transcript)=4735nt_BP=319nt
CGCGGCTCCGGGGTTCATGGTGACGAGGCGGCGGCCGCTCGAGCCCAGCGGCGGCGGCGGCGGGAGCTGGGGCGCGGGCCCGGGCCGCCT
CTCCCAGAGCGCGGGGCCGGGCGGCGGGCGCGCCCAGGCAGCGGCTGCGAGCGCCCCCCCGCGCCGCGCCCCCGCGCCCCCCGCGCCGCG
CCCCCGCGCGCTTGGCTTGCGGGGGGCCGGGCCTGCGGGCGGCCGCCGCGCCGCGCACCCATGGACGGCCCGGCCATCATCACCCAGGTG
ACCAACCCCAAGGAGGACGAGGGCCGGTTGCCGGGCGCGGGCGAGAAAGCGGAGCTGGAGTTTGTTCAGATCATCATCATCGTGGTGGTG
ATGATGGTGATGGTGGTGGTGATCACGTGCCTGCTGAGCCACTACAAGCTGTCTGCACGGTCCTTCATCAGCCGGCACAGCCAGGGGCGG
AGGAGAGAAGATGCCCTGTCCTCAGAAGGATGCCTGTGGCCCTCGGAGAGCACAGTGTCAGGCAACGGAATCCCAGAGCCGCAGGTCTAC
GCCCCGCCTCGGCCCACCGACCGCCTGGCCGTGCCGCCCTTCGCCCAGCGGGAGCGCTTCCACCGCTTCCAGCCCACCTATCCGTACCTG
CAGCACGAGATCGACCTGCCACCCACCATCTCGCTGTCAGACGGGGAGGAGCCCCCACCCTACCAGGGCCCCTGCACCCTCCAGCTTCGG
GACCCCGAGCAGCAGCTGGAACTGAACCGGGAGTCGGTGCGCGCACCCCCAAACAGAACCATCTTCGACAGTGACCTGATGGATAGTGCC
AGGCTGGGCGGCCCCTGCCCCCCCAGCAGTAACTCGGGCATCAGCGCCACGTGCTACGGCAGCGGCGGGCGCATGGAGGGGCCGCCGCCC
ACCTACAGCGAGGTCATCGGCCACTACCCGGGGTCCTCCTTCCAGCACCAGCAGAGCAGTGGGCCGCCCTCCTTGCTGGAGGGGACCCGG
CTCCACCACACACACATCGCGCCCCTAGAGAGCGCAGCCATCTGGAGCAAAGAGAAGGATAAACAGAAAGGACACCCTCTCTAGGGTCCC
CAGGGGGGCCGGGCTGGGGCTGCGTAGGTGAAAAGGCAGAACACTCCGCGCTTCTTAGAAGAGGAGTGAGAGGAAGGCGGGGGGCGCAGC
AACGCATCGTGTGGCCCTCCCCTCCCACCTCCCTGTGTATAAATATTTACATGTGATGTCTGGTCTGAATGCACAAGCTAAGAGAGCTTG
CAAAAAAAAAAAGAAAAAAGAAAAAAAAAAACCACGTTTCTTTGTTGAGCTGTGTCTTGAAGGCAAAAGAAAAAAAATTTCTACAGTAGT
CTTTCTTGTTTCTAGTTGAGCTGCGTGCGTGAATGCTTATTTTCTTTTGTTTATGATAATTTCACTTAACTTTAAAGACATATTTGCACA
AAACCTTTGTTTAAAGATCTGCAATATTATATATATAAATATATATAAGATAAGAGAAACTGTATGTGCGAGGGCAGGAGTATTTTTGTA
TTAGAAGAGGCCTATTAAAAAAAAAAGTTGTTTTCTGAACTAGAAGAGGAAAAAAATGGCAATTTTTGAGTGCCAAGTCAGAAAGTGTGT
ATTACCTTGTAAAGAAAAAAATTACAAAGCAGGGGTTTAGAGTTATTTATATAAATGTTGAGATTTTGCACTATTTTTTAATATAAATAT
GTCAGTGCTTGCTTGATGGAAACTTCTCTTGTGTCTGTTGAGACTTTAAGGGAGAAATGTCGGAATTTCAGAGTCGCCTGACGGCAGAGG
GTGAGCCCCCGTGGAGTCTGCAGAGAGGCCTTGGCCAGGAGCGGCGGGCTTTCCCGAGGGGCCACTGTCCCTGCAGAGTGGATGCTTCTG
CCTAGTGACAGGTTATCACCACGTTATATATTCCCTACCGAAGGAGACACCTTTTCCCCCCTGACCCAGAACAGCCTTTAAATCACAAGC
AAAATAGGAAAGTTAACCACGGAGGCACCGAGTTCCAGGTAGTGGTTTTGCCTTTCCCAAAAATGAAAATAAACTGTTACCGAAGGAATT
AGTTTTTCCTCTTCTTTTTTCCAACTGTGAAGGTCCCCGTGGGGTGGAGCATGGTGCCCCTCACAAGCCGCAGCGGCTGGTGCCCGGGCT
ACCAGGGACATGCCAGAGGGCTCGATGACTTGTCTCTGCAGGGCGCTTTGGTGGTTGTTCAGCTGGCTAAAGGTTCACCGGTGAAGGCAG
GTGCGGTAACTGCCGCACTGGACCCTAGGAAGCCCCAGGTATTCGCAATCTGACCTCCTCCTGTCTGTTTCCCTTCACGGATCAATTCTC
ACTTAAGAGGCCAATAAACAACCCAACATGAAAAGGTGACAAGCCTGGGTTTCTCCCAGGATAGGTGAAAGGGTTAAAATGAGTAAAGCA
GTTGAGCAAACACCAACCCGAGCTTCGGGCGCAGAATTCTTCACCTTCTCTTCCCCTTTCCATCTCCTTTCCCCGCGGAAACAACGCTTC
CCTTCTGGTGTGTCTGTTGATCTGTGTTTTCATTTACATCTCTCTTAGACTCCGCTCTTGTTCTCCAGGTTTTCACCAGATAGATTTGGG
GTTGGCGGGACCTGCTGGTGACGTGCAGGTGAAGGACAGGAAGGGGCATGTGAGCGTAAATAGAGGTGACCAGAGGAGAGCATGAGGGGT
GGGGCTTTGGGACCCACCGGGGCCAGTGGCTGGAGCTTGACGTCTTTCCTCCCCATGGGGGTGGGAGGGCCCCCAGCTGGAAGAGCAGAC
TCCCAGCTGCTACCCCCTCCCTTCCCATGGGAGTGGCTTTCCATTTTGGGCAGAATGCTGACTAGTAGACTAACATAAAAGATATAAAAG
GCAATAACTATTGTTTGTGAGCAACTTTTTTATAACTTCCAAAACAAAAACCTGAGCACAGTTTTGAAGTTCTAGCCACTCGAGCTCATG
CATGTGAAACGTGTGCTTTACGAAGGTGGCAGCTGACAGACGTGGGCTCTGCATGCCGCCAGCCTAGTAGAAAGTTCTCGTTCATTGGCA
ACAGCAGAACCTGCCTCTCCGTGAAGTCGTCAGCCTAAAATTTGTTTCTCTCTTGAAGAGGATTCTTTGAAAAGGTCCTGCAGAGAAATC
AGTACAGGTTATCCCGAAAGGTACAAGGACGCACTTGTAAAGATGATTAAAACGTATCTTTCCTTTATGTGACGCGTCTCTAGTGCCTTA
CTGAAGAAGCAGTGACACTCCCGTCGCTCGGTGAGGACGTTCCCGGACAGTGCCTCACTCACCTGGGACTGGTATCCCCTCCCAGGGTCC
ACCAAGGGCTCCTGCTTTTCAGACACCCCATCATCCTCGCGCGTCCTCACCCTGTCTCTACCAGGGAGGTGCCTAGCTTGGTGAGGTTAC
TCCTGCTCCTCCAACCTTTTTTTGCCAAGGTTTGTACACGACTCCCATCTAGGCTGAAAACCTAGAAGTGGACCTTGTGTGTGTGCATGG
TGTCAGCCCAAAGCCAGGCTGAGACAGTCCTCATATCCTCTTGAGCCAAACTGTTTGGGTCTCGTTGCTTCATGGTATGGTCTGGATTTG
TGGGAATGGCTTTGCGTGAGAAAGGGGAGGAGAGTGGTTGCTGCCCTCAGCCGGCTTGAGGACAGAGCCTGTCCCTCTCATGACAACTCA
GTGTTGAAGCCCAGTGTCCTCAGCTTCATGTCCAGTGGATGGCAGAAGTTCATGGGGTAGTGGCCTCTCAAAGGCTGGGCGCATCCCAAG
ACAGCCAGCAGGTTGTCTCTGGAAACGACCAGAGTTAAGCTCTCGGCTTCTCTGCTGAGGGTGCACCCTTTCCTCTAGATGGTAGTTGTC
ACGTTATCTTTGAAAACTCTTGGACTGCTCCTGAGGAGGCCCTCTTTTCCAGTAGGAAGTTAGATGGGGGTTCTCAGAAGTGGCTGATTG
GAAGGGGACAAGCTTCGTTTCAGGGGTCTGCCGTTCCATCCTGGTTCAGAGAAGGCCGAGCGTGGCTTTCTCTAGCCTTGTCACTGTCTC
CCTGCCTGTCAATCACCACCTTTCCTCCAGAGGAGGAAAATTATCTCCCCTGCAAAGCCCGGTTCTACACAGATTTCACAAATTGTGCTA
AGAACCGTCCGTGTTCTCAGAAAGCCCAGTGTTTTTGCAAAGAATGAAAAGGGACCCCATATGTAGCAAAAATCAGGGCTGGGGGAGAGC
CGGGTTCATTCCCTGTCCTCATTGGTCGTCCCTATGAATTGTACGTTTCAGAGAAATTTTTTTTCCTATGTGCAACACGAAGCTTCCAGA
ACCATAAAATATCCCGTCGATAAGGAAAGAAAATGTCGTTGTTGTTGTTTTTCTGGAAACTGCTTGAAATCTTGCTGTACTATAGAGCTC
AGAAGGACACAGCCCGTCCTCCCCTGCCTGCCTGATTCCATGGCTGTTGTGCTGATTCCAATGCTTTCACGTTGGTTCCTGGCGTGGGAA
CTGCTCTCCTTTGCAGCCCCATTTCCCAAGCTCTGTTCAAGTTAAACTTATGTAAGCTTTCCGTGGCATGCGGGGCGCGCACCCACGTCC
CCGCTGCGTAAGACTCTGTATTTGGATGCCAATCCACAGGCCTGAAGAAACTGCTTGTTGTGTATCAGTAATCATTAGTGGCAATGATGA

>20209_20209_2_CTDSPL-PMEPA1_CTDSPL_chr3_37903769_ENST00000443503_PMEPA1_chr20_56234753_ENST00000341744_length(amino acids)=335AA_BP=84
MGRGPGPPLPERGAGRRARPGSGCERPPAPRPRAPRAAPPRAWLAGGRACGRPPRRAPMDGPAIITQVTNPKEDEGRLPGAGEKAELEFV
QIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHR
FQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSG

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Fusion Gene PPI Analysis for CTDSPL-PMEPA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CTDSPL-PMEPA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTDSPL-PMEPA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source