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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYB561A3-CXCL16 (FusionGDB2 ID:20880)

Fusion Gene Summary for CYB561A3-CXCL16

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB561A3-CXCL16
Fusion gene ID: 20880
HgeneTgene
Gene symbol

CYB561A3

CXCL16

Gene ID

220002

58191

Gene namecytochrome b561 family member A3C-X-C motif chemokine ligand 16
SynonymsCYBASC3|LCYTBCXCLG16|SR-PSOX|SRPSOX
Cytomap

11q12.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b ascorbate-dependent protein 3cytochrome b, ascorbate dependent 3lysosomal cytochrome bC-X-C motif chemokine 16CXC chemokine ligand 16chemokine (C-X-C motif) ligand 16scavenger receptor for phosphatidylserine and oxidized low density lipoproteinsmall-inducible cytokine B16transmembrane chemokine CXCL16
Modification date2020032020200313
UniProtAcc

Q8NBI2

Q9H2A7

Ensembl transtripts involved in fusion geneENST00000294072, ENST00000426130, 
ENST00000447532, ENST00000536915, 
ENST00000539890, ENST00000540317, 
ENST00000544118, ENST00000546151, 
ENST00000293778, ENST00000576153, 
ENST00000574412, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 5 X 4=100
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYB561A3 [Title/Abstract] AND CXCL16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYB561A3(61125699)-CXCL16(4637313), # samples:24
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCXCL16

GO:0034097

response to cytokine

18373975

TgeneCXCL16

GO:0034341

response to interferon-gamma

18373975

TgeneCXCL16

GO:0034612

response to tumor necrosis factor

18373975


check buttonFusion gene breakpoints across CYB561A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CXCL16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA86CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4BLCATCGA-GU-AATOCYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4CESCTCGA-DS-A1O9CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4CESCTCGA-UC-A7PICYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4CESCTCGA-VS-A9UOCYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4CESCTCGA-VS-A9UOCYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4CESCTCGA-VS-A9V3CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4CESCTCGA-VS-AA62CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4MESOTCGA-ZN-A9VUCYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4SARCTCGA-DX-A3LY-01BCYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-BR-4191-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-BR-4362-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-BR-4362-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-BR-8058-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-BR-A4PD-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-BR-A4PD-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-BR-A4QI-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-BR-A4QI-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-CG-4475-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-CG-4476-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-CG-4476-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4STADTCGA-CG-4477-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4STADTCGA-EQ-A4SO-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4THYMTCGA-ZB-A969CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-A5-A2K4-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-AJ-A23N-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-AJ-A23N-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-AJ-A3NF-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-AJ-A3NF-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-AJ-A6NU-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-AJ-A6NU-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-AP-A3K1-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-D1-A3DH-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-D1-A3DH-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-D1-A3JQ-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-DF-A2KR-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-DF-A2KR-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-EO-A3AU-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-EO-A3KW-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-EO-A3KW-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-EY-A4KR-01ACYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCECTCGA-EY-A4KR-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCECTCGA-EY-A54A-01ACYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UCSTCGA-N9-A4Q7CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
ChimerDB4UCSTCGA-N9-A4Q7CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
ChimerDB4UVMTCGA-VD-A8KDCYB561A3chr11

61125718

-CXCL16chr17

4637332

-


Top

Fusion Gene ORF analysis for CYB561A3-CXCL16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000294072ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000294072ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000426130ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000426130ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000447532ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000447532ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000536915ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000536915ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000539890ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000539890ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000540317ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000540317ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000544118ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000544118ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-3UTRENST00000546151ENST00000293778CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-3UTRENST00000546151ENST00000293778CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000294072ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000294072ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000426130ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000426130ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000447532ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000447532ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000536915ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000536915ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000539890ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000539890ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000540317ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000540317ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000544118ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000544118ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-5UTRENST00000546151ENST00000576153CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-5UTRENST00000546151ENST00000576153CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000294072ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000294072ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000426130ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000426130ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000447532ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000447532ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000536915ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000536915ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000539890ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000539890ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000540317ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000540317ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000544118ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000544118ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-
intron-intronENST00000546151ENST00000574412CYB561A3chr11

61125718

-CXCL16chr17

4637332

-
intron-intronENST00000546151ENST00000574412CYB561A3chr11

61125699

-CXCL16chr17

4637313

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CYB561A3-CXCL16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CYB561A3-CXCL16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61125699/:4637313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB561A3

Q8NBI2

CXCL16

Q9H2A7

FUNCTION: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity). {ECO:0000250}.FUNCTION: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CYB561A3-CXCL16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CYB561A3-CXCL16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYB561A3-CXCL16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYB561A3-CXCL16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource