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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CTSO-NAA15 (FusionGDB2 ID:20531)

Fusion Gene Summary for CTSO-NAA15

Fusion gene summary

Fusion gene information	Fusion gene name: CTSO-NAA15
	Fusion gene ID: 20531
		Hgene	Tgene
	Gene symbol	CTSO	NAA15
	Gene ID	1519	80155
	Gene name	cathepsin O	N-alpha-acetyltransferase 15, NatA auxiliary subunit
	Synonyms	CTSO1	Ga19\|MRD50\|NARG1\|NAT1P\|NATH\|TBDN\|TBDN100
	Cytomap	4q32.1	4q31.1
	Type of gene	protein-coding	protein-coding
	Description	cathepsin O	N-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1
	Modification date	20200313	20200313
	UniProtAcc	P43234	Q9BXJ9
	Ensembl transtripts involved in fusion gene	ENST00000433477,	ENST00000480277, ENST00000515576, ENST00000296543, ENST00000398947,
Fusion gene scores	* DoF score	3 X 3 X 3=27	14 X 11 X 8=1232
	# samples	3	15
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(15/1232*10)=-3.03796785019902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CTSO [Title/Abstract] AND NAA15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTSO(156849488)-NAA15(140305986), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NAA15	GO:0006474	N-terminal protein amino acid acetylation	15496142
Tgene	NAA15	GO:0045893	positive regulation of transcription, DNA-templated	12145306

Fusion gene breakpoints across CTSO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NAA15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3495-01A	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+

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Fusion Gene ORF analysis for CTSO-NAA15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000433477	ENST00000480277	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+
5CDS-intron	ENST00000433477	ENST00000515576	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+
In-frame	ENST00000433477	ENST00000296543	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+
In-frame	ENST00000433477	ENST00000398947	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000433477

CTSO

chr4

156849488

ENST00000296543

NAA15

chr4

140305986

4745

1001

1446

458

ENST00000433477

CTSO

chr4

156849488

ENST00000398947

NAA15

chr4

140305986

4728

1001

1443

457

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000433477	ENST00000296543	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+	0.000149876	0.99985015
ENST00000433477	ENST00000398947	CTSO	chr4	156849488	-	NAA15	chr4	140305986	+	0.000141884	0.99985814

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Fusion Genomic Features for CTSO-NAA15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CTSO	chr4	156849487	-	NAA15	chr4	140305988	+	0.002002634	0.99799734
CTSO	chr4	156849487	-	NAA15	chr4	140305988	+	0.002002634	0.99799734

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTSO-NAA15

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:156849488/chr4:140305986)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTSO P43234	NAA15 Q9BXJ9
FUNCTION: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.	FUNCTION: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269\|PubMed:11687548, ECO:0000269\|PubMed:12145306, ECO:0000269\|PubMed:15496142}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

629_632

718

867.0

Compositional bias

Note=Poly-Asp

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

612_629

718

867.0

Motif

Bipartite nuclear localization signal

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

148_184

718

867.0

Repeat

Note=TPR 3

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

224_257

718

867.0

Repeat

Note=TPR 4

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

374_407

718

867.0

Repeat

Note=TPR 5

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

409_441

718

867.0

Repeat

Note=TPR 6

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

46_79

718

867.0

Repeat

Note=TPR 1

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

485_518

718

867.0

Repeat

Note=TPR 7

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

672_705

718

867.0

Repeat

Note=TPR 8

Tgene

NAA15

chr4:156849488

chr4:140305986

ENST00000296543

80_113

718

867.0

Repeat

Note=TPR 2

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Fusion Gene Sequence for CTSO-NAA15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20531_20531_1_CTSO-NAA15_CTSO_chr4_156849488_ENST00000433477_NAA15_chr4_140305986_ENST00000296543_length(transcript)=4745nt_BP=1001nt
AGGCTGGGAGGAGCCGAGGAACCGAAAGAGAAAACAGGCCGCGCGGGCGGCAGAGGAGCCGGGCGCCGCAATGGACGTGCGGGCGCTGCC
GTGGCTGCCGTGGCTGCTGTGGCTGCTGTGCCGGGGCGGCGGCGATGCGGACTCCCGCGCCCCCTTCACCCCGACCTGGCCGCGGAGCCG
CGAGCGTGAAGCCGCCGCCTTCCGGGAAAGTCTTAATAGACATCGATACTTGAATTCTTTATTTCCCAGTGAAAACTCCACCGCCTTCTA
TGGAATAAATCAGTTTTCCTATTTGTTTCCTGAAGAGTTTAAAGCCATTTATTTAAGAAGCAAACCTTCCAAGTTTCCCAGATACTCAGC
AGAAGTACATATGTCCATCCCCAATGTGTCTTTGCCGTTAAGATTTGACTGGAGGGACAAGCAGGTTGTGACACAAGTGAGAAACCAGCA
GATGTGTGGAGGATGCTGGGCCTTCAGCGTGGTGGGGGCAGTGGAATCTGCTTATGCAATAAAGGGGAAGCCCCTGGAAGACCTAAGTGT
CCAGCAGGTCATTGACTGTTCGTATAATAATTATGGCTGCAATGGAGGCTCTACTCTCAATGCTTTGAACTGGTTAAACAAGATGCAAGT
AAAACTGGTGAAAGATTCAGAATATCCTTTTAAAGCACAAAATGGTCTGTGCCATTACTTTTCTGGTTCACATTCTGGATTTTCAATCAA
AGGTTATTCTGCATATGACTTCAGTGACCAAGAAGATGAAATGGCAAAAGCACTTCTTACCTTTGGCCCTTTGGTAGTCATAGTAGATGC
AGTGAGCTGGCAAGATTATCTGGGAGGCATTATACAGCATCACTGCTCTAGTGGAGAAGCAAATCATGCAGTTCTCATAACTGGGTTTGA
TAAAACAGGAAGCACTCCATATTGGATTGTGCGGAATTCCTGGGGAAGTTCTTGGGGAGTAGATGGTTATGCCCATGTCAAAATGGGAAG
TAATGTTTGTGCAGTGTGTGAAAGTAAAGATTTATCTGATACAGTTAGAACAGTATTAAAACAAGAAATGAATCGTCTTTTTGGAGCAAC
GAATCCAAAGAATTTTAATGAAACTTTTCTGAAAAGGAATTCTGATTCATTGCCACACAGATTATCAGCTGCCAAAATGGTATATTACTT
AGATCCTTCTAGTCAGAAGCGAGCTATAGAGTTGGCAACAACACTTGATGAATCTCTCACTAACAGAAACCTCCAGACATGTATGGAGGT
ATTGGAAGCCTTGTATGATGGTAGCCTAGGAGACTGTAAAGAAGCTGCTGAAATTTATAGAGCAAATTGTCATAAGCTTTTCCCTTATGC
TTTGGCTTTCATGCCTCCTGGATATGAAGAGGATATGAAGATCACAGTTAATGGAGATAGTTCTGCAGAAGCTGAAGAACTGGCCAATGA
AATTTGAACATCACTAAACAAGCAAATGGAATGACTTTGGACCATATCTAGTATATAATATTTTTGTCACGCACCTGCTGCATTGCTCTA
ACTTACACAGAATGAGAGGAGTAAATGTTCTTGCCTTCAAATAGTGTTTTACGTTTTTTATCCTGCTGAAAAAGTATATATAAAATATCT
AACATTACAGGATAGAGGTTCAGTTTCTTAAAAAATTAAAGCTGCTAAAATTGAGTGGTTAAAAAAGATACCTTATCCTATTCCTCCCCA
CCCACCCATGTTTTTAAACTAATTTATATAAAATCTGGAGGCTGTTACAGCTAACAAAGCAGGTGTGTGGCAGAAATATTACTTTAAATT
TGTCTTGTGAGATTTTACTATATCTCAGACAGCATAAATGCTGTTTTAGCACTGGATTCTTTCACTGAGCACAAAGAGTTGTTGGGGCTT
TAGCATCTGACTGATTTTGTTACGGGGTTGATTCTGACCATAGGAAGTATGCAATGTGAATCACTATTTACAGAGAAACCTACAACAGAT
GCTTGATGTTGTAGAAACTGGGACATATAGATACCAAGCAAAATTATAAGAAACCTATAAGGTGTTCAATACGCTTGTGTTTCCAAAATT
CACTGTACATGATCAGTTTGGTGTTCTTGTACCACAGTTTTTAACTGAAGGAACCAGTTGTAACAGTCTCAATTTTAACTAAAACTTGAA
GAACTAAAACAACAATGCAAACCTTTCAGCATTGTTTGGCCAAACTTGTTAAAACTGTAATGCAAGAACCAAATGCACTGTGATGTGGCA
CCAACTAATTAGCAAGCATGAATTTTTCACCCAAGAGTGAAAAAAGGAAAATCTACCATGGCTTGAAGTTAAAGAGCAGAACTCCTGACT
ACCATTCTATGACTGATCAAAAGACTAATAGTTAAAAACCTCAGCAGGCCTTGTTCACGATATGCAGAAAAAAAAGTGCTGCAGTTTAGA
TACCTCTGGAATTTTTCCACAGTGTCACAGGTTTGTAATACTTGAAGCCCTACATTTCTAAGAATATATTTCTTGCTCAGTTGTTTCAGG
CAAGCCCAAGACTTTGTAATTTTTAAAGGGCCCAAGATTTTTTTTTTTTTTTTTTTTTTCAAATAACAGACCAGCTTCTTTTTCTTGCAG
TTACAGATGTAATTTCCTTTTTGTTGTCAAACATAAGGTACCAAATATGATGCAATAAATTGTTTTGAAAAACAGTTGTGTGAATATTTC
AACTAATCTGTGTTGGGCTTCTGTGAAATACACAGGTGGAAACAGAGGTGCAAGCCAGAGGCAATGTAATATGCTGTAAGGCTAGTGCAG
ATGGGAGCTTTTTAGAAGGGGCTAAGTGCTGGTGTCAGGGAAATTCCATAATGAAGTAGAATGCTGCTCCTGCATTAAGATTTCATTGAG
GGCAAGGCTGGTGGCAGGTACTATGAATGTAATTCATAATTTAAAAGGAAAACTAAAAACTATTTTGATTTGGGAAAATGAGCCTTAATT
TGTTAAACCTATACACTGAGAACTAGCCTCAGGCTTAATATTCTCATTGCATTTGCAAGATCTGAGCAAATAAGATTAAGTAAAACAAAT
CAATTGTATATATAATTGACCTTTTTGTGGAACATGTAGTTTATAGAAAGTATACTCTAAAGGGAATTTGCCGAAGACCTTTTACTGATT
GAACAGTTGTGCTACAATCAACTTTTCATAGTACATGACCTGCATTCCACATCTCAGTCTAACAGTTTAGTAGTGATGTAAAGAGAAGTA
CAAACCGAACTCCAGTGCTTTGTTATGTTTTATTAACTGGCCCTGTCTCAGGAACATCTTAACAGATGGCAAAAAAACAAAAACTTTTTT
TCAACTCCTATGAGTGGCAACTGAAGTTCTTATTGTTGGGAAAGAACACTAGTCCTACCTCTGCCACTAATGAGGTGTTTGGAGGAGGTA
CCAGCCATATAATAGGGGGTGTATGTGTGAATTTTGTTTAAACTCTACTGTATATTGAAATGAAATTCATTTATTTGTCTTGACAATGTT
CAAATGATGTAGATTGTCTTAGAATGAATATTCATAAGTACTCAGAACTCTTAAGATGCAGATGCCACCCGTGAGGAGCTAAATTCCTAA
TGTGTATTGTATTCCAACCCAATTTTACTGGAACTATTGAATAAATCTTTTATTTTCTTTCAGGTTTACTTGATAGTGGATACATTGGTG
TCAGAGGACCTTGACTGGGTTCATTTTATGTCCAGACATCACCCCTGAAACACTGTACTGTACTATCTTGCTCTGAGTAGTATCAACTGG
ATCGTCTCATATTTGCCTCATTCATCCTATTAATTTCAAATGATACTGTGGGGGAAAAACAGGGTTAGAAAAACAAGTGGAAAAAATGGA
GTGATGTTGTAATCTAAACAAGTGCCTTATGTTTATTGCTAAGAACTGGTGTTACCAACCCTTTTGAGAAGAAAGGGTCTCTTGACCTGT
ATTAACATAGGAAAGTAAAGTTCTTTTTGTTTTTCTTTATATTCAGCTACTCTTGTCATTTCTCGTTGAAAAACTAAAATCTGACTAGGT
TAGTTTACTCAGCTTTAATTAGATAGTTGAGTCATATATTTTCAACATTTTTCTGTATCGTATTTATTATGCACAAAAATAAAGTGTGAT
CTCTAATAGCATGGCTAAAGGTAATGCCAATATTAGTGAATAGCTTTGCTGTGGGCTTTATCAGGCCCTTGTTTTTCACAGTGTTGTTTG
TACTCCATGGTGTATTGCTATTAGAGCTGTGAAATGAAAGCTGTGACTTTATGAAGAGATCAAAAAAAGTGTGGTCCAGATTCAGGTAGG
TTGTGGTAAGTTCAGGGAAGTCTTGTATGATTTCTAAGAATATTTCAGTTACCATGTATAGTATTTGGGAAAAGCTGTAATGTAAAATAT
TGGACTTTGTTGCAAGATAGGTATATACTTGTGTCAGATAATTAAAGCCTTAAATTTTGAAATGAATCTTTGAGATTTCAAAGAAAGACT
GACCTTTCAAATAGAAGGCGGTCTTTCTATTCTAGCTAATGCCCCACTTCTTTAAGTTATAAACAAAGTTTCATGATACCATTCTGCTAT
CATCTAAACTTTGCTGAACTCTACTGCCAACCTACATTAAAAACAAAGTCCCACGAAATGGCTGTGTTACACCATAGTGAGCAGAAACTT

>20531_20531_1_CTSO-NAA15_CTSO_chr4_156849488_ENST00000433477_NAA15_chr4_140305986_ENST00000296543_length(amino acids)=458AA_BP=310
MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPS
KFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN
WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHA
VLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSA
AKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAE

--------------------------------------------------------------
>20531_20531_2_CTSO-NAA15_CTSO_chr4_156849488_ENST00000433477_NAA15_chr4_140305986_ENST00000398947_length(transcript)=4728nt_BP=1001nt
AGGCTGGGAGGAGCCGAGGAACCGAAAGAGAAAACAGGCCGCGCGGGCGGCAGAGGAGCCGGGCGCCGCAATGGACGTGCGGGCGCTGCC
GTGGCTGCCGTGGCTGCTGTGGCTGCTGTGCCGGGGCGGCGGCGATGCGGACTCCCGCGCCCCCTTCACCCCGACCTGGCCGCGGAGCCG
CGAGCGTGAAGCCGCCGCCTTCCGGGAAAGTCTTAATAGACATCGATACTTGAATTCTTTATTTCCCAGTGAAAACTCCACCGCCTTCTA
TGGAATAAATCAGTTTTCCTATTTGTTTCCTGAAGAGTTTAAAGCCATTTATTTAAGAAGCAAACCTTCCAAGTTTCCCAGATACTCAGC
AGAAGTACATATGTCCATCCCCAATGTGTCTTTGCCGTTAAGATTTGACTGGAGGGACAAGCAGGTTGTGACACAAGTGAGAAACCAGCA
GATGTGTGGAGGATGCTGGGCCTTCAGCGTGGTGGGGGCAGTGGAATCTGCTTATGCAATAAAGGGGAAGCCCCTGGAAGACCTAAGTGT
CCAGCAGGTCATTGACTGTTCGTATAATAATTATGGCTGCAATGGAGGCTCTACTCTCAATGCTTTGAACTGGTTAAACAAGATGCAAGT
AAAACTGGTGAAAGATTCAGAATATCCTTTTAAAGCACAAAATGGTCTGTGCCATTACTTTTCTGGTTCACATTCTGGATTTTCAATCAA
AGGTTATTCTGCATATGACTTCAGTGACCAAGAAGATGAAATGGCAAAAGCACTTCTTACCTTTGGCCCTTTGGTAGTCATAGTAGATGC
AGTGAGCTGGCAAGATTATCTGGGAGGCATTATACAGCATCACTGCTCTAGTGGAGAAGCAAATCATGCAGTTCTCATAACTGGGTTTGA
TAAAACAGGAAGCACTCCATATTGGATTGTGCGGAATTCCTGGGGAAGTTCTTGGGGAGTAGATGGTTATGCCCATGTCAAAATGGGAAG
TAATGTTTGTGTGTGTGAAAGTAAAGATTTATCTGATACAGTTAGAACAGTATTAAAACAAGAAATGAATCGTCTTTTTGGAGCAACGAA
TCCAAAGAATTTTAATGAAACTTTTCTGAAAAGGAATTCTGATTCATTGCCACACAGATTATCAGCTGCCAAAATGGTATATTACTTAGA
TCCTTCTAGTCAGAAGCGAGCTATAGAGTTGGCAACAACACTTGATGAATCTCTCACTAACAGAAACCTCCAGACATGTATGGAGGTATT
GGAAGCCTTGTATGATGGTAGCCTAGGAGACTGTAAAGAAGCTGCTGAAATTTATAGAGCAAATTGTCATAAGCTTTTCCCTTATGCTTT
GGCTTTCATGCCTCCTGGATATGAAGAGGATATGAAGATCACAGTTAATGGAGATAGTTCTGCAGAAGCTGAAGAACTGGCCAATGAAAT
TTGAACATCACTAAACAAGCAAATGGAATGACTTTGGACCATATCTAGTATATAATATTTTTGTCACGCACCTGCTGCATTGCTCTAACT
TACACAGAATGAGAGGAGTAAATGTTCTTGCCTTCAAATAGTGTTTTACGTTTTTTATCCTGCTGAAAAAGTATATATAAAATATCTAAC
ATTACAGGATAGAGGTTCAGTTTCTTAAAAAATTAAAGCTGCTAAAATTGAGTGGTTAAAAAAGATACCTTATCCTATTCCTCCCCACCC
ACCCATGTTTTTAAACTAATTTATATAAAATCTGGAGGCTGTTACAGCTAACAAAGCAGGTGTGTGGCAGAAATATTACTTTAAATTTGT
CTTGTGAGATTTTACTATATCTCAGACAGCATAAATGCTGTTTTAGCACTGGATTCTTTCACTGAGCACAAAGAGTTGTTGGGGCTTTAG
CATCTGACTGATTTTGTTACGGGGTTGATTCTGACCATAGGAAGTATGCAATGTGAATCACTATTTACAGAGAAACCTACAACAGATGCT
TGATGTTGTAGAAACTGGGACATATAGATACCAAGCAAAATTATAAGAAACCTATAAGGTGTTCAATACGCTTGTGTTTCCAAAATTCAC
TGTACATGATCAGTTTGGTGTTCTTGTACCACAGTTTTTAACTGAAGGAACCAGTTGTAACAGTCTCAATTTTAACTAAAACTTGAAGAA
CTAAAACAACAATGCAAACCTTTCAGCATTGTTTGGCCAAACTTGTTAAAACTGTAATGCAAGAACCAAATGCACTGTGATGTGGCACCA
ACTAATTAGCAAGCATGAATTTTTCACCCAAGAGTGAAAAAAGGAAAATCTACCATGGCTTGAAGTTAAAGAGCAGAACTCCTGACTACC
ATTCTATGACTGATCAAAAGACTAATAGTTAAAAACCTCAGCAGGCCTTGTTCACGATATGCAGAAAAAAAAGTGCTGCAGTTTAGATAC
CTCTGGAATTTTTCCACAGTGTCACAGGTTTGTAATACTTGAAGCCCTACATTTCTAAGAATATATTTCTTGCTCAGTTGTTTCAGGCAA
GCCCAAGACTTTGTAATTTTTAAAGGGCCCAAGATTTTTTTTTTTTTTTTTTTTTTCAAATAACAGACCAGCTTCTTTTTCTTGCAGTTA
CAGATGTAATTTCCTTTTTGTTGTCAAACATAAGGTACCAAATATGATGCAATAAATTGTTTTGAAAAACAGTTGTGTGAATATTTCAAC
TAATCTGTGTTGGGCTTCTGTGAAATACACAGGTGGAAACAGAGGTGCAAGCCAGAGGCAATGTAATATGCTGTAAGGCTAGTGCAGATG
GGAGCTTTTTAGAAGGGGCTAAGTGCTGGTGTCAGGGAAATTCCATAATGAAGTAGAATGCTGCTCCTGCATTAAGATTTCATTGAGGGC
AAGGCTGGTGGCAGGTACTATGAATGTAATTCATAATTTAAAAGGAAAACTAAAAACTATTTTGATTTGGGAAAATGAGCCTTAATTTGT
TAAACCTATACACTGAGAACTAGCCTCAGGCTTAATATTCTCATTGCATTTGCAAGATCTGAGCAAATAAGATTAAGTAAAACAAATCAA
TTGTATATATAATTGACCTTTTTGTGGAACATGTAGTTTATAGAAAGTATACTCTAAAGGGAATTTGCCGAAGACCTTTTACTGATTGAA
CAGTTGTGCTACAATCAACTTTTCATAGTACATGACCTGCATTCCACATCTCAGTCTAACAGTTTAGTAGTGATGTAAAGAGAAGTACAA
ACCGAACTCCAGTGCTTTGTTATGTTTTATTAACTGGCCCTGTCTCAGGAACATCTTAACAGATGGCAAAAAAACAAAAACTTTTTTTCA
ACTCCTATGAGTGGCAACTGAAGTTCTTATTGTTGGGAAAGAACACTAGTCCTACCTCTGCCACTAATGAGGTGTTTGGAGGAGGTACCA
GCCATATAATAGGGGGTGTATGTGTGAATTTTGTTTAAACTCTACTGTATATTGAAATGAAATTCATTTATTTGTCTTGACAATGTTCAA
ATGATGTAGATTGTCTTAGAATGAATATTCATAAGTACTCAGAACTCTTAAGATGCAGATGCCACCCGTGAGGAGCTAAATTCCTAATGT
GTATTGTATTCCAACCCAATTTTACTGGAACTATTGAATAAATCTTTTATTTTCTTTCAGGTTTACTTGATAGTGGATACATTGGTGTCA
GAGGACCTTGACTGGGTTCATTTTATGTCCAGACATCACCCCTGAAACACTGTACTGTACTATCTTGCTCTGAGTAGTATCAACTGGATC
GTCTCATATTTGCCTCATTCATCCTATTAATTTCAAATGATACTGTGGGGGAAAAACAGGGTTAGAAAAACAAGTGGAAAAAATGGAGTG
ATGTTGTAATCTAAACAAGTGCCTTATGTTTATTGCTAAGAACTGGTGTTACCAACCCTTTTGAGAAGAAAGGGTCTCTTGACCTGTATT
AACATAGGAAAGTAAAGTTCTTTTTGTTTTTCTTTATATTCAGCTACTCTTGTCATTTCTCGTTGAAAAACTAAAATCTGACTAGGTTAG
TTTACTCAGCTTTAATTAGATAGTTGAGTCATATATTTTCAACATTTTTCTGTATCGTATTTATTATGCACAAAAATAAAGTGTGATCTC
TAATAGCATGGCTAAAGGTAATGCCAATATTAGTGAATAGCTTTGCTGTGGGCTTTATCAGGCCCTTGTTTTTCACAGTGTTGTTTGTAC
TCCATGGTGTATTGCTATTAGAGCTGTGAAATGAAAGCTGTGACTTTATGAAGAGATCAAAAAAAGTGTGGTCCAGATTCAGGTAGGTTG
TGGTAAGTTCAGGGAAGTCTTGTATGATTTCTAAGAATATTTCAGTTACCATGTATAGTATTTGGGAAAAGCTGTAATGTAAAATATTGG
ACTTTGTTGCAAGATAGGTATATACTTGTGTCAGATAATTAAAGCCTTAAATTTTGAAATGAATCTTTGAGATTTCAAAGAAAGACTGAC
CTTTCAAATAGAAGGCGGTCTTTCTATTCTAGCTAATGCCCCACTTCTTTAAGTTATAAACAAAGTTTCATGATACCATTCTGCTATCAT
CTAAACTTTGCTGAACTCTACTGCCAACCTACATTAAAAACAAAGTCCCACGAAATGGCTGTGTTACACCATAGTGAGCAGAAACTTAAA

>20531_20531_2_CTSO-NAA15_CTSO_chr4_156849488_ENST00000433477_NAA15_chr4_140305986_ENST00000398947_length(amino acids)=457AA_BP=310
MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPS
KFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN
WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHA
VLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAA
KMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAEA

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Fusion Gene PPI Analysis for CTSO-NAA15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	NAA15	chr4:156849488	chr4:140305986	ENST00000296543		16	20	500_866	718.3333333333334	867.0	HYPK

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CTSO-NAA15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTSO-NAA15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source