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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CXCR4-CFLAR (FusionGDB2 ID:20840)

Fusion Gene Summary for CXCR4-CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CXCR4-CFLAR
	Fusion gene ID: 20840
		Hgene	Tgene
	Gene symbol	CXCR4	CFLAR
	Gene ID	7852	8837
	Gene name	C-X-C motif chemokine receptor 4	CASP8 and FADD like apoptosis regulator
	Synonyms	CD184\|D2S201E\|FB22\|HM89\|HSY3RR\|LAP-3\|LAP3\|LCR1\|LESTR\|NPY3R\|NPYR\|NPYRL\|NPYY3R\|WHIM\|WHIMS	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS\|cFLIP
	Cytomap	2q22.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	C-X-C chemokine receptor type 4CD184 antigenLPS-associated protein 3SDF-1 receptorchemokine (C-X-C motif) receptor 4chemokine receptorfusinleukocyte-derived seven transmembrane domain receptorlipopolysaccharide-associated protein 3neuropeptide Y	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20200313	20200322
	UniProtAcc	.	O15519
	Ensembl transtripts involved in fusion gene	ENST00000241393, ENST00000409817, ENST00000466288,	ENST00000309955, ENST00000340870, ENST00000341222, ENST00000341582, ENST00000342795, ENST00000355558, ENST00000395148, ENST00000423241, ENST00000440180, ENST00000443227, ENST00000479953, ENST00000494258, ENST00000457277, ENST00000490965,
Fusion gene scores	* DoF score	12 X 4 X 4=192	10 X 11 X 6=660
	# samples	14	14
	** MAII score	log2(14/192*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/660*10)=-2.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CXCR4 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CXCR4(136875616)-CFLAR(201994452), # samples:3
Anticipated loss of major functional domain due to fusion event.	CXCR4-CFLAR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CXCR4-CFLAR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CXCR4-CFLAR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CXCR4	GO:0007186	G protein-coupled receptor signaling pathway	10644702
Hgene	CXCR4	GO:0030155	regulation of cell adhesion	19703720
Hgene	CXCR4	GO:0038160	CXCL12-activated CXCR4 signaling pathway	28978524
Hgene	CXCR4	GO:0071345	cellular response to cytokine stimulus	21540189
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene breakpoints across CXCR4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFLAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	DLBC	TCGA-FA-A6HN-01A	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
ChimerDB4	DLBC	TCGA-FA-A6HN-01A	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
ChimerDB4	DLBC	TCGA-FA-A6HN	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+

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Fusion Gene ORF analysis for CXCR4-CFLAR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000241393	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000309955	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000340870	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000341222	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000341582	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000342795	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000355558	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000395148	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000423241	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000440180	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-5UTR	ENST00000241393	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-5UTR	ENST00000241393	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-intron	ENST00000241393	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-intron	ENST00000241393	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000443227	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-intron	ENST00000241393	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-intron	ENST00000241393	ENST00000457277	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-intron	ENST00000241393	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000479953	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-intron	ENST00000241393	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
5CDS-intron	ENST00000241393	ENST00000490965	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
5CDS-intron	ENST00000241393	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000494258	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
Frame-shift	ENST00000241393	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-3CDS	ENST00000409817	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-3CDS	ENST00000466288	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000309955	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000340870	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000341222	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000341582	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000342795	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000355558	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000395148	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000423241	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000440180	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000409817	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000409817	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000309955	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000340870	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000341222	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000341582	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000342795	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000355558	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000395148	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000423241	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000440180	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-5UTR	ENST00000466288	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-5UTR	ENST00000466288	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000409817	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000409817	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000443227	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000409817	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000409817	ENST00000457277	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000409817	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000479953	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000409817	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000409817	ENST00000490965	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000409817	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000494258	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000466288	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000466288	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000443227	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000466288	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000466288	ENST00000457277	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000466288	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000479953	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000466288	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201997752	+
intron-intron	ENST00000466288	ENST00000490965	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+
intron-intron	ENST00000466288	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000494258	CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CXCR4-CFLAR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CXCR4	chr2	136875615	-	CFLAR	chr2	201997751	+	0.48884457	0.5111554
CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+	0.17906764	0.8209324
CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+	0.17906764	0.8209324
CXCR4	chr2	136875615	-	CFLAR	chr2	201997751	+	0.48884457	0.5111554
CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+	0.17906764	0.8209324
CXCR4	chr2	136875615	-	CFLAR	chr2	201994451	+	0.17906764	0.8209324

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CXCR4-CFLAR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:136875616/:201994452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CFLAR O15519
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269\|PubMed:9880531}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CXCR4-CFLAR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CXCR4-CFLAR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CXCR4-CFLAR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CXCR4-CFLAR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source