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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CUBN-ALDH16A1 (FusionGDB2 ID:20612)

Fusion Gene Summary for CUBN-ALDH16A1

Fusion gene summary

Fusion gene information	Fusion gene name: CUBN-ALDH16A1
	Fusion gene ID: 20612
		Hgene	Tgene
	Gene symbol	CUBN	ALDH16A1
	Gene ID	8029	126133
	Gene name	cubilin	aldehyde dehydrogenase 16 family member A1
	Synonyms	IFCR\|MGA1\|gp280	-
	Cytomap	10p13	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	cubilin460 kDa receptorcubilin (intrinsic factor-cobalamin receptor)cubilin precursor variant 1cubilin precursor variant 2cubilin precursor variant 3intestinal intrinsic factor receptorintrinsic factor-vitamin B12 receptor	aldehyde dehydrogenase family 16 member A1
	Modification date	20200313	20200313
	UniProtAcc	O60494	Q8IZ83
	Ensembl transtripts involved in fusion gene	ENST00000377833, ENST00000377823,	ENST00000598015, ENST00000433981, ENST00000455361, ENST00000540132, ENST00000293350,
Fusion gene scores	* DoF score	7 X 7 X 3=147	9 X 10 X 7=630
	# samples	7	13
	** MAII score	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CUBN [Title/Abstract] AND ALDH16A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CUBN(17024483)-ALDH16A1(49961743), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CUBN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALDH16A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A3EV-06A	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+

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Fusion Gene ORF analysis for CUBN-ALDH16A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000377833	ENST00000598015	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000377833	ENST00000433981	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000377833	ENST00000455361	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
5CDS-intron	ENST00000377833	ENST00000540132	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
In-frame	ENST00000377833	ENST00000293350	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
intron-3CDS	ENST00000377823	ENST00000293350	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
intron-3UTR	ENST00000377823	ENST00000598015	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000377823	ENST00000433981	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000377823	ENST00000455361	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+
intron-intron	ENST00000377823	ENST00000540132	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000377833

CUBN

chr10

17024483

ENST00000293350

ALDH16A1

chr19

49961743

7661

4761

7079

2338

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377833	ENST00000293350	CUBN	chr10	17024483	-	ALDH16A1	chr19	49961743	+	0.00087974	0.9991203

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Fusion Genomic Features for CUBN-ALDH16A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CUBN	chr10	17024482	-	ALDH16A1	chr19	49961742	+	2.58E-06	0.9999974
CUBN	chr10	17024482	-	ALDH16A1	chr19	49961742	+	2.58E-06	0.9999974

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUBN-ALDH16A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:17024483/chr19:49961743)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CUBN O60494	ALDH16A1 Q8IZ83
FUNCTION: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:9572993, PubMed:10371504, PubMed:11717447, PubMed:11606717, PubMed:14576052). Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:9572993, PubMed:14576052). Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269\|PubMed:10371504, ECO:0000269\|PubMed:11606717, ECO:0000269\|PubMed:11717447, ECO:0000269\|PubMed:14576052, ECO:0000269\|PubMed:9572993}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1048_1161

1565

3624.0

Domain

CUB 6

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1165_1277

1565

3624.0

Domain

CUB 7

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1278_1389

1565

3624.0

Domain

CUB 8

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

132_168

1565

3624.0

Domain

EGF-like 1

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1391_1506

1565

3624.0

Domain

CUB 9

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

170_211

1565

3624.0

Domain

EGF-like 2%3B calcium-binding

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

263_304

1565

3624.0

Domain

EGF-like 3%3B calcium-binding

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

305_348

1565

3624.0

Domain

EGF-like 4%3B calcium-binding

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

349_385

1565

3624.0

Domain

EGF-like 5

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

395_430

1565

3624.0

Domain

EGF-like 6

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

432_468

1565

3624.0

Domain

EGF-like 7%3B calcium-binding

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

474_586

1565

3624.0

Domain

CUB 1

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

590_702

1565

3624.0

Domain

CUB 2

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

708_816

1565

3624.0

Domain

CUB 3

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

816_928

1565

3624.0

Domain

CUB 4

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

932_1042

1565

3624.0

Domain

CUB 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1510_1619

1565

3624.0

Domain

CUB 10

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1620_1734

1565

3624.0

Domain

CUB 11

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1738_1850

1565

3624.0

Domain

CUB 12

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1852_1963

1565

3624.0

Domain

CUB 13

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

1978_2091

1565

3624.0

Domain

CUB 14

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2092_2213

1565

3624.0

Domain

CUB 15

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2217_2334

1565

3624.0

Domain

CUB 16

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2336_2448

1565

3624.0

Domain

CUB 17

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2452_2565

1565

3624.0

Domain

CUB 18

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2570_2687

1565

3624.0

Domain

CUB 19

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2689_2801

1565

3624.0

Domain

CUB 20

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2805_2919

1565

3624.0

Domain

CUB 21

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

2920_3035

1565

3624.0

Domain

CUB 22

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

3037_3150

1565

3624.0

Domain

CUB 23

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

3157_3274

1565

3624.0

Domain

CUB 24

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

3278_3393

1565

3624.0

Domain

CUB 25

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

3395_3507

1565

3624.0

Domain

CUB 26

Hgene

CUBN

chr10:17024483

chr19:49961743

ENST00000377833

3511_3623

1565

3624.0

Domain

CUB 27

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Fusion Gene Sequence for CUBN-ALDH16A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20612_20612_1_CUBN-ALDH16A1_CUBN_chr10_17024483_ENST00000377833_ALDH16A1_chr19_49961743_ENST00000293350_length(transcript)=7661nt_BP=4761nt
TTCTCCAAAATCCCATGCTCAGTTGGTTGGAGTGGCCTCACTCTTACCTGCCAACCTGGGAGGTTGATGATGAACATGTCTTTACCTTTT
CTTTGGAGTTTGCTTACCTTATTAATATTTGCTGAAGTAAATGGCGAAGCTGGAGAACTTGAGCTGCAGAGACAAAAAAGAAGCATCAAT
CTCCAACAGCCTCGAATGGCTACAGAGAGAGGAAATTTGGTGTTTCTTACGGGGTCTGCTCAAAACATTGAGTTTAGAACCGGATCCCTG
GGAAAAATTAAATTAAATGATGAAGATCTCAGTGAGTGTTTACATCAGATCCAGAAAAACAAAGAAGATATTATAGAGTTAAAAGGGAGT
GCAATTGGTCTGCCTCAAAATATATCTAGTCAAATCTATCAGCTTAATTCCAAGCTGGTGGATCTTGAGAGAAAATTCCAAGGCTTGCAG
CAGACTGTTGACAAAAAGGTTTGCAGCAGCAATCCTTGCCAGAATGGTGGAACCTGCCTCAATCTGCATGATTCCTTTTTTTGTATCTGT
CCCCCACAGTGGAAGGGTCCTCTCTGCTCAGCTGATGTTAACGAATGTGAGATTTACTCAGGAACACCCTTGAGCTGCCAGAATGGAGGC
ACATGTGTTAATACAATGGGAAGTTACAGTTGTCACTGCCCACCTGAGACGTACGGACCCCAGTGTGCATCCAAATATGACGACTGTGAA
GGGGGTTCTGTGGCACGCTGTGTCCATGGCATCTGTGAGGATTTAATGCGAGAGCAAGCTGGAGAGCCCAAGTACAGCTGCGTCTGTGAT
GCTGGGTGGATGTTTTCACCCAACAGCCCTGCCTGCACGCTGGACAGAGACGAGTGCAGCTTCCAGCCCGGGCCTTGCTCCACACTTGTG
CAGTGTTTCAACACTCAAGGCTCTTTCTACTGTGGGGCCTGTCCAACAGGCTGGCAAGGCAATGGATATATTTGCGAAGATATCAATGAA
TGTGAGATAAATAACGGCGGCTGTTCTGTGGCTCCACCCGTTGAGTGTGTGAATACACCTGGGTCTTCCCACTGCCAGGCCTGTCCACCA
GGGTACCAGGGTGACGGAAGAGTGTGCACACTCACAGACATCTGCTCAGTCAGTAATGGAGGCTGCCACCCAGATGCCTCATGCTCCTCA
ACTCTAGGTTCCTTACCTCTCTGCACGTGTCTCCCGGGTTATACTGGAAATGGTTATGGGCCAAATGGATGTGTGCAGCTCAGTAATATT
TGCCTAAGTCACCCCTGTCTAAATGGACAATGCATCGACACTGTCTCTGGTTATTTTTGTAAGTGTGACTCAGGTTGGACAGGTGTCAAC
TGTACAGAAAACATCAATGAGTGTTTGAGCAACCCCTGTTTGAATGGAGGAACTTGTGTTGATGGCGTTGATTCTTTCAGTTGTGAATGC
ACACGTCTCTGGACTGGAGCTCTCTGTCAGGTTCCTCAGCAAGTTTGTGGAGAGTCCCTCTCAGGAATAAATGGAAGCTTCAGCTACAGG
AGCCCGGATGTTGGTTATGTTCATGATGTTAACTGCTTCTGGGTTATCAAAACTGAAATGGGAAAGGTCCTGCGTATCACTTTCACTTTT
TTCCGGTTAGAATCCATGGACAACTGTCCACACGAGTTTCTTCAGGTTTATGATGGAGATTCCTCTTCTGCTTTTCAACTTGGAAGATTT
TGTGGCTCCAGCCTCCCTCATGAACTCCTCAGCAGTGACAATGCTCTCTATTTTCATCTCTATTCTGAACATTTAAGAAATGGGAGAGGC
TTTACAGTAAGATGGGAAACACAGCAACCAGAGTGTGGAGGTATCCTGACTGGTCCTTACGGTTCTATTAAGTCTCCGGGGTATCCTGGA
AACTATCCCCCAGGAAGAGATTGTGTCTGGATTGTTGTAACTAGTCCTGACCTCCTGGTAACATTTACTTTTGGGACCTTGAGCCTCGAG
CACCATGATGACTGCAACAAAGATTACCTTGAGATTCGAGATGGTCCTTTGTATCAGGACCCCCTTCTTGGGAAGTTCTGCACCACTTTC
TCTGTCCCACCGCTCCAGACTACTGGCCCCTTTGCCAGAATTCACTTCCATTCAGACTCCCAGATTAGTGACCAAGGCTTCCATATCACC
TACTTAACATCACCTTCGGATCTGCGTTGTGGTGGGAACTACACGGACCCAGAGGGTGAACTCTTCTTGCCTGAGTTGTCTGGGCCTTTC
ACTCACACCAGGCAATGCGTCTATATGATGAAGCAGCCCCAGGGAGAACAAATACAAATCAACTTCACCCACGTGGAGCTGCAATGCCAG
AGTGACAGTTCTCAGAATTACATTGAGGTTCGAGATGGTGAAACCTTACTTGGAAAAGTCTGTGGCAACGGAACCATCTCTCACATTAAA
TCCATTACTAATAGTGTCTGGATCAGGTTTAAAATAGATGCTTCTGTTGAAAAAGCTAGTTTCAGAGCTGTTTATCAAGTCGCTTGCGGG
GATGAATTAACTGGAGAAGGGGTCATTCGCTCGCCTTTTTTTCCTAACGTGTATCCTGGAGAAAGAACCTGTAGGTGGACCATCCACCAG
CCCCAAAGCCAAGTCATTCTCCTCAACTTCACTGTCTTTGAAATTGGAAGTTCTGCCCACTGTGAAACAGATTATGTTGAGATTGGTAGC
AGTTCCATTTTGGGTTCTCCTGAAAATAAAAAGTATTGCGGTACAGACATACCTTCATTTATAACATCTGTGTACAATTTTCTTTATGTC
ACATTCGTGAAAAGTTCTTCTACTGAAAACCATGGTTTCATGGCTAAGTTCAGTGCTGAGGATTTGGCATGTGGAGAAATTCTTACAGAA
TCAACAGGGACCATTCAAAGTCCTGGCCATCCAAATGTCTACCCCCACGGTATCAACTGTACTTGGCATATATTAGTCCAACCTAATCAC
CTGATTCATTTAATGTTCGAAACATTTCATCTGGAGTTTCATTACAATTGCACAAACGACTACTTGGAAGTTTATGACACCGACTCTGAG
ACATCCCTTGGAAGATACTGTGGAAAGTCGATCCCGCCATCTCTCACAAGCAGTGGTAACTCATTGATGCTGGTGTTTGTGACTGACTCC
GACCTCGCTTATGAAGGCTTCTTAATAAACTATGAAGCAATCAGTGCAGCAACAGCATGTTTGCAAGACTACACAGATGATTTGGGGACA
TTCACTTCTCCAAACTTCCCCAATAATTATCCCAACAACTGGGAATGCATTTATCGGATCACAGTGAGAACTGGCCAACTGATTGCAGTG
CACTTCACAAACTTCTCCTTGGAGGAAGCCATTGGAAACTATTATACAGATTTTCTGGAAATCAGAGATGGAGGCTATGAAAAATCACCA
TTGCTGGGAATATTCTATGGCTCAAATCTACCCCCAACAATCATCTCTCATAGTAACAAACTATGGTTAAAATTTAAGAGTGACCAAATA
GACACAAGGTCTGGATTCTCAGCTTACTGGGATGGGTCATCAACAGGTTGCGGGGGTAATCTCACCACTTCAAGCGGCACGTTCATATCT
CCCAACTACCCGATGCCCTATTACCACAGCTCTGAATGCTACTGGTGGTTGAAATCTAGCCACGGCAGCGCATTTGAACTGGAATTCAAA
GACTTTCACTTGGAGCATCATCCAAACTGCACTTTAGATTACCTGGCTGTATATGATGGCCCAAGTAGCAACTCTCATCTGCTAACTCAG
CTTTGTGGGGATGAGAAACCCCCTCTTATTCGTTCTAGTGGAGACAGCATGTTTATAAAACTGAGGACAGATGAAGGTCAGCAAGGACGT
GGCTTCAAGGCTGAATACCGGCAGACATGTGAGAATGTGGTAATAGTCAATCAAACCTATGGCATCTTAGAGAGTATAGGGTATCCGAAT
CCTTATTCTGAAAATCAGCATTGCAACTGGACCATCCGGGCAACAACAGGCAACACTGTGAACTACACATTTTTAGCATTTGACTTGGAA
CATCACATAAACTGCTCCACAGATTATTTAGAGCTCTATGATGGACCACGGCAGATGGGACGCTACTGTGGAGTAGACCTGCCCCCTCCA
GGGAGTACTACAAGCTCCAAGCTTCAAGTGCTGCTCCTTACAGATGGGGTTGGCCGCCGTGAGAAAGGATTTCAGATGCAGTGGTTTGTT
TACGGTTGTGGTGGAGAGCTGTCTGGGGCCACAGGCTCCTTCAGCAGCCCCGGGTTCCCCAACAGGTATCCACCAAACAAGGAGTGTATC
TGGTACATTAGGACGGACCCCGGGAGTAGCATTCAGCTCACCATCCATGACTTCGATGTGGAGTATCATTCAAGGTGCAACTTTGATGTC
TTGGAGATCTATGGAGGCCCCGATTTCCACTCTCCCAGAATAGCCCAACTGTGTACCCAGAGATCACCTGAGAACCCCATGCAGGTCTCC
AGCACTGGAAATGAGCTAGCAATTCGATTCAAGACCGACTTGTCCATAAATGGGAGAGGCTTCAATGCGTCATGGCAAGCAGTCACTGGA
GGTTGTGGTGGGATTTTCCAGGCTCCCAGTGGAGAGATTCATTCTCCAAATTACCCCAGTCCTTATAGGAGCAACACAGACTGTTCTTGG
GTCATTCGGGTTGACAGAAATCATCGTGTTCTCTTGAACTTCACTGACTTTGATCTTGAACCACAAGACTCTTGTATTATGGCCTGGCTG
GACACCCAGGACCGGTGCTTGGGCCACTATGTGAATGGGAAGTGGTTAAAGCCTGAACACAGAAATTCAGTGCCTTGCCAGGATCCCATC
ACAGGAGAGAACTTGGCCAGTTGCCTGCAGGCACAGGCCGAGGATGTGGCTGCAGCCGTGGAGGCAGCCAGGATGGCATTTAAGGGCTGG
AGTGCGCACCCCGGCGTCGTCCGGGCCCAGCACCTGACCAGGCTGGCCGAGGTGATCCAGAAGCACCAGCGGCTGCTGTGGACCCTGGAA
TCCCTGGTGACTGGGCGGGCTGTTCGAGAGGTTCGAGACGGGGACGTCCAGCTGGCCCAGCAGCTGCTCCACTACCATGCAATCCAGGCA
TCCACCCAGGAGGAGGCACTGGCAGGCTGGGAGCCCATGGGAGTAATTGGCCTCATCCTGCCACCCACATTCTCCTTCCTTGAGATGATG
TGGAGGATTTGCCCTGCCCTGGCTGTGGGCTGCACCGTGGTGGCCCTCGTGCCCCCGGCCTCCCCGGCGCCCCTCCTCCTGGCCCAGCTG
GCGGGGGAGCTGGGCCCCTTCCCGGGAATCCTGAATGTCCTCAGTGGCCCTGCGTCCCTGGTGCCCATCCTGGCCTCCCAGCCTGGAATC
CGGAAGGTGGCCTTCTGCGGAGCCCCGGAGGAAGGGCGTGCCCTTCGACGGAGCCTGGCGGGAGAGTGTGCGGAGCTGGGCCTGGCGCTG
GGGACGGAGTCGCTGCTGCTGCTGACGGACACGGCGGACGTAGACTCGGCCGTGGAGGGTGTCGTGGACGCCGCCTGGTCCGACCGCGGC
CCGGGTGGCCTCAGGCTCCTCATCCAGGAGTCTGTGTGGGATGAAGCCATGAGACGGCTGCAGGAGCGGATGGGGCGGCTTCGGAGTGGC
CGAGGGCTGGATGGGGCCGTGGACATGGGGGCCCGGGGGGCTGCCGCATGTGACCTGGTCCAGCGCTTTGTGCGTGAGGCCCAGAGCCAG
GGTGCACAGGTGTTCCAGGCTGGTGATGTGCCTTCGGAACGCCCATTCTATCCCCCAACCTTGGTCTCCAACCTGCCCCCAGCCTCCCCA
TGTGCCCAGGTGGAGGTGCCGTGGCCTGTGGTCGTGGCCTCCCCCTTCCGCACAGCCAAGGAGGCACTGTTGGTGGCCAACGGGACGCCC
CGCGGGGGCAGCGCCAGTGTGTGGAGCGAGAGGCTGGGGCAGGCGCTGGAGCTGGGCTATGGGCTCCAGGTGGGCACTGTCTGGATCAAC
GCCCACGGCCTCAGAGACCCTTCGGTGCCCACAGGCGGCTGCAAGGAGAGTGGGTGTTCCTGGCACGGGGGCCCAGACGGGCTGTATGAG
TATCTGCGGCCCTCAGGGACCCCTGCCCGGCTGTCCTGCCTCTCCAAGAACCTGAACTATGACACCTTTGGCCTCGCTGTTCCCTCAACC
CTGCCGGCTGGGCCTGAAATAGGGCCCAGCCCAGCACCCCCCTATGGGCTCTTCGTTGGGGGCCGTTTCCAGGCTCCTGGGGCCCGAAGC
TCCAGGCCCATCCGGGATTCGTCTGGCAACCTCCATGGCTACGTGGCTGAGGGTGGAGCCAAGGACATCCGAGGTGCTGTGGAGGCCGCT
CACCAGGCTTTCCCTGGCTGGGCGGGCCAGTCCCCAGGAGCCCGGGCAGCCCTGCTGTGGGCCCTGGCGGCTGCACTGGAGCGCCGGAAG
TCTACCCTGGCCTCGAGGCTGGAGAGGCAGGGAGCGGAGCTCAAGGCTGCGGAGGCGGAGGTGGAGCTGAGCGCAAGACGACTTCGGGCG
TGGGGGGCCCGGGTGCAGGCCCAAGGCCACACCCTGCAGGTAGCCGGGCTGAGAGGCCCTGTGCTGCGCCTGCGGGAGCCGCTGGGTGTG
CTGGCTGTGGTGTGTCCGGACGAGTGGCCCCTGCTTGCCTTCGTGTCCCTGCTGGCTCCCGCCCTGGCCTACGGCAACACTGTGGTCATG
GTGCCCAGTGCGGCCTGTCCTCTGCTGGCCCTGGAGGTCTGCCAGGACATGGCCACCGTGTTCCCAGCAGGCCTGGCCAACGTGGTGACA
GGAGACCGGGACCATCTGACCCGCTGCCTGGCCTTGCACCAAGACGTCCAGGCCATGTGGTATTTCGGATCAGCCCAGGGTTCCCAGTTT
GTCGAGTGGGCCTCGGCAGGAAACCTCAAACCGGTGTGGGCGAGCAGGGGCTGCCCGCGGGCCTGGGACCAGGAGGCCGAGGGGGCAGGC
CCAGAGCTGGGGCTGCGAGTGGCGCGGACCAAGGCCCTGTGGCTGCCTATGGGGGACTGATGCCTGAGCGCCACCTACTGCATTTTGGAC
ACCTCACACCAAGGGGAGATGCACCCCACAGACACCTGGGACTTTCCCCTTCTGGTTCCTGTGTCTCCCAATAAACTCTCTGACCAACCC
TAGCTGTGCTTCTGCGAGAAGAAAGGGTGTAGCAACTTCTGGCAGATATGAGGCTTTTTTCTTTTTTTTTTTTTTTTTTGAGACAACGTC
TGGCTCTGTCACCCAGGCTGGAGCGCAGTGGCACAATCTCGGCCCACTGCAGCCTCGACCTCTGGGGCTCAAGGGATCCTCATGCCTCAG
CCTCATATGTAGCTGGGGCCACAGACATGCACCACCACACCTGGCTCGAGGCCATTTTAGTTCTGAGGTTGAGCAGCTCAGGAGCCGGCT
CCAGCACGGTGCTGTGTTTGTGAAACAGAGAAAGGGGACCCCCGAGGACCCCAGACAGGGCCTTAGGACTCTCATATCTTCTTGTCTTCT
CCATCTGGTGGCTCTTGCTCTCTGGTTTTCTCTACCTTTTCATGGCCCCAGAATCCATATGCAGTAAAGGAACTCTCTGGAATAAAATTA

>20612_20612_1_CUBN-ALDH16A1_CUBN_chr10_17024483_ENST00000377833_ALDH16A1_chr19_49961743_ENST00000293350_length(amino acids)=2338AA_BP=1566
MMMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNK
EDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSG
TPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSF
QPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG
CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVD
GVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDS
SSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVT
FTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGEL
FLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASF
RAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFI
TSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDY
LEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRIT
VRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNL
TTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKL
RTDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQMGR
YCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE
YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSP
YRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVE
AARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILP
PTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAG
ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQ
RFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG
LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGG
RFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEV
ELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVF

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Fusion Gene PPI Analysis for CUBN-ALDH16A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	CUBN	chr10:17024483	chr19:49961743	ENST00000377833	-	31	67	42_49	1565.0	3624.0	AMN

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CUBN-ALDH16A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CUBN-ALDH16A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source