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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CXorf23-SH3KBP1 (FusionGDB2 ID:20862)

Fusion Gene Summary for CXorf23-SH3KBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CXorf23-SH3KBP1
Fusion gene ID: 20862
HgeneTgene
Gene symbol

CXorf23

SH3KBP1

Gene ID

256643

30011

Gene nameBCLAF1 and THRAP3 family member 3SH3 domain containing kinase binding protein 1
SynonymsCXorf23AGMX2|CD2BP3|CIN85|GIG10|HSB-1|HSB1|IMD61|MIG18
Cytomap

Xp22.12

Xp22.12

Type of geneprotein-codingprotein-coding
DescriptionBCLAF1 and THRAP3 family member 3uncharacterized protein CXorf23SH3 domain-containing kinase-binding protein 1CD2-binding protein 3SH3-domain kinase binding protein 1Src family kinase-binding protein 1c-Cbl-interacting proteincbl-interacting protein of 85 kDahuman Src family kinase-binding protein 1migration-in
Modification date2020031320200327
UniProtAcc.

SHKBP1

Ensembl transtripts involved in fusion geneENST00000379682, ENST00000379687, 
ENST00000356980, ENST00000451208, 
ENST00000379697, ENST00000379698, 
ENST00000379716, ENST00000477102, 
ENST00000541422, ENST00000397821, 
Fusion gene scores* DoF score2 X 2 X 2=815 X 16 X 7=1680
# samples 216
** MAII scorelog2(2/8*10)=1.32192809488736log2(16/1680*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CXorf23 [Title/Abstract] AND SH3KBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCXorf23(19953927)-SH3KBP1(19764559), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CXorf23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH3KBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR188385CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-


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Fusion Gene ORF analysis for CXorf23-SH3KBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379682ENST00000379697CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379682ENST00000379698CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379682ENST00000379716CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379682ENST00000477102CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379682ENST00000541422CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379687ENST00000379697CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379687ENST00000379698CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379687ENST00000379716CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379687ENST00000477102CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
5CDS-intronENST00000379687ENST00000541422CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
In-frameENST00000379682ENST00000397821CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
In-frameENST00000379687ENST00000397821CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-3CDSENST00000356980ENST00000397821CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-3CDSENST00000451208ENST00000397821CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000356980ENST00000379697CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000356980ENST00000379698CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000356980ENST00000379716CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000356980ENST00000477102CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000356980ENST00000541422CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000451208ENST00000379697CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000451208ENST00000379698CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000451208ENST00000379716CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000451208ENST00000477102CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-
intron-intronENST00000451208ENST00000541422CXorf23chrX

19953927

-SH3KBP1chrX

19764559

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379687CXorf23chrX19953927-ENST00000397821SH3KBP1chrX19764559-617518973437321232
ENST00000379682CXorf23chrX19953927-ENST00000397821SH3KBP1chrX19764559-626219843438191261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379687ENST00000397821CXorf23chrX19953927-SH3KBP1chrX19764559-0.0001626690.9998373
ENST00000379682ENST00000397821CXorf23chrX19953927-SH3KBP1chrX19764559-0.0001655320.9998344

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Fusion Genomic Features for CXorf23-SH3KBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CXorf23-SH3KBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:19953927/chrX:19764559)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SH3KBP1

SHKBP1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.707

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379698017602_66417629.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379716013602_6640428.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000397821118602_66454666.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379698017327_42817629.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379716013327_4280428.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000397821118327_42854666.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379698017267_32817629.0DomainSH3 3
TgeneSH3KBP1chrX:19953927chrX:19764559ENST0000037969801798_15717629.0DomainSH3 2
TgeneSH3KBP1chrX:19953927chrX:19764559ENST000003797160131_580428.0DomainSH3 1
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000379716013267_3280428.0DomainSH3 3
TgeneSH3KBP1chrX:19953927chrX:19764559ENST0000037971601398_1570428.0DomainSH3 2
TgeneSH3KBP1chrX:19953927chrX:19764559ENST00000397821118267_32854666.0DomainSH3 3
TgeneSH3KBP1chrX:19953927chrX:19764559ENST0000039782111898_15754666.0DomainSH3 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3KBP1chrX:19953927chrX:19764559ENST000003796980171_5817629.0DomainSH3 1
TgeneSH3KBP1chrX:19953927chrX:19764559ENST000003978211181_5854666.0DomainSH3 1


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Fusion Gene Sequence for CXorf23-SH3KBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20862_20862_1_CXorf23-SH3KBP1_CXorf23_chrX_19953927_ENST00000379682_SH3KBP1_chrX_19764559_ENST00000397821_length(transcript)=6262nt_BP=1984nt
TGTAAAAAGTGGATAGTGGCTCACGTGTCAAAGGATGGCACGGTCACGATCTAGATCCCCCAGGTGGAAACACAGGTCTTTATCACCAGT
ACCTAGAAATGCTGAACACTACAAGCAAAGACATTCACACGGGCATTATGGCTGTGAATATAGGAAGGATCCAAAAAGACCCGTCGCGTG
GAGAATGGACAGTGAGAAACATGGACAGAGTAAACCAAGGATTCCCTCTCGTGGAAATATATATTACCAGTCTTATGAACATAGATCACC
TTCCCCTAACATAAGAAACTCTTTAGAAAATGTTTATATGTATAAGCCTCACAGAGGATATTCGCCTGGAAGAGGGGACAGTAACAGGAG
AGCTCAGTATATGCCCAAATACTCAGAGGGTATACCCTACAAAGAGCATGAAAGGAATTCTTATCCCCAGAAAGTGCAAGGAGGGCATAG
TCCTGATGACCACAGAGTTAGAGGAAGTGGAAAAGGAGGGAAACCACCTCAGAGGTCAATAGCAGATTCTTTTAGATTTGAAGGAAAGTG
GCATGAAGATGAGTTGAGGCACCAGAGGATACAAGAAGAAAAATACTCCCAGTCAACTAGAAGAGGCTCTGAAGACTTTGAGACAAGGAG
CTCATTTCAGAAGAGGTATCCTGAGGATCGTGATTTCAGAAAATATGGACACACATCAAAAAGACCTAAAGACGTGGAGAGGTATGAAAG
CAGAGAGCCTGCCAGGAACCCAAAGTGGAAGCCTGAGCATTCCCTCCCACCTTACCAAGAGGACACAGACCAGTGGAACCTTGGGCCCCA
AACTTATCGACATGCTGAGAGGGAACACCCAGAGACCAGTTCAGCAACCAAAGTATCCTATGACTATCGTCACAAACGTCCTAAGCTCTT
GGATGGGGACCAGGACTTTTCTGATGGGAGAACTCAGAAGTACTGTAAGGAAGAAGATAGAAAATATAGTTTTCAAAAAGGCCCTCTAAA
TAGAGAGTTAGATTGTTTTAATACTGGAAGAGGGAGAGAGACTCAAGATGGACAAGTCAAAGAACCTTTTAAACCGTCTAAGAAAGACAG
CATTGCCTGTACTTATTCAAATAAAAATGATGTTGATTTGCGATCTAGTAATGACAAATGGAAGGAAAAAATAAAGAAAGAAGGGGATTG
TAGAAAAGAGAGCAATTCTTCCAGTAACCAACTTGATAAAAGTCAAAAACTTCCTGATGTGAAACCCTCGCCTATCAATCTTAGGAAGAA
ATCACTTACAGTTAAAGTAGATGTGAAGAAAACAGTAGATACATTCAGGGTTGCTTCTAGCTATTCCACAGAGAGACAGATGTCACATGA
TTTGGTTGCTGTTGGCAGGAAAAGTGAGAACTTTCATCCAGTGTTTGAACATCTTGACTCAACTCAGAATACTGAAAACAAACCTACAGG
AGAATTTGCTCAGGAAATCATAACAATAATCCATCAAGTTAAAGCAAATTATTTTCCATCACCTGGCATTACTTTACATGAGCGTTTCTC
AACAATGCAAGATATACACAAGGCAGATGTAAATGAAATTCCATTGAATTCAGATCCAGAAATACACAGGAGAATAGATATGTCTTTGGC
CGAGCTTCAGAGTAAACAAGCTGTGATCTATGAATCGGAACAGACTCTGATCAAAATAATAGATCCAAATGACCTACGACATGACATTGA
AAGAAGGCGAAAAGAACGGTTACAGAATGAAGATGAGCACATTTTTCACATAGCTAGTGCTGCAGAGAGGGATGATCAGAATTCCAGTTT
TTCAAAGGTAAAGAATGTTCATACTGATGGATTCCAAAAACCCACACATTTTATAAAATCAAATTTTAGAAAATGTATTGAAAAACCTTA
CATGAATTATACTACGCAGAGAAAAGACATAATTACTCACAAACCATTTGAGGTTGAGGGAAACCACCGAAACACAAGAGTAAGACCTTT
TAAGGAAATAAAGAAAGAGATGAAGAAAGACCCTCTCACCAACAAAGCTCCAGAAAAGCCCCTGCACGAAGTGCCCAGTGGAAACTCTTT
GCTGTCTTCTGAAACGATTTTAAGAACCAATAAGAGAGGCGAGCGACGGAGGCGCCGGTGCCAGGTGGCATTCAGCTACCTGCCCCAGAA
TGACGATGAACTTGAGCTGAAAGTTGGCGACATCATAGAGGTGGTAGGAGAGGTAGAGGAAGGATGGTGGGAAGGTGTTCTCAACGGGAA
GACTGGAATGTTTCCTTCCAACTTCATCAAGGAGCTGTCAGGGGAGTCGGATGAGCTTGGCATTTCCCAGGATGAGCAGCTATCCAAGTC
AAGTTTAAGGGAAACCACAGGCTCCGAGAGTGATGGGGGTGACTCAAGCAGCACCAAGTCTGAAGGTGCCAACGGGACAGTGGCAACTGC
AGCAATCCAGCCCAAGAAAGTTAAGGGAGTGGGCTTTGGAGACATTTTCAAAGACAAGCCAATCAAACTAAGACCAAGGTCAATTGAAGT
AGAAAATGACTTTCTGCCGGTAGAAAAGACTATTGGGAAGAAGTTACCTGCAACTACAGCAACTCCAGACTCATCAAAAACAGAAATGGA
CAGCAGGACAAAGAGCAAGGATTACTGCAAAGTAATATTTCCATATGAGGCACAGAATGATGATGAATTGACAATCAAAGAAGGAGATAT
AGTCACTCTCATCAATAAGGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCTGAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGT
GAAGTTACTTCCACCGGACTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACCGCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGG
CACCACTGAGAGAAAACATGAAATTAAAAAGATACCTCCTGAAAGACCAGAAATGCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGA
GAGAGAGCCAAAACTGGATTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAAAAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAG
ACCTGGCGCACTGCCCCCGAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACACACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGG
CAGTTCGCTATCTGGCATCCTGGACAAAGATCTCTCGGACCGCAGCAATGACATTGACTTAGAAGGTTTTGACTCCGTGGTATCATCTAC
TGAGAAACTCAGTCATCCGACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCCTCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAG
CCCTGATATCTTCGACTCCCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTCACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAAC
TTCCAAGACTGTTACCATATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCCCAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCC
AGCCCCTCTGTCCTCAGCGGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGCTGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCAC
GGAAGGAAAACCAAAGATGGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGAGCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCAT
CGAGACCATGAAGGACCAGCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTTGGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGAT
GGAAGTGAACGACATAAAGAAAGCTCTACAATCAAAATGAATACTTGATCAATGAAATGTCACATTATTCATCCTGAGTCCGAGACTCAA
ATTTTCTGCCCCAGCCAAAATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCAAAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTT
GATAGCACAACACAAATTCCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCCTGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAA
ATTGTGCTAAAGGCTTTTCTACTCTGAGATCTCAATGCGAAATGAAAACTCAGGCAGTTTAGTCCATAGTGGTACTATTTTGATGATATT
TTCCATTAATAAAATGTAATTTCAGATTATTCGTTTACAAGCTTTATAATTTTATGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTA
GTGTTTGTACTACACGTAGTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCTAAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATT
CTATTACATATGCAATTGTAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCCCACCACCCTAAGAGAAATTTTAGCTTATATATGACG
GTATATTTACAAAAAGAGAAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCTTCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGAT
GCAGCTACCATGATTCAAAAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTTATCCAAGTCCACTAGAGGCCACTGTCTTCAAAGCTT
CTCTCACCCTAGCCAAAGGTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCTCTGTGGTACCAGCTGTGACTTTTCTATTTCTCCTAG
TTTTAGGTTGTTCATGAAACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCCAAGTTAAACCCCTGCTTTCTGTCCTTTGCACCTTTT
GCGTGAACAGAATATGCATTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAATGAAAACAAGGGAGGGAAAGTTGTATTATTTCCTGC
ACTGGGTTACCCGTGTGTGTTATCGTTTAAACTGTATTCACATAATGTCATTTGCCTTGCTCACTTGTAACCCCTTCCTCAGGTCCAAGA
GAATGGGAGGAGGGTCATGTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTATGGAGTTGCTTTTTCTTTCCCAAGGAAACTGATGTTT
GCCTGTCCGCTTTATCTTTGTAGTACATGAACAGTTCAGCCTTAGACTATGTAACTGTTTTCTCATCCTTAGCTGAAAATGAGGGGCCTA
CTGTATTGCGAGACTGTTCAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGCCCCTGAAGATGTTGGATGTGTTTCTCAAAAGCTGCT
TTGTCTCTTTCCTGAGTTTAATAGTGAAACTACTAAACATTAATAGATTTGCACAGCCACAAAGAATGAGAGTTGATAATACCGAAGAAG
TGATGCAAAAACAAAAAATCACATTACTGATCATTGATAGTATTACAAATAAATGTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCCTGC
CTTCCTCTTAACCTATGTGCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCCGAGTATTTAAGGAGCCCAAACACCTTGGTCTTCCTG
GGTGGGGGCATAATTAAGGGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCTCCATTCCCATCCCTGGATATATTGCCTTTTCAGCAG
CCTCGGGTTCAGTGTGCTTGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTAAAACATCCCTGTACCCCTTGACAGTTATAAGCATTT
CTGCGTTAAACTTGAAGATTCCAGAGATTCCCCACGACCTAATGATCTAAGAATGCAGATTGGATTCTTTGATGTTCAAATTTCTCATTT
ACTTATGAAAATCCCTAATTATATAGTTTTATATAATGTGTATACAGAGTAGGATTGTTGATGAAATTGAGCGGTTGGAACACCCTCATG
GAACACTGGCAACATGGAATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCCATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGTGAT
TCTGGAAGGAGAAGTTGGTATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCAGCAAGAGGATTCTGCATCAAGGAACTGGACGAGCCG
CTACCCAAACTGCCACCATCTTTACTCTTTACAAAATGGACCCATCGAGAATGTTGAAAAGCTTGGAAGTATCACTTTTGAAAAAAAAAA
AAATTATTTTGCATTCAGCATGGACTCGACCAGGCATCTATGGAGATTATTTTTTTGCTTCATTTTATAAAGTTGTATTTAGAAAAGTCT

>20862_20862_1_CXorf23-SH3KBP1_CXorf23_chrX_19953927_ENST00000379682_SH3KBP1_chrX_19764559_ENST00000397821_length(amino acids)=1261AA_BP=0
MARSRSRSPRWKHRSLSPVPRNAEHYKQRHSHGHYGCEYRKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSYEHRSPSPNIRNSLENV
YMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYKEHERNSYPQKVQGGHSPDDHRVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQRIQ
EEKYSQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKDVERYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPE
TSSATKVSYDYRHKRPKLLDGDQDFSDGRTQKYCKEEDRKYSFQKGPLNRELDCFNTGRGRETQDGQVKEPFKPSKKDSIACTYSNKNDV
DLRSSNDKWKEKIKKEGDCRKESNSSSNQLDKSQKLPDVKPSPINLRKKSLTVKVDVKKTVDTFRVASSYSTERQMSHDLVAVGRKSENF
HPVFEHLDSTQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDIHKADVNEIPLNSDPEIHRRIDMSLAELQSKQAVIYE
SEQTLIKIIDPNDLRHDIERRRKERLQNEDEHIFHIASAAERDDQNSSFSKVKNVHTDGFQKPTHFIKSNFRKCIEKPYMNYTTQRKDII
THKPFEVEGNHRNTRVRPFKEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDI
IEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVG
FGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDV
GWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPS
VPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRP
KATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPL
SSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQS

--------------------------------------------------------------
>20862_20862_2_CXorf23-SH3KBP1_CXorf23_chrX_19953927_ENST00000379687_SH3KBP1_chrX_19764559_ENST00000397821_length(transcript)=6175nt_BP=1897nt
TGTAAAAAGTGGATAGTGGCTCACGTGTCAAAGGATGGCACGGTCACGATCTAGATCCCCCAGGTGGAAACACAGGTCTTTATCACCAGT
ACCTAGAAATGCTGAACACTACAAGCAAAGACATTCACACGGGCATTATGGCTGTGAATATAGGAAGGATCCAAAAAGACCCGTCGCGTG
GAGAATGGACAGTGAGAAACATGGACAGAGTAAACCAAGGATTCCCTCTCGTGGAAATATATATTACCAGTCTTATGAACATAGATCACC
TTCCCCTAACATAAGAAACTCTTTAGAAAATGTTTATATGTATAAGCCTCACAGAGGATATTCGCCTGGAAGAGGGGACAGTAACAGGAG
AGCTCAGTATATGCCCAAATACTCAGAGGGTATACCCTACAAAGAGCATGAAAGGAATTCTTATCCCCAGAAAGTGCAAGGAGGGCATAG
TCCTGATGACCACAGAGTTAGAGGAAGTGGAAAAGGAGGGAAACCACCTCAGAGGTCAATAGCAGATTCTTTTAGATTTGAAGGAAAGTG
GCATGAAGATGAGTTGAGGCACCAGAGGATACAAGAAGAAAAATACTCCCAGTCAACTAGAAGAGGCTCTGAAGACTTTGAGACAAGGAG
CTCATTTCAGAAGAGGTATCCTGAGGATCGTGATTTCAGAAAATATGGACACACATCAAAAAGACCTAAAGACGTGGAGAGGTATGAAAG
CAGAGAGCCTGCCAGGAACCCAAAGTGGAAGCCTGAGCATTCCCTCCCACCTTACCAAGAGGACACAGACCAGTGGAACCTTGGGCCCCA
AACTTATCGACATGCTGAGAGGGAACACCCAGAGACCAGTTCAGCAACCAAAGTATCCTATGACTATCGTCACAAACGTCCTAAGCTCTT
GGATGGGGACCAGGACTTTTCTGATGGGAGAACTCAGAAGTACTGTAAGGAAGAAGATAGAAAATATAGTTTTCAAAAAGGCCCTCTAAA
TAGAGAGTTAGATTGTTTTAATACTGGAAGAGGGAGAGAGACTCAAGATGGACAAGTCAAAGAACCTTTTAAACCGTCTAAGAAAGACAG
CATTGCCTGTACTTATTCAAATAAAAATGATGTTGATTTGCGATCTAGTAATGACAAATGGAAGGAAAAAATAAAGAAAGAAGGGGATTG
TAGAAAAGAGAGCAATTCTTCCAGTAACCAACTTGATAAAAGTCAAAAACTTCCTGATGTGAAACCCTCGCCTATCAATCTTAGGAAGAA
ATCACTTACAGTTAAAGTAGATGTGAAGAAAACAGTAGATACATTCAGGGTTGCTTCTAGCTATTCCACAGAGAGACAGATGTCACATGA
TTTGGTTGCTGTTGGCAGGAAAAGTGAGAACTTTCATCCAGTGTTTGAACATCTTGACTCAACTCAGAATACTGAAAACAAACCTACAGG
AGAATTTGCTCAGGAAATCATAACAATAATCCATCAAGTTAAAGCAAATTATTTTCCATCACCTGGCATTACTTTACATGAGCGTTTCTC
AACAATGCAAGATATACACAAGGCAGATGTAAATGAAATTCCATTGAATTCAGATCCAGAAATACACAGGAGAATAGATATGTCTTTGGC
CGAGCTTCAGAGTAAACAAGCTGTGATCTATGAATCGGAACAGACTCTGATCAAAATAATAGATCCAAATGACCTACGACATGACATTGA
AAGAAGGCGAAAAGAACGGTTACAGAATGAAGATGAGCACATTTTTCACATAGCTAGTGCTGCAGAGAGGGATGATCAGAATTCCAGTTT
TTCAAAGAATTATACTACGCAGAGAAAAGACATAATTACTCACAAACCATTTGAGGTTGAGGGAAACCACCGAAACACAAGAGTAAGACC
TTTTAAGGAAATAAAGAAAGAGATGAAGAAAGACCCTCTCACCAACAAAGCTCCAGAAAAGCCCCTGCACGAAGTGCCCAGTGGAAACTC
TTTGCTGTCTTCTGAAACGATTTTAAGAACCAATAAGAGAGGCGAGCGACGGAGGCGCCGGTGCCAGGTGGCATTCAGCTACCTGCCCCA
GAATGACGATGAACTTGAGCTGAAAGTTGGCGACATCATAGAGGTGGTAGGAGAGGTAGAGGAAGGATGGTGGGAAGGTGTTCTCAACGG
GAAGACTGGAATGTTTCCTTCCAACTTCATCAAGGAGCTGTCAGGGGAGTCGGATGAGCTTGGCATTTCCCAGGATGAGCAGCTATCCAA
GTCAAGTTTAAGGGAAACCACAGGCTCCGAGAGTGATGGGGGTGACTCAAGCAGCACCAAGTCTGAAGGTGCCAACGGGACAGTGGCAAC
TGCAGCAATCCAGCCCAAGAAAGTTAAGGGAGTGGGCTTTGGAGACATTTTCAAAGACAAGCCAATCAAACTAAGACCAAGGTCAATTGA
AGTAGAAAATGACTTTCTGCCGGTAGAAAAGACTATTGGGAAGAAGTTACCTGCAACTACAGCAACTCCAGACTCATCAAAAACAGAAAT
GGACAGCAGGACAAAGAGCAAGGATTACTGCAAAGTAATATTTCCATATGAGGCACAGAATGATGATGAATTGACAATCAAAGAAGGAGA
TATAGTCACTCTCATCAATAAGGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCTGAACGGCAGACGAGGCGTGTTCCCCGATAACTT
CGTGAAGTTACTTCCACCGGACTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACCGCCTCCATCCGCTCCTGTCATCAAACAAGGGGC
AGGCACCACTGAGAGAAAACATGAAATTAAAAAGATACCTCCTGAAAGACCAGAAATGCTTCCAAACAGAACAGAAGAAAAAGAAAGACC
AGAGAGAGAGCCAAAACTGGATTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAAAAAGCCTCGGCCACCTAAGACCAATTCTCTCAG
CAGACCTGGCGCACTGCCCCCGAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACACACCAGGGGTGACAGTCCAAAGATTGACTTGGC
CGGCAGTTCGCTATCTGGCATCCTGGACAAAGATCTCTCGGACCGCAGCAATGACATTGACTTAGAAGGTTTTGACTCCGTGGTATCATC
TACTGAGAAACTCAGTCATCCGACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCCTCCGTCCCAGTCCCTCACATCTTCATCCCTTTC
AAGCCCTGATATCTTCGACTCCCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTCACTTGCGCACAGAGGAGTGGACGCGTCAAAGAA
AACTTCCAAGACTGTTACCATATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCCCAAGCCGGGGACCATGGCAGCAGGTGGCGGTGG
GCCAGCCCCTCTGTCCTCAGCGGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGCTGGACACAGAGCCAACTCCCCGTCTCTGTTCGG
CACGGAAGGAAAACCAAAGATGGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGAGCTAAGGACACAGGTCCGCGAGCTGAGGAGCAT
CATCGAGACCATGAAGGACCAGCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTTGGATGAAGAGAAGAAAATCCGGCTTCGGTTGCA
GATGGAAGTGAACGACATAAAGAAAGCTCTACAATCAAAATGAATACTTGATCAATGAAATGTCACATTATTCATCCTGAGTCCGAGACT
CAAATTTTCTGCCCCAGCCAAAATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCAAAATGTCCCTGTTTGAAAGATTAGCACAAAAGT
CTTGATAGCACAACACAAATTCCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCCTGGGGCTGGCACTCGTTGTGACTTACACAGAGC
AAAATTGTGCTAAAGGCTTTTCTACTCTGAGATCTCAATGCGAAATGAAAACTCAGGCAGTTTAGTCCATAGTGGTACTATTTTGATGAT
ATTTTCCATTAATAAAATGTAATTTCAGATTATTCGTTTACAAGCTTTATAATTTTATGATTTTTTAATCGTGTTTTGTCACAGACTTCC
CTAGTGTTTGTACTACACGTAGTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCTAAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGG
ATTCTATTACATATGCAATTGTAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCCCACCACCCTAAGAGAAATTTTAGCTTATATATG
ACGGTATATTTACAAAAAGAGAAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCTTCTTTTTACCACCCTCTTGATTGGAGCTTTTGT
GATGCAGCTACCATGATTCAAAAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTTATCCAAGTCCACTAGAGGCCACTGTCTTCAAAG
CTTCTCTCACCCTAGCCAAAGGTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCTCTGTGGTACCAGCTGTGACTTTTCTATTTCTCC
TAGTTTTAGGTTGTTCATGAAACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCCAAGTTAAACCCCTGCTTTCTGTCCTTTGCACCT
TTTGCGTGAACAGAATATGCATTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAATGAAAACAAGGGAGGGAAAGTTGTATTATTTCC
TGCACTGGGTTACCCGTGTGTGTTATCGTTTAAACTGTATTCACATAATGTCATTTGCCTTGCTCACTTGTAACCCCTTCCTCAGGTCCA
AGAGAATGGGAGGAGGGTCATGTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTATGGAGTTGCTTTTTCTTTCCCAAGGAAACTGATG
TTTGCCTGTCCGCTTTATCTTTGTAGTACATGAACAGTTCAGCCTTAGACTATGTAACTGTTTTCTCATCCTTAGCTGAAAATGAGGGGC
CTACTGTATTGCGAGACTGTTCAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGCCCCTGAAGATGTTGGATGTGTTTCTCAAAAGCT
GCTTTGTCTCTTTCCTGAGTTTAATAGTGAAACTACTAAACATTAATAGATTTGCACAGCCACAAAGAATGAGAGTTGATAATACCGAAG
AAGTGATGCAAAAACAAAAAATCACATTACTGATCATTGATAGTATTACAAATAAATGTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCC
TGCCTTCCTCTTAACCTATGTGCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCCGAGTATTTAAGGAGCCCAAACACCTTGGTCTTC
CTGGGTGGGGGCATAATTAAGGGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCTCCATTCCCATCCCTGGATATATTGCCTTTTCAG
CAGCCTCGGGTTCAGTGTGCTTGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTAAAACATCCCTGTACCCCTTGACAGTTATAAGCA
TTTCTGCGTTAAACTTGAAGATTCCAGAGATTCCCCACGACCTAATGATCTAAGAATGCAGATTGGATTCTTTGATGTTCAAATTTCTCA
TTTACTTATGAAAATCCCTAATTATATAGTTTTATATAATGTGTATACAGAGTAGGATTGTTGATGAAATTGAGCGGTTGGAACACCCTC
ATGGAACACTGGCAACATGGAATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCCATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGT
GATTCTGGAAGGAGAAGTTGGTATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCAGCAAGAGGATTCTGCATCAAGGAACTGGACGAG
CCGCTACCCAAACTGCCACCATCTTTACTCTTTACAAAATGGACCCATCGAGAATGTTGAAAAGCTTGGAAGTATCACTTTTGAAAAAAA
AAAAAATTATTTTGCATTCAGCATGGACTCGACCAGGCATCTATGGAGATTATTTTTTTGCTTCATTTTATAAAGTTGTATTTAGAAAAG

>20862_20862_2_CXorf23-SH3KBP1_CXorf23_chrX_19953927_ENST00000379687_SH3KBP1_chrX_19764559_ENST00000397821_length(amino acids)=1232AA_BP=0
MARSRSRSPRWKHRSLSPVPRNAEHYKQRHSHGHYGCEYRKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSYEHRSPSPNIRNSLENV
YMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYKEHERNSYPQKVQGGHSPDDHRVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQRIQ
EEKYSQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKDVERYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPE
TSSATKVSYDYRHKRPKLLDGDQDFSDGRTQKYCKEEDRKYSFQKGPLNRELDCFNTGRGRETQDGQVKEPFKPSKKDSIACTYSNKNDV
DLRSSNDKWKEKIKKEGDCRKESNSSSNQLDKSQKLPDVKPSPINLRKKSLTVKVDVKKTVDTFRVASSYSTERQMSHDLVAVGRKSENF
HPVFEHLDSTQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDIHKADVNEIPLNSDPEIHRRIDMSLAELQSKQAVIYE
SEQTLIKIIDPNDLRHDIERRRKERLQNEDEHIFHIASAAERDDQNSSFSKNYTTQRKDIITHKPFEVEGNHRNTRVRPFKEIKKEMKKD
PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK
ELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKT
IGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKE
GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPE
RPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPE
EDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAA

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Fusion Gene PPI Analysis for CXorf23-SH3KBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CXorf23-SH3KBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CXorf23-SH3KBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource