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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTSB-UBAP2L (FusionGDB2 ID:20480)

Fusion Gene Summary for CTSB-UBAP2L

check button Fusion gene summary
Fusion gene informationFusion gene name: CTSB-UBAP2L
Fusion gene ID: 20480
HgeneTgene
Gene symbol

CTSB

UBAP2L

Gene ID

1508

9898

Gene namecathepsin Bubiquitin associated protein 2 like
SynonymsAPPS|CPSB|RECEUPNICE-4|NICE4
Cytomap

8p23.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptioncathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseepididymis secretory sperm binding proteinubiquitin-associated protein 2-likeprotein NICE-4
Modification date2020031320200313
UniProtAcc

P07858

.
Ensembl transtripts involved in fusion geneENST00000345125, ENST00000353047, 
ENST00000415599, ENST00000434271, 
ENST00000453527, ENST00000530640, 
ENST00000531089, ENST00000533455, 
ENST00000534510, ENST00000525076, 
ENST00000484819, ENST00000271877, 
ENST00000343815, ENST00000361546, 
ENST00000428931, 
Fusion gene scores* DoF score24 X 19 X 10=456017 X 15 X 7=1785
# samples 2518
** MAII scorelog2(25/4560*10)=-4.18903382439002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1785*10)=-3.30985526258679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTSB [Title/Abstract] AND UBAP2L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTSB(11710837)-UBAP2L(154234067), # samples:1
Anticipated loss of major functional domain due to fusion event.CTSB-UBAP2L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CTSB-UBAP2L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSB

GO:0006508

proteolysis

7890620|8811434

HgeneCTSB

GO:0030574

collagen catabolic process

22952693

HgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check buttonFusion gene breakpoints across CTSB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBAP2L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2008CTSBchr8

11710837

-UBAP2Lchr1

154234067

+


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Fusion Gene ORF analysis for CTSB-UBAP2L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000345125ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000353047ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000415599ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000434271ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000453527ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000530640ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000531089ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000533455ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5CDS-intronENST00000534510ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5UTR-3CDSENST00000525076ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5UTR-3CDSENST00000525076ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5UTR-3CDSENST00000525076ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5UTR-3CDSENST00000525076ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
5UTR-intronENST00000525076ENST00000484819CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000345125ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000345125ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000345125ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000345125ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000353047ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000353047ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000353047ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000353047ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000453527ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000453527ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000453527ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000453527ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000531089ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000531089ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000531089ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000531089ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000534510ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000534510ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000534510ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
Frame-shiftENST00000534510ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000415599ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000415599ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000415599ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000415599ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000434271ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000434271ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000434271ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000434271ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000530640ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000530640ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000530640ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000530640ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000533455ENST00000271877CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000533455ENST00000343815CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000533455ENST00000361546CTSBchr8

11710837

-UBAP2Lchr1

154234067

+
In-frameENST00000533455ENST00000428931CTSBchr8

11710837

-UBAP2Lchr1

154234067

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000434271CTSBchr811710837-ENST00000343815UBAP2Lchr1154234067+873364817401138
ENST00000434271CTSBchr811710837-ENST00000428931UBAP2Lchr1154234067+1389364238831197
ENST00000434271CTSBchr811710837-ENST00000271877UBAP2Lchr1154234067+862364238771177
ENST00000434271CTSBchr811710837-ENST00000361546UBAP2Lchr1154234067+1390364238831197
ENST00000530640CTSBchr811710837-ENST00000343815UBAP2Lchr1154234067+772263716300138
ENST00000530640CTSBchr811710837-ENST00000428931UBAP2Lchr1154234067+1288263137730197
ENST00000530640CTSBchr811710837-ENST00000271877UBAP2Lchr1154234067+761263137670177
ENST00000530640CTSBchr811710837-ENST00000361546UBAP2Lchr1154234067+1289263137730197
ENST00000415599CTSBchr811710837-ENST00000343815UBAP2Lchr1154234067+707198651235138
ENST00000415599CTSBchr811710837-ENST00000428931UBAP2Lchr1154234067+122319872665197
ENST00000415599CTSBchr811710837-ENST00000271877UBAP2Lchr1154234067+69619872605177
ENST00000415599CTSBchr811710837-ENST00000361546UBAP2Lchr1154234067+122419872665197
ENST00000533455CTSBchr811710837-ENST00000343815UBAP2Lchr1154234067+854345798382138
ENST00000533455CTSBchr811710837-ENST00000428931UBAP2Lchr1154234067+1370345219812197
ENST00000533455CTSBchr811710837-ENST00000271877UBAP2Lchr1154234067+843345219752177
ENST00000533455CTSBchr811710837-ENST00000361546UBAP2Lchr1154234067+1371345219812197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434271ENST00000343815CTSBchr811710837-UBAP2Lchr1154234067+0.522969960.47703004
ENST00000434271ENST00000428931CTSBchr811710837-UBAP2Lchr1154234067+0.0156503020.98434967
ENST00000434271ENST00000271877CTSBchr811710837-UBAP2Lchr1154234067+0.0083250490.99167496
ENST00000434271ENST00000361546CTSBchr811710837-UBAP2Lchr1154234067+0.0154904660.9845095
ENST00000530640ENST00000343815CTSBchr811710837-UBAP2Lchr1154234067+0.393612920.606387
ENST00000530640ENST00000428931CTSBchr811710837-UBAP2Lchr1154234067+0.0100027610.98999727
ENST00000530640ENST00000271877CTSBchr811710837-UBAP2Lchr1154234067+0.0028366540.99716336
ENST00000530640ENST00000361546CTSBchr811710837-UBAP2Lchr1154234067+0.0098852540.9901148
ENST00000415599ENST00000343815CTSBchr811710837-UBAP2Lchr1154234067+0.572641730.4273583
ENST00000415599ENST00000428931CTSBchr811710837-UBAP2Lchr1154234067+0.0103093020.98969066
ENST00000415599ENST00000271877CTSBchr811710837-UBAP2Lchr1154234067+0.0030787160.9969213
ENST00000415599ENST00000361546CTSBchr811710837-UBAP2Lchr1154234067+0.0102422820.98975766
ENST00000533455ENST00000343815CTSBchr811710837-UBAP2Lchr1154234067+0.44363930.5563607
ENST00000533455ENST00000428931CTSBchr811710837-UBAP2Lchr1154234067+0.0131854450.9868146
ENST00000533455ENST00000271877CTSBchr811710837-UBAP2Lchr1154234067+0.0047068870.9952931
ENST00000533455ENST00000361546CTSBchr811710837-UBAP2Lchr1154234067+0.0130554650.9869445

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Fusion Genomic Features for CTSB-UBAP2L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTSBchr811710837-UBAP2Lchr1154234067+0.0138574830.9861426
CTSBchr811710837-UBAP2Lchr1154234067+0.0138574830.9861426

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CTSB-UBAP2L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11710837/chr1:154234067)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTSB

P07858

.
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBAP2Lchr8:11710837chr1:154234067ENST00000343815222549_89932984.0DomainUBA
TgeneUBAP2Lchr8:11710837chr1:154234067ENST00000361546212649_899321088.0DomainUBA
TgeneUBAP2Lchr8:11710837chr1:154234067ENST00000428931222749_899321088.0DomainUBA


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Fusion Gene Sequence for CTSB-UBAP2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20480_20480_1_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000271877_length(transcript)=696nt_BP=198nt
CGACCCACATAACAGAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCC
TCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAA
CGGAATACCACGTGGCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAG
CCGAGTGGATATGGGTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTAC
TCCAAAACCCAGTCCTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGC
CCCATCAATCCGGCCACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTT
CACCATCACCTGCAGCAGGATGGCCAGGACATCCTCAATTTCGTCGATGACCAGCTTGGTGAATAAGTATTACTGTACCAACTGGGCCTC

>20480_20480_1_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000271877_length(amino acids)=177AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD

--------------------------------------------------------------
>20480_20480_2_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000343815_length(transcript)=707nt_BP=198nt
CGACCCACATAACAGAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCC
TCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAA
CGGAATACCACGTGGCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAG
CCGAGTGGATATGGGTCTCATGGATACAACACTGGAAGAAAATATCCACCCCCTTACAAGCATTTCTGGACGGCTGAGAGCTAATTTGGC
CCAAGGCTGGGGGCTGTGTTTTGTGTGTGTGTATAAATTTGCACTGAAGTCTTGTTTCAGAAACCAGACCACTGAGGAGAGCCTGCTGAG
CTGAGGCCATGGCCTGCGTGGCTTGGGGAAATGAGTTGGTGGATACCTTCTGGGCTTTTGAACTTGCCCCTCCCCCATTTCCCTCTCCCC
CATGTGTCTGACCCTGTCTTACCCATTTCAAGTTCAAGCGGTGCAGCACCTTCGAAGCATCAATGCACACACCTGCTGTTGCTTTTGATT

>20480_20480_2_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000343815_length(amino acids)=138AA_BP=
MKLHAFQKSKATAGVCIDASKVLHRLNLKWVRQGQTHGGEGNGGGASSKAQKVSTNSFPQATQAMASAQQALLSGLVSETRLQCKFIHTH

--------------------------------------------------------------
>20480_20480_3_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000361546_length(transcript)=1224nt_BP=198nt
CGACCCACATAACAGAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCC
TCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAA
CGGAATACCACGTGGCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAG
CCGAGTGGATATGGGTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTAC
TCCAAAACCCAGCAGTCCTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGG
GGCCCCATCAATCCGGCCACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATC
CTTCACCATCACCTGCAGCAGGATGGCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAG
TCTGCCTACAACAGCTACAGCTGGGGGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGA
AACTATGGAAACAGCATCAAAGAGAAAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATG
TCTGTCCCATTCCTATACCATCCCCACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCC
CCTCTTGCATTCAAGATTATGAAACTTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCG
GGGAGGTGGGACCCCCAAACATATATCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAA
AATGGCGTCATGAATATGAACAGCATTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTC

>20480_20480_3_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000361546_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_4_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000428931_length(transcript)=1223nt_BP=198nt
CGACCCACATAACAGAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCC
TCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAA
CGGAATACCACGTGGCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAG
CCGAGTGGATATGGGTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTAC
TCCAAAACCCAGCAGTCCTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGG
GGCCCCATCAATCCGGCCACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATC
CTTCACCATCACCTGCAGCAGGATGGCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAG
TCTGCCTACAACAGCTACAGCTGGGGGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGA
AACTATGGAAACAGCATCAAAGAGAAAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATG
TCTGTCCCATTCCTATACCATCCCCACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCC
CCTCTTGCATTCAAGATTATGAAACTTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCG
GGGAGGTGGGACCCCCAAACATATATCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAA
AATGGCGTCATGAATATGAACAGCATTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTC

>20480_20480_4_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000415599_UBAP2L_chr1_154234067_ENST00000428931_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_5_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000271877_length(transcript)=862nt_BP=364nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGG
GTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGTC
CTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGC
CACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCA
GCAGGATGGCCAGGACATCCTCAATTTCGTCGATGACCAGCTTGGTGAATAAGTATTACTGTACCAACTGGGCCTCCTCTAGCAGGCCCC

>20480_20480_5_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000271877_length(amino acids)=177AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD

--------------------------------------------------------------
>20480_20480_6_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000343815_length(transcript)=873nt_BP=364nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGG
GTCTCATGGATACAACACTGGAAGAAAATATCCACCCCCTTACAAGCATTTCTGGACGGCTGAGAGCTAATTTGGCCCAAGGCTGGGGGC
TGTGTTTTGTGTGTGTGTATAAATTTGCACTGAAGTCTTGTTTCAGAAACCAGACCACTGAGGAGAGCCTGCTGAGCTGAGGCCATGGCC
TGCGTGGCTTGGGGAAATGAGTTGGTGGATACCTTCTGGGCTTTTGAACTTGCCCCTCCCCCATTTCCCTCTCCCCCATGTGTCTGACCC
TGTCTTACCCATTTCAAGTTCAAGCGGTGCAGCACCTTCGAAGCATCAATGCACACACCTGCTGTTGCTTTTGATTTCTGGAAGGCATGT

>20480_20480_6_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000343815_length(amino acids)=138AA_BP=
MKLHAFQKSKATAGVCIDASKVLHRLNLKWVRQGQTHGGEGNGGGASSKAQKVSTNSFPQATQAMASAQQALLSGLVSETRLQCKFIHTH

--------------------------------------------------------------
>20480_20480_7_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000361546_length(transcript)=1390nt_BP=364nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGG
GTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCA
GTCCTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCC
GGCCACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCT
GCAGCAGGATGGCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAG
CTACAGCTGGGGGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAG
CATCAAAGAGAAAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCT
ATACCATCCCCACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAA
GATTATGAAACTTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCC
CCAAACATATATCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAA
TATGAACAGCATTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATT

>20480_20480_7_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000361546_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_8_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000428931_length(transcript)=1389nt_BP=364nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGTGGCTCCTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGG
GTCTCATGGATACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCA
GTCCTTTGAGAAACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCC
GGCCACAGCTGCTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCT
GCAGCAGGATGGCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAG
CTACAGCTGGGGGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAG
CATCAAAGAGAAAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCT
ATACCATCCCCACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAA
GATTATGAAACTTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCC
CCAAACATATATCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAA
TATGAACAGCATTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATT

>20480_20480_8_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000434271_UBAP2L_chr1_154234067_ENST00000428931_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_9_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000271877_length(transcript)=761nt_BP=263nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTC
CTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGAT
ACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGTCCTTTGAGAAAC
AAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTGCTG
CCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATGGCC
AGGACATCCTCAATTTCGTCGATGACCAGCTTGGTGAATAAGTATTACTGTACCAACTGGGCCTCCTCTAGCAGGCCCCTGAAGGCAGTG

>20480_20480_9_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000271877_length(amino acids)=177AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD

--------------------------------------------------------------
>20480_20480_10_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000343815_length(transcript)=772nt_BP=263nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTC
CTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGAT
ACAACACTGGAAGAAAATATCCACCCCCTTACAAGCATTTCTGGACGGCTGAGAGCTAATTTGGCCCAAGGCTGGGGGCTGTGTTTTGTG
TGTGTGTATAAATTTGCACTGAAGTCTTGTTTCAGAAACCAGACCACTGAGGAGAGCCTGCTGAGCTGAGGCCATGGCCTGCGTGGCTTG
GGGAAATGAGTTGGTGGATACCTTCTGGGCTTTTGAACTTGCCCCTCCCCCATTTCCCTCTCCCCCATGTGTCTGACCCTGTCTTACCCA
TTTCAAGTTCAAGCGGTGCAGCACCTTCGAAGCATCAATGCACACACCTGCTGTTGCTTTTGATTTCTGGAAGGCATGTAGTTTCAACTT

>20480_20480_10_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000343815_length(amino acids)=138AA_BP=
MKLHAFQKSKATAGVCIDASKVLHRLNLKWVRQGQTHGGEGNGGGASSKAQKVSTNSFPQATQAMASAQQALLSGLVSETRLQCKFIHTH

--------------------------------------------------------------
>20480_20480_11_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000361546_length(transcript)=1289nt_BP=263nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTC
CTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGAT
ACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCAGTCCTTTGAGA
AACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTG
CTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATG
GCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAGCTACAGCTGGG
GGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAGCATCAAAGAGA
AAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCTATACCATCCCC
ACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAAGATTATGAAAC
TTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCCCCAAACATATA
TCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAATATGAACAGCA
TTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATTAATGTGTCTTG

>20480_20480_11_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000361546_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_12_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000428931_length(transcript)=1288nt_BP=263nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTC
CTACCTCTTCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGAT
ACAACACTGGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCAGTCCTTTGAGA
AACAAGGTTTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTG
CTGCCTACCCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATG
GCCAGACGGGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAGCTACAGCTGGG
GGGCCAACTGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAGCATCAAAGAGA
AAGGAATGTGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCTATACCATCCCC
ACCCTGTTGTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAAGATTATGAAAC
TTTGCTATGGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCCCCAAACATATA
TCAGCCCAACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAATATGAACAGCA
TTGTCAGATGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATTAATGTGTCTTG

>20480_20480_12_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000530640_UBAP2L_chr1_154234067_ENST00000428931_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_13_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000271877_length(transcript)=843nt_BP=345nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTCCTACCTCT
TCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGATACAACACT
GGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGTCCTTTGAGAAACAAGGTTTT
CATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTGCTGCCTACCCA
CCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATGGCCAGGACATC
CTCAATTTCGTCGATGACCAGCTTGGTGAATAAGTATTACTGTACCAACTGGGCCTCCTCTAGCAGGCCCCTGAAGGCAGTGGAATAAAA

>20480_20480_13_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000271877_length(amino acids)=177AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD

--------------------------------------------------------------
>20480_20480_14_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000343815_length(transcript)=854nt_BP=345nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTCCTACCTCT
TCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGATACAACACT
GGAAGAAAATATCCACCCCCTTACAAGCATTTCTGGACGGCTGAGAGCTAATTTGGCCCAAGGCTGGGGGCTGTGTTTTGTGTGTGTGTA
TAAATTTGCACTGAAGTCTTGTTTCAGAAACCAGACCACTGAGGAGAGCCTGCTGAGCTGAGGCCATGGCCTGCGTGGCTTGGGGAAATG
AGTTGGTGGATACCTTCTGGGCTTTTGAACTTGCCCCTCCCCCATTTCCCTCTCCCCCATGTGTCTGACCCTGTCTTACCCATTTCAAGT
TCAAGCGGTGCAGCACCTTCGAAGCATCAATGCACACACCTGCTGTTGCTTTTGATTTCTGGAAGGCATGTAGTTTCAACTTGTAACAAA

>20480_20480_14_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000343815_length(amino acids)=138AA_BP=
MKLHAFQKSKATAGVCIDASKVLHRLNLKWVRQGQTHGGEGNGGGASSKAQKVSTNSFPQATQAMASAQQALLSGLVSETRLQCKFIHTH

--------------------------------------------------------------
>20480_20480_15_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000361546_length(transcript)=1371nt_BP=345nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTCCTACCTCT
TCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGATACAACACT
GGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCAGTCCTTTGAGAAACAAGGT
TTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTGCTGCCTAC
CCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATGGCCAGACG
GGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAGCTACAGCTGGGGGGCCAAC
TGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAGCATCAAAGAGAAAGGAATG
TGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCTATACCATCCCCACCCTGTT
GTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAAGATTATGAAACTTTGCTAT
GGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCCCCAAACATATATCAGCCCA
ACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAATATGAACAGCATTGTCAGA
TGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATTAATGTGTCTTGTATATATA

>20480_20480_15_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000361546_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------
>20480_20480_16_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000428931_length(transcript)=1370nt_BP=345nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGTGGCTCCTACCTCT
TCCAAGCAGCATGGTGTGAATGTCAGTGTGAATGCATCGGCCACCCCTTTCCAACAGCCGAGTGGATATGGGTCTCATGGATACAACACT
GGTGTTTCAGTCACCTCCAGTAACACGGGCGTGCCAGATATCTCGGGTTCTGTGTACTCCAAAACCCAGCAGTCCTTTGAGAAACAAGGT
TTTCATTCCGGTACTCCTGCTGCTTCCTTCAACTTGCCTTCAGCCCTAGGAAGTGGGGGCCCCATCAATCCGGCCACAGCTGCTGCCTAC
CCACCTGCCCCCTTTATGCACATTCTGACCCCCCATCAGCAGCCGCATTCTCAGATCCTTCACCATCACCTGCAGCAGGATGGCCAGACG
GGCAGCGGGCAACGTAGCCAGACCAGCTCCATCCCGCAGAAGCCCCAGACCAACAAGTCTGCCTACAACAGCTACAGCTGGGGGGCCAAC
TGAGGCCCTGACCCTCTTCTCCCGGTCCCATCTTCTGAGAGGGCTTCTCAGCCTGGAAACTATGGAAACAGCATCAAAGAGAAAGGAATG
TGGGGGGTTTCCGCTGCCCCCCACCCCCAGCGGCCCACCCCATGCCTCAGCTTCATGTCTGTCCCATTCCTATACCATCCCCACCCTGTT
GTATGTATTATAGGATTTGTATTTTCTCCTTTTTTTTCCCCCTTCCATTCCTTCTCCCCTCTTGCATTCAAGATTATGAAACTTTGCTAT
GGGCCCTGCACTTCCTTTGCTTCCTCCTGTTCACCCTGGTGGTGTACGGATGAGGCGGGGAGGTGGGACCCCCAAACATATATCAGCCCA
ACAGCCCTAAGTCTCCTTCTTTATTATTAGGAAAACAACAACAACAACAAACAAAAAAATGGCGTCATGAATATGAACAGCATTGTCAGA
TGAATTAGTTGAAGTGGTTTTTTTTTTGTTTTTTTTTTTTTTTTGTACTGTGTCCTCAAATTTAATGGATTAATGTGTCTTGTATATATA

>20480_20480_16_CTSB-UBAP2L_CTSB_chr8_11710837_ENST00000533455_UBAP2L_chr1_154234067_ENST00000428931_length(amino acids)=197AA_BP=42
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPD
ISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTSB-UBAP2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTSB-UBAP2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTSB-UBAP2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource