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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CUL4B-CUL4B (FusionGDB2 ID:20688)

Fusion Gene Summary for CUL4B-CUL4B

Fusion gene summary

Fusion gene information	Fusion gene name: CUL4B-CUL4B
	Fusion gene ID: 20688
		Hgene	Tgene
	Gene symbol	CUL4B	CUL4B
	Gene ID	8450	8450
	Gene name	cullin 4B	cullin 4B
	Synonyms	CUL-4B\|MRXHF2\|MRXS15\|MRXSC\|SFM2	CUL-4B\|MRXHF2\|MRXS15\|MRXSC\|SFM2
	Cytomap	Xq24	Xq24
	Type of gene	protein-coding	protein-coding
	Description	cullin-4B	cullin-4B
	Modification date	20200327	20200327
	UniProtAcc	Q13620	Q13620
	Ensembl transtripts involved in fusion gene	ENST00000336592, ENST00000371322, ENST00000404115, ENST00000486604,	ENST00000336592, ENST00000371322, ENST00000404115, ENST00000486604,
Fusion gene scores	* DoF score	5 X 6 X 4=120	7 X 7 X 4=196
	# samples	6	8
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CUL4B [Title/Abstract] AND CUL4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CUL4B(119659462)-CUL4B(119659434), # samples:1 CUL4B(119672012)-CUL4B(119670891), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CUL4B	GO:0010498	proteasomal protein catabolic process	25970626
Hgene	CUL4B	GO:0035518	histone H2A monoubiquitination	22334663
Hgene	CUL4B	GO:0070914	UV-damage excision repair	22334663
Tgene	CUL4B	GO:0010498	proteasomal protein catabolic process	25970626
Tgene	CUL4B	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	CUL4B	GO:0070914	UV-damage excision repair	22334663

Fusion gene breakpoints across CUL4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CUL4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA654662	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
ChiTaRS5.0	N/A	CS190803	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-

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Fusion Gene ORF analysis for CUL4B-CUL4B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000336592	ENST00000336592	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000336592	ENST00000371322	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000336592	ENST00000404115	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000371322	ENST00000336592	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000371322	ENST00000371322	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000371322	ENST00000404115	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000404115	ENST00000336592	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000404115	ENST00000371322	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000404115	ENST00000404115	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000486604	ENST00000336592	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000486604	ENST00000371322	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3CDS	ENST00000486604	ENST00000404115	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-3UTR	ENST00000336592	ENST00000371322	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-3UTR	ENST00000371322	ENST00000371322	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-3UTR	ENST00000404115	ENST00000371322	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-3UTR	ENST00000486604	ENST00000371322	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000336592	ENST00000336592	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000336592	ENST00000404115	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000336592	ENST00000486604	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000336592	ENST00000486604	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-intron	ENST00000371322	ENST00000336592	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000371322	ENST00000404115	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000371322	ENST00000486604	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000371322	ENST00000486604	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-intron	ENST00000404115	ENST00000336592	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000404115	ENST00000404115	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000404115	ENST00000486604	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000404115	ENST00000486604	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-
intron-intron	ENST00000486604	ENST00000336592	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000486604	ENST00000404115	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000486604	ENST00000486604	CUL4B	chrX	119659462	-	CUL4B	chrX	119659434	+
intron-intron	ENST00000486604	ENST00000486604	CUL4B	chrX	119672012	+	CUL4B	chrX	119670891	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CUL4B-CUL4B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUL4B-CUL4B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:119659462/:119659434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CUL4B Q13620	CUL4B Q13620
FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:16322693, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18235224, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:19801544, ECO:0000269\|PubMed:22118460, ECO:0000269\|PubMed:26711351}.	FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:16322693, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18235224, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:19801544, ECO:0000269\|PubMed:22118460, ECO:0000269\|PubMed:26711351}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CUL4B-CUL4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CUL4B-CUL4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CUL4B-CUL4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CUL4B-CUL4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source