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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CUL4A-TMEM255B (FusionGDB2 ID:20687)

Fusion Gene Summary for CUL4A-TMEM255B

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL4A-TMEM255B
Fusion gene ID: 20687
HgeneTgene
Gene symbol

CUL4A

TMEM255B

Gene ID

8451

348013

Gene namecullin 4Atransmembrane protein 255B
Synonyms-FAM70B
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptioncullin-4ACUL-4Atransmembrane protein 255Bfamily with sequence similarity 70, member Bprotein FAM70B
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000326335, ENST00000375440, 
ENST00000375441, ENST00000451881, 
ENST00000463426, 		ENST00000467169, 
ENST00000375353, 
Fusion gene scores* DoF score12 X 16 X 11=21124 X 5 X 4=80
# samples 195
** MAII scorelog2(19/2112*10)=-3.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUL4A [Title/Abstract] AND TMEM255B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCUL4A(113897359)-TMEM255B(114502312), # samples:2
Anticipated loss of major functional domain due to fusion event.CUL4A-TMEM255B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL4A

GO:0016567

protein ubiquitination

26431207


check buttonFusion gene breakpoints across CUL4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM255B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-A4ZK-01ACUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
ChimerDB4LUSCTCGA-56-A4ZK-01ACUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
ChimerDB4LUSCTCGA-56-A4ZK-01ACUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
ChimerDB4LUSCTCGA-56-A4ZKCUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
ChimerDB4LUSCTCGA-56-A4ZKCUL4Achr13

113897359

+TMEM255Bchr13

114502312

+


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Fusion Gene ORF analysis for CUL4A-TMEM255B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326335ENST00000467169CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000326335ENST00000467169CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000326335ENST00000467169CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000326335ENST00000467169CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000375440ENST00000467169CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000375440ENST00000467169CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000375440ENST00000467169CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000375440ENST00000467169CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000375441ENST00000467169CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000375441ENST00000467169CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000375441ENST00000467169CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000375441ENST00000467169CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000451881ENST00000467169CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000451881ENST00000467169CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
5CDS-intronENST00000451881ENST00000467169CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
5CDS-intronENST00000451881ENST00000467169CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
Frame-shiftENST00000326335ENST00000375353CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
Frame-shiftENST00000326335ENST00000375353CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
Frame-shiftENST00000375440ENST00000375353CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
Frame-shiftENST00000375440ENST00000375353CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
Frame-shiftENST00000375441ENST00000375353CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
Frame-shiftENST00000375441ENST00000375353CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
Frame-shiftENST00000451881ENST00000375353CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
Frame-shiftENST00000451881ENST00000375353CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
In-frameENST00000326335ENST00000375353CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
In-frameENST00000326335ENST00000375353CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
In-frameENST00000375440ENST00000375353CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
In-frameENST00000375440ENST00000375353CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
In-frameENST00000375441ENST00000375353CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
In-frameENST00000375441ENST00000375353CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
In-frameENST00000451881ENST00000375353CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
In-frameENST00000451881ENST00000375353CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
intron-3CDSENST00000463426ENST00000375353CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
intron-3CDSENST00000463426ENST00000375353CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
intron-3CDSENST00000463426ENST00000375353CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
intron-3CDSENST00000463426ENST00000375353CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+
intron-intronENST00000463426ENST00000467169CUL4Achr13

113893864

+TMEM255Bchr13

114502311

+
intron-intronENST00000463426ENST00000467169CUL4Achr13

113897358

+TMEM255Bchr13

114502311

+
intron-intronENST00000463426ENST00000467169CUL4Achr13

113897359

+TMEM255Bchr13

114502312

+
intron-intronENST00000463426ENST00000467169CUL4Achr13

113893865

+TMEM255Bchr13

114502312

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375441CUL4Achr13113893865+ENST00000375353TMEM255Bchr13114502312+191912573811895504
ENST00000451881CUL4Achr13113893865+ENST00000375353TMEM255Bchr13114502312+1646984301622530
ENST00000326335CUL4Achr13113893865+ENST00000375353TMEM255Bchr13114502312+15578951601533457
ENST00000375440CUL4Achr13113893865+ENST00000375353TMEM255Bchr13114502312+17811119841757557
ENST00000375441CUL4Achr13113893864+ENST00000375353TMEM255Bchr13114502311+191912573811895504
ENST00000451881CUL4Achr13113893864+ENST00000375353TMEM255Bchr13114502311+1646984301622530
ENST00000326335CUL4Achr13113893864+ENST00000375353TMEM255Bchr13114502311+15578951601533457
ENST00000375440CUL4Achr13113893864+ENST00000375353TMEM255Bchr13114502311+17811119841757557

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375441ENST00000375353CUL4Achr13113893865+TMEM255Bchr13114502312+0.0169289620.983071
ENST00000451881ENST00000375353CUL4Achr13113893865+TMEM255Bchr13114502312+0.0146019560.98539805
ENST00000326335ENST00000375353CUL4Achr13113893865+TMEM255Bchr13114502312+0.0139918390.9860081
ENST00000375440ENST00000375353CUL4Achr13113893865+TMEM255Bchr13114502312+0.0122739580.98772603
ENST00000375441ENST00000375353CUL4Achr13113893864+TMEM255Bchr13114502311+0.0169289620.983071
ENST00000451881ENST00000375353CUL4Achr13113893864+TMEM255Bchr13114502311+0.0146019560.98539805
ENST00000326335ENST00000375353CUL4Achr13113893864+TMEM255Bchr13114502311+0.0139918390.9860081
ENST00000375440ENST00000375353CUL4Achr13113893864+TMEM255Bchr13114502311+0.0122739580.98772603

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Fusion Genomic Features for CUL4A-TMEM255B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CUL4Achr13113893865+TMEM255Bchr13114502311+7.85E-050.99992144
CUL4Achr13113893865+TMEM255Bchr13114502311+7.85E-050.99992144
CUL4Achr13113893865+TMEM255Bchr13114502311+7.85E-050.99992144
CUL4Achr13113893865+TMEM255Bchr13114502311+7.85E-050.99992144

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CUL4A-TMEM255B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113897359/chr13:114502312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM255Bchr13:113893864chr13:114502311ENST0000037535339257_326114327.0Compositional biasNote=Pro-rich
TgeneTMEM255Bchr13:113893865chr13:114502312ENST0000037535339257_326114327.0Compositional biasNote=Pro-rich
TgeneTMEM255Bchr13:113893864chr13:114502311ENST0000037535339200_220114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893865chr13:114502312ENST0000037535339200_220114327.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM255Bchr13:113893864chr13:114502311ENST000003753533926_46114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893864chr13:114502311ENST000003753533955_75114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893864chr13:114502311ENST000003753533985_105114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893865chr13:114502312ENST000003753533926_46114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893865chr13:114502312ENST000003753533955_75114327.0TransmembraneHelical
TgeneTMEM255Bchr13:113893865chr13:114502312ENST000003753533985_105114327.0TransmembraneHelical


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Fusion Gene Sequence for CUL4A-TMEM255B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20687_20687_1_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000326335_TMEM255B_chr13_114502311_ENST00000375353_length(transcript)=1557nt_BP=895nt
GTCCTCTCAGCCGGGACGCCAGCGGCTCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGG
CGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCG
TCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACAC
GTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCT
GCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCT
ACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTA
TAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCC
AGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGAT
TGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCC
GGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACC
GAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTC
CCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGC
CTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGG
CCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCC
ACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTA
CCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAG
CAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCACC

>20687_20687_1_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000326335_TMEM255B_chr13_114502311_ENST00000375353_length(amino acids)=457AA_BP=245
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS
KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQ
TEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQL
AYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQPCSRFPVAPSSALASSEDLQPPSPSSSGSGLPGQAPPCYAPTYFPPGE

--------------------------------------------------------------
>20687_20687_2_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000375440_TMEM255B_chr13_114502311_ENST00000375353_length(transcript)=1781nt_BP=1119nt
GGAGGCCGCGCGGACCGGGGCGGGCGGAGCGGAGCTCGGCGGGCGGCGGCGCTCGGGGCGGGGCGCGGCGGTTCCGGCCCAGCCATGGCG
GACGAGGCCCCGCGGAAGGGCAGCTTCTCGGCGCTCGTGGGCCGCACCAACGGCCTCACCAAGCCCGCGGCCCTGGCCGCCGCGCCCGCC
AAGCCGGGGGGCGCGGGCGGCTCCAAGAAGCTGGTCATCAAGAACTTCCGAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACG
TGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAAT
CTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGA
GAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATC
TTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATT
ATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGC
CTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTA
TATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGAC
AGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATT
CTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGG
CAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACCGAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTG
GGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTCCCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTAC
TGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGCCTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCAC
CTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGGCCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAG
GACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCCACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCA
GGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTACCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCC
TCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAGCAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCA

>20687_20687_2_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000375440_TMEM255B_chr13_114502311_ENST00000375353_length(amino acids)=557AA_BP=345
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV
ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE
GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSS
GVGYLYDVYQTEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGA
FKDMVPLSQLAYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQPCSRFPVAPSSALASSEDLQPPSPSSSGSGLPGQAPPC

--------------------------------------------------------------
>20687_20687_3_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000375441_TMEM255B_chr13_114502311_ENST00000375353_length(transcript)=1919nt_BP=1257nt
ACCGCCCACAGCGGGCCCTCGGCGTGGCCCGCAGGCCCTTCGGACCGCCTGGGAGCGCGGCCACACGTGCCAGCAAGTGAGGGCAGCGAC
CTGGGACCGCCGCGTCTACTTACACCGCGACGACTCCGCGATCCACGGACACCGCCCGGCCCCCACGGCGGCCCTGCAGGGGAGAACTCG
GGCCGCCTTCCCGAGTCCCGGCCGCCGCTGTTCGGCTCGCGCGGCTGCCCGCCGGGGACCCGAACGGAAGAAGGGTGGCGAGGCGGGAAA
GGAAAAGGCCTGAGGGTCCAAGGCAGGAGGGGACACACGGAACACGCCGAGGGCCAACCACGCCGCCGCGCGCTCCCCGGCTAGGACCCA
CCTGCTGCAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGC
ACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTG
CGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAAC
ACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACG
CTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATC
CTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTG
TATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTT
CCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTG
ATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTG
CCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAA
CCGAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCAC
TCCCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCC
GCCTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTG
GGCCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTC
CCACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCC
TACCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCA
AGCAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCA

>20687_20687_3_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000375441_TMEM255B_chr13_114502311_ENST00000375353_length(amino acids)=504AA_BP=292
MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC
RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL
KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY
QLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQTEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIG
VSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQLAYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQP

--------------------------------------------------------------
>20687_20687_4_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000451881_TMEM255B_chr13_114502311_ENST00000375353_length(transcript)=1646nt_BP=984nt
CCTGGGGACCGGCTCGGCGACGCGCTCGGGCTGAGGGGGCCCGGGGTCTTTCTGCCGGGGCCCCGTCCTCTCAGCCGGGACGCCAGCGGC
TCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACC
TCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGT
CAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACG
TGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTG
CCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTA
CTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTAT
AAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCA
GAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATT
GCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCG
GACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACCG
AGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTCC
CTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGCC
TACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGGC
CTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCCA
CCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTAC
CCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAGC
AGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCACCC

>20687_20687_4_CUL4A-TMEM255B_CUL4A_chr13_113893864_ENST00000451881_TMEM255B_chr13_114502311_ENST00000375353_length(amino acids)=530AA_BP=318
MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ
ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE
AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE
HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQTEVTCHSLDGKCQLKVR
SNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQLAYGPAVPPQTLYNPAQQ

--------------------------------------------------------------
>20687_20687_5_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000326335_TMEM255B_chr13_114502312_ENST00000375353_length(transcript)=1557nt_BP=895nt
GTCCTCTCAGCCGGGACGCCAGCGGCTCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGG
CGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCG
TCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACAC
GTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCT
GCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCT
ACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTA
TAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCC
AGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGAT
TGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCC
GGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACC
GAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTC
CCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGC
CTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGG
CCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCC
ACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTA
CCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAG
CAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCACC

>20687_20687_5_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000326335_TMEM255B_chr13_114502312_ENST00000375353_length(amino acids)=457AA_BP=245
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS
KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQ
TEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQL
AYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQPCSRFPVAPSSALASSEDLQPPSPSSSGSGLPGQAPPCYAPTYFPPGE

--------------------------------------------------------------
>20687_20687_6_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000375440_TMEM255B_chr13_114502312_ENST00000375353_length(transcript)=1781nt_BP=1119nt
GGAGGCCGCGCGGACCGGGGCGGGCGGAGCGGAGCTCGGCGGGCGGCGGCGCTCGGGGCGGGGCGCGGCGGTTCCGGCCCAGCCATGGCG
GACGAGGCCCCGCGGAAGGGCAGCTTCTCGGCGCTCGTGGGCCGCACCAACGGCCTCACCAAGCCCGCGGCCCTGGCCGCCGCGCCCGCC
AAGCCGGGGGGCGCGGGCGGCTCCAAGAAGCTGGTCATCAAGAACTTCCGAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACG
TGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAAT
CTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGA
GAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATC
TTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATT
ATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGC
CTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTA
TATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGAC
AGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATT
CTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGG
CAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACCGAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTG
GGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTCCCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTAC
TGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGCCTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCAC
CTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGGCCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAG
GACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCCACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCA
GGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTACCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCC
TCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAGCAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCA

>20687_20687_6_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000375440_TMEM255B_chr13_114502312_ENST00000375353_length(amino acids)=557AA_BP=345
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV
ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE
GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSS
GVGYLYDVYQTEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGA
FKDMVPLSQLAYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQPCSRFPVAPSSALASSEDLQPPSPSSSGSGLPGQAPPC

--------------------------------------------------------------
>20687_20687_7_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000375441_TMEM255B_chr13_114502312_ENST00000375353_length(transcript)=1919nt_BP=1257nt
ACCGCCCACAGCGGGCCCTCGGCGTGGCCCGCAGGCCCTTCGGACCGCCTGGGAGCGCGGCCACACGTGCCAGCAAGTGAGGGCAGCGAC
CTGGGACCGCCGCGTCTACTTACACCGCGACGACTCCGCGATCCACGGACACCGCCCGGCCCCCACGGCGGCCCTGCAGGGGAGAACTCG
GGCCGCCTTCCCGAGTCCCGGCCGCCGCTGTTCGGCTCGCGCGGCTGCCCGCCGGGGACCCGAACGGAAGAAGGGTGGCGAGGCGGGAAA
GGAAAAGGCCTGAGGGTCCAAGGCAGGAGGGGACACACGGAACACGCCGAGGGCCAACCACGCCGCCGCGCGCTCCCCGGCTAGGACCCA
CCTGCTGCAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGC
ACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTG
CGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAAC
ACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACG
CTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATC
CTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTG
TATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTT
CCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTG
ATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTG
CCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAA
CCGAGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCAC
TCCCTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCC
GCCTACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTG
GGCCTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTC
CCACCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCC
TACCCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCA
AGCAGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCA

>20687_20687_7_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000375441_TMEM255B_chr13_114502312_ENST00000375353_length(amino acids)=504AA_BP=292
MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC
RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL
KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY
QLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQTEVTCHSLDGKCQLKVRSNTCYCCDLYACGSAEPSPAYYEFIG
VSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQLAYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQP

--------------------------------------------------------------
>20687_20687_8_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000451881_TMEM255B_chr13_114502312_ENST00000375353_length(transcript)=1646nt_BP=984nt
CCTGGGGACCGGCTCGGCGACGCGCTCGGGCTGAGGGGGCCCGGGGTCTTTCTGCCGGGGCCCCGTCCTCTCAGCCGGGACGCCAGCGGC
TCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACC
TCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGT
CAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACG
TGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTG
CCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTA
CTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTAT
AAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCA
GAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATT
GCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCG
GACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGGAACCG
AGGCCCCTCACCACGGGAAGATGCCAGTTTTACTCCAGTGGGGTGGGGTACTTGTACGATGTCTACCAGACAGAGGTCACCTGTCACTCC
CTGGACGGCAAGTGCCAGCTGAAGGTGAGAAGCAACACCTGTTACTGCTGTGACCTCTATGCCTGCGGGAGCGCAGAGCCCTCGCCCGCC
TACTATGAGTTCATCGGCGTCAGCGGCTGCCAGGACGTGCTGCACCTGTACCGCCTGCTCTGGGCCTCTGCAGTTCTGAACGTCCTGGGC
CTGTTCCTGGGCATCATCACCGCCGCCGTCCTGGGGGCCTTCAAGGACATGGTGCCTCTGTCCCAGCTGGCCTATGGCCCAGCCGTCCCA
CCACAGACCCTCTACAACCCCGCCCAGCAGATCCTGGCCTACGCAGGCTTCCGCCTGACGCCCGAGCCCGTCCCGACCTGCTCGTCCTAC
CCTCTGCCCCTTCAGCCCTGCAGCCGCTTCCCAGTTGCGCCCTCCTCTGCCCTGGCTTCGTCTGAGGACCTGCAGCCCCCTTCTCCAAGC
AGCTCTGGCTCTGGGCTTCCCGGCCAGGCTCCACCGTGCTACGCACCCACCTACTTTCCCCCGGGGGAGAAGCCACCCCCCTACGCACCC

>20687_20687_8_CUL4A-TMEM255B_CUL4A_chr13_113893865_ENST00000451881_TMEM255B_chr13_114502312_ENST00000375353_length(amino acids)=530AA_BP=318
MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ
ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE
AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE
HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKEPRPLTTGRCQFYSSGVGYLYDVYQTEVTCHSLDGKCQLKVR
SNTCYCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLGAFKDMVPLSQLAYGPAVPPQTLYNPAQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CUL4A-TMEM255B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CUL4A-TMEM255B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CUL4A-TMEM255B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource