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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTNNAL1-TLE1 (FusionGDB2 ID:20311)

Fusion Gene Summary for CTNNAL1-TLE1

Fusion gene summary

Fusion gene information	Fusion gene name: CTNNAL1-TLE1
	Fusion gene ID: 20311
		Hgene	Tgene
	Gene symbol	CTNNAL1	TLE1
	Gene ID	8727	7088
	Gene name	catenin alpha like 1	TLE family member 1, transcriptional corepressor
	Synonyms	ACRP\|CLLP\|alpha-CATU	ESG\|ESG1\|GRG1
	Cytomap	9q31.3	9q21.32
	Type of gene	protein-coding	protein-coding
	Description	alpha-catulinalpha-catenin-related proteinalpha2-catulincatenin (cadherin-associated protein), alpha-like 1catenin alpha-like protein 1	transducin-like enhancer protein 1enhancer of split groucho-like protein 1transducin like enhancer of split 1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000325551, ENST00000325580, ENST00000374593, ENST00000374595, ENST00000374594, ENST00000488130,	ENST00000376463, ENST00000376472, ENST00000376484, ENST00000464999, ENST00000376499,
Fusion gene scores	* DoF score	5 X 5 X 4=100	6 X 6 X 3=108
	# samples	5	6
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTNNAL1 [Title/Abstract] AND TLE1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTNNAL1(111775581)-TLE1(84268951), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CTNNAL1	GO:0007266	Rho protein signal transduction	12270917
Tgene	TLE1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	17680780
Tgene	TLE1	GO:0045892	negative regulation of transcription, DNA-templated	9751710

Fusion gene breakpoints across CTNNAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TLE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8534	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-

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Fusion Gene ORF analysis for CTNNAL1-TLE1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000325551	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000325551	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000325580	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000325580	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000374593	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000374593	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000374595	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-5UTR	ENST00000374595	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000325551	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000325551	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000325580	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000325580	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000374593	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000374593	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000374595	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
5CDS-intron	ENST00000374595	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
In-frame	ENST00000325551	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
In-frame	ENST00000325580	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
In-frame	ENST00000374593	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
In-frame	ENST00000374595	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-3CDS	ENST00000374594	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-3CDS	ENST00000488130	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-5UTR	ENST00000374594	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-5UTR	ENST00000374594	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-5UTR	ENST00000488130	ENST00000376463	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-5UTR	ENST00000488130	ENST00000376472	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-intron	ENST00000374594	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-intron	ENST00000374594	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-intron	ENST00000488130	ENST00000376484	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-
intron-intron	ENST00000488130	ENST00000464999	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374595	CTNNAL1	chr9	111775581	-	ENST00000376499	TLE1	chr9	84268951	-	2815	221	59	2299	746
ENST00000325551	CTNNAL1	chr9	111775581	-	ENST00000376499	TLE1	chr9	84268951	-	2822	228	66	2306	746
ENST00000325580	CTNNAL1	chr9	111775581	-	ENST00000376499	TLE1	chr9	84268951	-	2792	198	36	2276	746
ENST00000374593	CTNNAL1	chr9	111775581	-	ENST00000376499	TLE1	chr9	84268951	-	2805	211	49	2289	746

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374595	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-	0.004751	0.995249
ENST00000325551	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-	0.004733037	0.99526703
ENST00000325580	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-	0.004774101	0.9952259
ENST00000374593	ENST00000376499	CTNNAL1	chr9	111775581	-	TLE1	chr9	84268951	-	0.004644603	0.99535537

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Fusion Genomic Features for CTNNAL1-TLE1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTNNAL1-TLE1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:111775581/chr9:84268951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

225_228

771.0

Motif

Nuclear localization signal

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

132_199

771.0

Region

GP domain

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

200_268

771.0

Region

CcN domain

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

269_450

771.0

Region

SP domain

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

470_501

771.0

Repeat

Note=WD 1

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

528_558

771.0

Repeat

Note=WD 2

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

572_602

771.0

Repeat

Note=WD 3

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

614_644

771.0

Repeat

Note=WD 4

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

696_726

771.0

Repeat

Note=WD 5

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

737_767

771.0

Repeat

Note=WD 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TLE1

chr9:111775581

chr9:84268951

ENST00000376499

1_131

771.0

Region

Q domain

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Fusion Gene Sequence for CTNNAL1-TLE1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20311_20311_1_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000325551_TLE1_chr9_84268951_ENST00000376499_length(transcript)=2822nt_BP=228nt
CCTGTCGCCGCCGCCTCGGGCGGGTGGGCTGACTGGCGGCAGGCTCGCCGCGGCGCGGAGTCCCGGCTGCGGGATAGACCGAGGGCCATG
GCCGCCTCTCCCGGACCCGCCGGCGTTGGCGGCGCCGGAGCAGTCTACGGCTCCGGCTCTTCGGGCTTCGCCCTCGACTCGGGACTGGAG
ATCAAAACTCGCTCGGTGGAGCAGACGCTACTCCCGCTGGTTTCTCAGACTGAAATCGCCAAGAGATTGAATACGATTTGTGCACAAGTC
ATCCCATTTCTGTCTCAGGAACATCAACAACAGGTGGCCCAGGCTGTTGAACGTGCCAAACAGGTGACCATGGCAGAATTGAATGCCATC
ATCGGGCAGCAGCAGTTGCAAGCTCAGCATCTTTCTCATGGCCACGGACCCCCAGTTCCCCTTACGCCTCACCCTTCGGGACTTCAGCCT
CCTGGAATCCCGCCCCTCGGGGGCAGTGCCGGCCTTCTTGCGCTGTCTAGTGCTCTGAGTGGGCAGTCTCACTTGGCAATAAAAGATGAC
AAGAAGCACCACGATGCAGAGCACCACAGAGACAGAGAGCCGGGCACAAGTAATTCCCTCCTGGTCCCAGACAGTCTAAGAGGCACAGAT
AAACGCAGAAATGGACCTGAATTTTCCAATGACATCAAGAAAAGGAAGGTGGATGATAAGGACTCCAGCCACTATGACAGTGATGGTGAC
AAAAGCGATGACAACTTAGTTGTGGATGTGTCTAATGAGGACCCTTCTTCTCCGCGAGCAAGCCCTGCCCACTCGCCCCGGGAAAATGGA
ATCGACAAAAATCGCCTGCTAAAGAAGGATGCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCGGCAAGTTCCACTTCTTTGAAATCCAAA
GAAATGAGCTTGCATGAAAAAGCCAGCACGCCTGTTCTGAAATCCAGCACACCAACGCCTCGGAGCGACATGCCAACGCCGGGCACCAGC
GCCACTCCAGGCCTCCGTCCAGGTCTCGGCAAGCCTCCAGCCATAGACCCCCTCGTTAACCAAGCGGCAGCTGGCTTGAGGACACCCCTG
GCAGTGCCCGGCCCATATCCTGCTCCTTTTGGGATGGTCCCCCACGCTGGCATGAACGGCGAGCTGACCAGCCCAGGCGCTGCCTACGCC
AGTTTACACAACATGTCGCCCCAGATGAGCGCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTACGGGCGCTCCCCCATGGTGGGGTTTGAT
CCTCCCCCTCACATGAGAGTACCTACCATTCCTCCAAACCTGGCAGGAATCCCTGGGGGGAAACCTGCATACTCCTTCCACGTTACTGCA
GACGGTCAGATGCAGCCTGTCCCTTTTCCCCCCGACGCCCTCATCGGACCCGGAATCCCCCGGCATGCTCGCCAGATCAACACCCTCAAC
CACGGGGAGGTGGTGTGCGCTGTGACCATCAGCAACCCCACGAGACACGTGTACACAGGCGGGAAGGGCTGCGTCAAGGTCTGGGACATC
AGCCACCCTGGCAATAAGAGCCCTGTCTCCCAGCTCGACTGTCTGAACAGAGACAATTATATCCGTTCCTGTAAATTGCTACCCGATGGC
TGCACTCTCATAGTGGGAGGGGAAGCCAGTACTTTGTCCATTTGGGACCTGGCGGCTCCAACCCCGCGCATCAAGGCGGAGCTGACGTCC
TCGGCCCCCGCCTGCTACGCCCTGGCCATCAGCCCCGATTCCAAGGTCTGCTTCTCATGCTGCAGCGACGGCAACATCGCTGTGTGGGAT
CTGCACAACCAGACACTAGTGAGGCAATTCCAGGGCCACACAGACGGAGCCAGCTGTATTGACATTTCTAATGATGGCACCAAGCTCTGG
ACGGGTGGTTTGGACAACACAGTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAGCACGACTTCACCTCCCAGATCTTCTCC
CTGGGGTACTGCCCCACCGGGGAGTGGCTGGCAGTGGGCATGGAGAGCAGCAATGTGGAGGTGCTGCACGTGAACAAGCCTGACAAGTAC
CAGCTGCACCTGCATGAGAGCTGCGTGCTGTCCCTGAAATTTGCTTACTGTGGTAAATGGTTTGTGAGTACTGGAAAAGATAACCTCCTC
AATGCTTGGCGGACCCCCTATGGAGCCAGCATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTTAGCTGTGACATCTCTGTGGATGATAAG
TACATAGTCACTGGCTCGGGGGACAAGAAGGCTACAGTCTATGAAGTCATCTACTGAAAACATTATGTGGTTTAACGTTTATAGTTGAAT
TGGGCCAAAATGTTTCGAATTTATAGAAATAGAAAAGTTGTAACTTTAAAAGAGAAAAAAAATTACAAACACCTGTTTCCAAACCTTGAC
AGAAAACTACTTTGAGTCTACAAAGAGGAGGCGACAAGTCCATCAGCAGAAAGTCACCTGTCTACATAGACCAAATGGAGCACCAAGGCC
AAGCGGACAGAGGGGCCATGGGTTGTAGGATTGAGGAACGGAATCTGCCGACTCACATGACAGCCCATTCTTTCTTTCTGGGTGATCTGG
GGATCACGCCTTGCCCAAGTGTGAGATTACCTTTCTGTTCCTTGCAGTTCACCTCACTTTCCGTCCTTTGTAGAGCAGTGGTGTCTCCAA
TGAACTTGTTTCCTGGTTTTGCATCTTGTGAAATGTTTTTTTGTATTTTTGTTGAAGGTTAAACATTTGTATAAATTGTAAATATATTTG

>20311_20311_1_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000325551_TLE1_chr9_84268951_ENST00000376499_length(amino acids)=746AA_BP=54
MRDRPRAMAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQV
TMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLV
PDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSA
SSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGEL
TSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH
ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP
RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH
DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS

--------------------------------------------------------------
>20311_20311_2_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000325580_TLE1_chr9_84268951_ENST00000376499_length(transcript)=2792nt_BP=198nt
GACTGGCGGCAGGCTCGCCGCGGCGCGGAGTCCCGGCTGCGGGATAGACCGAGGGCCATGGCCGCCTCTCCCGGACCCGCCGGCGTTGGC
GGCGCCGGAGCAGTCTACGGCTCCGGCTCTTCGGGCTTCGCCCTCGACTCGGGACTGGAGATCAAAACTCGCTCGGTGGAGCAGACGCTA
CTCCCGCTGGTTTCTCAGACTGAAATCGCCAAGAGATTGAATACGATTTGTGCACAAGTCATCCCATTTCTGTCTCAGGAACATCAACAA
CAGGTGGCCCAGGCTGTTGAACGTGCCAAACAGGTGACCATGGCAGAATTGAATGCCATCATCGGGCAGCAGCAGTTGCAAGCTCAGCAT
CTTTCTCATGGCCACGGACCCCCAGTTCCCCTTACGCCTCACCCTTCGGGACTTCAGCCTCCTGGAATCCCGCCCCTCGGGGGCAGTGCC
GGCCTTCTTGCGCTGTCTAGTGCTCTGAGTGGGCAGTCTCACTTGGCAATAAAAGATGACAAGAAGCACCACGATGCAGAGCACCACAGA
GACAGAGAGCCGGGCACAAGTAATTCCCTCCTGGTCCCAGACAGTCTAAGAGGCACAGATAAACGCAGAAATGGACCTGAATTTTCCAAT
GACATCAAGAAAAGGAAGGTGGATGATAAGGACTCCAGCCACTATGACAGTGATGGTGACAAAAGCGATGACAACTTAGTTGTGGATGTG
TCTAATGAGGACCCTTCTTCTCCGCGAGCAAGCCCTGCCCACTCGCCCCGGGAAAATGGAATCGACAAAAATCGCCTGCTAAAGAAGGAT
GCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCGGCAAGTTCCACTTCTTTGAAATCCAAAGAAATGAGCTTGCATGAAAAAGCCAGCACG
CCTGTTCTGAAATCCAGCACACCAACGCCTCGGAGCGACATGCCAACGCCGGGCACCAGCGCCACTCCAGGCCTCCGTCCAGGTCTCGGC
AAGCCTCCAGCCATAGACCCCCTCGTTAACCAAGCGGCAGCTGGCTTGAGGACACCCCTGGCAGTGCCCGGCCCATATCCTGCTCCTTTT
GGGATGGTCCCCCACGCTGGCATGAACGGCGAGCTGACCAGCCCAGGCGCTGCCTACGCCAGTTTACACAACATGTCGCCCCAGATGAGC
GCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTACGGGCGCTCCCCCATGGTGGGGTTTGATCCTCCCCCTCACATGAGAGTACCTACCATT
CCTCCAAACCTGGCAGGAATCCCTGGGGGGAAACCTGCATACTCCTTCCACGTTACTGCAGACGGTCAGATGCAGCCTGTCCCTTTTCCC
CCCGACGCCCTCATCGGACCCGGAATCCCCCGGCATGCTCGCCAGATCAACACCCTCAACCACGGGGAGGTGGTGTGCGCTGTGACCATC
AGCAACCCCACGAGACACGTGTACACAGGCGGGAAGGGCTGCGTCAAGGTCTGGGACATCAGCCACCCTGGCAATAAGAGCCCTGTCTCC
CAGCTCGACTGTCTGAACAGAGACAATTATATCCGTTCCTGTAAATTGCTACCCGATGGCTGCACTCTCATAGTGGGAGGGGAAGCCAGT
ACTTTGTCCATTTGGGACCTGGCGGCTCCAACCCCGCGCATCAAGGCGGAGCTGACGTCCTCGGCCCCCGCCTGCTACGCCCTGGCCATC
AGCCCCGATTCCAAGGTCTGCTTCTCATGCTGCAGCGACGGCAACATCGCTGTGTGGGATCTGCACAACCAGACACTAGTGAGGCAATTC
CAGGGCCACACAGACGGAGCCAGCTGTATTGACATTTCTAATGATGGCACCAAGCTCTGGACGGGTGGTTTGGACAACACAGTCAGGTCC
TGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAGCACGACTTCACCTCCCAGATCTTCTCCCTGGGGTACTGCCCCACCGGGGAGTGGCTG
GCAGTGGGCATGGAGAGCAGCAATGTGGAGGTGCTGCACGTGAACAAGCCTGACAAGTACCAGCTGCACCTGCATGAGAGCTGCGTGCTG
TCCCTGAAATTTGCTTACTGTGGTAAATGGTTTGTGAGTACTGGAAAAGATAACCTCCTCAATGCTTGGCGGACCCCCTATGGAGCCAGC
ATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTTAGCTGTGACATCTCTGTGGATGATAAGTACATAGTCACTGGCTCGGGGGACAAGAAG
GCTACAGTCTATGAAGTCATCTACTGAAAACATTATGTGGTTTAACGTTTATAGTTGAATTGGGCCAAAATGTTTCGAATTTATAGAAAT
AGAAAAGTTGTAACTTTAAAAGAGAAAAAAAATTACAAACACCTGTTTCCAAACCTTGACAGAAAACTACTTTGAGTCTACAAAGAGGAG
GCGACAAGTCCATCAGCAGAAAGTCACCTGTCTACATAGACCAAATGGAGCACCAAGGCCAAGCGGACAGAGGGGCCATGGGTTGTAGGA
TTGAGGAACGGAATCTGCCGACTCACATGACAGCCCATTCTTTCTTTCTGGGTGATCTGGGGATCACGCCTTGCCCAAGTGTGAGATTAC
CTTTCTGTTCCTTGCAGTTCACCTCACTTTCCGTCCTTTGTAGAGCAGTGGTGTCTCCAATGAACTTGTTTCCTGGTTTTGCATCTTGTG
AAATGTTTTTTTGTATTTTTGTTGAAGGTTAAACATTTGTATAAATTGTAAATATATTTGGTTTATTACAGTAAAGGCTTTAGTACCAAT

>20311_20311_2_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000325580_TLE1_chr9_84268951_ENST00000376499_length(amino acids)=746AA_BP=54
MRDRPRAMAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQV
TMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLV
PDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSA
SSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGEL
TSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH
ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP
RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH
DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS

--------------------------------------------------------------
>20311_20311_3_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000374593_TLE1_chr9_84268951_ENST00000376499_length(transcript)=2805nt_BP=211nt
GGGCGGGTGGGCTGACTGGCGGCAGGCTCGCCGCGGCGCGGAGTCCCGGCTGCGGGATAGACCGAGGGCCATGGCCGCCTCTCCCGGACC
CGCCGGCGTTGGCGGCGCCGGAGCAGTCTACGGCTCCGGCTCTTCGGGCTTCGCCCTCGACTCGGGACTGGAGATCAAAACTCGCTCGGT
GGAGCAGACGCTACTCCCGCTGGTTTCTCAGACTGAAATCGCCAAGAGATTGAATACGATTTGTGCACAAGTCATCCCATTTCTGTCTCA
GGAACATCAACAACAGGTGGCCCAGGCTGTTGAACGTGCCAAACAGGTGACCATGGCAGAATTGAATGCCATCATCGGGCAGCAGCAGTT
GCAAGCTCAGCATCTTTCTCATGGCCACGGACCCCCAGTTCCCCTTACGCCTCACCCTTCGGGACTTCAGCCTCCTGGAATCCCGCCCCT
CGGGGGCAGTGCCGGCCTTCTTGCGCTGTCTAGTGCTCTGAGTGGGCAGTCTCACTTGGCAATAAAAGATGACAAGAAGCACCACGATGC
AGAGCACCACAGAGACAGAGAGCCGGGCACAAGTAATTCCCTCCTGGTCCCAGACAGTCTAAGAGGCACAGATAAACGCAGAAATGGACC
TGAATTTTCCAATGACATCAAGAAAAGGAAGGTGGATGATAAGGACTCCAGCCACTATGACAGTGATGGTGACAAAAGCGATGACAACTT
AGTTGTGGATGTGTCTAATGAGGACCCTTCTTCTCCGCGAGCAAGCCCTGCCCACTCGCCCCGGGAAAATGGAATCGACAAAAATCGCCT
GCTAAAGAAGGATGCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCGGCAAGTTCCACTTCTTTGAAATCCAAAGAAATGAGCTTGCATGA
AAAAGCCAGCACGCCTGTTCTGAAATCCAGCACACCAACGCCTCGGAGCGACATGCCAACGCCGGGCACCAGCGCCACTCCAGGCCTCCG
TCCAGGTCTCGGCAAGCCTCCAGCCATAGACCCCCTCGTTAACCAAGCGGCAGCTGGCTTGAGGACACCCCTGGCAGTGCCCGGCCCATA
TCCTGCTCCTTTTGGGATGGTCCCCCACGCTGGCATGAACGGCGAGCTGACCAGCCCAGGCGCTGCCTACGCCAGTTTACACAACATGTC
GCCCCAGATGAGCGCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTACGGGCGCTCCCCCATGGTGGGGTTTGATCCTCCCCCTCACATGAG
AGTACCTACCATTCCTCCAAACCTGGCAGGAATCCCTGGGGGGAAACCTGCATACTCCTTCCACGTTACTGCAGACGGTCAGATGCAGCC
TGTCCCTTTTCCCCCCGACGCCCTCATCGGACCCGGAATCCCCCGGCATGCTCGCCAGATCAACACCCTCAACCACGGGGAGGTGGTGTG
CGCTGTGACCATCAGCAACCCCACGAGACACGTGTACACAGGCGGGAAGGGCTGCGTCAAGGTCTGGGACATCAGCCACCCTGGCAATAA
GAGCCCTGTCTCCCAGCTCGACTGTCTGAACAGAGACAATTATATCCGTTCCTGTAAATTGCTACCCGATGGCTGCACTCTCATAGTGGG
AGGGGAAGCCAGTACTTTGTCCATTTGGGACCTGGCGGCTCCAACCCCGCGCATCAAGGCGGAGCTGACGTCCTCGGCCCCCGCCTGCTA
CGCCCTGGCCATCAGCCCCGATTCCAAGGTCTGCTTCTCATGCTGCAGCGACGGCAACATCGCTGTGTGGGATCTGCACAACCAGACACT
AGTGAGGCAATTCCAGGGCCACACAGACGGAGCCAGCTGTATTGACATTTCTAATGATGGCACCAAGCTCTGGACGGGTGGTTTGGACAA
CACAGTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAGCACGACTTCACCTCCCAGATCTTCTCCCTGGGGTACTGCCCCAC
CGGGGAGTGGCTGGCAGTGGGCATGGAGAGCAGCAATGTGGAGGTGCTGCACGTGAACAAGCCTGACAAGTACCAGCTGCACCTGCATGA
GAGCTGCGTGCTGTCCCTGAAATTTGCTTACTGTGGTAAATGGTTTGTGAGTACTGGAAAAGATAACCTCCTCAATGCTTGGCGGACCCC
CTATGGAGCCAGCATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTTAGCTGTGACATCTCTGTGGATGATAAGTACATAGTCACTGGCTC
GGGGGACAAGAAGGCTACAGTCTATGAAGTCATCTACTGAAAACATTATGTGGTTTAACGTTTATAGTTGAATTGGGCCAAAATGTTTCG
AATTTATAGAAATAGAAAAGTTGTAACTTTAAAAGAGAAAAAAAATTACAAACACCTGTTTCCAAACCTTGACAGAAAACTACTTTGAGT
CTACAAAGAGGAGGCGACAAGTCCATCAGCAGAAAGTCACCTGTCTACATAGACCAAATGGAGCACCAAGGCCAAGCGGACAGAGGGGCC
ATGGGTTGTAGGATTGAGGAACGGAATCTGCCGACTCACATGACAGCCCATTCTTTCTTTCTGGGTGATCTGGGGATCACGCCTTGCCCA
AGTGTGAGATTACCTTTCTGTTCCTTGCAGTTCACCTCACTTTCCGTCCTTTGTAGAGCAGTGGTGTCTCCAATGAACTTGTTTCCTGGT
TTTGCATCTTGTGAAATGTTTTTTTGTATTTTTGTTGAAGGTTAAACATTTGTATAAATTGTAAATATATTTGGTTTATTACAGTAAAGG

>20311_20311_3_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000374593_TLE1_chr9_84268951_ENST00000376499_length(amino acids)=746AA_BP=54
MRDRPRAMAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQV
TMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLV
PDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSA
SSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGEL
TSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH
ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP
RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH
DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS

--------------------------------------------------------------
>20311_20311_4_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000374595_TLE1_chr9_84268951_ENST00000376499_length(transcript)=2815nt_BP=221nt
CCGCCGCCTCGGGCGGGTGGGCTGACTGGCGGCAGGCTCGCCGCGGCGCGGAGTCCCGGCTGCGGGATAGACCGAGGGCCATGGCCGCCT
CTCCCGGACCCGCCGGCGTTGGCGGCGCCGGAGCAGTCTACGGCTCCGGCTCTTCGGGCTTCGCCCTCGACTCGGGACTGGAGATCAAAA
CTCGCTCGGTGGAGCAGACGCTACTCCCGCTGGTTTCTCAGACTGAAATCGCCAAGAGATTGAATACGATTTGTGCACAAGTCATCCCAT
TTCTGTCTCAGGAACATCAACAACAGGTGGCCCAGGCTGTTGAACGTGCCAAACAGGTGACCATGGCAGAATTGAATGCCATCATCGGGC
AGCAGCAGTTGCAAGCTCAGCATCTTTCTCATGGCCACGGACCCCCAGTTCCCCTTACGCCTCACCCTTCGGGACTTCAGCCTCCTGGAA
TCCCGCCCCTCGGGGGCAGTGCCGGCCTTCTTGCGCTGTCTAGTGCTCTGAGTGGGCAGTCTCACTTGGCAATAAAAGATGACAAGAAGC
ACCACGATGCAGAGCACCACAGAGACAGAGAGCCGGGCACAAGTAATTCCCTCCTGGTCCCAGACAGTCTAAGAGGCACAGATAAACGCA
GAAATGGACCTGAATTTTCCAATGACATCAAGAAAAGGAAGGTGGATGATAAGGACTCCAGCCACTATGACAGTGATGGTGACAAAAGCG
ATGACAACTTAGTTGTGGATGTGTCTAATGAGGACCCTTCTTCTCCGCGAGCAAGCCCTGCCCACTCGCCCCGGGAAAATGGAATCGACA
AAAATCGCCTGCTAAAGAAGGATGCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCGGCAAGTTCCACTTCTTTGAAATCCAAAGAAATGA
GCTTGCATGAAAAAGCCAGCACGCCTGTTCTGAAATCCAGCACACCAACGCCTCGGAGCGACATGCCAACGCCGGGCACCAGCGCCACTC
CAGGCCTCCGTCCAGGTCTCGGCAAGCCTCCAGCCATAGACCCCCTCGTTAACCAAGCGGCAGCTGGCTTGAGGACACCCCTGGCAGTGC
CCGGCCCATATCCTGCTCCTTTTGGGATGGTCCCCCACGCTGGCATGAACGGCGAGCTGACCAGCCCAGGCGCTGCCTACGCCAGTTTAC
ACAACATGTCGCCCCAGATGAGCGCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTACGGGCGCTCCCCCATGGTGGGGTTTGATCCTCCCC
CTCACATGAGAGTACCTACCATTCCTCCAAACCTGGCAGGAATCCCTGGGGGGAAACCTGCATACTCCTTCCACGTTACTGCAGACGGTC
AGATGCAGCCTGTCCCTTTTCCCCCCGACGCCCTCATCGGACCCGGAATCCCCCGGCATGCTCGCCAGATCAACACCCTCAACCACGGGG
AGGTGGTGTGCGCTGTGACCATCAGCAACCCCACGAGACACGTGTACACAGGCGGGAAGGGCTGCGTCAAGGTCTGGGACATCAGCCACC
CTGGCAATAAGAGCCCTGTCTCCCAGCTCGACTGTCTGAACAGAGACAATTATATCCGTTCCTGTAAATTGCTACCCGATGGCTGCACTC
TCATAGTGGGAGGGGAAGCCAGTACTTTGTCCATTTGGGACCTGGCGGCTCCAACCCCGCGCATCAAGGCGGAGCTGACGTCCTCGGCCC
CCGCCTGCTACGCCCTGGCCATCAGCCCCGATTCCAAGGTCTGCTTCTCATGCTGCAGCGACGGCAACATCGCTGTGTGGGATCTGCACA
ACCAGACACTAGTGAGGCAATTCCAGGGCCACACAGACGGAGCCAGCTGTATTGACATTTCTAATGATGGCACCAAGCTCTGGACGGGTG
GTTTGGACAACACAGTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAGCACGACTTCACCTCCCAGATCTTCTCCCTGGGGT
ACTGCCCCACCGGGGAGTGGCTGGCAGTGGGCATGGAGAGCAGCAATGTGGAGGTGCTGCACGTGAACAAGCCTGACAAGTACCAGCTGC
ACCTGCATGAGAGCTGCGTGCTGTCCCTGAAATTTGCTTACTGTGGTAAATGGTTTGTGAGTACTGGAAAAGATAACCTCCTCAATGCTT
GGCGGACCCCCTATGGAGCCAGCATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTTAGCTGTGACATCTCTGTGGATGATAAGTACATAG
TCACTGGCTCGGGGGACAAGAAGGCTACAGTCTATGAAGTCATCTACTGAAAACATTATGTGGTTTAACGTTTATAGTTGAATTGGGCCA
AAATGTTTCGAATTTATAGAAATAGAAAAGTTGTAACTTTAAAAGAGAAAAAAAATTACAAACACCTGTTTCCAAACCTTGACAGAAAAC
TACTTTGAGTCTACAAAGAGGAGGCGACAAGTCCATCAGCAGAAAGTCACCTGTCTACATAGACCAAATGGAGCACCAAGGCCAAGCGGA
CAGAGGGGCCATGGGTTGTAGGATTGAGGAACGGAATCTGCCGACTCACATGACAGCCCATTCTTTCTTTCTGGGTGATCTGGGGATCAC
GCCTTGCCCAAGTGTGAGATTACCTTTCTGTTCCTTGCAGTTCACCTCACTTTCCGTCCTTTGTAGAGCAGTGGTGTCTCCAATGAACTT
GTTTCCTGGTTTTGCATCTTGTGAAATGTTTTTTTGTATTTTTGTTGAAGGTTAAACATTTGTATAAATTGTAAATATATTTGGTTTATT

>20311_20311_4_CTNNAL1-TLE1_CTNNAL1_chr9_111775581_ENST00000374595_TLE1_chr9_84268951_ENST00000376499_length(amino acids)=746AA_BP=54
MRDRPRAMAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQV
TMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLV
PDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSA
SSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGEL
TSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH
ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP
RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH
DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CTNNAL1-TLE1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CTNNAL1-TLE1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CTNNAL1-TLE1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source