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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:CUL3-AP1S3 (FusionGDB2 ID:20663)

Fusion Gene Summary for CUL3-AP1S3

Fusion gene summary

Fusion gene information	Fusion gene name: CUL3-AP1S3
	Fusion gene ID: 20663
		Hgene	Tgene
	Gene symbol	CUL3	AP1S3
	Gene ID	8452	130340
	Gene name	cullin 3	adaptor related protein complex 1 subunit sigma 3
	Synonyms	CUL-3\|PHA2E	PSORS15
	Cytomap	2q36.2	2q36.1
	Type of gene	protein-coding	protein-coding
	Description	cullin-3	AP-1 complex subunit sigma-3adapter-related protein complex 1 subunit sigma-1Cadaptor protein complex AP-1 sigma-1C subunitadaptor related protein complex 1 sigma 3 subunitadaptor-related protein complex 1 subunit sigma-1Cclathrin assembly protein co
	Modification date	20200327	20200313
	UniProtAcc	Q13618	Q96PC3
	Ensembl transtripts involved in fusion gene	ENST00000432260, ENST00000409777, ENST00000264414, ENST00000344951, ENST00000409096,	ENST00000396653, ENST00000396654, ENST00000409375, ENST00000423110, ENST00000443700, ENST00000446015,
Fusion gene scores	* DoF score	12 X 12 X 7=1008	4 X 2 X 3=24
	# samples	14	5
	** MAII score	log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CUL3 [Title/Abstract] AND AP1S3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CUL3(225400245)-AP1S3(224642586), # samples:1
Anticipated loss of major functional domain due to fusion event.	CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CUL3	GO:0000209	protein polyubiquitination	19261606
Hgene	CUL3	GO:0006511	ubiquitin-dependent protein catabolic process	25401743\|27561354
Hgene	CUL3	GO:0006513	protein monoubiquitination	22358839
Hgene	CUL3	GO:0006888	ER to Golgi vesicle-mediated transport	22358839
Hgene	CUL3	GO:0016567	protein ubiquitination	17543862\|19782033\|19995937\|20389280\|23213400
Hgene	CUL3	GO:0031145	anaphase-promoting complex-dependent catabolic process	10500095
Hgene	CUL3	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	19261606\|19782033\|20389280
Hgene	CUL3	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	27561354

Fusion gene breakpoints across CUL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AP1S3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8078-01A	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-

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Fusion Gene ORF analysis for CUL3-AP1S3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000432260	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
5UTR-3CDS	ENST00000432260	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
5UTR-3CDS	ENST00000432260	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
5UTR-3CDS	ENST00000432260	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
5UTR-3CDS	ENST00000432260	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
5UTR-3CDS	ENST00000432260	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
Frame-shift	ENST00000409777	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000264414	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000344951	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-
In-frame	ENST00000409096	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264414	CUL3	chr2	225400245	-	ENST00000443700	AP1S3	chr2	224642586	-	2347	717	339	1208	289
ENST00000264414	CUL3	chr2	225400245	-	ENST00000396654	AP1S3	chr2	224642586	-	1412	717	339	1178	279
ENST00000264414	CUL3	chr2	225400245	-	ENST00000396653	AP1S3	chr2	224642586	-	1171	717	339	905	188
ENST00000264414	CUL3	chr2	225400245	-	ENST00000446015	AP1S3	chr2	224642586	-	1179	717	339	1178	279
ENST00000264414	CUL3	chr2	225400245	-	ENST00000409375	AP1S3	chr2	224642586	-	1175	717	339	1127	262
ENST00000264414	CUL3	chr2	225400245	-	ENST00000423110	AP1S3	chr2	224642586	-	1029	717	339	1028	229
ENST00000344951	CUL3	chr2	225400245	-	ENST00000443700	AP1S3	chr2	224642586	-	2194	564	384	1055	223
ENST00000344951	CUL3	chr2	225400245	-	ENST00000396654	AP1S3	chr2	224642586	-	1259	564	384	1025	213
ENST00000344951	CUL3	chr2	225400245	-	ENST00000396653	AP1S3	chr2	224642586	-	1018	564	528	1	176
ENST00000344951	CUL3	chr2	225400245	-	ENST00000446015	AP1S3	chr2	224642586	-	1026	564	384	1025	213
ENST00000344951	CUL3	chr2	225400245	-	ENST00000409375	AP1S3	chr2	224642586	-	1022	564	384	974	196
ENST00000344951	CUL3	chr2	225400245	-	ENST00000423110	AP1S3	chr2	224642586	-	876	564	384	875	163
ENST00000409096	CUL3	chr2	225400245	-	ENST00000443700	AP1S3	chr2	224642586	-	2079	449	53	940	295
ENST00000409096	CUL3	chr2	225400245	-	ENST00000396654	AP1S3	chr2	224642586	-	1144	449	53	910	285
ENST00000409096	CUL3	chr2	225400245	-	ENST00000396653	AP1S3	chr2	224642586	-	903	449	53	637	194
ENST00000409096	CUL3	chr2	225400245	-	ENST00000446015	AP1S3	chr2	224642586	-	911	449	53	910	286
ENST00000409096	CUL3	chr2	225400245	-	ENST00000409375	AP1S3	chr2	224642586	-	907	449	53	859	268
ENST00000409096	CUL3	chr2	225400245	-	ENST00000423110	AP1S3	chr2	224642586	-	761	449	53	760	236

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264414	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.002816699	0.99718326
ENST00000264414	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.001964411	0.9980356
ENST00000264414	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.010842396	0.98915756
ENST00000264414	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.005646271	0.9943538
ENST00000264414	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.013889241	0.9861108
ENST00000264414	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.009725555	0.9902744
ENST00000344951	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.007973109	0.99202687
ENST00000344951	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.004738181	0.9952618
ENST00000344951	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.18305075	0.81694925
ENST00000344951	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.011051531	0.98894846
ENST00000344951	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.03476724	0.96523273
ENST00000344951	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.044889018	0.95511097
ENST00000409096	ENST00000443700	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.000887068	0.9991129
ENST00000409096	ENST00000396654	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.000491135	0.99950886
ENST00000409096	ENST00000396653	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.019250307	0.98074967
ENST00000409096	ENST00000446015	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.001084041	0.99891603
ENST00000409096	ENST00000409375	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.002743589	0.99725646
ENST00000409096	ENST00000423110	CUL3	chr2	225400245	-	AP1S3	chr2	224642586	-	0.003105511	0.9968945

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Fusion Genomic Features for CUL3-AP1S3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUL3-AP1S3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:225400245/chr2:224642586)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CUL3 Q13618	AP1S3 Q96PC3
FUNCTION: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). {ECO:0000269\|PubMed:10500095, ECO:0000269\|PubMed:11311237, ECO:0000269\|PubMed:15601839, ECO:0000269\|PubMed:15897469, ECO:0000269\|PubMed:15983046, ECO:0000269\|PubMed:16006525, ECO:0000269\|PubMed:16524876, ECO:0000269\|PubMed:17543862, ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:19261606, ECO:0000269\|PubMed:19995937, ECO:0000269\|PubMed:20389280, ECO:0000269\|PubMed:21670212, ECO:0000269\|PubMed:21840486, ECO:0000269\|PubMed:22085717, ECO:0000269\|PubMed:22358839, ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:22632832, ECO:0000269\|PubMed:23213400, ECO:0000269\|PubMed:23387299, ECO:0000269\|PubMed:23453970, ECO:0000269\|PubMed:23455478, ECO:0000269\|PubMed:23576762, ECO:0000269\|PubMed:24768539, ECO:0000269\|PubMed:25270598, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:27565346, ECO:0000269\|PubMed:27716508, ECO:0000269\|PubMed:27798626, ECO:0000269\|PubMed:29769719}.	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). {ECO:0000269\|PubMed:24791904}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CUL3-AP1S3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20663_20663_1_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=1171nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTGT
CTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAA
GAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGAGAAAGATGATGATGATG
ATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGGTACAGTTTCTAAACTATTTATATGTAT

>20663_20663_1_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=188AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL

--------------------------------------------------------------
>20663_20663_2_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1412nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT
GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC
AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA
ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGACAATGGAAGAATACATGAACAAGCCT
ACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGCAACGCCTCCCATCCGGTTTTTTGATGG
AGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGTTGTTTAACATATTTATAATTACTATGT

>20663_20663_2_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=279AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL
KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQETM

--------------------------------------------------------------
>20663_20663_3_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=1175nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT
GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC
AAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGATTCCTGGTCTACGCCTGCCTTGAACTCC
GAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAG

>20663_20663_3_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=262AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL

--------------------------------------------------------------
>20663_20663_4_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=1029nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT
GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC

>20663_20663_4_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=229AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL

--------------------------------------------------------------
>20663_20663_5_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2347nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT
GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC
AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA
ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGAATCGTTTGAGCCCCAGAGGCAGAGAT
TGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTAAAAAAAAAAAAAAAGAAAAGAAAAAGG
AGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTAAACTTTTTTAAAACTTTTATTTTTTGT
GGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAACATGTCTGTAAAACTTAGGACTATAGA
AATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAAATAATTTAGGTCATTTGCATTTTTTAG
TATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTAAAATTGAAAACATTGAAATATTATAAT
TTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAATATATTTCTGATAATCTGTCCTCTATA
ATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACAACTTTTTAATGAGATTTTATCAAACAT
TAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAAAACAAGGCACATTAATAGAAAAAAATG
AATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAACAATTTGTACATACTTTATTAGTCGAAC
ATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACATACAAATACCCTCAAGAATAATAAATCA
TGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTTTATTCAAGTCCTCTTTGCTTTCTGCTA
GTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAGTAGCACGATAGCAGCGCACTGCAACCT
GGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGTGTGCCACCATACTTGGCTAATTAAAAA

>20663_20663_5_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=289AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL
KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENR

--------------------------------------------------------------
>20663_20663_6_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=1179nt_BP=717nt
CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC
CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC
CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC
CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC
ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG
AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT
AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG
AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA
CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC
CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT
GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC
AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA
ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGA

>20663_20663_6_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=279AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR
EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL
KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQEVS

--------------------------------------------------------------
>20663_20663_7_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=1018nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAAT
AGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCA
AACCATGGGAGAAAGATGATGATGATGATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGG

>20663_20663_7_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=176AA_BP=
MFDDHSKLDLAFEESCYSMNLVHLLAPERPGSASWCPSGCPCLCSDSTWCSSPPRRRLQVALRDAGVTFKAGRQARGDAGGGGGATPGQG

--------------------------------------------------------------
>20663_20663_8_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1259nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT
GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC
CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG
ACAATGGAAGAATACATGAACAAGCCTACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGC
AACGCCTCCCATCCGGTTTTTTGATGGAGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGT

>20663_20663_8_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=213AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI
TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG

--------------------------------------------------------------
>20663_20663_9_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=1022nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT
GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGAT
TCCTGGTCTACGCCTGCCTTGAACTCCGAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAG

>20663_20663_9_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=196AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI
TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNEFNCWFLLMRLLSVLDSWSTPALN

--------------------------------------------------------------
>20663_20663_10_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=876nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT

>20663_20663_10_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=163AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI

--------------------------------------------------------------
>20663_20663_11_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2194nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT
GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC
CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG
AATCGTTTGAGCCCCAGAGGCAGAGATTGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTA
AAAAAAAAAAAAAAGAAAAGAAAAAGGAGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTA
AACTTTTTTAAAACTTTTATTTTTTGTGGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAA
CATGTCTGTAAAACTTAGGACTATAGAAATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAA
ATAATTTAGGTCATTTGCATTTTTTAGTATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTA
AAATTGAAAACATTGAAATATTATAATTTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAA
TATATTTCTGATAATCTGTCCTCTATAATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACA
ACTTTTTAATGAGATTTTATCAAACATTAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAA
AACAAGGCACATTAATAGAAAAAAATGAATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAAC
AATTTGTACATACTTTATTAGTCGAACATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACAT
ACAAATACCCTCAAGAATAATAAATCATGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTT
TATTCAAGTCCTCTTTGCTTTCTGCTAGTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAG
TAGCACGATAGCAGCGCACTGCAACCTGGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGT

>20663_20663_11_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=223AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI
TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG

--------------------------------------------------------------
>20663_20663_12_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=1026nt_BP=564nt
GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG
CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT
CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG
GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC
GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG
GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG
ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC
CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG
GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT
GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC
CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG

>20663_20663_12_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=213AA_BP=0
MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI
TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG

--------------------------------------------------------------
>20663_20663_13_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=903nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
GTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCC
AAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGAGAAAGATGATGATGA
TGATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGGTACAGTTTCTAAACTATTTATATGT

>20663_20663_13_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=194AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF

--------------------------------------------------------------
>20663_20663_14_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1144nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG
ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG
AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGACAATGGAAGAATACATGAACAAGC
CTACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGCAACGCCTCCCATCCGGTTTTTTGAT
GGAGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGTTGTTTAACATATTTATAATTACTAT

>20663_20663_14_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=285AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF
VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD

--------------------------------------------------------------
>20663_20663_15_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=907nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG
ACAAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGATTCCTGGTCTACGCCTGCCTTGAACT
CCGAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAGCTGGATATTATCTTTAATTTTGAAA

>20663_20663_15_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=268AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF

--------------------------------------------------------------
>20663_20663_16_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=761nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG

>20663_20663_16_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=236AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF

--------------------------------------------------------------
>20663_20663_17_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2079nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG
ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG
AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGAATCGTTTGAGCCCCAGAGGCAGAG
ATTGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTAAAAAAAAAAAAAAAGAAAAGAAAAA
GGAGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTAAACTTTTTTAAAACTTTTATTTTTT
GTGGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAACATGTCTGTAAAACTTAGGACTATA
GAAATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAAATAATTTAGGTCATTTGCATTTTTT
AGTATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTAAAATTGAAAACATTGAAATATTATA
ATTTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAATATATTTCTGATAATCTGTCCTCTA
TAATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACAACTTTTTAATGAGATTTTATCAAAC
ATTAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAAAACAAGGCACATTAATAGAAAAAAA
TGAATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAACAATTTGTACATACTTTATTAGTCGA
ACATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACATACAAATACCCTCAAGAATAATAAAT
CATGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTTTATTCAAGTCCTCTTTGCTTTCTGC
TAGTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAGTAGCACGATAGCAGCGCACTGCAAC
CTGGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGTGTGCCACCATACTTGGCTAATTAAA

>20663_20663_17_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=295AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF
VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD

--------------------------------------------------------------
>20663_20663_18_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=911nt_BP=449nt
GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT
TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC
TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC
ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT
TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA
TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA
CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT
ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG
ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG
AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGG

>20663_20663_18_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=286AA_BP=0
MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH
LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF
VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CUL3-AP1S3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	CUL3	chr2:225400245	chr2:224642586	ENST00000264414	-	3	16	2_41	126.0	769.0	KLHL18
Hgene	CUL3	chr2:225400245	chr2:224642586	ENST00000344951	-	2	15	2_41	60.0	703.0	KLHL18
Hgene	CUL3	chr2:225400245	chr2:224642586	ENST00000409096	-	3	16	2_41	102.0	745.0	KLHL18
Hgene	CUL3	chr2:225400245	chr2:224642586	ENST00000409777	-	3	16	2_41	102.0	745.0	KLHL18

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CUL3-AP1S3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CUL3-AP1S3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source