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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTNND2-POLR1A (FusionGDB2 ID:20398)

Fusion Gene Summary for CTNND2-POLR1A

Fusion gene summary

Fusion gene information	Fusion gene name: CTNND2-POLR1A
	Fusion gene ID: 20398
		Hgene	Tgene
	Gene symbol	CTNND2	POLR1A
	Gene ID	1501	25885
	Gene name	catenin delta 2	RNA polymerase I subunit A
	Synonyms	GT24\|NPRAP	A190\|AFDCIN\|RPA1\|RPA194\|RPO1-4\|RPO14
	Cytomap	5p15.2	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	catenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin	DNA-directed RNA polymerase I subunit RPA1DNA-directed RNA polymerase I largest subunitDNA-directed RNA polymerase I subunit ADNA-directed RNA polymerase I subunit A1RNA polymerase I 194 kDa subunitpolymerase (RNA) I polypeptide A, 194kDapolymerase
	Modification date	20200320	20200313
	UniProtAcc	Q9UQB3	.
	Ensembl transtripts involved in fusion gene	ENST00000304623, ENST00000359640, ENST00000458100, ENST00000495388, ENST00000503622, ENST00000511377,	ENST00000483538, ENST00000263857, ENST00000409681,
Fusion gene scores	* DoF score	14 X 13 X 7=1274	4 X 5 X 4=80
	# samples	15	5
	** MAII score	log2(15/1274*10)=-3.08633087176042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTNND2 [Title/Abstract] AND POLR1A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTNND2(11732248)-POLR1A(86257519), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POLR1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D3-A2JC-06A	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-

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Fusion Gene ORF analysis for CTNND2-POLR1A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000304623	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
5CDS-intron	ENST00000359640	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
5UTR-3CDS	ENST00000458100	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
5UTR-3CDS	ENST00000458100	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
5UTR-intron	ENST00000458100	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
In-frame	ENST00000304623	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
In-frame	ENST00000304623	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
In-frame	ENST00000359640	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
In-frame	ENST00000359640	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000495388	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000495388	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000503622	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000503622	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000511377	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-3CDS	ENST00000511377	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-intron	ENST00000495388	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-intron	ENST00000503622	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-
intron-intron	ENST00000511377	ENST00000483538	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304623	CTNND2	chr5	11732248	-	ENST00000263857	POLR1A	chr2	86257519	-	8156	364	190	948	252
ENST00000304623	CTNND2	chr5	11732248	-	ENST00000409681	POLR1A	chr2	86257519	-	2044	364	190	948	252
ENST00000359640	CTNND2	chr5	11732248	-	ENST00000263857	POLR1A	chr2	86257519	-	8111	319	145	903	252
ENST00000359640	CTNND2	chr5	11732248	-	ENST00000409681	POLR1A	chr2	86257519	-	1999	319	145	903	252

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304623	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-	0.003733951	0.99626607
ENST00000304623	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-	0.005840999	0.994159
ENST00000359640	ENST00000263857	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-	0.003672615	0.99632734
ENST00000359640	ENST00000409681	CTNND2	chr5	11732248	-	POLR1A	chr2	86257519	-	0.006098391	0.9939016

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Fusion Genomic Features for CTNND2-POLR1A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTNND2-POLR1A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11732248/chr2:86257519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTNND2 Q9UQB3	.
FUNCTION: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250\|UniProtKB:O35927, ECO:0000269\|PubMed:25807484, ECO:0000269\|PubMed:9971746}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

49_84

1226.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

49_84

1168.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

216_226

1226.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

811_817

1226.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

216_226

1168.0

Compositional bias

Note=Poly-Pro

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

811_817

1168.0

Compositional bias

Note=Poly-Lys

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

394_438

1226.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

540_579

1226.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

582_621

1226.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

626_666

1226.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

682_724

1226.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

728_773

1226.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

835_875

1226.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

882_921

1226.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000304623

975_1018

1226.0

Repeat

Note=ARM 9

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

394_438

1168.0

Repeat

Note=ARM 1

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

540_579

1168.0

Repeat

Note=ARM 2

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

582_621

1168.0

Repeat

Note=ARM 3

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

626_666

1168.0

Repeat

Note=ARM 4

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

682_724

1168.0

Repeat

Note=ARM 5

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

728_773

1168.0

Repeat

Note=ARM 6

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

835_875

1168.0

Repeat

Note=ARM 7

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

882_921

1168.0

Repeat

Note=ARM 8

Hgene

CTNND2

chr5:11732248

chr2:86257519

ENST00000359640

975_1018

1168.0

Repeat

Note=ARM 9

Tgene

POLR1A

chr5:11732248

chr2:86257519

ENST00000263857

961_973

1526

1721.0

Region

Bridging helix

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Fusion Gene Sequence for CTNND2-POLR1A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20398_20398_1_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000263857_length(transcript)=8156nt_BP=364nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACATGAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGC
GACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAATAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCT
CCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCTCTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGA
GGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGCCGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGC
TGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTTTGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGA
AACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCACGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGT
CGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAGATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTG
GTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAGACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAG
CGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTTCACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCT
CTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAGATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAA
CCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAGGGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGT
AGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGACAAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTG
CCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAGTCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACA
GCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGGGTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACA
TCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTCACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAG
GTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATGTTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACAC
AGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCCACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATG
GACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCAGAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCG
GGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAACTTGGTTTTTTTTACAACAATTTTTTCCCTTGGTTTGCAGTTTCTG
CATTTGGATTTGAGAACCCAGGGCGGGGATTTTCTTGGCACAGTCAGGTCTTGGGTCCCTCTTCCTGTGCTTTCTTGTCTGAGGCCTTAG
GGGGAAGAGCTCAGCCTCTGCAGCCTCCTCCACCTCTGCCCCTGGCCTGCCTCTGCTGTGACCTCCTTCCAGAGCTAGCTGCTGGCCCTG
TGGCCAGGAGAAGCAGAGGGGAGAAGCCTTTATGCAGAAGCTGTGCTAGCCTTGGTCTGGGGTGGGGAGGCTGCTGCTGTGACCTTAGGG
GTAGGGTTGGGGATCAAGGGAGGCTTTGTCAAGGGAGAGTGACCATGTTGCTCCCTACATCCATGCAATAGGACCCAGCCTGCACCTCCT
AGGCCTACACTGGGGAAAGCCTGACAGAAATCAGTACCTCCTAACGGGGTCTGCCAGGTTCACCAAGGCATGGGCACAGAGGAATATGAC
AGTTTTGAGGCAGGCAGGAAGGGCCCAGCCTGCAGGGTAAGACATTCATTCTTTGAGTTAAAGGCCATATTCACTTGATGATTTCTACAC
ACACTAGAATTGTGAGAGTGTCCTTGAAGGAGATCACAAAGTAACCTGGTGACTGTGGCACAGGGTCCGTGGATTCCATCTCTCCCAGGC
ACTGAGGGCGCAGAGGCGAAGGAGCAAGCCCTGCATATTGGCAGGGCTGTGACCATCGCACTTAGATCAGACCCCCGACCTGTGTTGGGA
TGTGAGGGATGCCCTCCTGCCCCACCCATCCACATGGTTCCTGGGCAGCTCTGTTTTATTCCTGTGTCTTTCCTGATGGATGAGTATTAA
GACAGCATGTCTGGTTTTTAAACAGACATTTGGGAGCTTGCACATCCTGATGAGCAGGGACTCACTGTGGTGGCCTTAGGGAATTACACG
CTCACTTTGGTGGTTCTCTATGCTCGGAAGCCTCTGAGAGTGGCCTTGGCAGCTTAAGATGGCAGAGGCTTTGGAGTCTTCTTAGGACTG
TAAGTGCCCATTGAGGATGCATTTGAGTTTTGGAAAGTAGGCCCAAGTCAAATCTGATGGATGGATTCAAGAACATGGACTAATCTGCGT
TGTCATTTTTAATCAAAATGTAATGGAGATTGATCATCTGGTGGGGTTCACAAACTTTTCATGAGAGCTGTGAGTTCTTTTTTTGAGATG
CACTTTTGCACTTGTTACCCAGGCTGAGTGCAATGGCGCAATCTCGGCTCCACTGCAACCTCCATCTCCCGAGTTCAAGCGATTCTCCTG
CCTCAGCCTCCCGAGTAGCTGAGATTACAGGCATGCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATG
TTGGCCAGGCTAGTCTCGAACTCCTAATCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGAGCTACTGTG
CCGGCCAGAGCTATGAGTTCTTTCAGAATCCTCAGATGCCATTAGCTAGCCACTGTTTGGACATCCTTCTCACCTTGCCCTTTGGGGTGA
TATCCATACCTACTTGCTTGCTTCTAACAGTTTTTTTATTTGTTTTGTAGAGACGGGTTTTGGTTTATTGCTCAGGCTGGTTTCAAACTC
CTAGGCTCAAGCGGTCCTCCCACTGTGGCCTCCCAAAGTGCTGGGTGGTGTGAGCCACCGTGCCTGGCCAGTTAATTTTTTTTAGTGTCT
CTTTTTTGGGTTCTCACCAGAAACACTATCAGCATTCCCACAGATATTCCTGTGAGTCTTTGAAACATTTTCTATCCTGCATTGAGTAAG
AATAAAACCGAGGAAGGGGTGAAGCACCTTGTCTCATCCCCAGTCTGGAACTTGAACCTTCTTTTCTCTTCACTTTGCCCTACCCCCAAA
TAATATGTACAAATGTCTGTATCCATTGAGCACTAACTCCCTATTCCTTCCACCTCCCCAGCCCCTGGCAACCACTGTTCTACGTTCTGT
CTCTACGAATTTGACTTCTCTAGGTCCCTCATACAAGTGGAAAAGTACAGCATGTCTTTTTGTGACCGGCTTATTTCACTTAGCATAATG
TCCTCAAGGTTCATCCATGCTGTAGCATGTGTCAGAATTGCCTTCTTGCTTGAGGCTGCTGATACCTCCTCATGTGTATATACCGTATTT
TGTTTAATCACTCATCTGTTGGTGGACACTTGGGTTGCCTCCACCTCTTGGCTGTTGCAAATAACGCTGTGAACATGGATATACAGATAT
CTGAGGCCAGGCCAGGCGTTCACACCTGTAATCCCAATACGTTGGGAGGCCGAGGCGGGCAGATCATCTGAGGTCAGGATTCGAGACCAC
CCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCGCGCCTATAATCCCAGCTACTCGGG
AGGCTGAGGCAGGAGAATCTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTG
AGATTCCGTCTCAAAAAAAAAAAAAAACAAAAACTCAGACCCTGCTTTCCTTTGAATATATACTAGAAGTGGAATTGCTGGATCATATGG
TAATTCTTTAATTTTTCTGGGGGAACTGCTGTCCCATTTTCCACAGCAGCTACACCATTTTATGTTCCCACCAACGGTGTACAACAATTT
CAATTTCTCCACATCCTTGTTCTTGTTAATAGTAGCCACCCTAATGTGTATGAGGTGCCATCTCGTGGTTTGGTGTGGGCTGTGTTTCAA
TCAGATGTTGGGACCCTTAAGTGTTCTGCACCTGGGGAGAGTTAGGAACCACTTAAGGAGTGTCTGTTGCTTGCCAATCTTAAAATTTTT
AGTTTGCACCTGAATCAGGGGCTGTCAGAGTCCAGACTGCTCTTGAAATAGAAAAGACTGGTCGTTAAAGGCTGGTTCGTTGAGTCTTTC
ATCGTTGAGTGATACCACCTCTGCAGATGGCTCAGTGGGGCAGCCCCGTACCACAGCCTGCCCTTGAGGTTGTGTAGTTTAGATAGGTCA
CAGAGTTGCTGGGCCTACCGCAGGTCTCCTGACCCTGGTGCAGTTTTACTTCAATTACAACCACCAAAATAGCTACAGTCAAAAATTCCA
AAGTTCCTACACCATCAACCTCCACCCCACTTCCGTCCAAAGTCCACTTAGAGGCTCTCAGTTTTGGACCTTAGAAACACTTAGGGAGCT
TTTTAAAAAGATCGATTCTGTATTTTTAGTAGAGATGGGGTTTCACCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCGGG
GAGTTGGAGGTTGCAGTGAGCCGAGATTATGTCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTTAGGAAAAAAAAAAAGATTGATT
CTGGCCGGGCACAGTGGCTCACGCTTACAGTCCCAGCACTTTAAGAGACTCAGGCAGGAGGATCACTTGAGCTTAGGAGTTTGAGACTAG
CCTGGGCAACCCAGTGAGACCCCGTATCTACAAAAATTAGCCAGGTGTTGTGACATGTGCCTGTGGTCCCAGCTACTCAAGAGGCTGAGG
TGAGAGGAGCAAGTGAGCCCAGGAGTTCAAGGCTGCAATGAGCTGTGATCGCACCACTGCACTCCAGCTCGGGTGACAAGAGTGAGACCC
CGTCTGAAAAAAAGATTGATCCCAAGGCCTTGCCCAGATTCTGATTTTATTGGCCTGGAGTGTGGCCTAGGCATTAGAAAATCTTCAAGA
GAGTCTAAGGTGCAGCGGAATTGAGAGCCACGGACAGAAAAAGCCCTAAATTGTGGAAATGCACAGCCACCGTCACCACCTATCGGTACG
ATGACATCTCAAGGAGTCACTGGCCCTAGGTTTCTGCAGTAGGATCTTAAGATCTGATCTCTGCCCTCAAGTGAGTGCACGTGCAGTAAA
GCTGTCATCGTGCCATGACAGATGTCTGCAAGGACTTTACAGTGGGGTCCAAAGGATGCCACCATCAGCTCCACCTGGGGCTCAACAAAG
CCTGAAAGAAGAAAGGGATGATGCTTCCAGCAGAAACCTGGAGGCCTGCAGCTCTGCCAGCCCAGCACAGCAAGCGAGGCCATTTGTCCA
GCAGGGGCAGAAGGAGGGAACTCAGCCAGCCAGCGTTTCCTACAAGCAGCTCCATGAGAGGTTTCCACTTAAAATGCTAAATCATAATTA
TTTAATCAGATTCGTTCCTTAAGTTCTTTAAGCAGCATCGCTGTCCTACCACGAGTGGTCATCAAGGAGCAGGGTTTAACTCAACTCTGA
GTTACCCGGCAGGGTACCTGGGTAACTGCCTGGGTTGAGGTACCCAGCAGGCTTCATGTGCATGTGCACACTGCCCCCTGATAGGACCTG
GTTTATTCACAGGCTCAGGTGTCACTGCAGCTCCCCAGTGACTATCTTCGCGCAAGTTGGACTCAATGGCCTGGGAGGTTTGTCCCAGCC
GACAGATACCTGACCATGCCCATCCTCACCATTCCCTCCCCCATGCTGCATCCATCCAACCTTGATCTCCACTGTGTCCCAGGCACCCTA
AGATGCACAAGCTATGTGGGCCCTGCCCTCACAGAACTTGTAGTCTTCTGCCCCAAACAAGCCAGTTCACCGTCTTCATGATCAGGCCAA
AGGTTGAGGTACCCAGCAGGCTTCATATGCACATGCACACTGTCCCCTATAGGACCATGCCTTGCCCAGCTGGCTGCACTCTAGAGGGTG
CTTTGTAGGAAGGACAGAGTGGAGAGGACAGTGGGGAGGTACTTGGGTGTTCAACAGCCAGAAGGGAGGGAAACTGAAAAAGAATCAGGA
GTCCAGCCATCCCCTCCCCACCTCCTGCCCCCACTTCCACCCTGGCTGCTGGCCCTTTGCCCTTGAATATGGGTGATATAGGTGTGGCTA
TTCAGTTCCAGTCACAGTGCTGCCTCTATGTCTTTTGCAAGCTGGGGTCTTCCTTACTCAGAAGGCCTGGAGGCCCTGCCAGATGCTGCC
TTCCGGACTGGCTGCCCGCTGCAGTGTTTTCACGGGAGCCAAGCCAGCCCCGGGCCTGTAGCCTCCCATGTGACAAAGTTTCAGACACCA
CAGTCCTCAGCTGGACCACAGTAAACACTTGCCTTCCCCAACCCATGATTCTTGCTTGGAAACATGAACCTGATGTTCCACGTGCGTTCA
GCCAATCAAACCTCAAGAATGTGATTGAGCAGTGAGGCTGCGTTTTGGGCAAGACACTGAGCTCTGAAATAAGACTTTTCTTGGAATCTC
AAGCCCTCAACTTACAGTGGGACCCTAAGAAATGCACTTCAGTTTCCTTTTATGTAAAATGGTGGTAAAATTAATTGTGTTCATTAAATT
GCACACAACTATACATGTTTACCTATACACTAAGTGGTTCTCAACTTGGGGCAATTTGCCCCCCAGGGGACATTCAGCAGTGTCTGCGGA
CATTTTTTGTTGCTACTGGAGGGAGGTGCTACTGGCATCTAGGGAGTGGAGGCTAGAGATGCTGCTAAACTACAGTCCACAGGACAGTCT
CCACAGCAAAGAATTGTCCAGCCCCAAATATCAATAATGCCGAGGTTGAGGAAACCCTGCCACATACACATAGATGCGGGTTAACATTGT
TTATTTTACAAAGTGGAATCATTTACATTTTAGCCATTCTGATAGATGAAGCAGTGGCATCTTTTTTTTTTTTTTTTTTTTTTTGAGACG
GGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGGGTTGCAATCACGGCTCACAGCAGCCTCGAAGTCCCAGGACCAAGCAACCCTCCCAC
CGCAGCCTTCCAAGTAACTGGGACTACAGGCACACAACACCATGCCCAGCTAATTTTTTAATTTTTTTGTAGAGACGGGGTTTCACCATG
TTGCCCAGGCTCAAACTCCTGAGCTCACACGATCTGCTGCCTTCACCTTCCAAAGTGCTGGGATTACAGGTGTAAGCCACTATGCCCAGC

>20398_20398_1_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000263857_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_2_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000409681_length(transcript)=2044nt_BP=364nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACATGAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGC
GACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAATAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCT
CCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCTCTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGA
GGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGCCGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGC
TGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTTTGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGA
AACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCACGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGT
CGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAGATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTG
GTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAGACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAG
CGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTTCACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCT
CTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAGATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAA
CCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAGGGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGT
AGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGACAAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTG
CCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAGTCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACA
GCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGGGTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACA
TCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTCACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAG
GTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATGTTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACAC
AGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCCACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATG
GACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCAGAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCG

>20398_20398_2_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000304623_POLR1A_chr2_86257519_ENST00000409681_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_3_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000263857_length(transcript)=8111nt_BP=319nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACAT
GAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGCGACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAA
TAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCTCCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCT
CTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGAGGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGC
CGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGCTGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTT
TGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGAAACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCA
CGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGTCGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAG
ATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTGGTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAG
ACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAGCGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTT
CACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCTCTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAG
ATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAACCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAG
GGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGTAGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGAC
AAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTGCCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAG
TCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACAGCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGG
GTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACATCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTC
ACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAGGTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATG
TTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACACAGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCC
ACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATGGACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCA
GAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCGGGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAAC
TTGGTTTTTTTTACAACAATTTTTTCCCTTGGTTTGCAGTTTCTGCATTTGGATTTGAGAACCCAGGGCGGGGATTTTCTTGGCACAGTC
AGGTCTTGGGTCCCTCTTCCTGTGCTTTCTTGTCTGAGGCCTTAGGGGGAAGAGCTCAGCCTCTGCAGCCTCCTCCACCTCTGCCCCTGG
CCTGCCTCTGCTGTGACCTCCTTCCAGAGCTAGCTGCTGGCCCTGTGGCCAGGAGAAGCAGAGGGGAGAAGCCTTTATGCAGAAGCTGTG
CTAGCCTTGGTCTGGGGTGGGGAGGCTGCTGCTGTGACCTTAGGGGTAGGGTTGGGGATCAAGGGAGGCTTTGTCAAGGGAGAGTGACCA
TGTTGCTCCCTACATCCATGCAATAGGACCCAGCCTGCACCTCCTAGGCCTACACTGGGGAAAGCCTGACAGAAATCAGTACCTCCTAAC
GGGGTCTGCCAGGTTCACCAAGGCATGGGCACAGAGGAATATGACAGTTTTGAGGCAGGCAGGAAGGGCCCAGCCTGCAGGGTAAGACAT
TCATTCTTTGAGTTAAAGGCCATATTCACTTGATGATTTCTACACACACTAGAATTGTGAGAGTGTCCTTGAAGGAGATCACAAAGTAAC
CTGGTGACTGTGGCACAGGGTCCGTGGATTCCATCTCTCCCAGGCACTGAGGGCGCAGAGGCGAAGGAGCAAGCCCTGCATATTGGCAGG
GCTGTGACCATCGCACTTAGATCAGACCCCCGACCTGTGTTGGGATGTGAGGGATGCCCTCCTGCCCCACCCATCCACATGGTTCCTGGG
CAGCTCTGTTTTATTCCTGTGTCTTTCCTGATGGATGAGTATTAAGACAGCATGTCTGGTTTTTAAACAGACATTTGGGAGCTTGCACAT
CCTGATGAGCAGGGACTCACTGTGGTGGCCTTAGGGAATTACACGCTCACTTTGGTGGTTCTCTATGCTCGGAAGCCTCTGAGAGTGGCC
TTGGCAGCTTAAGATGGCAGAGGCTTTGGAGTCTTCTTAGGACTGTAAGTGCCCATTGAGGATGCATTTGAGTTTTGGAAAGTAGGCCCA
AGTCAAATCTGATGGATGGATTCAAGAACATGGACTAATCTGCGTTGTCATTTTTAATCAAAATGTAATGGAGATTGATCATCTGGTGGG
GTTCACAAACTTTTCATGAGAGCTGTGAGTTCTTTTTTTGAGATGCACTTTTGCACTTGTTACCCAGGCTGAGTGCAATGGCGCAATCTC
GGCTCCACTGCAACCTCCATCTCCCGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCATGCGCCACCACG
CCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTAATCTCAGGTGATCCGCCTG
CCTCAGCCTCCCAAAGTGCTGGGTTTACAGGCGTGAGCTACTGTGCCGGCCAGAGCTATGAGTTCTTTCAGAATCCTCAGATGCCATTAG
CTAGCCACTGTTTGGACATCCTTCTCACCTTGCCCTTTGGGGTGATATCCATACCTACTTGCTTGCTTCTAACAGTTTTTTTATTTGTTT
TGTAGAGACGGGTTTTGGTTTATTGCTCAGGCTGGTTTCAAACTCCTAGGCTCAAGCGGTCCTCCCACTGTGGCCTCCCAAAGTGCTGGG
TGGTGTGAGCCACCGTGCCTGGCCAGTTAATTTTTTTTAGTGTCTCTTTTTTGGGTTCTCACCAGAAACACTATCAGCATTCCCACAGAT
ATTCCTGTGAGTCTTTGAAACATTTTCTATCCTGCATTGAGTAAGAATAAAACCGAGGAAGGGGTGAAGCACCTTGTCTCATCCCCAGTC
TGGAACTTGAACCTTCTTTTCTCTTCACTTTGCCCTACCCCCAAATAATATGTACAAATGTCTGTATCCATTGAGCACTAACTCCCTATT
CCTTCCACCTCCCCAGCCCCTGGCAACCACTGTTCTACGTTCTGTCTCTACGAATTTGACTTCTCTAGGTCCCTCATACAAGTGGAAAAG
TACAGCATGTCTTTTTGTGACCGGCTTATTTCACTTAGCATAATGTCCTCAAGGTTCATCCATGCTGTAGCATGTGTCAGAATTGCCTTC
TTGCTTGAGGCTGCTGATACCTCCTCATGTGTATATACCGTATTTTGTTTAATCACTCATCTGTTGGTGGACACTTGGGTTGCCTCCACC
TCTTGGCTGTTGCAAATAACGCTGTGAACATGGATATACAGATATCTGAGGCCAGGCCAGGCGTTCACACCTGTAATCCCAATACGTTGG
GAGGCCGAGGCGGGCAGATCATCTGAGGTCAGGATTCGAGACCACCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAA
TTAGCTGGGTGTGGTGGTGCGCGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCTTGAACTCAGGAGGTGGAGGTTGCAG
TGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGATTCCGTCTCAAAAAAAAAAAAAAACAAAAACTCAGACCCTGC
TTTCCTTTGAATATATACTAGAAGTGGAATTGCTGGATCATATGGTAATTCTTTAATTTTTCTGGGGGAACTGCTGTCCCATTTTCCACA
GCAGCTACACCATTTTATGTTCCCACCAACGGTGTACAACAATTTCAATTTCTCCACATCCTTGTTCTTGTTAATAGTAGCCACCCTAAT
GTGTATGAGGTGCCATCTCGTGGTTTGGTGTGGGCTGTGTTTCAATCAGATGTTGGGACCCTTAAGTGTTCTGCACCTGGGGAGAGTTAG
GAACCACTTAAGGAGTGTCTGTTGCTTGCCAATCTTAAAATTTTTAGTTTGCACCTGAATCAGGGGCTGTCAGAGTCCAGACTGCTCTTG
AAATAGAAAAGACTGGTCGTTAAAGGCTGGTTCGTTGAGTCTTTCATCGTTGAGTGATACCACCTCTGCAGATGGCTCAGTGGGGCAGCC
CCGTACCACAGCCTGCCCTTGAGGTTGTGTAGTTTAGATAGGTCACAGAGTTGCTGGGCCTACCGCAGGTCTCCTGACCCTGGTGCAGTT
TTACTTCAATTACAACCACCAAAATAGCTACAGTCAAAAATTCCAAAGTTCCTACACCATCAACCTCCACCCCACTTCCGTCCAAAGTCC
ACTTAGAGGCTCTCAGTTTTGGACCTTAGAAACACTTAGGGAGCTTTTTAAAAAGATCGATTCTGTATTTTTAGTAGAGATGGGGTTTCA
CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCGGGGAGTTGGAGGTTGCAGTGAGCCGAGATTATGTCACTCCAGCCTGG
GCAACAGAGTGAGACTCCGTCTTAGGAAAAAAAAAAAGATTGATTCTGGCCGGGCACAGTGGCTCACGCTTACAGTCCCAGCACTTTAAG
AGACTCAGGCAGGAGGATCACTTGAGCTTAGGAGTTTGAGACTAGCCTGGGCAACCCAGTGAGACCCCGTATCTACAAAAATTAGCCAGG
TGTTGTGACATGTGCCTGTGGTCCCAGCTACTCAAGAGGCTGAGGTGAGAGGAGCAAGTGAGCCCAGGAGTTCAAGGCTGCAATGAGCTG
TGATCGCACCACTGCACTCCAGCTCGGGTGACAAGAGTGAGACCCCGTCTGAAAAAAAGATTGATCCCAAGGCCTTGCCCAGATTCTGAT
TTTATTGGCCTGGAGTGTGGCCTAGGCATTAGAAAATCTTCAAGAGAGTCTAAGGTGCAGCGGAATTGAGAGCCACGGACAGAAAAAGCC
CTAAATTGTGGAAATGCACAGCCACCGTCACCACCTATCGGTACGATGACATCTCAAGGAGTCACTGGCCCTAGGTTTCTGCAGTAGGAT
CTTAAGATCTGATCTCTGCCCTCAAGTGAGTGCACGTGCAGTAAAGCTGTCATCGTGCCATGACAGATGTCTGCAAGGACTTTACAGTGG
GGTCCAAAGGATGCCACCATCAGCTCCACCTGGGGCTCAACAAAGCCTGAAAGAAGAAAGGGATGATGCTTCCAGCAGAAACCTGGAGGC
CTGCAGCTCTGCCAGCCCAGCACAGCAAGCGAGGCCATTTGTCCAGCAGGGGCAGAAGGAGGGAACTCAGCCAGCCAGCGTTTCCTACAA
GCAGCTCCATGAGAGGTTTCCACTTAAAATGCTAAATCATAATTATTTAATCAGATTCGTTCCTTAAGTTCTTTAAGCAGCATCGCTGTC
CTACCACGAGTGGTCATCAAGGAGCAGGGTTTAACTCAACTCTGAGTTACCCGGCAGGGTACCTGGGTAACTGCCTGGGTTGAGGTACCC
AGCAGGCTTCATGTGCATGTGCACACTGCCCCCTGATAGGACCTGGTTTATTCACAGGCTCAGGTGTCACTGCAGCTCCCCAGTGACTAT
CTTCGCGCAAGTTGGACTCAATGGCCTGGGAGGTTTGTCCCAGCCGACAGATACCTGACCATGCCCATCCTCACCATTCCCTCCCCCATG
CTGCATCCATCCAACCTTGATCTCCACTGTGTCCCAGGCACCCTAAGATGCACAAGCTATGTGGGCCCTGCCCTCACAGAACTTGTAGTC
TTCTGCCCCAAACAAGCCAGTTCACCGTCTTCATGATCAGGCCAAAGGTTGAGGTACCCAGCAGGCTTCATATGCACATGCACACTGTCC
CCTATAGGACCATGCCTTGCCCAGCTGGCTGCACTCTAGAGGGTGCTTTGTAGGAAGGACAGAGTGGAGAGGACAGTGGGGAGGTACTTG
GGTGTTCAACAGCCAGAAGGGAGGGAAACTGAAAAAGAATCAGGAGTCCAGCCATCCCCTCCCCACCTCCTGCCCCCACTTCCACCCTGG
CTGCTGGCCCTTTGCCCTTGAATATGGGTGATATAGGTGTGGCTATTCAGTTCCAGTCACAGTGCTGCCTCTATGTCTTTTGCAAGCTGG
GGTCTTCCTTACTCAGAAGGCCTGGAGGCCCTGCCAGATGCTGCCTTCCGGACTGGCTGCCCGCTGCAGTGTTTTCACGGGAGCCAAGCC
AGCCCCGGGCCTGTAGCCTCCCATGTGACAAAGTTTCAGACACCACAGTCCTCAGCTGGACCACAGTAAACACTTGCCTTCCCCAACCCA
TGATTCTTGCTTGGAAACATGAACCTGATGTTCCACGTGCGTTCAGCCAATCAAACCTCAAGAATGTGATTGAGCAGTGAGGCTGCGTTT
TGGGCAAGACACTGAGCTCTGAAATAAGACTTTTCTTGGAATCTCAAGCCCTCAACTTACAGTGGGACCCTAAGAAATGCACTTCAGTTT
CCTTTTATGTAAAATGGTGGTAAAATTAATTGTGTTCATTAAATTGCACACAACTATACATGTTTACCTATACACTAAGTGGTTCTCAAC
TTGGGGCAATTTGCCCCCCAGGGGACATTCAGCAGTGTCTGCGGACATTTTTTGTTGCTACTGGAGGGAGGTGCTACTGGCATCTAGGGA
GTGGAGGCTAGAGATGCTGCTAAACTACAGTCCACAGGACAGTCTCCACAGCAAAGAATTGTCCAGCCCCAAATATCAATAATGCCGAGG
TTGAGGAAACCCTGCCACATACACATAGATGCGGGTTAACATTGTTTATTTTACAAAGTGGAATCATTTACATTTTAGCCATTCTGATAG
ATGAAGCAGTGGCATCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGGGTTGCAATCAC
GGCTCACAGCAGCCTCGAAGTCCCAGGACCAAGCAACCCTCCCACCGCAGCCTTCCAAGTAACTGGGACTACAGGCACACAACACCATGC
CCAGCTAATTTTTTAATTTTTTTGTAGAGACGGGGTTTCACCATGTTGCCCAGGCTCAAACTCCTGAGCTCACACGATCTGCTGCCTTCA
CCTTCCAAAGTGCTGGGATTACAGGTGTAAGCCACTATGCCCAGCCTCATTTGTACTTCAGTTTGCAATTCTCTATTAATAAATCTAAGC

>20398_20398_3_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000263857_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------
>20398_20398_4_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000409681_length(transcript)=1999nt_BP=319nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGTGACAGTGAAGCTCCCTCTGATGAAGATCAACTTTGACAT
GAGCTCCCTGGTAGTATCTTTGGCCCATGGTGCCGTCATCTATGCGACCAAGGGCATCACTCGGTGCCTCCTGAATGAAACAACCAACAA
TAAGAACGAGAAGGAGCTTGTGCTAAACACAGAAGGAATCAACCTCCCAGAGCTATTCAAGTATGCAGAGGTCCTGGATCTGCGCCGCCT
CTACTCCAACGACATCCACGCCATAGCCAACACGTATGGCATTGAGGCCGCGCTGCGGGTGATCGAGAAGGAGATCAAGGATGTGTTTGC
CGTGTATGGCATCGCGGTCGACCCTCGCCATCTCTCCCTGGTTGCTGATTATATGTGCTTCGAGGGTGTTTACAAGCCACTGAATCGCTT
TGGGATCCGGTCAAACTCTTCCCCGCTACAGCAGATGACATTTGAAACCAGCTTCCAGTTTCTGAAGCAAGCCACCATGCTGGGATCCCA
CGATGAGCTGAGGTCTCCTTCTGCCTGCCTTGTGGTCGGGAAGGTCGTCAGGGGCGGGACAGGCCTGTTCGAGCTCAAGCAGCCTCTGAG
ATAGCAGCTACCCCGGCACCATCTGCCCAGCTCCAAGGACCCTTGGTGAGGGCGTGGCCCAGCCTGCCTTCTGCATGAGAGGACCAGGAG
ACTGGAATCCAGGGCAGTTCCAAGTGACAGTACAGAGCACAGCAGCGACCTTGGGCCTGAAAGCAGTGGGCCTCTGAGCTGGGCCAGCTT
CACCTGGAAAGTGACAGAGTTGCTCATCCTTGCCCCTCCCTGTCTCTGGATTTTTATCAAGGTTTACCAAGTCTTCTGAGTCCCCCTGAG
ATGGCTGGGGCCTCACCTGTGCTGCAGGAGGCCTCTGTGGCATAACCCCTAAGGAGAAGTCCTGATTCACGATTCACTGAGAAGACCAAG
GGGAAGCCATGCTTTGCTGCTGGGGACCCCAGGCACCTCCAGAGTAGGGAAGCGGGGTTCTTTTGCTGTGAGTGGCCAGGGACAACAGAC
AAGATTCCTGGGGGCTCCCGATGAGCAGGAACGTGGAGCCTGCTGCCCAAGGCCTGCTCCTTCCGGCTGCTCCAGCCCCTGGGGGCAGAG
TCCACAAAGAGTCCCCATCAAGACTTCTTCCCTGAGTCAAGTACAGCGTAGCATAGTCCTCCACCCACCCAACCTCTCTGCCTGGCCAGG
GTCCTGGCCCTGCCACTGTGTGGCGAGGTGTCCTTCTAGACCACATCAGCCCCAAGGCTGGGAGCAGTCGCTCCAGGGCCGCAGCAGTTC
ACTCCCACACATAGAACCCAGGTCACTGCTGGGGCGATTGAACAGGTTGCCTGGCTTTTCTCTGCTGTCAGTTTGGTGTGGAGGCCTATG
TTCTGCCCCATACACCCCACAGGCCCTGCTTATGGGAAGGAACACAGGCCTCCAGCCCAGAGGACTGTGCCGCCCTGTTCTTGGCCGTCC
ACGTTTCCTCTCCCTCTAGCACCAGCAATACATTTCCCTGGCATGGACAGAAAAGACAGAGAGGACTTATACAAAGGCTTTGTAAAACCA
GAGGCTAGCTTCTATCTTTGTCTACTGTTATTTCAGCTCAGGGCGGGTAATTAACATCATTGGAACTAGCTATTAGGAAAGAAAAAAAAC

>20398_20398_4_CTNND2-POLR1A_CTNND2_chr5_11732248_ENST00000359640_POLR1A_chr2_86257519_ENST00000409681_length(amino acids)=252AA_BP=57
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKG
ITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CTNND2-POLR1A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CTNND2-POLR1A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CTNND2-POLR1A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source