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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTSB-TXNL1 (FusionGDB2 ID:20479)

Fusion Gene Summary for CTSB-TXNL1

Fusion gene summary

Fusion gene information	Fusion gene name: CTSB-TXNL1
	Fusion gene ID: 20479
		Hgene	Tgene
	Gene symbol	CTSB	TXNL1
	Gene ID	1508	9352
	Gene name	cathepsin B	thioredoxin like 1
	Synonyms	APPS\|CPSB\|RECEUP	HEL-S-114\|TRP32\|TXL-1\|TXNL\|Txl
	Cytomap	8p23.1	18q21.31
	Type of gene	protein-coding	protein-coding
	Description	cathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseepididymis secretory sperm binding protein	thioredoxin-like protein 132 kDa thioredoxin-related proteinepididymis secretory protein Li 114thioredoxin-related 32 kDa proteinthioredoxin-related protein 1
	Modification date	20200313	20200313
	UniProtAcc	P07858	.
	Ensembl transtripts involved in fusion gene	ENST00000345125, ENST00000353047, ENST00000415599, ENST00000434271, ENST00000453527, ENST00000530640, ENST00000531089, ENST00000533455, ENST00000534510, ENST00000525076,	ENST00000540155, ENST00000585497, ENST00000590954, ENST00000217515,
Fusion gene scores	* DoF score	24 X 19 X 10=4560	9 X 8 X 4=288
	# samples	25	10
	** MAII score	log2(25/4560*10)=-4.18903382439002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTSB [Title/Abstract] AND TXNL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTSB(11710119)-TXNL1(54293688), # samples:1
Anticipated loss of major functional domain due to fusion event.	CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CTSB-TXNL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CTSB	GO:0006508	proteolysis	7890620\|8811434
Hgene	CTSB	GO:0030574	collagen catabolic process	22952693
Hgene	CTSB	GO:0051603	proteolysis involved in cellular protein catabolic process	22952693

Fusion gene breakpoints across CTSB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TXNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CG-5730-11A	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-

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Fusion Gene ORF analysis for CTSB-TXNL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000345125	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000353047	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000415599	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000434271	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000453527	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000530640	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000531089	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000533455	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-5UTR	ENST00000534510	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000345125	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000345125	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000353047	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000353047	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000415599	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000415599	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000434271	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000434271	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000453527	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000453527	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000530640	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000530640	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000531089	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000531089	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000533455	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000533455	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000534510	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5CDS-intron	ENST00000534510	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5UTR-3CDS	ENST00000525076	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5UTR-5UTR	ENST00000525076	ENST00000540155	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5UTR-intron	ENST00000525076	ENST00000585497	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
5UTR-intron	ENST00000525076	ENST00000590954	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000345125	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000353047	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000415599	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000453527	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000531089	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
Frame-shift	ENST00000534510	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
In-frame	ENST00000434271	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
In-frame	ENST00000530640	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-
In-frame	ENST00000533455	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000434271	CTSB	chr8	11710119	-	ENST00000217515	TXNL1	chr18	54293688	-	7041	450	238	1221	327
ENST00000530640	CTSB	chr8	11710119	-	ENST00000217515	TXNL1	chr18	54293688	-	6940	349	137	1120	327
ENST00000533455	CTSB	chr8	11710119	-	ENST00000217515	TXNL1	chr18	54293688	-	7022	431	219	1202	327

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000434271	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-	4.63E-05	0.99995375
ENST00000530640	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-	4.66E-05	0.9999534
ENST00000533455	ENST00000217515	CTSB	chr8	11710119	-	TXNL1	chr18	54293688	-	4.72E-05	0.9999528

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Fusion Genomic Features for CTSB-TXNL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTSB-TXNL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11710119/chr18:54293688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTSB P07858	.
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250\|UniProtKB:P10605, ECO:0000269\|PubMed:12220505, ECO:0000269\|PubMed:3972105}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TXNL1

chr8:11710119

chr18:54293688

ENST00000217515

115_285

290.0

Domain

PITH

Tgene

TXNL1

chr8:11710119

chr18:54293688

ENST00000590954

115_285

290.0

Domain

PITH

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TXNL1

chr8:11710119

chr18:54293688

ENST00000217515

2_109

290.0

Domain

Note=Thioredoxin

Tgene

TXNL1

chr8:11710119

chr18:54293688

ENST00000590954

2_109

290.0

Domain

Note=Thioredoxin

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Fusion Gene Sequence for CTSB-TXNL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20479_20479_1_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000434271_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=7041nt_BP=450nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAG
GTGTGGGCCATGTTTGAGGATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCA
GTGTCAGGGAACAGCTGCCACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGG
AGCAGATGCTGTGGGATTAGAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTA
TATGGATTTAATGCCTTTTATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGA
CACAACCTTCTTGGAATCTGACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCA
AGGGCCAGATAATGGTCAGGGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGA
ACCAACTCAAGCTCTGGAACTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAG
TGTAACTATATTTGTTCAGTCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAAC
AAATATGAATGACTTCAAACGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGAT
CTACAGCTCCTGGATAATTGCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAG
ATGGTATCACTAGTGTTTCCATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCT
AAATCAGTATTTTCTCTTTCCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAA
AGCCAGTTTCTTTAGAAAAGGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAAC
CTGGAACAGCTAACCATGTTAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAAT
TAGAAGAAATAAACAGGTTTAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAA
GATTTTAATCTCTTCTGGTAAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCA
GACAGTTGGGGAAAAAATACAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGG
GAGGCCAAGGCGGGCGAATCACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAA
ATTAGCCAGGCATGGTGGCGGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTG
CAGTGAGCTGAGATTGCGCCATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAA
TCAAGTATTTATTACCTGAACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAA
ATGTTTAAAAGGTCTTTCACAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGT
TTTAATTTTAAAATTTCTGAGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGC
ATTCTTGTCTAGGAATATGGTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTT
TAGTGTTGAAAGAGTCCCTTTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGAT
CTTAACACTCCTTAAATAGACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGT
ACACTTAACCTTTCTGAGTAATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAG
TGAAACAAATTTCGTATTTGTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGT
ATTACATAATTCAAATTGTAAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAAT
GTGCATAATTGGCATTTAAAATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATT
TATATATAACACTGAATTTTCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATC
TAGAAAACTGGTATTCAGTTTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAG
GTGCTTTTGATGAGAAACAACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAAT
GCTGAAGCCAAGAGTAGCACAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCC
ACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATA
TACTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATA
ACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCC
CCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAA
TATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACT
TAACAATTAGAGTTGAAACCTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAG
TTGTTTATTTGGCCTCAGCAGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCT
TGTTCCTCTTAATGTCTAAAAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAA
AAACATGAAATTTAAGGCTTACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTC
TTCTGGAACTGATAATTTGTAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCAT
GCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCC
TGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTG
AACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAA
AAAAAAATCCATTCACAGAACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTT
TACAGTTTTGTAAATATAGATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGA
CTATTCCCCAGTTAAGCCTATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAAT
AAGGTTTTTTTTTTTTTTTAACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTT
GTGGTCCATGTAAAATTATTAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAAT
TGTACACAGCTTGGAATATTAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTAT
GGGAAGAGGAATTTTATTTTGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACA
CGCATTTGGAGATACTGGCTCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATC
TTGAGCAAGTAACATCCTTCAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTT
ACTTTGTATCTGGAACAAGGATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACT
GCAGTGCCTCCTAATTGTCTCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTC
TTTGTAATGTAATCTCTCCTCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCC
TAATATCGCATGCCTTCCTCTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGG
GAATAATCATAACAATTGTGCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGA
TCTGTAGTCTTATTTGGACTACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATT
AAATACAATGTTGAAAAAATTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTA
AGGAAGATAATTTAGCTGAAGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAG
GAGAAGCTGAAAGAGCAAGTAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGA
GCGAGCATAGAGAAGTCTGTGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAG
AGGGGAAGATGAATATGGTTTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAA
TGTGATTTTAGAGCTTAGAGCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAG
AATATAAAGGGAGAGAATGAAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTA
GAGTAGTAAACAGGAAAGGGAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATG
TGATATTGAAATTAGCTGGGATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGAT
CATATTAATAAACTTTCAGTTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCAT
TGAACACAGTTTTACATGACACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCA

>20479_20479_1_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000434271_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------
>20479_20479_2_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000530640_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=6940nt_BP=349nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGC
ACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGGTGTGGGCCAT
GTTTGAGGATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCAGTGTCAGGGAA
CAGCTGCCACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGGAGCAGATGCTG
TGGGATTAGAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTATATGGATTTAA
TGCCTTTTATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGACACAACCTTCT
TGGAATCTGACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCAAGGGCCAGATA
ATGGTCAGGGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGAACCAACTCAAG
CTCTGGAACTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAGTGTAACTATAT
TTGTTCAGTCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAACAAATATGAATG
ACTTCAAACGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGATCTACAGCTCCT
GGATAATTGCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAGATGGTATCACT
AGTGTTTCCATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCTAAATCAGTATT
TTCTCTTTCCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAAAGCCAGTTTCT
TTAGAAAAGGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAACCTGGAACAGCT
AACCATGTTAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAATTAGAAGAAATA
AACAGGTTTAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAAGATTTTAATCT
CTTCTGGTAAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCAGACAGTTGGGG
AAAAAATACAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGGGAGGCCAAGGC
GGGCGAATCACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGC
ATGGTGGCGGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGA
GATTGCGCCATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAATCAAGTATTTA
TTACCTGAACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAAATGTTTAAAAG
GTCTTTCACAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGTTTTAATTTTAA
AATTTCTGAGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGCATTCTTGTCTA
GGAATATGGTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTTTAGTGTTGAAA
GAGTCCCTTTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGATCTTAACACTCC
TTAAATAGACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGTACACTTAACCT
TTCTGAGTAATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAGTGAAACAAATT
TCGTATTTGTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGTATTACATAATT
CAAATTGTAAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAATGTGCATAATTG
GCATTTAAAATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATTTATATATAACA
CTGAATTTTCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATCTAGAAAACTGG
TATTCAGTTTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAGGTGCTTTTGAT
GAGAAACAACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAATGCTGAAGCCAA
GAGTAGCACAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCCACGTTGTTCCC
CAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAG
GCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATAACAATTAGAGT
TGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTC
CCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAATATTCTGTTGG
AGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACTTAACAATTAGA
GTTGAAACCTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAGTTGTTTATTTG
GCCTCAGCAGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCTTGTTCCTCTTA
ATGTCTAAAAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAAAAACATGAAAT
TTAAGGCTTACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTCTTCTGGAACTG
ATAATTTGTAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCATGCCTGTAATCC
CAGCATTTTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCCTGTCTCTACTA
AAAATACAAAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCGGGAGG
CGGAGGTTGCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAAAAAAAAATCCA
TTCACAGAACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTTTACAGTTTTGT
AAATATAGATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGACTATTCCCCAG
TTAAGCCTATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAATAAGGTTTTTTT
TTTTTTTTAACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTTGTGGTCCATGT
AAAATTATTAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAATTGTACACAGCT
TGGAATATTAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTATGGGAAGAGGAA
TTTTATTTTGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACACGCATTTGGAG
ATACTGGCTCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATCTTGAGCAAGTA
ACATCCTTCAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTTACTTTGTATCT
GGAACAAGGATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACTGCAGTGCCTCC
TAATTGTCTCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTCTTTGTAATGTA
ATCTCTCCTCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCCTAATATCGCAT
GCCTTCCTCTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGGGAATAATCATA
ACAATTGTGCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGATCTGTAGTCTT
ATTTGGACTACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATTAAATACAATGT
TGAAAAAATTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTAAGGAAGATAAT
TTAGCTGAAGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAGGAGAAGCTGAA
AGAGCAAGTAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGAGCGAGCATAGA
GAAGTCTGTGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAGAGGGGAAGATG
AATATGGTTTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAATGTGATTTTAG
AGCTTAGAGCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAGAATATAAAGGG
AGAGAATGAAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTAGAGTAGTAAAC
AGGAAAGGGAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATGTGATATTGAAA
TTAGCTGGGATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGATCATATTAATAA
ACTTTCAGTTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCATTGAACACAGTT
TTACATGACACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCATTAAAGGATCT

>20479_20479_2_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000530640_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------
>20479_20479_3_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000533455_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=7022nt_BP=431nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGCACAACTTC
TACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGGTGTGGGCCATGTTTGAGG
ATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCAGTGTCAGGGAACAGCTGCC
ACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGGAGCAGATGCTGTGGGATTA
GAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTATATGGATTTAATGCCTTTT
ATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGACACAACCTTCTTGGAATCT
GACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCAAGGGCCAGATAATGGTCAG
GGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGAACCAACTCAAGCTCTGGAA
CTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAGTGTAACTATATTTGTTCAG
TCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAACAAATATGAATGACTTCAAA
CGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGATCTACAGCTCCTGGATAATT
GCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAGATGGTATCACTAGTGTTTC
CATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCTAAATCAGTATTTTCTCTTT
CCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAAAGCCAGTTTCTTTAGAAAA
GGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAACCTGGAACAGCTAACCATGT
TAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAATTAGAAGAAATAAACAGGTT
TAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAAGATTTTAATCTCTTCTGGT
AAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCAGACAGTTGGGGAAAAAATA
CAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGGGAGGCCAAGGCGGGCGAAT
CACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGC
GGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGC
CATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAATCAAGTATTTATTACCTGA
ACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAAATGTTTAAAAGGTCTTTCA
CAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGTTTTAATTTTAAAATTTCTG
AGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGCATTCTTGTCTAGGAATATG
GTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTTTAGTGTTGAAAGAGTCCCT
TTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGATCTTAACACTCCTTAAATAG
ACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGTACACTTAACCTTTCTGAGT
AATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAGTGAAACAAATTTCGTATTT
GTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGTATTACATAATTCAAATTGT
AAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAATGTGCATAATTGGCATTTAA
AATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATTTATATATAACACTGAATTT
TCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATCTAGAAAACTGGTATTCAGT
TTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAGGTGCTTTTGATGAGAAACA
ACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAATGCTGAAGCCAAGAGTAGCA
CAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCCACGTTGTTCCCCAGTCTCA
ATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCAC
GTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATAACAATTAGAGTTGAAACCT
GCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCT
CAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCC
ACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACTTAACAATTAGAGTTGAAAC
CTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAGTTGTTTATTTGGCCTCAGC
AGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCTTGTTCCTCTTAATGTCTAA
AAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAAAAACATGAAATTTAAGGCT
TACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTCTTCTGGAACTGATAATTTG
TAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCATGCCTGTAATCCCAGCATTT
TGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCCTGTCTCTACTAAAAATACA
AAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCGGGAGGCGGAGGTT
GCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAAAAAAAAATCCATTCACAGA
ACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTTTACAGTTTTGTAAATATAG
ATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGACTATTCCCCAGTTAAGCCT
ATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAATAAGGTTTTTTTTTTTTTTT
AACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTTGTGGTCCATGTAAAATTAT
TAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAATTGTACACAGCTTGGAATAT
TAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTATGGGAAGAGGAATTTTATTT
TGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACACGCATTTGGAGATACTGGC
TCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATCTTGAGCAAGTAACATCCTT
CAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTTACTTTGTATCTGGAACAAG
GATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACTGCAGTGCCTCCTAATTGTC
TCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTCTTTGTAATGTAATCTCTCC
TCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCCTAATATCGCATGCCTTCCT
CTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGGGAATAATCATAACAATTGT
GCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGATCTGTAGTCTTATTTGGAC
TACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATTAAATACAATGTTGAAAAAA
TTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTAAGGAAGATAATTTAGCTGA
AGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAGGAGAAGCTGAAAGAGCAAG
TAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGAGCGAGCATAGAGAAGTCTG
TGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAGAGGGGAAGATGAATATGGT
TTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAATGTGATTTTAGAGCTTAGA
GCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAGAATATAAAGGGAGAGAATG
AAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTAGAGTAGTAAACAGGAAAGG
GAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATGTGATATTGAAATTAGCTGG
GATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGATCATATTAATAAACTTTCAG
TTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCATTGAACACAGTTTTACATGA
CACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCATTAAAGGATCTTATCAGGT

>20479_20479_3_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000533455_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CTSB-TXNL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CTSB-TXNL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTSB-TXNL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source