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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNNBL1-ETFA (FusionGDB2 ID:20349)

Fusion Gene Summary for CTNNBL1-ETFA

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNBL1-ETFA
Fusion gene ID: 20349
HgeneTgene
Gene symbol

CTNNBL1

ETFA

Gene ID

56259

2108

Gene namecatenin beta like 1electron transfer flavoprotein subunit alpha
SynonymsC20orf33|NAP|P14L|PP8304|dJ633O20.1EMA|GA2|MADD
Cytomap

20q11.23

15q24.2-q24.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-catenin-like protein 1nuclear associated proteintestis development protein NYD-SP19electron transfer flavoprotein subunit alpha, mitochondrialalpha-ETFelectron transfer flavoprotein alpha subunitelectron transfer flavoprotein, alpha polypeptideepididymis secretory sperm binding proteinglutaric aciduria II
Modification date2020032720200313
UniProtAcc

Q8WYA6

P13804

Ensembl transtripts involved in fusion geneENST00000473857, ENST00000361383, 
ENST00000373469, ENST00000373473, 
ENST00000405275, 		ENST00000433983, 
ENST00000557943, ENST00000559602, 
ENST00000560726, ENST00000560816, 
Fusion gene scores* DoF score7 X 5 X 5=1758 X 7 X 6=336
# samples 78
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNNBL1 [Title/Abstract] AND ETFA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNNBL1(36431450)-ETFA(76508938), # samples:2
Anticipated loss of major functional domain due to fusion event.CTNNBL1-ETFA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNBL1

GO:0043065

positive regulation of apoptotic process

12659813

TgeneETFA

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

25416781


check buttonFusion gene breakpoints across CTNNBL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01ACTNNBL1chr20

36431450

+ETFAchr15

76508938

-


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Fusion Gene ORF analysis for CTNNBL1-ETFA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473857ENST00000433983CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
3UTR-3CDSENST00000473857ENST00000557943CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
3UTR-3CDSENST00000473857ENST00000559602CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
3UTR-3CDSENST00000473857ENST00000560726CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
3UTR-intronENST00000473857ENST00000560816CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
5CDS-intronENST00000361383ENST00000560816CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
5CDS-intronENST00000373469ENST00000560816CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
5CDS-intronENST00000373473ENST00000560816CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
5CDS-intronENST00000405275ENST00000560816CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000361383ENST00000433983CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000361383ENST00000557943CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000361383ENST00000560726CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373469ENST00000433983CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373469ENST00000557943CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373469ENST00000560726CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373473ENST00000433983CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373473ENST00000557943CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000373473ENST00000560726CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000405275ENST00000433983CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000405275ENST00000557943CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
Frame-shiftENST00000405275ENST00000560726CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
In-frameENST00000361383ENST00000559602CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
In-frameENST00000373469ENST00000559602CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
In-frameENST00000373473ENST00000559602CTNNBL1chr20

36431450

+ETFAchr15

76508938

-
In-frameENST00000405275ENST00000559602CTNNBL1chr20

36431450

+ETFAchr15

76508938

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361383CTNNBL1chr2036431450+ENST00000559602ETFAchr1576508938-144513301171340407
ENST00000405275CTNNBL1chr2036431450+ENST00000559602ETFAchr1576508938-149013752431385380
ENST00000373473CTNNBL1chr2036431450+ENST00000559602ETFAchr1576508938-1013898246908220
ENST00000373469CTNNBL1chr2036431450+ENST00000559602ETFAchr1576508938-65053578545155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361383ENST00000559602CTNNBL1chr2036431450+ETFAchr1576508938-0.0012566560.99874336
ENST00000405275ENST00000559602CTNNBL1chr2036431450+ETFAchr1576508938-0.0009881590.9990119
ENST00000373473ENST00000559602CTNNBL1chr2036431450+ETFAchr1576508938-0.0012069630.998793
ENST00000373469ENST00000559602CTNNBL1chr2036431450+ETFAchr1576508938-0.0021465060.99785346

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Fusion Genomic Features for CTNNBL1-ETFA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTNNBL1-ETFA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:36431450/chr15:76508938)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNNBL1

Q8WYA6

ETFA

P13804

FUNCTION: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.FUNCTION: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+111622_25404564.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+111668_75404564.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+4922_25152312.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+4968_75152312.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+81322_25217377.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+81368_75217377.0Compositional biasNote=Poly-Glu
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116130_140404564.0MotifNuclear export signal (NES)
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49130_140152312.0MotifNuclear export signal (NES)
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813130_140217377.0MotifNuclear export signal (NES)
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116134_176404564.0RepeatNote=HEAT 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116178_228404564.0RepeatNote=ARM 1
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116229_273404564.0RepeatNote=ARM 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116274_323404564.0RepeatNote=ARM 3
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116325_363404564.0RepeatNote=ARM 4
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+111679_129404564.0RepeatNote=HEAT 1
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+4979_129152312.0RepeatNote=HEAT 1
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813134_176217377.0RepeatNote=HEAT 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+81379_129217377.0RepeatNote=HEAT 1
TgeneETFAchr20:36431450chr15:76508938ENST00000433983911281_286272285.0Nucleotide bindingFAD
TgeneETFAchr20:36431450chr15:76508938ENST00000433983911318_319272285.0Nucleotide bindingFAD
TgeneETFAchr20:36431450chr15:76508938ENST000005579431012318_319321334.0Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116476_540404564.0Coiled coilOntology_term=ECO:0000269
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49476_540152312.0Coiled coilOntology_term=ECO:0000269
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813476_540217377.0Coiled coilOntology_term=ECO:0000269
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000361383+1116364_417404564.0RepeatNote=ARM 5
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49134_176152312.0RepeatNote=HEAT 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49178_228152312.0RepeatNote=ARM 1
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49229_273152312.0RepeatNote=ARM 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49274_323152312.0RepeatNote=ARM 3
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49325_363152312.0RepeatNote=ARM 4
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373469+49364_417152312.0RepeatNote=ARM 5
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813178_228217377.0RepeatNote=ARM 1
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813229_273217377.0RepeatNote=ARM 2
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813274_323217377.0RepeatNote=ARM 3
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813325_363217377.0RepeatNote=ARM 4
HgeneCTNNBL1chr20:36431450chr15:76508938ENST00000373473+813364_417217377.0RepeatNote=ARM 5
TgeneETFAchr20:36431450chr15:76508938ENST00000433983911263_266272285.0Nucleotide bindingFAD
TgeneETFAchr20:36431450chr15:76508938ENST000005579431012263_266321334.0Nucleotide bindingFAD
TgeneETFAchr20:36431450chr15:76508938ENST000005579431012281_286321334.0Nucleotide bindingFAD
TgeneETFAchr20:36431450chr15:76508938ENST00000433983911205_333272285.0RegionDomain II
TgeneETFAchr20:36431450chr15:76508938ENST0000043398391120_204272285.0RegionDomain I
TgeneETFAchr20:36431450chr15:76508938ENST000005579431012205_333321334.0RegionDomain II
TgeneETFAchr20:36431450chr15:76508938ENST00000557943101220_204321334.0RegionDomain I


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Fusion Gene Sequence for CTNNBL1-ETFA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20349_20349_1_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000361383_ETFA_chr15_76508938_ENST00000559602_length(transcript)=1445nt_BP=1330nt
ATTGGCTCTGCGGCTCCGCTCGCCGCACTTTACGGCAGTGTGGCTGGAGCCGCGGCTGACGGGCCCGCGGTCTGGGCGTGAGTGCAGGGA
AGTGGAGTATTTGCTGGGCCGGGTACCATGGACGTGGGCGAACTTCTGAGCTACCAGCCCAATAGGGGCACAAAACGTCCCCGGGATGAT
GAAGAGGAGGAGCAGAAGATGCGTCGGAAACAAACTGGTACTCGAGAACGCGGCCGCTATCGGGAAGAAGAAATGACTGTGGTGGAGGAA
GCGGATGATGACAAAAAAAGGCTGCTGCAGATTATTGACAGAGATGGGGAAGAGGAAGAGGAAGAGGAGGAGCCATTGGATGAAAGCTCA
GTGAAGAAAATGATCCTCACATTTGAAAAGAGATCATATAAAAACCAAGAATTGCGGATTAAGTTTCCAGACAATCCAGAGAAGTTCATG
GAATCCGAGCTGGACCTAAATGACATCATTCAGGAGATGCACGTGGTGGCCACCATGCCAGACCTGTACCACCTTCTGGTGGAGCTGAAT
GCTGTACAGTCGCTTCTCGGCTTGCTCGGACACGATAATACAGATGTGTCCATAGCTGTGGTCGATTTGCTTCAGGAATTAACAGATATA
GACACCCTCCATGAGAGTGAAGAGGGAGCAGAAGTGCTCATCGATGCTCTGGTGGATGGGCAGGTGGTAGCACTGCTGGTACAGAATCTG
GAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCACAACACTCTGGCTATTGTGGAAAACATGGCTGAGTTCCGGCCTGAG
ATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTGAAGAGGCTGAAGGCAAAGATGCCTTTTGATGCCAACAAACTGTAT
TGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGGGAATTGCTTGGGGAGCTGGATGGAATCGATGTGCTTCTTCAG
CAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGATTCCCTCTGCTCCTGTCTA
ATGCTTAGTTCCAATCGTGAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAAAAGAAGATCTCCCGGAGC
AGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGACATTCTTGGCTTACGAACC
ATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGGTAGTTCCTGAAATGACTGA
GATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCACTGAAATCACAGATATTTGTGGGTAT

>20349_20349_1_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000361383_ETFA_chr15_76508938_ENST00000559602_length(amino acids)=407AA_BP=
MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFE
KRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEG
AEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILL
QDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHA

--------------------------------------------------------------
>20349_20349_2_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000373469_ETFA_chr15_76508938_ENST00000559602_length(transcript)=650nt_BP=535nt
CGTGAAAAATTTGTCCTGGGGAAGGAAGCAAGACCCCTTAACATTTTTCTCATTTCTCCTATTTCCCCATAGGCAAAGATGCCTTTTGAT
GCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGGGAATTGCTTGGGGAGCTGGATGGAATC
GATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGATTCC
CTCTGCTCCTGTCTAATGCTTAGTTCCAATCGTGAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAAAAG
AAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGACATT
CTTGGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGGTAGT
TCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCACTGAAATCACA

>20349_20349_2_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000373469_ETFA_chr15_76508938_ENST00000559602_length(amino acids)=155AA_BP=
MPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLM

--------------------------------------------------------------
>20349_20349_3_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000373473_ETFA_chr15_76508938_ENST00000559602_length(transcript)=1013nt_BP=898nt
GGGAAGAGTGCTGTGGTGAGTGAGGGATTTTGCCATGGAGAAGGAGAAGGACCCATAGCAGTTTGTCAGGTTCATGGAATCCGAGCTGGA
CCTAAATGACATCATTCAGGAGATGCACGTGGTGGCCACCATGCCAGACCTGTACCACCTTCTGGTGGAGCTGAATGCTGTACAGTCGCT
TCTCGGCTTGCTCGGACACGATAATACAGATATCCTTTCAGATCTGACCTCAGTAGGAGAGCTGACATGGTGGATGGGCAGGTGGTAGCA
CTGCTGGTACAGAATCTGGAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCACAACACTCTGGCTATTGTGGAAAACATG
GCTGAGTTCCGGCCTGAGATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTGAAGAGGCTGAAGGCAAAGATGCCTTTT
GATGCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGGGAATTGCTTGGGGAGCTGGATGGA
ATCGATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGAT
TCCCTCTGCTCCTGTCTAATGCTTAGTTCCAATCGTGAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAA
AAGAAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGAC
ATTCTTGGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGGT
AGTTCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCACTGAAATC

>20349_20349_3_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000373473_ETFA_chr15_76508938_ENST00000559602_length(amino acids)=220AA_BP=
MVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENR
ELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGT

--------------------------------------------------------------
>20349_20349_4_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000405275_ETFA_chr15_76508938_ENST00000559602_length(transcript)=1490nt_BP=1375nt
TGACGGGCCCGCGGTCTGGGCGTGAGTGCAGGGAAGTGGAGTATTTGCTGGGCCGGGTACCATGGACGTGGGCGAACTTCTGAGCTACCA
GGGGCATGGATGGAGACACGCACACACACAGGCAATAGGCCTCAAGATTATTGGCGAGTAAAGGCATCTATCTATTATCGTGAAGCCTAC
TCTGAGCTTTGACCCAATAGGGGCACAAAACGTCCCCGGGATGATGAAGAGGAGGAGCAGAAGATGCGTCGGAAACAAACTGGTACTCGA
GAACGCGGCCGCTATCGGGAAGAAGAAATGACTGTGGTGGAGGAAGCGGATGATGACAAAAAAAGGCTGCTGCAGATTATTGACAGAGAT
GGGGAAGAGGAAGAGGAAGAGGAGGAGCCATTGGATGAAAGCTCAGTGAAGAAAATGATCCTCACATTTGAAAAGAGATCATATAAAAAC
CAAGAATTGCGGATTAAGTTTCCAGACAATCCAGAGAAGTTCATGGAATCCGAGCTGGACCTAAATGACATCATTCAGGAGATGCACGTG
GTGGCCACCATGCCAGACCTGTACCACCTTCTGGTGGAGCTGAATGCTGTACAGTCGCTTCTCGGCTTGCTCGGACACGATAATACAGAT
GTGTCCATAGCTGTGGTCGATTTGCTTCAGGAATTAACAGATATAGACACCCTCCATGAGAGTGAAGAGGGAGCAGAAGTGCTCATCGAT
GCTCTGGTGGATGGGCAGGTGGTAGCACTGCTGGTACAGAATCTGGAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCAC
AACACTCTGGCTATTGTGGAAAACATGGCTGAGTTCCGGCCTGAGATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTG
AAGAGGCTGAAGGCAAAGATGCCTTTTGATGCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAAC
AGGGAATTGCTTGGGGAGCTGGATGGAATCGATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAG
CAGGAGATGATGGAGAATCTGTTTGATTCCCTCTGCTCCTGTCTAATGCTTAGTTCCAATCGTGAGCGCTTCCTGAAGGGCGAGGGTCTT
CAGCTGATGAATCTCATGCTCAGGGAAAAGAAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGC
ACAGACAACTGCCATAAGTTTGTTGACATTCTTGGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTG
GGAACCACTGAGAAGGAACATGAAGGTAGTTCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAA

>20349_20349_4_CTNNBL1-ETFA_CTNNBL1_chr20_36431450_ENST00000405275_ETFA_chr15_76508938_ENST00000559602_length(amino acids)=380AA_BP=
MRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDL
NDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDES
VKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFK
RHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFM

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Fusion Gene PPI Analysis for CTNNBL1-ETFA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNNBL1-ETFA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNNBL1-ETFA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource