FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CTNND1-STARD10 (FusionGDB2 ID:20378)

Fusion Gene Summary for CTNND1-STARD10

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1-STARD10
Fusion gene ID: 20378
HgeneTgene
Gene symbol

CTNND1

STARD10

Gene ID

100528016

10809

Gene nameTMX2-CTNND1 readthrough (NMD candidate)StAR related lipid transfer domain containing 10
SynonymsCAS|CTNND1|p120(cas)|p120(ctn)CGI-52|NY-CO-28|PCTP2|SDCCAG28
Cytomap

11q12.1

11q13.4

Type of genencRNAprotein-coding
DescriptionCadherin-associated Src substrateCatenin delta-1TMX2-CTNND1 readthrough (non-protein coding)p120 cateninSTART domain-containing protein 10PCTP-LPCTP-like proteinSTART domain containing 10StAR-related lipid transfer (START) domain containing 10antigen NY-CO-28serologically defined colon cancer antigen 28stAR-related lipid transfer protein 10
Modification date2020031320200313
UniProtAcc

O60716

.
Ensembl transtripts involved in fusion geneENST00000358694, ENST00000360682, 
ENST00000361332, ENST00000361391, 
ENST00000361796, ENST00000399050, 
ENST00000415361, ENST00000426142, 
ENST00000428599, ENST00000525902, 
ENST00000526357, ENST00000526772, 
ENST00000526938, ENST00000527467, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529986, ENST00000530094, 
ENST00000530748, ENST00000531014, 
ENST00000532245, ENST00000532463, 
ENST00000532649, ENST00000532787, 
ENST00000532844, ENST00000533667, 
ENST00000534579, ENST00000399039, 
ENST00000524630, ENST00000529919, 
ENST00000334805, ENST00000538437, 
ENST00000538536, ENST00000543304, 
ENST00000545082, 
Fusion gene scores* DoF score29 X 18 X 15=78307 X 4 X 6=168
# samples 357
** MAII scorelog2(35/7830*10)=-4.48358548034607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND STARD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND1(57529518)-STARD10(72504969), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CTNND1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STARD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-A7IJ-01ACTNND1chr11

57529518

+STARD10chr11

72504969

-


Top

Fusion Gene ORF analysis for CTNND1-STARD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000358694ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000358694ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000358694ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000358694ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000358694ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000360682ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000360682ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000360682ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000360682ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000360682ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361332ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361332ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361332ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361332ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361332ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361391ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361391ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361391ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361391ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361391ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361796ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361796ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361796ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361796ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000361796ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000399050ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000399050ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000399050ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000399050ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000399050ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000415361ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000415361ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000415361ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000415361ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000415361ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000426142ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000426142ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000426142ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000426142ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000426142ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000428599ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000428599ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000428599ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000428599ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000428599ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000525902ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000525902ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000525902ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000525902ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000525902ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526357ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526357ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526357ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526357ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526357ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526772ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526772ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526772ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526772ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526772ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526938ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526938ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526938ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526938ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000526938ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000527467ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000527467ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000527467ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000527467ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000527467ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528232ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528232ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528232ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528232ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528232ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528621ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528621ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528621ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528621ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000528621ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529526ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529526ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529526ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529526ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529526ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529873ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529873ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529873ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529873ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529873ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529986ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529986ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529986ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529986ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000529986ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530094ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530094ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530094ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530094ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530094ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530748ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530748ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530748ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530748ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000530748ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000531014ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000531014ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000531014ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000531014ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000531014ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532245ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532245ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532245ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532245ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532245ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532463ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532463ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532463ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532463ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532463ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532649ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532649ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532649ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532649ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532649ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532787ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532787ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532787ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532787ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532787ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532844ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532844ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532844ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532844ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000532844ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000533667ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000533667ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000533667ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000533667ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000533667ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000534579ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000534579ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000534579ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000534579ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
5UTR-intronENST00000534579ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000399039ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000399039ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000399039ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000399039ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000399039ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000524630ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000524630ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000524630ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000524630ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000524630ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000529919ENST00000334805CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000529919ENST00000538437CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000529919ENST00000538536CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000529919ENST00000543304CTNND1chr11

57529518

+STARD10chr11

72504969

-
intron-intronENST00000529919ENST00000545082CTNND1chr11

57529518

+STARD10chr11

72504969

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CTNND1-STARD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CTNND1-STARD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57529518/:72504969)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

.
FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CTNND1-STARD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CTNND1-STARD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CTNND1-STARD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CTNND1-STARD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource