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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CUL2-CYP2C18 (FusionGDB2 ID:20658)

Fusion Gene Summary for CUL2-CYP2C18

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL2-CYP2C18
Fusion gene ID: 20658
HgeneTgene
Gene symbol

CUL2

CYP2C18

Gene ID

8453

1562

Gene namecullin 2cytochrome P450 family 2 subfamily C member 18
Synonyms-CPCI|CYP2C|CYP2C17|P450-6B/29C|P450IIC17
Cytomap

10p11.21

10q23.33

Type of geneprotein-codingprotein-coding
Descriptioncullin-2CUL-2testis secretory sperm-binding protein Li 238Ecytochrome P450 2C18(S)-mephenytoin hydroxylase associated cytochrome P450CYPIIC18cytochrome P450, family 2, subfamily C, polypeptide 18cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17cytochrome P450, subfamily IIC (mephenyt
Modification date2020032720200313
UniProtAcc.

P33260

Ensembl transtripts involved in fusion geneENST00000374742, ENST00000374748, 
ENST00000374749, ENST00000374751, 
ENST00000602371, ENST00000374746, 
ENST00000478044, ENST00000537177, 
ENST00000285979, ENST00000339022, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 3 X 3=36
# samples 86
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CUL2 [Title/Abstract] AND CYP2C18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCUL2(35379358)-CYP2C18(96447527), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCYP2C18

GO:0042573

retinoic acid metabolic process

11093772


check buttonFusion gene breakpoints across CUL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CYP2C18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A9ZK-01ACUL2chr10

35379358

-CYP2C18chr10

96447527

+
ChimerDB4PRADTCGA-V1-A9ZKCUL2chr10

35379107

-CYP2C18chr10

96447527

+
ChimerDB4PRADTCGA-V1-A9ZKCUL2chr10

35379358

-CYP2C18chr10

96447527

+


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Fusion Gene ORF analysis for CUL2-CYP2C18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000374742ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374742ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374748ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374748ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374749ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374749ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374751ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374751ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000602371ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000602371ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374742ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374742ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374746ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374746ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374746ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374746ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374748ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374748ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374749ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374749ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374751ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374751ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000602371ENST00000285979CUL2chr10

35379107

-CYP2C18chr10

96447527

+
intron-3CDSENST00000602371ENST00000339022CUL2chr10

35379107

-CYP2C18chr10

96447527

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CUL2-CYP2C18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CUL2chr1035379106-CYP2C18chr1096447526+4.37E-060.9999956
CUL2chr1035379357-CYP2C18chr1096447526+1.36E-070.9999999
CUL2chr1035379357-CYP2C18chr1096447526+1.36E-070.9999999
CUL2chr1035379106-CYP2C18chr1096447526+4.37E-060.9999956
CUL2chr1035379357-CYP2C18chr1096447526+1.36E-070.9999999
CUL2chr1035379357-CYP2C18chr1096447526+1.36E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CUL2-CYP2C18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35379358/:96447527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYP2C18

P33260

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:11093772}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CUL2-CYP2C18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CUL2-CYP2C18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CUL2-CYP2C18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CUL2-CYP2C18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource