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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTNND2-BTF3 (FusionGDB2 ID:20388)

Fusion Gene Summary for CTNND2-BTF3

Fusion gene summary

Fusion gene information	Fusion gene name: CTNND2-BTF3
	Fusion gene ID: 20388
		Hgene	Tgene
	Gene symbol	CTNND2	BTF3
	Gene ID	1501	10384
	Gene name	catenin delta 2	butyrophilin subfamily 3 member A3
	Synonyms	GT24\|NPRAP	BTF3\|BTN3.3
	Cytomap	5p15.2	6p22.2
	Type of gene	protein-coding	protein-coding
	Description	catenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin	butyrophilin subfamily 3 member A3butyrophilin 3butyrophilin subfamily 3 member A3 secreted isoform
	Modification date	20200320	20200313
	UniProtAcc	Q9UQB3	Q96K17
	Ensembl transtripts involved in fusion gene	ENST00000304623, ENST00000359640, ENST00000458100, ENST00000503622, ENST00000511377, ENST00000495388,	ENST00000380591, ENST00000514505, ENST00000335895,
Fusion gene scores	* DoF score	14 X 13 X 7=1274	9 X 7 X 6=378
	# samples	15	11
	** MAII score	log2(15/1274*10)=-3.08633087176042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/378*10)=-1.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTNND2 [Title/Abstract] AND BTF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTNND2(11117562)-BTF3(72798313), # samples:1
Anticipated loss of major functional domain due to fusion event.	CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CTNND2-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-12-0821-01A	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+

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Fusion Gene ORF analysis for CTNND2-BTF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000304623	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000304623	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000359640	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000359640	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000458100	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000458100	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000503622	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000503622	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000511377	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5CDS-3UTR	ENST00000511377	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5UTR-3CDS	ENST00000495388	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5UTR-3UTR	ENST00000495388	ENST00000380591	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
5UTR-3UTR	ENST00000495388	ENST00000514505	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
Frame-shift	ENST00000458100	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
Frame-shift	ENST00000503622	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
Frame-shift	ENST00000511377	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
In-frame	ENST00000304623	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+
In-frame	ENST00000359640	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000304623

CTNND2

chr5

11117562

ENST00000335895

BTF3

chr5

72798313

3144

2467

190

2886

898

ENST00000359640

CTNND2

chr5

11117562

ENST00000335895

BTF3

chr5

72798313

3099

2422

145

2841

898

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304623	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+	0.007309885	0.99269015
ENST00000359640	ENST00000335895	CTNND2	chr5	11117562	-	BTF3	chr5	72798313	+	0.007099581	0.9929005

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Fusion Genomic Features for CTNND2-BTF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CTNND2	chr5	11117561	-	BTF3	chr5	72798312	+	0.000239208	0.9997608
CTNND2	chr5	11117561	-	BTF3	chr5	72798312	+	0.000239208	0.9997608

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTNND2-BTF3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11117562/chr5:72798313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTNND2 Q9UQB3	BTF3 Q96K17
FUNCTION: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250\|UniProtKB:O35927, ECO:0000269\|PubMed:25807484, ECO:0000269\|PubMed:9971746}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

49_84

759

1226.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

49_84

759

1168.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

216_226

759

1226.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

216_226

759

1168.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

394_438

759

1226.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

540_579

759

1226.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

582_621

759

1226.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

626_666

759

1226.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

682_724

759

1226.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

394_438

759

1168.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

540_579

759

1168.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

582_621

759

1168.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

626_666

759

1168.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

682_724

759

1168.0

Repeat

Note=ARM 5

Tgene

BTF3

chr5:11117562

chr5:72798313

ENST00000335895

185_188

163.0

Compositional bias

Note=Poly-Asp

Tgene

BTF3

chr5:11117562

chr5:72798313

ENST00000380591

185_188

207.0

Compositional bias

Note=Poly-Asp

Tgene

BTF3

chr5:11117562

chr5:72798313

ENST00000335895

82_147

163.0

Domain

NAC-A/B

Tgene

BTF3

chr5:11117562

chr5:72798313

ENST00000380591

82_147

207.0

Domain

NAC-A/B

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

811_817

759

1226.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

811_817

759

1168.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

728_773

759

1226.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

835_875

759

1226.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

882_921

759

1226.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000304623

975_1018

759

1226.0

Repeat

Note=ARM 9

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

728_773

759

1168.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

835_875

759

1168.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

882_921

759

1168.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11117562

chr5:72798313

ENST00000359640

975_1018

759

1168.0

Repeat

Note=ARM 9

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Fusion Gene Sequence for CTNND2-BTF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20388_20388_1_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000304623_BTF3_chr5_72798313_ENST00000335895_length(transcript)=3144nt_BP=2467nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGAACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATC
CGAGACTGGCAGCATGAGCAGCATGAGTTCAGCAGAAGAGCAGTTTCAGTGGCAGTCACAAGATGGTCAAAAAGATATCGAAGATGAGCT
TACAACAGGTCTCGAGCTGGTGGACTCCTGTATTAGGTCACTACAGGAATCAGGAATACTTGACCCACAGGATTATTCTACAGGTGAAAG
GCCCAGCCTGCTCTCCCAGAGTGCACTTCAGCTCAATTCCAAACCTGAAGGGTCTTTCCAGTATCCGGCCAGCTACCATAGCAACCAGAC
CCTGGCCCTGGGGGAAACCACCCCTTCACAGCTCCCGGCCCGAGGCACACAAGCCCGAGCTACGGGCCAGAGCTTCAGCCAGGGCACGAC
CAGCCGCGCCGGCCACCTGGCGGGGCCCGAGCCCGCGCCGCCGCCGCCGCCGCCGCCGCGGGAGCCGTTCGCGCCCAGCCTGGGCAGCGC
CTTCCACCTGCCCGACGCGCCGCCCGCCGCCGCCGCCGCCGCGCTCTACTACTCCAGCTCCACGCTGCCCGCGCCGCCGCGCGGGGGCTC
CCCGCTGGCCGCGCCCCAGGGCGGTTCGCCCACCAAGCTGCAGCGCGGCGGCTCGGCCCCCGAGGGCGCCACCTACGCCGCGCCGCGCGG
CTCCTCGCCCAAGCAGTCGCCCAGCCGCCTGGCCAAGTCCTACAGCACCAGCTCGCCCATCAACATCGTCGTGTCCTCGGCCGGCCTGTC
CCCGATCCGCGTGACCTCGCCCCCCACCGTGCAGTCCACCATCTCCTCCTCGCCCATCCACCAGCTGAGCTCCACCATCGGCACGTACGC
CACCCTGTCGCCCACCAAGCGCCTGGTCCACGCGTCCGAGCAGTACAGCAAGCACTCGCAGGAGCTGTATGCCACGGCCACCCTCCAGAG
GCCGGGCAGCCTGGCAGCTGGTTCCCGAGCCTCATACAGCAGCCAGCATGGGCACCTGGGCCCAGAGTTGCGGGCCCTGCAGTCCCCAGA
ACACCACATAGATCCCATCTATGAAGACCGCGTCTATCAGAAGCCCCCTATGAGGAGTCTCAGCCAGAGCCAGGGGGACCCTCTGCCGCC
AGCACACACCGGCACCTACCGCACGAGCACAGCCCCATCTTCCCCTGGTGTCGACTCCGTCCCCTTGCAGCGCACAGGCAGCCAGCACGG
CCCACAGAATGCCGCCGCGGCCACCTTCCAGAGGGCCAGCTATGCCGCCGGCCCAGCCTCCAATTACGCGGACCCCTACCGACAGCTGCA
GTATTGTCCCTCTGTTGAGTCTCCATACAGCAAATCCGGCCCTGCTCTCCCGCCTGAAGGCACCTTGGCCAGGTCCCCGTCCATTGATAG
CATTCAGAAAGATCCCAGAGAATTTGGATGGAGAGACCCGGAACTGCCGGAAGTGATTCAGATGTTGCAGCACCAGTTTCCCTCGGTCCA
GTCTAACGCGGCAGCCTACTTGCAACACCTCTGTTTTGGAGACAACAAAATTAAAGCCGAGATAAGGAGACAAGGAGGCATCCAGCTCCT
GGTGGACCTGTTGGATCATCGGATGACCGAAGTCCACCGTAGTGCCTGTGGAGCTCTGAGAAACCTGGTGTATGGGAAGGCCAACGATGA
TAACAAAATTGCCCTGAAAAACTGTGGTGGCATCCCAGCACTGGTGAGGTTACTCCGCAAGACGACTGACCTGGAGATCCGGGAGCTGGT
CACAGGAGTCCTTTGGAACCTCTCCTCATGCGATGCACTCAAAATGCCAATCATCCAGGATGCCCTAGCAGTACTGACCAACGCGGTGAT
TATCCCCCACTCAGGCTGGGAAAATTCGCCTCTTCAGGATGATCGGAAAATACAGCTGCATTCATCACAGGTGCTGCGTAACGCCACCGG
GTGCCTAAGGAATGTTAGTTCGGCCGGAGAGGAGGCCCGCAGAAGGATGAGAGAGTGTGATGGGCTTACGGATGCCTTGCTGTACGTGAT
CCAGTCTGCGCTGGGGAGCAGTGAGATCGATAGCAAGGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGA
CAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGT
GATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGA
AATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGA
TGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGC
AAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTT
TGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACA

>20388_20388_1_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000304623_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=898AA_BP=759
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETG
SMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLAL
GETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLA
APQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLS
PTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT
GTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQK
DPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKI
ALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR
NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHF

--------------------------------------------------------------
>20388_20388_2_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000359640_BTF3_chr5_72798313_ENST00000335895_length(transcript)=3099nt_BP=2422nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGA
ACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATCCGAGACTGGCAGCATGAGCAGCATGAGTTCAGCAGAAGAGCAGTT
TCAGTGGCAGTCACAAGATGGTCAAAAAGATATCGAAGATGAGCTTACAACAGGTCTCGAGCTGGTGGACTCCTGTATTAGGTCACTACA
GGAATCAGGAATACTTGACCCACAGGATTATTCTACAGGTGAAAGGCCCAGCCTGCTCTCCCAGAGTGCACTTCAGCTCAATTCCAAACC
TGAAGGGTCTTTCCAGTATCCGGCCAGCTACCATAGCAACCAGACCCTGGCCCTGGGGGAAACCACCCCTTCACAGCTCCCGGCCCGAGG
CACACAAGCCCGAGCTACGGGCCAGAGCTTCAGCCAGGGCACGACCAGCCGCGCCGGCCACCTGGCGGGGCCCGAGCCCGCGCCGCCGCC
GCCGCCGCCGCCGCGGGAGCCGTTCGCGCCCAGCCTGGGCAGCGCCTTCCACCTGCCCGACGCGCCGCCCGCCGCCGCCGCCGCCGCGCT
CTACTACTCCAGCTCCACGCTGCCCGCGCCGCCGCGCGGGGGCTCCCCGCTGGCCGCGCCCCAGGGCGGTTCGCCCACCAAGCTGCAGCG
CGGCGGCTCGGCCCCCGAGGGCGCCACCTACGCCGCGCCGCGCGGCTCCTCGCCCAAGCAGTCGCCCAGCCGCCTGGCCAAGTCCTACAG
CACCAGCTCGCCCATCAACATCGTCGTGTCCTCGGCCGGCCTGTCCCCGATCCGCGTGACCTCGCCCCCCACCGTGCAGTCCACCATCTC
CTCCTCGCCCATCCACCAGCTGAGCTCCACCATCGGCACGTACGCCACCCTGTCGCCCACCAAGCGCCTGGTCCACGCGTCCGAGCAGTA
CAGCAAGCACTCGCAGGAGCTGTATGCCACGGCCACCCTCCAGAGGCCGGGCAGCCTGGCAGCTGGTTCCCGAGCCTCATACAGCAGCCA
GCATGGGCACCTGGGCCCAGAGTTGCGGGCCCTGCAGTCCCCAGAACACCACATAGATCCCATCTATGAAGACCGCGTCTATCAGAAGCC
CCCTATGAGGAGTCTCAGCCAGAGCCAGGGGGACCCTCTGCCGCCAGCACACACCGGCACCTACCGCACGAGCACAGCCCCATCTTCCCC
TGGTGTCGACTCCGTCCCCTTGCAGCGCACAGGCAGCCAGCACGGCCCACAGAATGCCGCCGCGGCCACCTTCCAGAGGGCCAGCTATGC
CGCCGGCCCAGCCTCCAATTACGCGGACCCCTACCGACAGCTGCAGTATTGTCCCTCTGTTGAGTCTCCATACAGCAAATCCGGCCCTGC
TCTCCCGCCTGAAGGCACCTTGGCCAGGTCCCCGTCCATTGATAGCATTCAGAAAGATCCCAGAGAATTTGGATGGAGAGACCCGGAACT
GCCGGAAGTGATTCAGATGTTGCAGCACCAGTTTCCCTCGGTCCAGTCTAACGCGGCAGCCTACTTGCAACACCTCTGTTTTGGAGACAA
CAAAATTAAAGCCGAGATAAGGAGACAAGGAGGCATCCAGCTCCTGGTGGACCTGTTGGATCATCGGATGACCGAAGTCCACCGTAGTGC
CTGTGGAGCTCTGAGAAACCTGGTGTATGGGAAGGCCAACGATGATAACAAAATTGCCCTGAAAAACTGTGGTGGCATCCCAGCACTGGT
GAGGTTACTCCGCAAGACGACTGACCTGGAGATCCGGGAGCTGGTCACAGGAGTCCTTTGGAACCTCTCCTCATGCGATGCACTCAAAAT
GCCAATCATCCAGGATGCCCTAGCAGTACTGACCAACGCGGTGATTATCCCCCACTCAGGCTGGGAAAATTCGCCTCTTCAGGATGATCG
GAAAATACAGCTGCATTCATCACAGGTGCTGCGTAACGCCACCGGGTGCCTAAGGAATGTTAGTTCGGCCGGAGAGGAGGCCCGCAGAAG
GATGAGAGAGTGTGATGGGCTTACGGATGCCTTGCTGTACGTGATCCAGTCTGCGCTGGGGAGCAGTGAGATCGATAGCAAGGGAACTGC
TCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATAT
CTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAA
CACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGAC
TAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGT
TCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTA
CTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCC
CAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATC

>20388_20388_2_CTNND2-BTF3_CTNND2_chr5_11117562_ENST00000359640_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=898AA_BP=759
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETG
SMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLAL
GETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLA
APQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLS
PTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT
GTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQK
DPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKI
ALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLR
NVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHF

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Fusion Gene PPI Analysis for CTNND2-BTF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CTNND2-BTF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTNND2-BTF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source