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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNNA1-MGME1 (FusionGDB2 ID:20264)

Fusion Gene Summary for CTNNA1-MGME1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNA1-MGME1
Fusion gene ID: 20264
HgeneTgene
Gene symbol

CTNNA1

MGME1

Gene ID

1495

92667

Gene namecatenin alpha 1mitochondrial genome maintenance exonuclease 1
SynonymsCAP102|MDPT2C20orf72|DDK1|MTDPS11|bA504H3.4
Cytomap

5q31.2

20p11.23

Type of geneprotein-codingprotein-coding
Descriptioncatenin alpha-1alpha-E-catenincatenin (cadherin-associated protein), alpha 1, 102kDaepididymis secretory sperm binding proteinrenal carcinoma antigen NY-REN-13mitochondrial genome maintenance exonuclease 1
Modification date2020031320200313
UniProtAcc.

Q9BQP7

Ensembl transtripts involved in fusion geneENST00000302763, ENST00000355078, 
ENST00000518825, ENST00000520400, 
ENST00000540387, 		ENST00000467391, 
ENST00000377704, ENST00000377709, 
ENST00000377710, 
Fusion gene scores* DoF score25 X 19 X 12=57006 X 5 X 4=120
# samples 347
** MAII scorelog2(34/5700*10)=-4.06735526780176
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNNA1 [Title/Abstract] AND MGME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNNA1(138163407)-MGME1(17970582), # samples:1
CTNNA1(138163407)-MGME1(17968809), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNA1

GO:0071681

cellular response to indole-3-methanol

10868478


check buttonFusion gene breakpoints across CTNNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MGME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AP-A0LI-01ACTNNA1chr5

138163407

+MGME1chr20

17968809

+
ChimerDB4UCECTCGA-AP-A0LI-01ACTNNA1chr5

138163407

+MGME1chr20

17970582

+


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Fusion Gene ORF analysis for CTNNA1-MGME1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000302763ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17968809

+
5CDS-3UTRENST00000302763ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17970582

+
5CDS-3UTRENST00000355078ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17968809

+
5CDS-3UTRENST00000355078ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17970582

+
5CDS-3UTRENST00000518825ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17968809

+
5CDS-3UTRENST00000518825ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17970582

+
5CDS-intronENST00000302763ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17968809

+
5CDS-intronENST00000355078ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17968809

+
5CDS-intronENST00000518825ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000302763ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000302763ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17970582

+
Frame-shiftENST00000302763ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000302763ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17970582

+
Frame-shiftENST00000355078ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000355078ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17970582

+
Frame-shiftENST00000355078ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000355078ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17970582

+
Frame-shiftENST00000518825ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000518825ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17970582

+
Frame-shiftENST00000518825ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17968809

+
Frame-shiftENST00000518825ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17970582

+
In-frameENST00000302763ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17970582

+
In-frameENST00000355078ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17970582

+
In-frameENST00000518825ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000520400ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000520400ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3CDSENST00000520400ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000520400ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3CDSENST00000520400ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000540387ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000540387ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3CDSENST00000540387ENST00000377709CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3CDSENST00000540387ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3CDSENST00000540387ENST00000377710CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3UTRENST00000520400ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3UTRENST00000520400ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-3UTRENST00000540387ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-3UTRENST00000540387ENST00000467391CTNNA1chr5

138163407

+MGME1chr20

17970582

+
intron-intronENST00000520400ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17968809

+
intron-intronENST00000540387ENST00000377704CTNNA1chr5

138163407

+MGME1chr20

17968809

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355078CTNNA1chr5138163407+ENST00000377704MGME1chr2017970582+21429582021128308
ENST00000302763CTNNA1chr5138163407+ENST00000377704MGME1chr2017970582+23361152901322410
ENST00000518825CTNNA1chr5138163407+ENST00000377704MGME1chr2017970582+2248106421234410

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355078ENST00000377704CTNNA1chr5138163407+MGME1chr2017970582+0.000941010.999059
ENST00000302763ENST00000377704CTNNA1chr5138163407+MGME1chr2017970582+0.0008952240.9991048
ENST00000518825ENST00000377704CTNNA1chr5138163407+MGME1chr2017970582+0.0008022120.9991978

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Fusion Genomic Features for CTNNA1-MGME1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNNA1chr5138163407+MGME1chr2017970581+0.0029523640.9970476
CTNNA1chr5138163407+MGME1chr2017968808+2.49E-060.9999975
CTNNA1chr5138163407+MGME1chr2017970581+0.0029523640.9970476
CTNNA1chr5138163407+MGME1chr2017968808+2.49E-060.9999975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTNNA1-MGME1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:138163407/chr20:17970582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MGME1

Q9BQP7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000302763+7182_228354907.0RegionNote=Involved in homodimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000540387+1122_2280537.0RegionNote=Involved in homodimerization


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Fusion Gene Sequence for CTNNA1-MGME1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20264_20264_1_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000302763_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2336nt_BP=1152nt
TCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAGAA
ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG
CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT
TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT
GTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAG
CGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTA
CTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTA
AAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCT
AGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAAC
AGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCAC
CAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGC
TTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGT
GAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGTTCAATGTGGCTTAATT
GTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGA
CTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTC
AGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAA
GTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCG
AAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGA
CATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTC
CCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATG
CCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATT
AGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAG
AAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCA
ATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTC
CCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGT

>20264_20264_1_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000302763_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=410AA_BP=354
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNVQCGLI

--------------------------------------------------------------
>20264_20264_2_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000355078_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2142nt_BP=958nt
TTTCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAG
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAGCGAGGCAACATGGT
TCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTACTTGTTCAGCTGAA
AGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTAAAACCTGAAGTGGA
TAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCTAGAGGAATCCTGCA
GAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAACAGGGACCTGATATA
CAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCACCAGGGTGGAGGAGG
AGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGCTTTAGGCCTTCCCT
GGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGTGAGCGAATTGTGGC
AGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGTTCAATGTGGCTTAATTGTGGTGGCCTACAA
AGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATAC
GGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACA
GTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAAT
TTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATG
CTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGG
GGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCC
AGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTT
CATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAAC
ATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGC
CAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGG
AGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAA
ACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAAT

>20264_20264_2_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000355078_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=308AA_BP=252
MMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAA
KRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYAL
NNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNVQCGLIVVAYKDGSPAHP

--------------------------------------------------------------
>20264_20264_3_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000518825_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2248nt_BP=1064nt
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATG
TTTTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGC
TTGTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGA
AGCGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAAT
TACTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCC
TAAAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAG
CTAGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCA
ACAGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGC
ACCAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGC
GCTTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTC
GTGAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGTTCAATGTGGCTTAA
TTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTC
GACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACAT
TCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACAC
AAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACG
CGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGG
GACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATT
TCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAA
TGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGA
TTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCC
AGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGT
CAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTG
TCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACA

>20264_20264_3_CTNNA1-MGME1_CTNNA1_chr5_138163407_ENST00000518825_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=410AA_BP=354
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNVQCGLI

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Fusion Gene PPI Analysis for CTNNA1-MGME1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000302763+71897_148354.0907.0JUP and CTNNB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000302763+718325_394354.0907.0alpha-actinin
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000540387+112325_3940537.0alpha-actinin
HgeneCTNNA1chr5:138163407chr20:17970582ENST00000540387+11297_1480537.0JUP and CTNNB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNNA1-MGME1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNNA1-MGME1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource