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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CUL4A-DDX17 (FusionGDB2 ID:20677)

Fusion Gene Summary for CUL4A-DDX17

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL4A-DDX17
Fusion gene ID: 20677
HgeneTgene
Gene symbol

CUL4A

DDX17

Gene ID

8451

10521

Gene namecullin 4ADEAD-box helicase 17
Synonyms-P72|RH70
Cytomap

13q34

22q13.1

Type of geneprotein-codingprotein-coding
Descriptioncullin-4ACUL-4Aprobable ATP-dependent RNA helicase DDX17DEAD (Asp-Glu-Ala-Asp) box helicase 17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17DEAD box protein p72DEAD box protein p82DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)RNA-dependent helicase p72
Modification date2020032720200327
UniProtAcc.

Q92841

Ensembl transtripts involved in fusion geneENST00000326335, ENST00000375440, 
ENST00000375441, ENST00000451881, 
ENST00000463426, 		ENST00000432525, 
ENST00000381633, ENST00000444597, 
ENST00000396821, 
Fusion gene scores* DoF score12 X 16 X 11=211220 X 21 X 7=2940
# samples 1925
** MAII scorelog2(19/2112*10)=-3.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2940*10)=-3.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUL4A [Title/Abstract] AND DDX17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCUL4A(113889459)-DDX17(38897285), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL4A

GO:0016567

protein ubiquitination

26431207

TgeneDDX17

GO:0045944

positive regulation of transcription by RNA polymerase II

17226766


check buttonFusion gene breakpoints across CUL4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AL-01ACUL4Achr13

113889459

+DDX17chr22

38897285

-


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Fusion Gene ORF analysis for CUL4A-DDX17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000326335ENST00000432525CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-5UTRENST00000375440ENST00000432525CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-5UTRENST00000375441ENST00000432525CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-5UTRENST00000451881ENST00000432525CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000326335ENST00000381633CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000326335ENST00000444597CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000375440ENST00000381633CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000375440ENST00000444597CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000375441ENST00000381633CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000375441ENST00000444597CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000451881ENST00000381633CUL4Achr13

113889459

+DDX17chr22

38897285

-
5CDS-intronENST00000451881ENST00000444597CUL4Achr13

113889459

+DDX17chr22

38897285

-
In-frameENST00000326335ENST00000396821CUL4Achr13

113889459

+DDX17chr22

38897285

-
In-frameENST00000375440ENST00000396821CUL4Achr13

113889459

+DDX17chr22

38897285

-
In-frameENST00000375441ENST00000396821CUL4Achr13

113889459

+DDX17chr22

38897285

-
In-frameENST00000451881ENST00000396821CUL4Achr13

113889459

+DDX17chr22

38897285

-
intron-3CDSENST00000463426ENST00000396821CUL4Achr13

113889459

+DDX17chr22

38897285

-
intron-5UTRENST00000463426ENST00000432525CUL4Achr13

113889459

+DDX17chr22

38897285

-
intron-intronENST00000463426ENST00000381633CUL4Achr13

113889459

+DDX17chr22

38897285

-
intron-intronENST00000463426ENST00000444597CUL4Achr13

113889459

+DDX17chr22

38897285

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375441CUL4Achr13113889459+ENST00000396821DDX17chr2238897285-547410703812978865
ENST00000451881CUL4Achr13113889459+ENST00000396821DDX17chr2238897285-5201797302705891
ENST00000326335CUL4Achr13113889459+ENST00000396821DDX17chr2238897285-51127081602616818
ENST00000375440CUL4Achr13113889459+ENST00000396821DDX17chr2238897285-5336932842840918

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375441ENST00000396821CUL4Achr13113889459+DDX17chr2238897285-0.000473230.99952674
ENST00000451881ENST00000396821CUL4Achr13113889459+DDX17chr2238897285-0.0004176430.99958235
ENST00000326335ENST00000396821CUL4Achr13113889459+DDX17chr2238897285-0.0004156060.9995844
ENST00000375440ENST00000396821CUL4Achr13113889459+DDX17chr2238897285-0.0001794960.99982053

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Fusion Genomic Features for CUL4A-DDX17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUL4A-DDX17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113889459/chr22:38897285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDX17

Q92841

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CUL4A-DDX17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20677_20677_1_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000326335_DDX17_chr22_38897285_ENST00000396821_length(transcript)=5112nt_BP=708nt
GTCCTCTCAGCCGGGACGCCAGCGGCTCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGG
CGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCG
TCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACAC
GTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCT
GCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCT
ACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTA
TAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCC
AGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAATTTGGAGCAAG
AGGTGGTGGTGGCCTTCCCCCGAAGAAATTTGGTAATCCTGGGGAGCGTTTGCGTAAAAAAAAGTGGGATTTGAGTGAGCTCCCCAAGTT
TGAGAAAAATTTTTATGTGGAACATCCGGAAGTAGCAAGGCTGACACCATATGAGGTTGATGAGCTACGCCGAAAGAAGGAGATTACAGT
GAGGGGGGGAGATGTTTGTCCTAAACCCGTGTTTGCCTTCCATCATGCTAACTTCCCACAATATGTAATGGATGTGTTGATGGATCAGCA
CTTTACAGAACCAACTCCAATTCAGTGCCAGGGATTTCCGTTGGCTCTTAGTGGCCGGGATATGGTGGGCATTGCTCAGACTGGCTCTGG
GAAGACGTTGGCGTATCTCCTGCCTGCAATTGTTCATATTAACCACCAGCCATACTTGGAAAGGGGAGATGGCCCAATCTGTCTAGTTCT
GGCTCCTACCAGAGAGCTTGCCCAGCAAGTACAGCAGGTGGCCGATGACTATGGCAAATGTTCTAGATTGAAGAGTACTTGTATTTATGG
AGGTGCTCCTAAAGGTCCCCAGATTCGAGACTTGGAAAGAGGTGTTGAGATCTGCATAGCCACTCCTGGACGTCTGATAGATTTCCTGGA
GTCAGGAAAGACAAATCTTCGCCGATGTACTTACCTTGTATTGGACGAAGCTGACAGAATGCTTGATATGGGGTTTGAACCCCAGATCCG
TAAAATTGTTGACCAAATCAGGCCTGATAGGCAGACACTGATGTGGAGTGCAACCTGGCCAAAAGAAGTAAGACAGCTTGCAGAGGATTT
CCTTCGTGATTACACCCAGATCAACGTAGGCAATCTGGAGTTGAGTGCCAACCACAACATCCTCCAGATAGTGGATGTCTGCATGGAAAG
TGAAAAAGACCACAAGTTGATCCAACTAATGGAAGAAATAATGGCTGAAAAGGAAAACAAAACAATAATATTTGTGGAGACAAAGAGACG
CTGTGATGATCTGACTCGAAGGATGCGCAGAGATGGTTGGCCAGCTATGTGTATCCATGGAGACAAGAGTCAACCAGAAAGAGATTGGGT
ACTTAATGAGTTCCGTTCTGGAAAGGCACCCATCCTTATTGCTACAGATGTAGCCTCCCGTGGGCTAGATGTGGAAGATGTCAAGTTTGT
GATCAACTATGACTATCCAAACAGCTCAGAGGATTATGTGCACCGTATTGGCCGAACAGCCCGTAGCACCAACAAGGGTACCGCCTATAC
CTTCTTCACCCCAGGGAACCTAAAACAGGCCAGAGAGCTTATCAAAGTGCTGGAAGAGGCCAATCAGGCTATCAATCCAAAACTGATGCA
GCTTGTGGACCACAGAGGAGGCGGCGGAGGCGGGGGTAAGGGTGGTCGTTCTCGTTACCGGACCACTTCTTCAGCCAACAATCCCAATCT
GATGTATCAGGATGAGTGTGACCGAAGGCTTCGAGGAGTCAAGGATGGTGGCCGGAGAGACTCTGCAAGCTATCGGGATCGTAGTGAAAC
CGATAGAGCTGGTTATGCTAATGGCAGTGGCTATGGAAGTCCAAATTCTGCCTTTGGAGCACAAGCAGGCCAATACACCTATGGTCAAGG
CACCTATGGGGCAGCTGCTTATGGCACCAGTAGCTATACAGCTCAAGAATATGGTGCTGGCACTTATGGAGCTAGTAGCACCACCTCAAC
TGGGAGAAGTTCACAGAGCTCTAGCCAGCAGTTTAGTGGGATAGGCCGGTCTGGGCAGCAGCCACAGCCACTGATGTCACAACAGTTTGC
ACAGCCTCCGGGAGCTACCAATATGATAGGTTACATGGGGCAGACTGCCTACCAATACCCTCCTCCTCCTCCCCCTCCTCCTCCTTCACG
TAAATGAAACCACTCAAGTGGTAGTGACTCCAGCAGACTTAATTACATTTTAAGGAACACTGTCTTTCCTTTTTTTTTCCTCTTCGCCTT
TTCTTTTTTTTTCCTTTTTTCTTTTTTTTTTTTTAATTTTTCCCCCCAACCATCGTGATTTGTCTTTTCATGCAGATTAGTTAGAATTCA
CTGCCAGGTTTCTTCTGCCCACCAAAATGATCCAGTCTGGAATAACATTTTGTAAAAAAAAAAAAAATATATATATATATATATAGCTGA
CTGGAAGAGATTAATTTCTTCCCCCAACTTCTTGCATGTTGAAGATATTTGAGCTATTTTTCATCTAAAAGAGTAAGGTATTAGGCCCTT
TTGTGGGAGCCCCATGTTTTGTTTTTCTGAGTTGGTGGGGAGGGAGGGAGGGGGAGGGCTGAATTGTTTTGCAGAGGAAGATGGCATCTG
TGCTTTAAATTTCTCATTACTGGGTTAGAAAACAAAGAGGGATTGCCCTGCACATTTTCTTTTGTGCTTTTAAATGTTTCTTAAGTTGGA
ACAGGTTTCCTCGGGCCTGTTTTGACTGATTGCTGGAGTGCATTTGATAGTTAAAAATTACTAATTGGTTTTATTTCCCTTCACACTCTG
CCTCCCCACTTCTCCCCCCGTTACTGAAAAATAACCATTTTAGTGTCAGGCTAGAAATTGAATTGCTGAGTTTTGTGTATCCTTTAAATT
AAAAACCACAAGTGTTTATTGTAGTGGTTAAACTGTAGCATCTCAGCATCTGGGTGGAAGCTGCCTATATTTCTTCCCAGTTTAACTGGG
GACCATCTGTGAAATTAATTTTCCATCCAGACAGCTGCTGTGAGCAAATGAACATAAATGCTCGCTGGAAATTTACTAACCAGTTTTTAT
ATTGACCTGCAGTGTAAAAAGCACATTTAATTATAAACAATATATTCAAAATGGGCAAATTTTATTTTCAAATGCAGTGTAGAGCTAGAT
TAAAAGCAACTCTTTGCCACCTACTCTGCCCTTTTGGCAAAGTTACCTTGAACAAAGAATCTTAAGGGTTTATTAAGAACTCTTTATTTT
CTTCATACCCTGTTCTCTGCAGTGCTTTCTAACAGCTTCTGGGTGCAGATTTTCTTCGGCATCCTTTTGCACTCAGCTTATTACAGGTAG
GTAGTGCTTAAGAAAAGTCATGGAGGACTAAAGCCTAAGTCCTTTTCACTTTTCCTCCATCTGAAGGTAGGTGAGTTCATCCTCTTCATG
GTAATGCTGTTTTACCAAGACTTTATAGCAGATGGACCCAGAAAGAATTTTCTGCTATTGTGTTCACTACAACAGGATAGGGACATCAGA
CAGCCCCAGAAACCCCTTCCAGATCTGATATGGGACTATTAATTTTTATGCTGTTAATTGGTATTCATTCACAATGCAGTTGAAGGGGGA
AGGCTCCACTGCATTCTTTGGCTAAGGCCTGAATGCTTGCTCATCTGTAAGATCTATACTCGAGGTTTTGTTTTCCTTTTAAAATTCTTT
AGGGAGAGAGGGATGGTTTCTGAGGGGTTCTGAAAGTATGATTCAATGTGCAACATACAGGTAGGTCTTCAGCATAAGCTGAAATATATG
CATGTAAAAACTTTGACATCTTTTTTTTTAATTTTCCACTTTCTTCTTAACTTTACTTCTCTTTTTGTCCCCCCCCCATCTTACAGAAGT
TGAGGCCAAGGGAGAATGGTAGGCACAGAAGAAACATGGCAAACTGCTCTGTGCTTTCAAACCAAAGTGTTCCCCCCAACCCCAAATTTG
TCTAAGCACTGGCCAGTCTGTTGTGGGCATTGTTTTCTACAACCAAATTCTGGGTTTTTTTCTTCTTTCTTTAAACATAGAGGTACCACC
ACAAGGGATGCCCTACTCTCTCGCAGCTCTTGAAAGCATCTGTTTGAGGGAAAGGTCTCTGGGCAAGCAAGTGGTTATTTGGATTGCTTG
CTTCCCTTTTTCCACCTGGGACATTGTAATCATAAAATAACAGTAAATTCCAAACCTCAAAAACTATTATGGCCTGAGCACAGCTGAAAT
CTAGCAGAGTTTAACTCTTCTGCCTCCATGTCTGTCACTTATAATTCAGGTTCTGCTGTTGGCTTCAGAACATGAGCAGAAGAATCGTTT
TATGCTAGTTATTGCATTCATGGTTGAAACTCAACTTAGGGAAAGGGTTCCAATGTATTAAGCAATGGGCTGCTTCTCCCCAATCCTCCC
TAACAATTCGTTGTGTGGACTTCTCATCTAAAAGGTTAGTGGCTTTTGCTTGGGATCAGTGCTCTCTATTGATGTTCTTGCTGGTCTCCA
GACACATTCCTGTTGCATTAAGACTTGAAAGACTTGTAGATGTGTGATGTTCAGGCACAGGATGCTGAAAGCTATGTTACTATTCTTAGT

>20677_20677_1_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000326335_DDX17_chr22_38897285_ENST00000396821_length(amino acids)=818AA_BP=183
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS
KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
STQFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVM
DVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRL
KSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEV
RQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKS
QPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQA
INPKLMQLVDHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAG
QYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPPP

--------------------------------------------------------------
>20677_20677_2_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000375440_DDX17_chr22_38897285_ENST00000396821_length(transcript)=5336nt_BP=932nt
GGAGGCCGCGCGGACCGGGGCGGGCGGAGCGGAGCTCGGCGGGCGGCGGCGCTCGGGGCGGGGCGCGGCGGTTCCGGCCCAGCCATGGCG
GACGAGGCCCCGCGGAAGGGCAGCTTCTCGGCGCTCGTGGGCCGCACCAACGGCCTCACCAAGCCCGCGGCCCTGGCCGCCGCGCCCGCC
AAGCCGGGGGGCGCGGGCGGCTCCAAGAAGCTGGTCATCAAGAACTTCCGAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACG
TGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAAT
CTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGA
GAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATC
TTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATT
ATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGC
CTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTA
TATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGAC
AGAGTAATCACTTACTTGGACCACAGCACACAATTTGGAGCAAGAGGTGGTGGTGGCCTTCCCCCGAAGAAATTTGGTAATCCTGGGGAG
CGTTTGCGTAAAAAAAAGTGGGATTTGAGTGAGCTCCCCAAGTTTGAGAAAAATTTTTATGTGGAACATCCGGAAGTAGCAAGGCTGACA
CCATATGAGGTTGATGAGCTACGCCGAAAGAAGGAGATTACAGTGAGGGGGGGAGATGTTTGTCCTAAACCCGTGTTTGCCTTCCATCAT
GCTAACTTCCCACAATATGTAATGGATGTGTTGATGGATCAGCACTTTACAGAACCAACTCCAATTCAGTGCCAGGGATTTCCGTTGGCT
CTTAGTGGCCGGGATATGGTGGGCATTGCTCAGACTGGCTCTGGGAAGACGTTGGCGTATCTCCTGCCTGCAATTGTTCATATTAACCAC
CAGCCATACTTGGAAAGGGGAGATGGCCCAATCTGTCTAGTTCTGGCTCCTACCAGAGAGCTTGCCCAGCAAGTACAGCAGGTGGCCGAT
GACTATGGCAAATGTTCTAGATTGAAGAGTACTTGTATTTATGGAGGTGCTCCTAAAGGTCCCCAGATTCGAGACTTGGAAAGAGGTGTT
GAGATCTGCATAGCCACTCCTGGACGTCTGATAGATTTCCTGGAGTCAGGAAAGACAAATCTTCGCCGATGTACTTACCTTGTATTGGAC
GAAGCTGACAGAATGCTTGATATGGGGTTTGAACCCCAGATCCGTAAAATTGTTGACCAAATCAGGCCTGATAGGCAGACACTGATGTGG
AGTGCAACCTGGCCAAAAGAAGTAAGACAGCTTGCAGAGGATTTCCTTCGTGATTACACCCAGATCAACGTAGGCAATCTGGAGTTGAGT
GCCAACCACAACATCCTCCAGATAGTGGATGTCTGCATGGAAAGTGAAAAAGACCACAAGTTGATCCAACTAATGGAAGAAATAATGGCT
GAAAAGGAAAACAAAACAATAATATTTGTGGAGACAAAGAGACGCTGTGATGATCTGACTCGAAGGATGCGCAGAGATGGTTGGCCAGCT
ATGTGTATCCATGGAGACAAGAGTCAACCAGAAAGAGATTGGGTACTTAATGAGTTCCGTTCTGGAAAGGCACCCATCCTTATTGCTACA
GATGTAGCCTCCCGTGGGCTAGATGTGGAAGATGTCAAGTTTGTGATCAACTATGACTATCCAAACAGCTCAGAGGATTATGTGCACCGT
ATTGGCCGAACAGCCCGTAGCACCAACAAGGGTACCGCCTATACCTTCTTCACCCCAGGGAACCTAAAACAGGCCAGAGAGCTTATCAAA
GTGCTGGAAGAGGCCAATCAGGCTATCAATCCAAAACTGATGCAGCTTGTGGACCACAGAGGAGGCGGCGGAGGCGGGGGTAAGGGTGGT
CGTTCTCGTTACCGGACCACTTCTTCAGCCAACAATCCCAATCTGATGTATCAGGATGAGTGTGACCGAAGGCTTCGAGGAGTCAAGGAT
GGTGGCCGGAGAGACTCTGCAAGCTATCGGGATCGTAGTGAAACCGATAGAGCTGGTTATGCTAATGGCAGTGGCTATGGAAGTCCAAAT
TCTGCCTTTGGAGCACAAGCAGGCCAATACACCTATGGTCAAGGCACCTATGGGGCAGCTGCTTATGGCACCAGTAGCTATACAGCTCAA
GAATATGGTGCTGGCACTTATGGAGCTAGTAGCACCACCTCAACTGGGAGAAGTTCACAGAGCTCTAGCCAGCAGTTTAGTGGGATAGGC
CGGTCTGGGCAGCAGCCACAGCCACTGATGTCACAACAGTTTGCACAGCCTCCGGGAGCTACCAATATGATAGGTTACATGGGGCAGACT
GCCTACCAATACCCTCCTCCTCCTCCCCCTCCTCCTCCTTCACGTAAATGAAACCACTCAAGTGGTAGTGACTCCAGCAGACTTAATTAC
ATTTTAAGGAACACTGTCTTTCCTTTTTTTTTCCTCTTCGCCTTTTCTTTTTTTTTCCTTTTTTCTTTTTTTTTTTTTAATTTTTCCCCC
CAACCATCGTGATTTGTCTTTTCATGCAGATTAGTTAGAATTCACTGCCAGGTTTCTTCTGCCCACCAAAATGATCCAGTCTGGAATAAC
ATTTTGTAAAAAAAAAAAAAATATATATATATATATATAGCTGACTGGAAGAGATTAATTTCTTCCCCCAACTTCTTGCATGTTGAAGAT
ATTTGAGCTATTTTTCATCTAAAAGAGTAAGGTATTAGGCCCTTTTGTGGGAGCCCCATGTTTTGTTTTTCTGAGTTGGTGGGGAGGGAG
GGAGGGGGAGGGCTGAATTGTTTTGCAGAGGAAGATGGCATCTGTGCTTTAAATTTCTCATTACTGGGTTAGAAAACAAAGAGGGATTGC
CCTGCACATTTTCTTTTGTGCTTTTAAATGTTTCTTAAGTTGGAACAGGTTTCCTCGGGCCTGTTTTGACTGATTGCTGGAGTGCATTTG
ATAGTTAAAAATTACTAATTGGTTTTATTTCCCTTCACACTCTGCCTCCCCACTTCTCCCCCCGTTACTGAAAAATAACCATTTTAGTGT
CAGGCTAGAAATTGAATTGCTGAGTTTTGTGTATCCTTTAAATTAAAAACCACAAGTGTTTATTGTAGTGGTTAAACTGTAGCATCTCAG
CATCTGGGTGGAAGCTGCCTATATTTCTTCCCAGTTTAACTGGGGACCATCTGTGAAATTAATTTTCCATCCAGACAGCTGCTGTGAGCA
AATGAACATAAATGCTCGCTGGAAATTTACTAACCAGTTTTTATATTGACCTGCAGTGTAAAAAGCACATTTAATTATAAACAATATATT
CAAAATGGGCAAATTTTATTTTCAAATGCAGTGTAGAGCTAGATTAAAAGCAACTCTTTGCCACCTACTCTGCCCTTTTGGCAAAGTTAC
CTTGAACAAAGAATCTTAAGGGTTTATTAAGAACTCTTTATTTTCTTCATACCCTGTTCTCTGCAGTGCTTTCTAACAGCTTCTGGGTGC
AGATTTTCTTCGGCATCCTTTTGCACTCAGCTTATTACAGGTAGGTAGTGCTTAAGAAAAGTCATGGAGGACTAAAGCCTAAGTCCTTTT
CACTTTTCCTCCATCTGAAGGTAGGTGAGTTCATCCTCTTCATGGTAATGCTGTTTTACCAAGACTTTATAGCAGATGGACCCAGAAAGA
ATTTTCTGCTATTGTGTTCACTACAACAGGATAGGGACATCAGACAGCCCCAGAAACCCCTTCCAGATCTGATATGGGACTATTAATTTT
TATGCTGTTAATTGGTATTCATTCACAATGCAGTTGAAGGGGGAAGGCTCCACTGCATTCTTTGGCTAAGGCCTGAATGCTTGCTCATCT
GTAAGATCTATACTCGAGGTTTTGTTTTCCTTTTAAAATTCTTTAGGGAGAGAGGGATGGTTTCTGAGGGGTTCTGAAAGTATGATTCAA
TGTGCAACATACAGGTAGGTCTTCAGCATAAGCTGAAATATATGCATGTAAAAACTTTGACATCTTTTTTTTTAATTTTCCACTTTCTTC
TTAACTTTACTTCTCTTTTTGTCCCCCCCCCATCTTACAGAAGTTGAGGCCAAGGGAGAATGGTAGGCACAGAAGAAACATGGCAAACTG
CTCTGTGCTTTCAAACCAAAGTGTTCCCCCCAACCCCAAATTTGTCTAAGCACTGGCCAGTCTGTTGTGGGCATTGTTTTCTACAACCAA
ATTCTGGGTTTTTTTCTTCTTTCTTTAAACATAGAGGTACCACCACAAGGGATGCCCTACTCTCTCGCAGCTCTTGAAAGCATCTGTTTG
AGGGAAAGGTCTCTGGGCAAGCAAGTGGTTATTTGGATTGCTTGCTTCCCTTTTTCCACCTGGGACATTGTAATCATAAAATAACAGTAA
ATTCCAAACCTCAAAAACTATTATGGCCTGAGCACAGCTGAAATCTAGCAGAGTTTAACTCTTCTGCCTCCATGTCTGTCACTTATAATT
CAGGTTCTGCTGTTGGCTTCAGAACATGAGCAGAAGAATCGTTTTATGCTAGTTATTGCATTCATGGTTGAAACTCAACTTAGGGAAAGG
GTTCCAATGTATTAAGCAATGGGCTGCTTCTCCCCAATCCTCCCTAACAATTCGTTGTGTGGACTTCTCATCTAAAAGGTTAGTGGCTTT
TGCTTGGGATCAGTGCTCTCTATTGATGTTCTTGCTGGTCTCCAGACACATTCCTGTTGCATTAAGACTTGAAAGACTTGTAGATGTGTG
ATGTTCAGGCACAGGATGCTGAAAGCTATGTTACTATTCTTAGTTTGTAAATTGTCCTTTTGATACCATCATCTTGTTTTCTTTTTGTAG

>20677_20677_2_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000375440_DDX17_chr22_38897285_ENST00000396821_length(amino acids)=918AA_BP=283
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV
ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE
GDRVITYLDHSTQFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAF
HHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQV
ADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL
MWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGW
PAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQAREL
IKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGS
PNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMG

--------------------------------------------------------------
>20677_20677_3_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000375441_DDX17_chr22_38897285_ENST00000396821_length(transcript)=5474nt_BP=1070nt
ACCGCCCACAGCGGGCCCTCGGCGTGGCCCGCAGGCCCTTCGGACCGCCTGGGAGCGCGGCCACACGTGCCAGCAAGTGAGGGCAGCGAC
CTGGGACCGCCGCGTCTACTTACACCGCGACGACTCCGCGATCCACGGACACCGCCCGGCCCCCACGGCGGCCCTGCAGGGGAGAACTCG
GGCCGCCTTCCCGAGTCCCGGCCGCCGCTGTTCGGCTCGCGCGGCTGCCCGCCGGGGACCCGAACGGAAGAAGGGTGGCGAGGCGGGAAA
GGAAAAGGCCTGAGGGTCCAAGGCAGGAGGGGACACACGGAACACGCCGAGGGCCAACCACGCCGCCGCGCGCTCCCCGGCTAGGACCCA
CCTGCTGCAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGC
ACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTG
CGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAAC
ACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACG
CTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATC
CTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTG
TATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTT
CCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAATTTGGAGCA
AGAGGTGGTGGTGGCCTTCCCCCGAAGAAATTTGGTAATCCTGGGGAGCGTTTGCGTAAAAAAAAGTGGGATTTGAGTGAGCTCCCCAAG
TTTGAGAAAAATTTTTATGTGGAACATCCGGAAGTAGCAAGGCTGACACCATATGAGGTTGATGAGCTACGCCGAAAGAAGGAGATTACA
GTGAGGGGGGGAGATGTTTGTCCTAAACCCGTGTTTGCCTTCCATCATGCTAACTTCCCACAATATGTAATGGATGTGTTGATGGATCAG
CACTTTACAGAACCAACTCCAATTCAGTGCCAGGGATTTCCGTTGGCTCTTAGTGGCCGGGATATGGTGGGCATTGCTCAGACTGGCTCT
GGGAAGACGTTGGCGTATCTCCTGCCTGCAATTGTTCATATTAACCACCAGCCATACTTGGAAAGGGGAGATGGCCCAATCTGTCTAGTT
CTGGCTCCTACCAGAGAGCTTGCCCAGCAAGTACAGCAGGTGGCCGATGACTATGGCAAATGTTCTAGATTGAAGAGTACTTGTATTTAT
GGAGGTGCTCCTAAAGGTCCCCAGATTCGAGACTTGGAAAGAGGTGTTGAGATCTGCATAGCCACTCCTGGACGTCTGATAGATTTCCTG
GAGTCAGGAAAGACAAATCTTCGCCGATGTACTTACCTTGTATTGGACGAAGCTGACAGAATGCTTGATATGGGGTTTGAACCCCAGATC
CGTAAAATTGTTGACCAAATCAGGCCTGATAGGCAGACACTGATGTGGAGTGCAACCTGGCCAAAAGAAGTAAGACAGCTTGCAGAGGAT
TTCCTTCGTGATTACACCCAGATCAACGTAGGCAATCTGGAGTTGAGTGCCAACCACAACATCCTCCAGATAGTGGATGTCTGCATGGAA
AGTGAAAAAGACCACAAGTTGATCCAACTAATGGAAGAAATAATGGCTGAAAAGGAAAACAAAACAATAATATTTGTGGAGACAAAGAGA
CGCTGTGATGATCTGACTCGAAGGATGCGCAGAGATGGTTGGCCAGCTATGTGTATCCATGGAGACAAGAGTCAACCAGAAAGAGATTGG
GTACTTAATGAGTTCCGTTCTGGAAAGGCACCCATCCTTATTGCTACAGATGTAGCCTCCCGTGGGCTAGATGTGGAAGATGTCAAGTTT
GTGATCAACTATGACTATCCAAACAGCTCAGAGGATTATGTGCACCGTATTGGCCGAACAGCCCGTAGCACCAACAAGGGTACCGCCTAT
ACCTTCTTCACCCCAGGGAACCTAAAACAGGCCAGAGAGCTTATCAAAGTGCTGGAAGAGGCCAATCAGGCTATCAATCCAAAACTGATG
CAGCTTGTGGACCACAGAGGAGGCGGCGGAGGCGGGGGTAAGGGTGGTCGTTCTCGTTACCGGACCACTTCTTCAGCCAACAATCCCAAT
CTGATGTATCAGGATGAGTGTGACCGAAGGCTTCGAGGAGTCAAGGATGGTGGCCGGAGAGACTCTGCAAGCTATCGGGATCGTAGTGAA
ACCGATAGAGCTGGTTATGCTAATGGCAGTGGCTATGGAAGTCCAAATTCTGCCTTTGGAGCACAAGCAGGCCAATACACCTATGGTCAA
GGCACCTATGGGGCAGCTGCTTATGGCACCAGTAGCTATACAGCTCAAGAATATGGTGCTGGCACTTATGGAGCTAGTAGCACCACCTCA
ACTGGGAGAAGTTCACAGAGCTCTAGCCAGCAGTTTAGTGGGATAGGCCGGTCTGGGCAGCAGCCACAGCCACTGATGTCACAACAGTTT
GCACAGCCTCCGGGAGCTACCAATATGATAGGTTACATGGGGCAGACTGCCTACCAATACCCTCCTCCTCCTCCCCCTCCTCCTCCTTCA
CGTAAATGAAACCACTCAAGTGGTAGTGACTCCAGCAGACTTAATTACATTTTAAGGAACACTGTCTTTCCTTTTTTTTTCCTCTTCGCC
TTTTCTTTTTTTTTCCTTTTTTCTTTTTTTTTTTTTAATTTTTCCCCCCAACCATCGTGATTTGTCTTTTCATGCAGATTAGTTAGAATT
CACTGCCAGGTTTCTTCTGCCCACCAAAATGATCCAGTCTGGAATAACATTTTGTAAAAAAAAAAAAAATATATATATATATATATAGCT
GACTGGAAGAGATTAATTTCTTCCCCCAACTTCTTGCATGTTGAAGATATTTGAGCTATTTTTCATCTAAAAGAGTAAGGTATTAGGCCC
TTTTGTGGGAGCCCCATGTTTTGTTTTTCTGAGTTGGTGGGGAGGGAGGGAGGGGGAGGGCTGAATTGTTTTGCAGAGGAAGATGGCATC
TGTGCTTTAAATTTCTCATTACTGGGTTAGAAAACAAAGAGGGATTGCCCTGCACATTTTCTTTTGTGCTTTTAAATGTTTCTTAAGTTG
GAACAGGTTTCCTCGGGCCTGTTTTGACTGATTGCTGGAGTGCATTTGATAGTTAAAAATTACTAATTGGTTTTATTTCCCTTCACACTC
TGCCTCCCCACTTCTCCCCCCGTTACTGAAAAATAACCATTTTAGTGTCAGGCTAGAAATTGAATTGCTGAGTTTTGTGTATCCTTTAAA
TTAAAAACCACAAGTGTTTATTGTAGTGGTTAAACTGTAGCATCTCAGCATCTGGGTGGAAGCTGCCTATATTTCTTCCCAGTTTAACTG
GGGACCATCTGTGAAATTAATTTTCCATCCAGACAGCTGCTGTGAGCAAATGAACATAAATGCTCGCTGGAAATTTACTAACCAGTTTTT
ATATTGACCTGCAGTGTAAAAAGCACATTTAATTATAAACAATATATTCAAAATGGGCAAATTTTATTTTCAAATGCAGTGTAGAGCTAG
ATTAAAAGCAACTCTTTGCCACCTACTCTGCCCTTTTGGCAAAGTTACCTTGAACAAAGAATCTTAAGGGTTTATTAAGAACTCTTTATT
TTCTTCATACCCTGTTCTCTGCAGTGCTTTCTAACAGCTTCTGGGTGCAGATTTTCTTCGGCATCCTTTTGCACTCAGCTTATTACAGGT
AGGTAGTGCTTAAGAAAAGTCATGGAGGACTAAAGCCTAAGTCCTTTTCACTTTTCCTCCATCTGAAGGTAGGTGAGTTCATCCTCTTCA
TGGTAATGCTGTTTTACCAAGACTTTATAGCAGATGGACCCAGAAAGAATTTTCTGCTATTGTGTTCACTACAACAGGATAGGGACATCA
GACAGCCCCAGAAACCCCTTCCAGATCTGATATGGGACTATTAATTTTTATGCTGTTAATTGGTATTCATTCACAATGCAGTTGAAGGGG
GAAGGCTCCACTGCATTCTTTGGCTAAGGCCTGAATGCTTGCTCATCTGTAAGATCTATACTCGAGGTTTTGTTTTCCTTTTAAAATTCT
TTAGGGAGAGAGGGATGGTTTCTGAGGGGTTCTGAAAGTATGATTCAATGTGCAACATACAGGTAGGTCTTCAGCATAAGCTGAAATATA
TGCATGTAAAAACTTTGACATCTTTTTTTTTAATTTTCCACTTTCTTCTTAACTTTACTTCTCTTTTTGTCCCCCCCCCATCTTACAGAA
GTTGAGGCCAAGGGAGAATGGTAGGCACAGAAGAAACATGGCAAACTGCTCTGTGCTTTCAAACCAAAGTGTTCCCCCCAACCCCAAATT
TGTCTAAGCACTGGCCAGTCTGTTGTGGGCATTGTTTTCTACAACCAAATTCTGGGTTTTTTTCTTCTTTCTTTAAACATAGAGGTACCA
CCACAAGGGATGCCCTACTCTCTCGCAGCTCTTGAAAGCATCTGTTTGAGGGAAAGGTCTCTGGGCAAGCAAGTGGTTATTTGGATTGCT
TGCTTCCCTTTTTCCACCTGGGACATTGTAATCATAAAATAACAGTAAATTCCAAACCTCAAAAACTATTATGGCCTGAGCACAGCTGAA
ATCTAGCAGAGTTTAACTCTTCTGCCTCCATGTCTGTCACTTATAATTCAGGTTCTGCTGTTGGCTTCAGAACATGAGCAGAAGAATCGT
TTTATGCTAGTTATTGCATTCATGGTTGAAACTCAACTTAGGGAAAGGGTTCCAATGTATTAAGCAATGGGCTGCTTCTCCCCAATCCTC
CCTAACAATTCGTTGTGTGGACTTCTCATCTAAAAGGTTAGTGGCTTTTGCTTGGGATCAGTGCTCTCTATTGATGTTCTTGCTGGTCTC
CAGACACATTCCTGTTGCATTAAGACTTGAAAGACTTGTAGATGTGTGATGTTCAGGCACAGGATGCTGAAAGCTATGTTACTATTCTTA

>20677_20677_3_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000375441_DDX17_chr22_38897285_ENST00000396821_length(amino acids)=865AA_BP=230
MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC
RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL
KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYV
EHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYL
LPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNL
RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKL
IQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYP
NSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDEC
DRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQS

--------------------------------------------------------------
>20677_20677_4_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000451881_DDX17_chr22_38897285_ENST00000396821_length(transcript)=5201nt_BP=797nt
CCTGGGGACCGGCTCGGCGACGCGCTCGGGCTGAGGGGGCCCGGGGTCTTTCTGCCGGGGCCCCGTCCTCTCAGCCGGGACGCCAGCGGC
TCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACC
TCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGT
CAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACG
TGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTG
CCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTA
CTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTAT
AAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCA
GAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAATTTGGAGCAAGA
GGTGGTGGTGGCCTTCCCCCGAAGAAATTTGGTAATCCTGGGGAGCGTTTGCGTAAAAAAAAGTGGGATTTGAGTGAGCTCCCCAAGTTT
GAGAAAAATTTTTATGTGGAACATCCGGAAGTAGCAAGGCTGACACCATATGAGGTTGATGAGCTACGCCGAAAGAAGGAGATTACAGTG
AGGGGGGGAGATGTTTGTCCTAAACCCGTGTTTGCCTTCCATCATGCTAACTTCCCACAATATGTAATGGATGTGTTGATGGATCAGCAC
TTTACAGAACCAACTCCAATTCAGTGCCAGGGATTTCCGTTGGCTCTTAGTGGCCGGGATATGGTGGGCATTGCTCAGACTGGCTCTGGG
AAGACGTTGGCGTATCTCCTGCCTGCAATTGTTCATATTAACCACCAGCCATACTTGGAAAGGGGAGATGGCCCAATCTGTCTAGTTCTG
GCTCCTACCAGAGAGCTTGCCCAGCAAGTACAGCAGGTGGCCGATGACTATGGCAAATGTTCTAGATTGAAGAGTACTTGTATTTATGGA
GGTGCTCCTAAAGGTCCCCAGATTCGAGACTTGGAAAGAGGTGTTGAGATCTGCATAGCCACTCCTGGACGTCTGATAGATTTCCTGGAG
TCAGGAAAGACAAATCTTCGCCGATGTACTTACCTTGTATTGGACGAAGCTGACAGAATGCTTGATATGGGGTTTGAACCCCAGATCCGT
AAAATTGTTGACCAAATCAGGCCTGATAGGCAGACACTGATGTGGAGTGCAACCTGGCCAAAAGAAGTAAGACAGCTTGCAGAGGATTTC
CTTCGTGATTACACCCAGATCAACGTAGGCAATCTGGAGTTGAGTGCCAACCACAACATCCTCCAGATAGTGGATGTCTGCATGGAAAGT
GAAAAAGACCACAAGTTGATCCAACTAATGGAAGAAATAATGGCTGAAAAGGAAAACAAAACAATAATATTTGTGGAGACAAAGAGACGC
TGTGATGATCTGACTCGAAGGATGCGCAGAGATGGTTGGCCAGCTATGTGTATCCATGGAGACAAGAGTCAACCAGAAAGAGATTGGGTA
CTTAATGAGTTCCGTTCTGGAAAGGCACCCATCCTTATTGCTACAGATGTAGCCTCCCGTGGGCTAGATGTGGAAGATGTCAAGTTTGTG
ATCAACTATGACTATCCAAACAGCTCAGAGGATTATGTGCACCGTATTGGCCGAACAGCCCGTAGCACCAACAAGGGTACCGCCTATACC
TTCTTCACCCCAGGGAACCTAAAACAGGCCAGAGAGCTTATCAAAGTGCTGGAAGAGGCCAATCAGGCTATCAATCCAAAACTGATGCAG
CTTGTGGACCACAGAGGAGGCGGCGGAGGCGGGGGTAAGGGTGGTCGTTCTCGTTACCGGACCACTTCTTCAGCCAACAATCCCAATCTG
ATGTATCAGGATGAGTGTGACCGAAGGCTTCGAGGAGTCAAGGATGGTGGCCGGAGAGACTCTGCAAGCTATCGGGATCGTAGTGAAACC
GATAGAGCTGGTTATGCTAATGGCAGTGGCTATGGAAGTCCAAATTCTGCCTTTGGAGCACAAGCAGGCCAATACACCTATGGTCAAGGC
ACCTATGGGGCAGCTGCTTATGGCACCAGTAGCTATACAGCTCAAGAATATGGTGCTGGCACTTATGGAGCTAGTAGCACCACCTCAACT
GGGAGAAGTTCACAGAGCTCTAGCCAGCAGTTTAGTGGGATAGGCCGGTCTGGGCAGCAGCCACAGCCACTGATGTCACAACAGTTTGCA
CAGCCTCCGGGAGCTACCAATATGATAGGTTACATGGGGCAGACTGCCTACCAATACCCTCCTCCTCCTCCCCCTCCTCCTCCTTCACGT
AAATGAAACCACTCAAGTGGTAGTGACTCCAGCAGACTTAATTACATTTTAAGGAACACTGTCTTTCCTTTTTTTTTCCTCTTCGCCTTT
TCTTTTTTTTTCCTTTTTTCTTTTTTTTTTTTTAATTTTTCCCCCCAACCATCGTGATTTGTCTTTTCATGCAGATTAGTTAGAATTCAC
TGCCAGGTTTCTTCTGCCCACCAAAATGATCCAGTCTGGAATAACATTTTGTAAAAAAAAAAAAAATATATATATATATATATAGCTGAC
TGGAAGAGATTAATTTCTTCCCCCAACTTCTTGCATGTTGAAGATATTTGAGCTATTTTTCATCTAAAAGAGTAAGGTATTAGGCCCTTT
TGTGGGAGCCCCATGTTTTGTTTTTCTGAGTTGGTGGGGAGGGAGGGAGGGGGAGGGCTGAATTGTTTTGCAGAGGAAGATGGCATCTGT
GCTTTAAATTTCTCATTACTGGGTTAGAAAACAAAGAGGGATTGCCCTGCACATTTTCTTTTGTGCTTTTAAATGTTTCTTAAGTTGGAA
CAGGTTTCCTCGGGCCTGTTTTGACTGATTGCTGGAGTGCATTTGATAGTTAAAAATTACTAATTGGTTTTATTTCCCTTCACACTCTGC
CTCCCCACTTCTCCCCCCGTTACTGAAAAATAACCATTTTAGTGTCAGGCTAGAAATTGAATTGCTGAGTTTTGTGTATCCTTTAAATTA
AAAACCACAAGTGTTTATTGTAGTGGTTAAACTGTAGCATCTCAGCATCTGGGTGGAAGCTGCCTATATTTCTTCCCAGTTTAACTGGGG
ACCATCTGTGAAATTAATTTTCCATCCAGACAGCTGCTGTGAGCAAATGAACATAAATGCTCGCTGGAAATTTACTAACCAGTTTTTATA
TTGACCTGCAGTGTAAAAAGCACATTTAATTATAAACAATATATTCAAAATGGGCAAATTTTATTTTCAAATGCAGTGTAGAGCTAGATT
AAAAGCAACTCTTTGCCACCTACTCTGCCCTTTTGGCAAAGTTACCTTGAACAAAGAATCTTAAGGGTTTATTAAGAACTCTTTATTTTC
TTCATACCCTGTTCTCTGCAGTGCTTTCTAACAGCTTCTGGGTGCAGATTTTCTTCGGCATCCTTTTGCACTCAGCTTATTACAGGTAGG
TAGTGCTTAAGAAAAGTCATGGAGGACTAAAGCCTAAGTCCTTTTCACTTTTCCTCCATCTGAAGGTAGGTGAGTTCATCCTCTTCATGG
TAATGCTGTTTTACCAAGACTTTATAGCAGATGGACCCAGAAAGAATTTTCTGCTATTGTGTTCACTACAACAGGATAGGGACATCAGAC
AGCCCCAGAAACCCCTTCCAGATCTGATATGGGACTATTAATTTTTATGCTGTTAATTGGTATTCATTCACAATGCAGTTGAAGGGGGAA
GGCTCCACTGCATTCTTTGGCTAAGGCCTGAATGCTTGCTCATCTGTAAGATCTATACTCGAGGTTTTGTTTTCCTTTTAAAATTCTTTA
GGGAGAGAGGGATGGTTTCTGAGGGGTTCTGAAAGTATGATTCAATGTGCAACATACAGGTAGGTCTTCAGCATAAGCTGAAATATATGC
ATGTAAAAACTTTGACATCTTTTTTTTTAATTTTCCACTTTCTTCTTAACTTTACTTCTCTTTTTGTCCCCCCCCCATCTTACAGAAGTT
GAGGCCAAGGGAGAATGGTAGGCACAGAAGAAACATGGCAAACTGCTCTGTGCTTTCAAACCAAAGTGTTCCCCCCAACCCCAAATTTGT
CTAAGCACTGGCCAGTCTGTTGTGGGCATTGTTTTCTACAACCAAATTCTGGGTTTTTTTCTTCTTTCTTTAAACATAGAGGTACCACCA
CAAGGGATGCCCTACTCTCTCGCAGCTCTTGAAAGCATCTGTTTGAGGGAAAGGTCTCTGGGCAAGCAAGTGGTTATTTGGATTGCTTGC
TTCCCTTTTTCCACCTGGGACATTGTAATCATAAAATAACAGTAAATTCCAAACCTCAAAAACTATTATGGCCTGAGCACAGCTGAAATC
TAGCAGAGTTTAACTCTTCTGCCTCCATGTCTGTCACTTATAATTCAGGTTCTGCTGTTGGCTTCAGAACATGAGCAGAAGAATCGTTTT
ATGCTAGTTATTGCATTCATGGTTGAAACTCAACTTAGGGAAAGGGTTCCAATGTATTAAGCAATGGGCTGCTTCTCCCCAATCCTCCCT
AACAATTCGTTGTGTGGACTTCTCATCTAAAAGGTTAGTGGCTTTTGCTTGGGATCAGTGCTCTCTATTGATGTTCTTGCTGGTCTCCAG
ACACATTCCTGTTGCATTAAGACTTGAAAGACTTGTAGATGTGTGATGTTCAGGCACAGGATGCTGAAAGCTATGTTACTATTCTTAGTT

>20677_20677_4_CUL4A-DDX17_CUL4A_chr13_113889459_ENST00000451881_DDX17_chr22_38897285_ENST00000396821_length(amino acids)=891AA_BP=256
MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ
ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE
AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQFGARGGGGLPPKKF
GNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQ
GFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRD
LERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVG
NLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAP
ILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGG
GGKGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTS

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Fusion Gene PPI Analysis for CUL4A-DDX17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CUL4A-DDX17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CUL4A-DDX17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource