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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYB561D2-RBM6 (FusionGDB2 ID:20892)

Fusion Gene Summary for CYB561D2-RBM6

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB561D2-RBM6
Fusion gene ID: 20892
HgeneTgene
Gene symbol

CYB561D2

RBM6

Gene ID

11068

10180

Gene namecytochrome b561 family member D2RNA binding motif protein 6
Synonyms101F6|TSP10|XXcos-LUCA11.43G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b561 domain-containing protein 2putative tumor suppressor protein 101F6transmembrane ascorbate ferrireductaseRNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11
Modification date2020031320200313
UniProtAcc

O14569

.
Ensembl transtripts involved in fusion geneENST00000419046, ENST00000232508, 
ENST00000418577, ENST00000424512, 
ENST00000425346, 		ENST00000441115, 
ENST00000266022, ENST00000422955, 
ENST00000442092, ENST00000443081, 
ENST00000421682, ENST00000539992, 
Fusion gene scores* DoF score7 X 9 X 4=25222 X 21 X 10=4620
# samples 1030
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4620*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYB561D2 [Title/Abstract] AND RBM6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYB561D2(50388991)-RBM6(50085678), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CYB561D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RBM6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A3KW-01ACYB561D2chr3

50388991

-RBM6chr3

50085678

+
ChimerDB4UCECTCGA-EO-A3KW-01ACYB561D2chr3

50388991

+RBM6chr3

50085678

+
ChimerDB4UCECTCGA-EO-A3KWCYB561D2chr3

50388991

+RBM6chr3

50085677

+


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Fusion Gene ORF analysis for CYB561D2-RBM6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000419046ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-3UTRENST00000419046ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-5UTRENST00000419046ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-5UTRENST00000419046ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-5UTRENST00000419046ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-5UTRENST00000419046ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-5UTRENST00000419046ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-5UTRENST00000419046ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-5UTRENST00000419046ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-5UTRENST00000419046ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-intronENST00000419046ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-intronENST00000419046ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085677

+
3UTR-intronENST00000419046ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085678

+
3UTR-intronENST00000419046ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-3UTRENST00000232508ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-3UTRENST00000232508ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-3UTRENST00000418577ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-3UTRENST00000418577ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-3UTRENST00000424512ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-3UTRENST00000424512ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-3UTRENST00000425346ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-3UTRENST00000425346ENST00000441115CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000232508ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000232508ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000232508ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000232508ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000232508ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000232508ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000232508ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000232508ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000418577ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000418577ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000418577ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000418577ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000418577ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000418577ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000418577ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000418577ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000424512ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000424512ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000424512ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000424512ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000424512ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000424512ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000424512ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000424512ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000425346ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000425346ENST00000266022CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000425346ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000425346ENST00000422955CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000425346ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000425346ENST00000442092CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-5UTRENST00000425346ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-5UTRENST00000425346ENST00000443081CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000232508ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000232508ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000232508ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000232508ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000418577ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000418577ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000418577ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000418577ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000424512ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000424512ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000424512ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000424512ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000425346ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000425346ENST00000421682CYB561D2chr3

50388991

+RBM6chr3

50085677

+
5CDS-intronENST00000425346ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085678

+
5CDS-intronENST00000425346ENST00000539992CYB561D2chr3

50388991

+RBM6chr3

50085677

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CYB561D2-RBM6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CYB561D2chr350388991+RBM6chr350085677+0.003340010.99666
CYB561D2chr350388991+RBM6chr350085677+0.003340010.99666
CYB561D2chr350388991+RBM6chr350085677+0.003340010.99666
CYB561D2chr350388991+RBM6chr350085677+0.003340010.99666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CYB561D2-RBM6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50388991/:50085678)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB561D2

O14569

.
FUNCTION: Two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction. {ECO:0000269|PubMed:23235316, ECO:0000269|PubMed:23641721}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CYB561D2-RBM6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CYB561D2-RBM6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYB561D2-RBM6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYB561D2-RBM6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource