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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTSE-WBP2 (FusionGDB2 ID:20508)

Fusion Gene Summary for CTSE-WBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTSE-WBP2
Fusion gene ID: 20508
HgeneTgene
Gene symbol

CTSE

WBP2

Gene ID

1510

23558

Gene namecathepsin EWW domain binding protein 2
SynonymsCATEDFNB107|GRAMD6|WBP-2
Cytomap

1q32.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptioncathepsin Eerythrocyte membrane aspartic proteinaseslow-moving proteinaseWW domain-binding protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000468617, ENST00000358184, 
ENST00000360218, ENST00000361052, 
ENST00000432969, 		ENST00000254806, 
ENST00000344296, ENST00000433525, 
ENST00000585462, ENST00000590221, 
ENST00000591399, ENST00000590450, 
Fusion gene scores* DoF score5 X 3 X 2=305 X 5 X 3=75
# samples 46
** MAII scorelog2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTSE [Title/Abstract] AND WBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTSE(206325437)-WBP2(73842868), # samples:1
Anticipated loss of major functional domain due to fusion event.CTSE-WBP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSE

GO:0006508

proteolysis

16997486

HgeneCTSE

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

8765029

TgeneWBP2

GO:0032570

response to progesterone

16772533

TgeneWBP2

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

TgeneWBP2

GO:0043627

response to estrogen

16772533

TgeneWBP2

GO:0050847

progesterone receptor signaling pathway

16772533


check buttonFusion gene breakpoints across CTSE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer215NCTSEchr1

206325437

+WBP2chr17

73842868

-


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Fusion Gene ORF analysis for CTSE-WBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000468617ENST00000254806CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-3CDSENST00000468617ENST00000344296CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-3CDSENST00000468617ENST00000433525CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-3CDSENST00000468617ENST00000585462CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-3CDSENST00000468617ENST00000590221CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-3CDSENST00000468617ENST00000591399CTSEchr1

206325437

+WBP2chr17

73842868

-
3UTR-intronENST00000468617ENST00000590450CTSEchr1

206325437

+WBP2chr17

73842868

-
5CDS-intronENST00000358184ENST00000590450CTSEchr1

206325437

+WBP2chr17

73842868

-
5CDS-intronENST00000360218ENST00000590450CTSEchr1

206325437

+WBP2chr17

73842868

-
5CDS-intronENST00000361052ENST00000590450CTSEchr1

206325437

+WBP2chr17

73842868

-
5CDS-intronENST00000432969ENST00000590450CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000358184ENST00000254806CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000358184ENST00000344296CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000358184ENST00000585462CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000358184ENST00000590221CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000358184ENST00000591399CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000360218ENST00000254806CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000360218ENST00000344296CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000360218ENST00000585462CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000360218ENST00000590221CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000360218ENST00000591399CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000361052ENST00000254806CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000361052ENST00000344296CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000361052ENST00000585462CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000361052ENST00000590221CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000361052ENST00000591399CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000432969ENST00000254806CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000432969ENST00000344296CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000432969ENST00000585462CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000432969ENST00000590221CTSEchr1

206325437

+WBP2chr17

73842868

-
Frame-shiftENST00000432969ENST00000591399CTSEchr1

206325437

+WBP2chr17

73842868

-
In-frameENST00000358184ENST00000433525CTSEchr1

206325437

+WBP2chr17

73842868

-
In-frameENST00000360218ENST00000433525CTSEchr1

206325437

+WBP2chr17

73842868

-
In-frameENST00000361052ENST00000433525CTSEchr1

206325437

+WBP2chr17

73842868

-
In-frameENST00000432969ENST00000433525CTSEchr1

206325437

+WBP2chr17

73842868

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361052CTSEchr1206325437+ENST00000433525WBP2chr1773842868-1088795100960286
ENST00000358184CTSEchr1206325437+ENST00000433525WBP2chr1773842868-1073780100945281
ENST00000360218CTSEchr1206325437+ENST00000433525WBP2chr1773842868-105976686931281
ENST00000432969CTSEchr1206325437+ENST00000433525WBP2chr1773842868-76947639641200

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361052ENST00000433525CTSEchr1206325437+WBP2chr1773842868-0.103447170.8965528
ENST00000358184ENST00000433525CTSEchr1206325437+WBP2chr1773842868-0.176463190.82353675
ENST00000360218ENST00000433525CTSEchr1206325437+WBP2chr1773842868-0.18899530.81100464
ENST00000432969ENST00000433525CTSEchr1206325437+WBP2chr1773842868-0.13563410.8643659

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Fusion Genomic Features for CTSE-WBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTSE-WBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:206325437/chr17:73842868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTSEchr1:206325437chr17:73842868ENST00000358184+5978_396220397.0DomainPeptidase A1
HgeneCTSEchr1:206325437chr17:73842868ENST00000360218+5878_396220364.0DomainPeptidase A1
TgeneWBP2chr1:206325437chr17:73842868ENST0000025480668146_255244262.0Compositional biasNote=Pro-rich
TgeneWBP2chr1:206325437chr17:73842868ENST0000059139979146_255244262.0Compositional biasNote=Pro-rich
TgeneWBP2chr1:206325437chr17:73842868ENST00000254806681_84244262.0DomainNote=GRAM
TgeneWBP2chr1:206325437chr17:73842868ENST00000591399791_84244262.0DomainNote=GRAM
TgeneWBP2chr1:206325437chr17:73842868ENST0000025480668196_200244262.0MotifNote=PPxY motif 1
TgeneWBP2chr1:206325437chr17:73842868ENST0000059139979196_200244262.0MotifNote=PPxY motif 1


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Fusion Gene Sequence for CTSE-WBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20508_20508_1_CTSE-WBP2_CTSE_chr1_206325437_ENST00000358184_WBP2_chr17_73842868_ENST00000433525_length(transcript)=1073nt_BP=780nt
ATCATTCGGCCCTCAGACTGGGCTGGGCAGGTCTGAGAGTTAGGGAAAGTCCGTTCCCACTGCCCTCGGGGAGAGAAGAAAGGAGGGGGC
AAGGGAGAAGCTGCTGGTCGGACTCACAATGAAAACGCTCCTTCTTTTGCTGCTGGTGCTCCTGGAGCTGGGAGAGGCCCAAGGATCCCT
TCACAGGGTGCCCCTCAGGAGGCATCCGTCCCTCAAGAAGAAGCTGCGGGCACGGAGCCAGCTCTCTGAGTTCTGGAAATCCCATAATTT
GGACATGATCCAGTTCACCGAGTCCTGCTCAATGGACCAGAGTGCCAAGGAACCCCTCATCAACTACTTGGATATGGAATACTTCGGCAC
TATCTCCATTGGCTCCCCACCACAGAACTTCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAG
CCCAGCCTGCAAGACGCACAGCAGGTTCCAGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAAC
CGGGAGCTTGTCCGGGATCATTGGAGCCGACCAAGTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGA
GCCAGGCCAGACCTTTGTGGATGCAGAGTTTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATT
TGACAACATGATGGCTCAGAACCTGGTGGACTTGCCGATGTTTTCTGTCTACATGAGCAGAGCCAGCCGCCGCCACCTCCCTACTACCCA
CCGGAAGATAAGAAGACCCAGTAGGCCCTCCTGCCTCCCTGCCTCCCACCCTCATCTCTCTACCCTACCCCTCCCATCGGGGCTGTGCTG
GGGCTTGGGGAGGGGAGGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGGGACATTAGGGCC

>20508_20508_1_CTSE-WBP2_CTSE_chr1_206325437_ENST00000358184_WBP2_chr17_73842868_ENST00000433525_length(amino acids)=281AA_BP=226
MLVGLTMKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISI
GSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQ
TFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSRASRRHLPTTHRKIRRPSRPSCLPASHPHLSTLPLPSGLCWGLG

--------------------------------------------------------------
>20508_20508_2_CTSE-WBP2_CTSE_chr1_206325437_ENST00000360218_WBP2_chr17_73842868_ENST00000433525_length(transcript)=1059nt_BP=766nt
AGACTGGGCTGGGCAGGTCTGAGAGTTAGGGAAAGTCCGTTCCCACTGCCCTCGGGGAGAGAAGAAAGGAGGGGGCAAGGGAGAAGCTGC
TGGTCGGACTCACAATGAAAACGCTCCTTCTTTTGCTGCTGGTGCTCCTGGAGCTGGGAGAGGCCCAAGGATCCCTTCACAGGGTGCCCC
TCAGGAGGCATCCGTCCCTCAAGAAGAAGCTGCGGGCACGGAGCCAGCTCTCTGAGTTCTGGAAATCCCATAATTTGGACATGATCCAGT
TCACCGAGTCCTGCTCAATGGACCAGAGTGCCAAGGAACCCCTCATCAACTACTTGGATATGGAATACTTCGGCACTATCTCCATTGGCT
CCCCACCACAGAACTTCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGA
CGCACAGCAGGTTCCAGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCG
GGATCATTGGAGCCGACCAAGTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCT
TTGTGGATGCAGAGTTTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGG
CTCAGAACCTGGTGGACTTGCCGATGTTTTCTGTCTACATGAGCAGAGCCAGCCGCCGCCACCTCCCTACTACCCACCGGAAGATAAGAA
GACCCAGTAGGCCCTCCTGCCTCCCTGCCTCCCACCCTCATCTCTCTACCCTACCCCTCCCATCGGGGCTGTGCTGGGGCTTGGGGAGGG
GAGGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGGGACATTAGGGCCCCCGGCCTCGGGAG

>20508_20508_2_CTSE-WBP2_CTSE_chr1_206325437_ENST00000360218_WBP2_chr17_73842868_ENST00000433525_length(amino acids)=281AA_BP=226
MLVGLTMKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISI
GSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQ
TFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSRASRRHLPTTHRKIRRPSRPSCLPASHPHLSTLPLPSGLCWGLG

--------------------------------------------------------------
>20508_20508_3_CTSE-WBP2_CTSE_chr1_206325437_ENST00000361052_WBP2_chr17_73842868_ENST00000433525_length(transcript)=1088nt_BP=795nt
ATCATTCGGCCCTCAGACTGGGCTGGGCAGGTCTGAGAGTTAGGGAAAGTCCGTTCCCACTGCCCTCGGGGAGAGAAGAAAGGAGGGGGC
AAGGGAGAAGCTGCTGGTCGGACTCACAATGAAAACGCTCCTTCTTTTGCTGCTGGTGCTCCTGGAGCTGGGAGAGGCCCAAGGATCCCT
TCACAGGGTGCCCCTCAGGAGGCATCCGTCCCTCAAGAAGAAGCTGCGGGCACGGAGCCAGCTCTCTGAGTTCTGGAAATCCCATAATTT
GGACATGATCCAGTTCACCGAGTCCTGCTCAATGGACCAGAGTGCCAAGGAACCCCTCATCAACTACTTGGATATGGAATACTTCGGCAC
TATCTCCATTGGCTCCCCACCACAGAACTTCACTGTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAG
CCCAGCCTGCAAGACGCACAGCAGGTTCCAGCCTTCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAAC
CGGGAGCTTGTCCGGGATCATTGGAGCCGACCAAGTCTCTGCTTTCTCCTACCAGGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGG
AGAAAGTGTCACAGAGCCAGGCCAGACCTTTGTGGATGCAGAGTTTGATGGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGG
AGTGACTCCAGTATTTGACAACATGATGGCTCAGAACCTGGTGGACTTGCCGATGTTTTCTGTCTACATGAGCAGAGCCAGCCGCCGCCA
CCTCCCTACTACCCACCGGAAGATAAGAAGACCCAGTAGGCCCTCCTGCCTCCCTGCCTCCCACCCTCATCTCTCTACCCTACCCCTCCC
ATCGGGGCTGTGCTGGGGCTTGGGGAGGGGAGGGGGCGCCTTGTTCTCCCTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTG
TGGGACATTAGGGCCCCCGGCCTCGGGAGAGGTGCCGCCCAGCTTCCCATGCCAGCCCGGAGCCCACAGTGCTGCCCAGCGTACCTCCCT

>20508_20508_3_CTSE-WBP2_CTSE_chr1_206325437_ENST00000361052_WBP2_chr17_73842868_ENST00000433525_length(amino acids)=286AA_BP=231
MLVGLTMKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISI
GSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESV
TEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSRASRRHLPTTHRKIRRPSRPSCLPASHPHLSTLPLPSGL

--------------------------------------------------------------
>20508_20508_4_CTSE-WBP2_CTSE_chr1_206325437_ENST00000432969_WBP2_chr17_73842868_ENST00000433525_length(transcript)=769nt_BP=476nt
GCTCCTGGAGCTGGGAGAGGCCCAAGGATCCCTTCACAGATGGAATACTTCGGCACTATCTCCATTGGCTCCCCACCACAGAACTTCACT
GTCATCTTCGACACTGGCTCCTCCAACCTCTGGGTCCCCTCTGTGTACTGCACTAGCCCAGCCTGCAAGACGCACAGCAGGTTCCAGCCT
TCCCAGTCCAGCACATACAGCCAGCCAGGTCAATCTTTCTCCATTCAGTATGGAACCGGGAGCTTGTCCGGGATCATTGGAGCCGACCAA
GTCTCTGTGGAAGGACTAACCGTGGTTGGCCAGCAGTTTGGAGAAAGTGTCACAGAGCCAGGCCAGACCTTTGTGGATGCAGAGTTTGAT
GGAATTCTGGGCCTGGGATACCCCTCCTTGGCTGTGGGAGGAGTGACTCCAGTATTTGACAACATGATGGCTCAGAACCTGGTGGACTTG
CCGATGTTTTCTGTCTACATGAGCAGAGCCAGCCGCCGCCACCTCCCTACTACCCACCGGAAGATAAGAAGACCCAGTAGGCCCTCCTGC
CTCCCTGCCTCCCACCCTCATCTCTCTACCCTACCCCTCCCATCGGGGCTGTGCTGGGGCTTGGGGAGGGGAGGGGGCGCCTTGTTCTCC
CTCCAGGTCTGATCATAAACAATTACCAGGAACTAGCATTGTGGGACATTAGGGCCCCCGGCCTCGGGAGAGGTGCCGCCCAGCTTCCCA

>20508_20508_4_CTSE-WBP2_CTSE_chr1_206325437_ENST00000432969_WBP2_chr17_73842868_ENST00000433525_length(amino acids)=200AA_BP=145
MEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQF
GESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSRASRRHLPTTHRKIRRPSRPSCLPASHPHLSTLPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTSE-WBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTSE-WBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTSE-WBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource