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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTIF-DYM (FusionGDB2 ID:20234)

Fusion Gene Summary for CTIF-DYM

check button Fusion gene summary
Fusion gene informationFusion gene name: CTIF-DYM
Fusion gene ID: 20234
HgeneTgene
Gene symbol

CTIF

DYM

Gene ID

9811

54808

Gene namecap binding complex dependent translation initiation factordymeclin
SynonymsGm672|KIAA0427DMC|SMC
Cytomap

18q21.1

18q21.1

Type of geneprotein-codingprotein-coding
DescriptionCBP80/20-dependent translation initiation factordymeclindyggve-Melchior-Clausen syndrome protein
Modification date2020031320200313
UniProtAcc

O43310

Q7RTS9

Ensembl transtripts involved in fusion geneENST00000256413, ENST00000382998, 
ENST00000592658, 		ENST00000578396, 
ENST00000584977, ENST00000269445, 
ENST00000442713, 
Fusion gene scores* DoF score20 X 11 X 10=220019 X 11 X 13=2717
# samples 2324
** MAII scorelog2(23/2200*10)=-3.25779775746765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2717*10)=-3.50090825461346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTIF [Title/Abstract] AND DYM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTIF(46197115)-DYM(46645296), # samples:1
DYM(46956625)-CTIF(46343592), # samples:2
Anticipated loss of major functional domain due to fusion event.DYM-CTIF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CTIF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DYM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A141-01ACTIFchr18

46197115

+DYMchr18

46645296

-


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Fusion Gene ORF analysis for CTIF-DYM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000256413ENST00000578396CTIFchr18

46197115

+DYMchr18

46645296

-
5CDS-intronENST00000256413ENST00000584977CTIFchr18

46197115

+DYMchr18

46645296

-
5CDS-intronENST00000382998ENST00000578396CTIFchr18

46197115

+DYMchr18

46645296

-
5CDS-intronENST00000382998ENST00000584977CTIFchr18

46197115

+DYMchr18

46645296

-
In-frameENST00000256413ENST00000269445CTIFchr18

46197115

+DYMchr18

46645296

-
In-frameENST00000256413ENST00000442713CTIFchr18

46197115

+DYMchr18

46645296

-
In-frameENST00000382998ENST00000269445CTIFchr18

46197115

+DYMchr18

46645296

-
In-frameENST00000382998ENST00000442713CTIFchr18

46197115

+DYMchr18

46645296

-
intron-3CDSENST00000592658ENST00000269445CTIFchr18

46197115

+DYMchr18

46645296

-
intron-3CDSENST00000592658ENST00000442713CTIFchr18

46197115

+DYMchr18

46645296

-
intron-intronENST00000592658ENST00000578396CTIFchr18

46197115

+DYMchr18

46645296

-
intron-intronENST00000592658ENST00000584977CTIFchr18

46197115

+DYMchr18

46645296

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256413CTIFchr1846197115+ENST00000442713DYMchr1846645296-16358022951248317
ENST00000256413CTIFchr1846197115+ENST00000269445DYMchr1846645296-14848022951248317
ENST00000382998CTIFchr1846197115+ENST00000442713DYMchr1846645296-15977642571210317
ENST00000382998CTIFchr1846197115+ENST00000269445DYMchr1846645296-14467642571210317

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256413ENST00000442713CTIFchr1846197115+DYMchr1846645296-0.0044277240.9955722
ENST00000256413ENST00000269445CTIFchr1846197115+DYMchr1846645296-0.0051417210.99485826
ENST00000382998ENST00000442713CTIFchr1846197115+DYMchr1846645296-0.0046149360.9953851
ENST00000382998ENST00000269445CTIFchr1846197115+DYMchr1846645296-0.0058549430.9941451

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Fusion Genomic Features for CTIF-DYM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTIF-DYM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:46197115/chr18:46645296)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTIF

O43310

DYM

Q7RTS9

FUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.FUNCTION: Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTIFchr18:46197115chr18:46645296ENST00000256413+612376_577169599.0DomainNote=MIF4G
HgeneCTIFchr18:46197115chr18:46645296ENST00000382998+713376_577169601.0DomainNote=MIF4G


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Fusion Gene Sequence for CTIF-DYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20234_20234_1_CTIF-DYM_CTIF_chr18_46197115_ENST00000256413_DYM_chr18_46645296_ENST00000269445_length(transcript)=1484nt_BP=802nt
CTTTCCCTGTGTCAGATCAGGGATCATTTTTTTTCCTTCCTCTACTCCCTCCCCCCTACCCGCCCCTCCCTCCCTGTTTCCCTTCCCTCC
CTCCCTCCCCTCTCTGCTGGGTCTGTGCGCTGGGGCGCCCGATCCCCTCCGCAGCTGGGACGCTCCGAACTCGAGGCAGGAGTCGGCTCT
CCGGAGCCTCGTCCCTCCCTTCCCCTTCCCTGCCCCCTTCCCCCACCCCCGACTCGGGCTTGGCGCGGCGGCCAGAGGAACCCCGAGTCC
CGGCCCAGGCCCCTGAGCTGGAGGGATGGAAAACTCCTCTGCAGCATCAGCCTCCTCGGAGGCAGGGAGCAGCCGCTCCCAGGAGATCGA
GGAGCTGGAGCGCTTCATCGACAGCTACGTGCTGGAGTACCAGGTGCAGGGGCTGCTGGCTGACAAGACGGAGGGTGATGGCGAGAGCGA
GAGGACCCAGTCCCACATCTCCCAGTGGACAGCGGACTGCAGCGAACCGCTGGACAGCAGCTGTTCCTTCTCCCGAGGGCGAGCCCCCCC
ACAGCAGAATGGCAGCAAAGACAACTCTCTGGACATGCTGGGCACGGACATCTGGGCGGCCAACACCTTCGATTCCTTCAGTGGTGCCAC
CTGGGACCTGCAGCCGGAAAAGCTGGACTTCACCCAGTTCCACCGCAAAGTCCGACACACGCCCAAGCAGCCCCTGCCACACATCGACCG
CGAAGGGTGTGGCAAAGGGAAGCTGGAAGATGGGGATGGCATCAACCTGAATGACATCGAGAAGGTCCTTCCAGCCTGGCAGGCACAAGA
CCTAAATGTCATTGAAGAAGTGATTCGAATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGT
ATACGCCCTGCTTTACAAACGCGATCTCTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGAT
CTCCTTCTTTAGCTCAAGGTTGCTGCAAGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCT
GCCCAAAGACAGACTGAAGAAATTTCCAGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTG
GTCTCTTGTCTACAACTCAGCAGTCGGCCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGC
TCTCCCACCCGGACCCCTCCAGCCAAGCAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATC
TTCTGTTAAAGAGGATTGCACGAGTGTGTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAG

>20234_20234_1_CTIF-DYM_CTIF_chr18_46197115_ENST00000256413_DYM_chr18_46645296_ENST00000269445_length(amino acids)=317AA_BP=169
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQAQDLNVIEEVI
RMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKF

--------------------------------------------------------------
>20234_20234_2_CTIF-DYM_CTIF_chr18_46197115_ENST00000256413_DYM_chr18_46645296_ENST00000442713_length(transcript)=1635nt_BP=802nt
CTTTCCCTGTGTCAGATCAGGGATCATTTTTTTTCCTTCCTCTACTCCCTCCCCCCTACCCGCCCCTCCCTCCCTGTTTCCCTTCCCTCC
CTCCCTCCCCTCTCTGCTGGGTCTGTGCGCTGGGGCGCCCGATCCCCTCCGCAGCTGGGACGCTCCGAACTCGAGGCAGGAGTCGGCTCT
CCGGAGCCTCGTCCCTCCCTTCCCCTTCCCTGCCCCCTTCCCCCACCCCCGACTCGGGCTTGGCGCGGCGGCCAGAGGAACCCCGAGTCC
CGGCCCAGGCCCCTGAGCTGGAGGGATGGAAAACTCCTCTGCAGCATCAGCCTCCTCGGAGGCAGGGAGCAGCCGCTCCCAGGAGATCGA
GGAGCTGGAGCGCTTCATCGACAGCTACGTGCTGGAGTACCAGGTGCAGGGGCTGCTGGCTGACAAGACGGAGGGTGATGGCGAGAGCGA
GAGGACCCAGTCCCACATCTCCCAGTGGACAGCGGACTGCAGCGAACCGCTGGACAGCAGCTGTTCCTTCTCCCGAGGGCGAGCCCCCCC
ACAGCAGAATGGCAGCAAAGACAACTCTCTGGACATGCTGGGCACGGACATCTGGGCGGCCAACACCTTCGATTCCTTCAGTGGTGCCAC
CTGGGACCTGCAGCCGGAAAAGCTGGACTTCACCCAGTTCCACCGCAAAGTCCGACACACGCCCAAGCAGCCCCTGCCACACATCGACCG
CGAAGGGTGTGGCAAAGGGAAGCTGGAAGATGGGGATGGCATCAACCTGAATGACATCGAGAAGGTCCTTCCAGCCTGGCAGGCACAAGA
CCTAAATGTCATTGAAGAAGTGATTCGAATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGT
ATACGCCCTGCTTTACAAACGCGATCTCTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGAT
CTCCTTCTTTAGCTCAAGGTTGCTGCAAGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCT
GCCCAAAGACAGACTGAAGAAATTTCCAGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTG
GTCTCTTGTCTACAACTCAGCAGTCGGCCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGC
TCTCCCACCCGGACCCCTCCAGCCAAGCAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATC
TTCTGTTAAAGAGGATTGCACGAGTGTGTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAG
ATAGTATTGCAAAAAGGGGAGGAAATACACAACAATAATAAATGTAAAAACCTGCTATTCAACATGCAGTTTTATTTCGAAGCCAAAAAT
CTAGAGCTTTCCCAAGATCCTGTTGCCTTAGGCACATCACACTTCAACAGTGCACACTATCCAACAGTGCACACTATTCAACAGTGCACA

>20234_20234_2_CTIF-DYM_CTIF_chr18_46197115_ENST00000256413_DYM_chr18_46645296_ENST00000442713_length(amino acids)=317AA_BP=169
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQAQDLNVIEEVI
RMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKF

--------------------------------------------------------------
>20234_20234_3_CTIF-DYM_CTIF_chr18_46197115_ENST00000382998_DYM_chr18_46645296_ENST00000269445_length(transcript)=1446nt_BP=764nt
CTGTGCGCTGGGGCGCCCGATCCCCTCCGCAGCTGGGACGCTCCGAACTCGAGGCAGGAGTCGGCTCTCCGGAGCCTCGTCCCTCCCTTC
CCCTTCCCTGCCCCCTTCCCCCACCCCCGACTCGGGCTTGGCGCGGCGGCCAGAGGAACCCCGAGCCCGCATTTGCTGCATCGAGCAGTT
GGTTTAGTATCAGCCAAACTTGCAGCTGTTCAGACCGCGCTCCGCCGAGTCCCGGCCCAGGCCCCTGAGCTGGAGGGATGGAAAACTCCT
CTGCAGCATCAGCCTCCTCGGAGGCAGGGAGCAGCCGCTCCCAGGAGATCGAGGAGCTGGAGCGCTTCATCGACAGCTACGTGCTGGAGT
ACCAGGTGCAGGGGCTGCTGGCTGACAAGACGGAGGGTGATGGCGAGAGCGAGAGGACCCAGTCCCACATCTCCCAGTGGACAGCGGACT
GCAGCGAACCGCTGGACAGCAGCTGTTCCTTCTCCCGAGGGCGAGCCCCCCCACAGCAGAATGGCAGCAAAGACAACTCTCTGGACATGC
TGGGCACGGACATCTGGGCGGCCAACACCTTCGATTCCTTCAGTGGTGCCACCTGGGACCTGCAGCCGGAAAAGCTGGACTTCACCCAGT
TCCACCGCAAAGTCCGACACACGCCCAAGCAGCCCCTGCCACACATCGACCGCGAAGGGTGTGGCAAAGGGAAGCTGGAAGATGGGGATG
GCATCAACCTGAATGACATCGAGAAGGTCCTTCCAGCCTGGCAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCGAATGATGTTAG
AGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCTCTTTGAACAAT
TTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCAAGCTGGAGCTG
AGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCCAGAATTGAAAT
TCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGGCCTGTACTGGA
ATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAGCAGCCCTTCAA
GTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGTGTTTTCCTCAC
ACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATACACAACAATAA

>20234_20234_3_CTIF-DYM_CTIF_chr18_46197115_ENST00000382998_DYM_chr18_46645296_ENST00000269445_length(amino acids)=317AA_BP=169
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQAQDLNVIEEVI
RMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKF

--------------------------------------------------------------
>20234_20234_4_CTIF-DYM_CTIF_chr18_46197115_ENST00000382998_DYM_chr18_46645296_ENST00000442713_length(transcript)=1597nt_BP=764nt
CTGTGCGCTGGGGCGCCCGATCCCCTCCGCAGCTGGGACGCTCCGAACTCGAGGCAGGAGTCGGCTCTCCGGAGCCTCGTCCCTCCCTTC
CCCTTCCCTGCCCCCTTCCCCCACCCCCGACTCGGGCTTGGCGCGGCGGCCAGAGGAACCCCGAGCCCGCATTTGCTGCATCGAGCAGTT
GGTTTAGTATCAGCCAAACTTGCAGCTGTTCAGACCGCGCTCCGCCGAGTCCCGGCCCAGGCCCCTGAGCTGGAGGGATGGAAAACTCCT
CTGCAGCATCAGCCTCCTCGGAGGCAGGGAGCAGCCGCTCCCAGGAGATCGAGGAGCTGGAGCGCTTCATCGACAGCTACGTGCTGGAGT
ACCAGGTGCAGGGGCTGCTGGCTGACAAGACGGAGGGTGATGGCGAGAGCGAGAGGACCCAGTCCCACATCTCCCAGTGGACAGCGGACT
GCAGCGAACCGCTGGACAGCAGCTGTTCCTTCTCCCGAGGGCGAGCCCCCCCACAGCAGAATGGCAGCAAAGACAACTCTCTGGACATGC
TGGGCACGGACATCTGGGCGGCCAACACCTTCGATTCCTTCAGTGGTGCCACCTGGGACCTGCAGCCGGAAAAGCTGGACTTCACCCAGT
TCCACCGCAAAGTCCGACACACGCCCAAGCAGCCCCTGCCACACATCGACCGCGAAGGGTGTGGCAAAGGGAAGCTGGAAGATGGGGATG
GCATCAACCTGAATGACATCGAGAAGGTCCTTCCAGCCTGGCAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCGAATGATGTTAG
AGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCTCTTTGAACAAT
TTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCAAGCTGGAGCTG
AGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCCAGAATTGAAAT
TCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGGCCTGTACTGGA
ATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAGCAGCCCTTCAA
GTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGTGTTTTCCTCAC
ACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATACACAACAATAA
TAAATGTAAAAACCTGCTATTCAACATGCAGTTTTATTTCGAAGCCAAAAATCTAGAGCTTTCCCAAGATCCTGTTGCCTTAGGCACATC

>20234_20234_4_CTIF-DYM_CTIF_chr18_46197115_ENST00000382998_DYM_chr18_46645296_ENST00000442713_length(amino acids)=317AA_BP=169
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQAQDLNVIEEVI
RMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTIF-DYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCTIFchr18:46197115chr18:46645296ENST00000256413+6121_305169.0599.0NCBP1/CBP80
HgeneCTIFchr18:46197115chr18:46645296ENST00000382998+7131_305169.0601.0NCBP1/CBP80


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTIF-DYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTIF-DYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource