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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS12-FBXO38 (FusionGDB2 ID:2042)

Fusion Gene Summary for ADAMTS12-FBXO38

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS12-FBXO38
Fusion gene ID: 2042
HgeneTgene
Gene symbol

ADAMTS12

FBXO38

Gene ID

81792

81545

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 12F-box protein 38
SynonymsPRO4389Fbx38|HMN2D|MOKA|SP329
Cytomap

5p13.3-p13.2

5q32

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12F-box only protein 38modulator of KLF7 activity homolog
Modification date2020031320200313
UniProtAcc

P58397

Q6PIJ6

Ensembl transtripts involved in fusion geneENST00000352040, ENST00000504830, 
ENST00000504582, ENST00000515401, 
ENST00000509699, ENST00000513826, 
ENST00000296701, ENST00000340253, 
ENST00000394370, 
Fusion gene scores* DoF score6 X 6 X 4=1448 X 6 X 7=336
# samples 68
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS12 [Title/Abstract] AND FBXO38 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS12(33751509)-FBXO38(147812987), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

HgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

HgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

HgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

HgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

HgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

HgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

HgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370

TgeneFBXO38

GO:0002842

positive regulation of T cell mediated immune response to tumor cell

30487606

TgeneFBXO38

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

30487606

TgeneFBXO38

GO:0070936

protein K48-linked ubiquitination

30487606


check buttonFusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXO38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-5782-01AADAMTS12chr5

33751509

-FBXO38chr5

147812987

+


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Fusion Gene ORF analysis for ADAMTS12-FBXO38

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000352040ENST00000509699ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5CDS-intronENST00000352040ENST00000513826ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5CDS-intronENST00000504830ENST00000509699ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5CDS-intronENST00000504830ENST00000513826ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5UTR-3CDSENST00000504582ENST00000296701ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5UTR-3CDSENST00000504582ENST00000340253ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5UTR-3CDSENST00000504582ENST00000394370ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5UTR-intronENST00000504582ENST00000509699ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
5UTR-intronENST00000504582ENST00000513826ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000352040ENST00000296701ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000352040ENST00000340253ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000352040ENST00000394370ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000504830ENST00000296701ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000504830ENST00000340253ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
In-frameENST00000504830ENST00000394370ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
intron-3CDSENST00000515401ENST00000296701ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
intron-3CDSENST00000515401ENST00000340253ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
intron-3CDSENST00000515401ENST00000394370ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
intron-intronENST00000515401ENST00000509699ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+
intron-intronENST00000515401ENST00000513826ADAMTS12chr5

33751509

-FBXO38chr5

147812987

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000504830ADAMTS12chr533751509-ENST00000340253FBXO38chr5147812987+25739703361883515
ENST00000504830ADAMTS12chr533751509-ENST00000296701FBXO38chr5147812987+25649703361883515
ENST00000504830ADAMTS12chr533751509-ENST00000394370FBXO38chr5147812987+25739703361883515
ENST00000352040ADAMTS12chr533751509-ENST00000340253FBXO38chr5147812987+2322719851632515
ENST00000352040ADAMTS12chr533751509-ENST00000296701FBXO38chr5147812987+2313719851632515
ENST00000352040ADAMTS12chr533751509-ENST00000394370FBXO38chr5147812987+2322719851632515

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504830ENST00000340253ADAMTS12chr533751509-FBXO38chr5147812987+0.0003249550.99967504
ENST00000504830ENST00000296701ADAMTS12chr533751509-FBXO38chr5147812987+0.0003443810.9996556
ENST00000504830ENST00000394370ADAMTS12chr533751509-FBXO38chr5147812987+0.0003249550.99967504
ENST00000352040ENST00000340253ADAMTS12chr533751509-FBXO38chr5147812987+0.0002822080.9997178
ENST00000352040ENST00000296701ADAMTS12chr533751509-FBXO38chr5147812987+0.0003001130.99969995
ENST00000352040ENST00000394370ADAMTS12chr533751509-FBXO38chr5147812987+0.0002822080.9997178

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Fusion Genomic Features for ADAMTS12-FBXO38


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAMTS12chr533751508-FBXO38chr5147812986+6.38E-070.9999994
ADAMTS12chr533751508-FBXO38chr5147812986+6.38E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADAMTS12-FBXO38


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33751509/chr5:147812987)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS12

P58397

FBXO38

Q6PIJ6

FUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322208_2132111510.0MotifCysteine switch
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324208_2132111595.0MotifCysteine switch
TgeneFBXO38chr5:33751509chr5:147812987ENST000002967011321896_899639944.0MotifNuclear localization signal
TgeneFBXO38chr5:33751509chr5:147812987ENST000003402531422896_8998841189.0MotifNuclear localization signal
TgeneFBXO38chr5:33751509chr5:147812987ENST000003943701422896_8998091114.0MotifNuclear localization signal
TgeneFBXO38chr5:33751509chr5:147812987ENST000005138261220896_899639944.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322302_3052111510.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322597_7002111510.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324302_3052111595.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324597_7002111595.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-3221313_13662111510.0DomainTSP type-1 5
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-3221368_14222111510.0DomainTSP type-1 6
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-3221423_14712111510.0DomainTSP type-1 7
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-3221472_15322111510.0DomainTSP type-1 8
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-3221535_15752111510.0DomainPLAC
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322246_4562111510.0DomainPeptidase M12B
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322465_5442111510.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322542_5972111510.0DomainTSP type-1 1
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322823_8832111510.0DomainTSP type-1 2
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322887_9432111510.0DomainTSP type-1 3
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322944_9972111510.0DomainTSP type-1 4
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-3241313_13662111595.0DomainTSP type-1 5
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-3241368_14222111595.0DomainTSP type-1 6
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-3241423_14712111595.0DomainTSP type-1 7
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-3241472_15322111595.0DomainTSP type-1 8
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-3241535_15752111595.0DomainPLAC
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324246_4562111595.0DomainPeptidase M12B
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324465_5442111595.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324542_5972111595.0DomainTSP type-1 1
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324823_8832111595.0DomainTSP type-1 2
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324887_9432111595.0DomainTSP type-1 3
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324944_9972111595.0DomainTSP type-1 4
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322701_8272111510.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000352040-322997_13162111510.0RegionNote=Spacer 2
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324701_8272111595.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33751509chr5:147812987ENST00000504830-324997_13162111595.0RegionNote=Spacer 2
TgeneFBXO38chr5:33751509chr5:147812987ENST00000296701132130_75639944.0DomainF-box
TgeneFBXO38chr5:33751509chr5:147812987ENST00000340253142230_758841189.0DomainF-box
TgeneFBXO38chr5:33751509chr5:147812987ENST00000394370142230_758091114.0DomainF-box
TgeneFBXO38chr5:33751509chr5:147812987ENST00000513826122030_75639944.0DomainF-box
TgeneFBXO38chr5:33751509chr5:147812987ENST000002967011321194_201639944.0MotifNuclear export signal 1
TgeneFBXO38chr5:33751509chr5:147812987ENST000002967011321307_316639944.0MotifNuclear export signal 2
TgeneFBXO38chr5:33751509chr5:147812987ENST000002967011321451_460639944.0MotifNuclear export signal 3
TgeneFBXO38chr5:33751509chr5:147812987ENST000003402531422194_2018841189.0MotifNuclear export signal 1
TgeneFBXO38chr5:33751509chr5:147812987ENST000003402531422307_3168841189.0MotifNuclear export signal 2
TgeneFBXO38chr5:33751509chr5:147812987ENST000003402531422451_4608841189.0MotifNuclear export signal 3
TgeneFBXO38chr5:33751509chr5:147812987ENST000003943701422194_2018091114.0MotifNuclear export signal 1
TgeneFBXO38chr5:33751509chr5:147812987ENST000003943701422307_3168091114.0MotifNuclear export signal 2
TgeneFBXO38chr5:33751509chr5:147812987ENST000003943701422451_4608091114.0MotifNuclear export signal 3
TgeneFBXO38chr5:33751509chr5:147812987ENST000005138261220194_201639944.0MotifNuclear export signal 1
TgeneFBXO38chr5:33751509chr5:147812987ENST000005138261220307_316639944.0MotifNuclear export signal 2
TgeneFBXO38chr5:33751509chr5:147812987ENST000005138261220451_460639944.0MotifNuclear export signal 3


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Fusion Gene Sequence for ADAMTS12-FBXO38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2042_2042_1_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000296701_length(transcript)=2313nt_BP=719nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC
CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA
CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG
ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT
TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA
TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA
AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA
CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG
TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA
TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC
AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA
CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT
CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA
TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA
AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC
AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA
TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC
TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA
AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT
AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG
TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG
TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG
CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA

>2042_2042_1_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000296701_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------
>2042_2042_2_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000340253_length(transcript)=2322nt_BP=719nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC
CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA
CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG
ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT
TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA
TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA
AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA
CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG
TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA
TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC
AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA
CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT
CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA
TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA
AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC
AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA
TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC
TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA
AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT
AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG
TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG
TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG
CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA

>2042_2042_2_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000340253_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------
>2042_2042_3_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000394370_length(transcript)=2322nt_BP=719nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC
CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA
CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG
ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT
TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA
TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA
AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA
CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG
TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA
TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC
AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA
CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT
CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA
TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA
AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC
AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA
TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC
TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA
AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT
AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG
TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG
TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG
CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA

>2042_2042_3_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000352040_FBXO38_chr5_147812987_ENST00000394370_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------
>2042_2042_4_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000296701_length(transcript)=2564nt_BP=970nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA
TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG
GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT
GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT
GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG
TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA
CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA
TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC
CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG
AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT
CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT
AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT
GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG
ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT
ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG
AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC
CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA
GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT
TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT
TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG
CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC
TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA
GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG

>2042_2042_4_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000296701_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------
>2042_2042_5_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000340253_length(transcript)=2573nt_BP=970nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA
TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG
GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT
GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT
GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG
TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA
CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA
TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC
CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG
AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT
CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT
AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT
GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG
ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT
ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG
AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC
CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA
GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT
TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT
TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG
CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC
TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA
GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG

>2042_2042_5_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000340253_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------
>2042_2042_6_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000394370_length(transcript)=2573nt_BP=970nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA
TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG
GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT
GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT
GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG
TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA
CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA
TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC
CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG
AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT
CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT
AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT
GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG
ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT
ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG
AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC
CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA
GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT
TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT
TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG
CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC
TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA
GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG

>2042_2042_6_ADAMTS12-FBXO38_ADAMTS12_chr5_33751509_ENST00000504830_FBXO38_chr5_147812987_ENST00000394370_length(amino acids)=515AA_BP=211
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK
DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF
SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAMTS12-FBXO38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFBXO38chr5:33751509chr5:147812987ENST00000296701132159_119639.3333333333334944.0KLF7
TgeneFBXO38chr5:33751509chr5:147812987ENST00000340253142259_119884.33333333333341189.0KLF7
TgeneFBXO38chr5:33751509chr5:147812987ENST00000394370142259_119809.33333333333341114.0KLF7
TgeneFBXO38chr5:33751509chr5:147812987ENST00000513826122059_119639.3333333333334944.0KLF7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS12-FBXO38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS12-FBXO38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource