FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CYB5A-NRP2 (FusionGDB2 ID:20910)

Fusion Gene Summary for CYB5A-NRP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB5A-NRP2
Fusion gene ID: 20910
HgeneTgene
Gene symbol

CYB5A

NRP2

Gene ID

1528

8828

Gene namecytochrome b5 type Aneuropilin 2
SynonymsCYB5|MCB5|METAGNP2|NPN2|PRO2714|VEGF165R2
Cytomap

18q22.3

2q33.3

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b5cytochrome b5 type A (microsomal)epididymis secretory sperm binding proteintype 1 cyt-b5neuropilin-2neuropilin-2a(17)neuropilin-2a(22)neuropilin-2b(0)receptor for VEGF165 and semaphorins class3vascular endothelial cell growth factor 165 receptor 2
Modification date2020031320200313
UniProtAcc

P00167

O60462

Ensembl transtripts involved in fusion geneENST00000299438, ENST00000340533, 
ENST00000494131, ENST00000397914, 
ENST00000579064, 		ENST00000272849, 
ENST00000355117, ENST00000357118, 
ENST00000357785, ENST00000360409, 
ENST00000412873, ENST00000417189, 
ENST00000485684, ENST00000540178, 
ENST00000540841, 
Fusion gene scores* DoF score10 X 10 X 3=3006 X 5 X 5=150
# samples 106
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYB5A [Title/Abstract] AND NRP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYB5A(71920533)-NRP2(206631535), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CYB5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NRP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV682747CYB5Achr18

71920533

-NRP2chr2

206631535

+


Top

Fusion Gene ORF analysis for CYB5A-NRP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000299438ENST00000272849CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000355117CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000357118CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000357785CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000360409CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000412873CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000417189CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000485684CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000540178CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000299438ENST00000540841CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000272849CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000355117CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000357118CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000357785CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000360409CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000412873CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000417189CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000485684CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000540178CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000340533ENST00000540841CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000272849CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000355117CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000357118CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000357785CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000360409CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000412873CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000417189CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000485684CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000540178CYB5Achr18

71920533

-NRP2chr2

206631535

+
5CDS-intronENST00000494131ENST00000540841CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000272849CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000355117CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000357118CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000357785CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000360409CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000412873CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000417189CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000485684CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000540178CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000397914ENST00000540841CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000272849CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000355117CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000357118CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000357785CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000360409CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000412873CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000417189CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000485684CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000540178CYB5Achr18

71920533

-NRP2chr2

206631535

+
intron-intronENST00000579064ENST00000540841CYB5Achr18

71920533

-NRP2chr2

206631535

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CYB5A-NRP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CYB5A-NRP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:71920533/:206631535)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB5A

P00167

NRP2

O60462

FUNCTION: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.FUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. {ECO:0000269|PubMed:30057110}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CYB5A-NRP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CYB5A-NRP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CYB5A-NRP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CYB5A-NRP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource