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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYLD-HAGH (FusionGDB2 ID:20992)

Fusion Gene Summary for CYLD-HAGH

check button Fusion gene summary
Fusion gene informationFusion gene name: CYLD-HAGH
Fusion gene ID: 20992
HgeneTgene
Gene symbol

CYLD

HAGH

Gene ID

1540

3029

Gene nameCYLD lysine 63 deubiquitinasehydroxyacylglutathione hydrolase
SynonymsBRSS|CDMT|CYLD1|CYLDI|EAC|MFT|MFT1|SBS|TEM|USPL2GLO2|GLX2|GLXII|HAGH1
Cytomap

16q12.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase CYLDcylindromatosis (turban tumor syndrome)deubiquitinating enzyme CYLDprobable ubiquitin carboxyl-terminal hydrolase CYLDubiquitin specific peptidase like 2ubiquitin thioesterase CYLDubiquitin thiolesterase CYLhydroxyacylglutathione hydrolase, mitochondrialglyoxalase IIhydroxyacylglutathione hydroxylase
Modification date2020032920200313
UniProtAcc

Q9NQC7

Q6PII5

Ensembl transtripts involved in fusion geneENST00000311559, ENST00000398568, 
ENST00000427738, ENST00000540145, 
ENST00000564326, ENST00000566206, 
ENST00000568704, ENST00000569418, 
ENST00000566709, ENST00000567398, 
ENST00000397353, ENST00000397356, 
ENST00000455446, 
Fusion gene scores* DoF score6 X 4 X 4=964 X 2 X 4=32
# samples 64
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYLD [Title/Abstract] AND HAGH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYLD(50788335)-HAGH(1859834), # samples:1
Anticipated loss of major functional domain due to fusion event.CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CYLD-HAGH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYLD

GO:0010803

regulation of tumor necrosis factor-mediated signaling pathway

26997266|27458237|27591049

HgeneCYLD

GO:0016579

protein deubiquitination

29291351

HgeneCYLD

GO:0032088

negative regulation of NF-kappaB transcription factor activity

18313383

HgeneCYLD

GO:0045087

innate immune response

26997266

HgeneCYLD

GO:0046329

negative regulation of JNK cascade

29291351

HgeneCYLD

GO:0050727

regulation of inflammatory response

27591049

HgeneCYLD

GO:0060544

regulation of necroptotic process

27458237

HgeneCYLD

GO:0070536

protein K63-linked deubiquitination

18313383|18636086|26997266|27458237|27591049|29291351

HgeneCYLD

GO:1901223

negative regulation of NIK/NF-kappaB signaling

18313383

HgeneCYLD

GO:1903753

negative regulation of p38MAPK cascade

29291351

HgeneCYLD

GO:1990108

protein linear deubiquitination

26997266|27458237|27591049

TgeneHAGH

GO:0006750

glutathione biosynthetic process

8550579


check buttonFusion gene breakpoints across CYLD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HAGH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0736-02ACYLDchr16

50788335

+HAGHchr16

1859834

-


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Fusion Gene ORF analysis for CYLD-HAGH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311559ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000311559ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000398568ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000398568ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000427738ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000427738ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000540145ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000540145ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000564326ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000564326ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000566206ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000566206ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000568704ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000568704ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000569418ENST00000566709CYLDchr16

50788335

+HAGHchr16

1859834

-
5CDS-5UTRENST00000569418ENST00000567398CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000311559ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000311559ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000398568ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000398568ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000427738ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000427738ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000540145ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000540145ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000564326ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000564326ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000566206ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000566206ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000568704ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000568704ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000569418ENST00000397353CYLDchr16

50788335

+HAGHchr16

1859834

-
Frame-shiftENST00000569418ENST00000397356CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000311559ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000398568ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000427738ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000540145ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000564326ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000566206ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000568704ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-
In-frameENST00000569418ENST00000455446CYLDchr16

50788335

+HAGHchr16

1859834

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569418CYLDchr1650788335+ENST00000455446HAGHchr161859834-178211912781300340
ENST00000540145CYLDchr1650788335+ENST00000455446HAGHchr161859834-191913284151437340
ENST00000311559CYLDchr1650788335+ENST00000455446HAGHchr161859834-189513043911413340
ENST00000564326CYLDchr1650788335+ENST00000455446HAGHchr161859834-169811071941216340
ENST00000566206CYLDchr1650788335+ENST00000455446HAGHchr161859834-175411632501272340
ENST00000398568CYLDchr1650788335+ENST00000455446HAGHchr161859834-180412133001322340
ENST00000427738CYLDchr1650788335+ENST00000455446HAGHchr161859834-170911182051227340
ENST00000568704CYLDchr1650788335+ENST00000455446HAGHchr161859834-165410631501172340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569418ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0003564860.99964356
ENST00000540145ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0002150280.999785
ENST00000311559ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0002126410.9997874
ENST00000564326ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0004034010.99959666
ENST00000566206ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0003622950.9996377
ENST00000398568ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0003427770.9996573
ENST00000427738ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0003570530.99964297
ENST00000568704ENST00000455446CYLDchr1650788335+HAGHchr161859834-0.0003790310.9996209

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Fusion Genomic Features for CYLD-HAGH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CYLD-HAGH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:50788335/chr16:1859834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYLD

Q9NQC7

HAGH

Q6PII5

FUNCTION: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26997266, PubMed:26670046, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:29291351}.FUNCTION: Hydrolase acting on ester bonds. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620153_198304957.0DomainCAP-Gly 1
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620253_286304957.0DomainCAP-Gly 2
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518153_198304954.0DomainCAP-Gly 1
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518253_286304954.0DomainCAP-Gly 2
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418153_198304957.0DomainCAP-Gly 1
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418253_286304957.0DomainCAP-Gly 2
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417153_198304954.0DomainCAP-Gly 1
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417253_286304954.0DomainCAP-Gly 2
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518153_198304954.0DomainCAP-Gly 1
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518253_286304954.0DomainCAP-Gly 2
TgeneHAGHchr16:50788335chr16:1859834ENST00000397353710221_223201261.0RegionSubstrate binding
TgeneHAGHchr16:50788335chr16:1859834ENST00000397353710297_300201261.0RegionSubstrate binding
TgeneHAGHchr16:50788335chr16:1859834ENST0000039735669297_300249309.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620492_535304957.0DomainCAP-Gly 3
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620592_950304957.0DomainNote=USP
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518492_535304954.0DomainCAP-Gly 3
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518592_950304954.0DomainNote=USP
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418492_535304957.0DomainCAP-Gly 3
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418592_950304957.0DomainNote=USP
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417492_535304954.0DomainCAP-Gly 3
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417592_950304954.0DomainNote=USP
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518492_535304954.0DomainCAP-Gly 3
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518592_950304954.0DomainNote=USP
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620781_833304957.0RegionB-box
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518781_833304954.0RegionB-box
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418781_833304957.0RegionB-box
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417781_833304954.0RegionB-box
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518781_833304954.0RegionB-box
TgeneHAGHchr16:50788335chr16:1859834ENST00000397353710191_193201261.0RegionSubstrate binding
TgeneHAGHchr16:50788335chr16:1859834ENST0000039735669191_193249309.0RegionSubstrate binding
TgeneHAGHchr16:50788335chr16:1859834ENST0000039735669221_223249309.0RegionSubstrate binding


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Fusion Gene Sequence for CYLD-HAGH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20992_20992_1_CYLD-HAGH_CYLD_chr16_50788335_ENST00000311559_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1895nt_BP=1304nt
GGGGGCGGGCCCAGGTAGCAGGTTTGGCTGCGCGGGGGCCGCGCGTCGGAGTTTCCCCCTTTCTAGGGTGAGGATGGTTCTACACAGCCA
CCCGGAGTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGAATGTGGTAATTGTAATCTTTAACATTTTCATGTAAAACATATTTCCTG
ATCATCTTTCCATTGTCTTCATGGAAAATTGATAAATATTTGTGCCTTCCAACTCTCGTCTTGGTTGAATGACTTCATCTTAATACAACA
TGGACACCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTT
TTTGAATTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGAT
TTTTTACTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATAT
TCAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGC
AGTTCTCTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTT
CAGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGA
AAAATTTCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGA
AGGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGA
CAAGCTAGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTT
GGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAG
CTTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTG
TGTTGAAAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAG
AGGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGG
CCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGG
TAACTGGCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTA
ATGCATATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTG
TCCCCTCGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGC
CTTGGCTGGGTGCTGATGGGACTGTCAGGCCCACTGCTGCGGTCGGTACCTTTGCAGCCTGTGCTTGTGGTCTGATCTGCTCAGGCCCCC

>20992_20992_1_CYLD-HAGH_CYLD_chr16_50788335_ENST00000311559_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_2_CYLD-HAGH_CYLD_chr16_50788335_ENST00000398568_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1804nt_BP=1213nt
CGGAGGTAAATACTAGGGCGGTGGGTGTGGGGAGCCGGGGCCGGCCCGGGACGCGGGCTGGGGAGCCGGGGCGAGGGGCGACGCCCCGCC
GCCCGAGTTTCCCCCTTTCTAGGGTGAGGATGGTTCTACACAGCCACCCGGAGTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGCAT
GGACACCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTTT
TTGAATTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATT
TTTTACTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATATT
CAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCA
GTTCTCTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTTC
AGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAA
AAATTTCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGAA
GGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGAC
AAGCTAGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTTG
GAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGC
TTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTGT
GTTGAAAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGA
GGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGC
CGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGGT
AACTGGCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTAA
TGCATATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTGT
CCCCTCGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGCC
TTGGCTGGGTGCTGATGGGACTGTCAGGCCCACTGCTGCGGTCGGTACCTTTGCAGCCTGTGCTTGTGGTCTGATCTGCTCAGGCCCCCG

>20992_20992_2_CYLD-HAGH_CYLD_chr16_50788335_ENST00000398568_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_3_CYLD-HAGH_CYLD_chr16_50788335_ENST00000427738_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1709nt_BP=1118nt
AGTTTCCCCCTTTCTAGGGTGAGGATGGTTCTACACAGCCACCCGGAGTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGCATGGACA
CCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTTTTTGAA
TTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATTTTTTA
CTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATATTCAAGA
TCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCAGTTCT
CTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTTCAGCCT
GTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATT
TCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGAAGGTCG
TGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCT
AGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTTGGAAAT
AAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGG
ATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTGTGTTGA
AAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGT
TTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGCCGTGC
GCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGGTAACTG
GCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTAATGCAT
ATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTGTCCCCT
CGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGCCTTGGC

>20992_20992_3_CYLD-HAGH_CYLD_chr16_50788335_ENST00000427738_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_4_CYLD-HAGH_CYLD_chr16_50788335_ENST00000540145_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1919nt_BP=1328nt
GTGCGGTTCGGAGGCGGGGCAGGTGGGGGCGGGCCCAGGTAGCAGGTTTGGCTGCGCGGGGGCCGCGCGTCGGAGTTTCCCCCTTTCTAG
GGTGAGGATGGTTCTACACAGCCACCCGGAGTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGAATGTGGTAATTGTAATCTTTAACA
TTTTCATGTAAAACATATTTCCTGATCATCTTTCCATTGTCTTCATGGAAAATTGATAAATATTTGTGCCTTCCAACTCTCGTCTTGGTT
GAATGACTTCATCTTAATACAACATGGACACCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGA
CAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCAC
TTCACCCTACTGGGAAGAGCGGATTTTTTACTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACC
GAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATT
AAAAATTCTAGAGCAACCTCATGCAGTTCTCTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGC
AATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAA
AGTACAGCTGAGATCTGGGGAAGAAAAATTTCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATT
CTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGA
TTGTGGCGTGTTTGTTGCATTGGACAAGCTAGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACAC
AATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTG
TGATGTTTTGCCAGGAAAAGAAAGCTTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGG
AGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGC
CCACAGTGCCATCCACCCTGGCAGAGGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGA
CGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGG
ATTTGGGGATTAGGCTCTTTTAGGTAACTGGCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCT
TGGCTTGTGTTATCGGACATTCTAATGCATATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTC
TTCTGGCCTTTAGGCCTCTGCTTGTCCCCTCGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGC
GTGAGCCGGTGCCTTTGCTGTGGCCTTGGCTGGGTGCTGATGGGACTGTCAGGCCCACTGCTGCGGTCGGTACCTTTGCAGCCTGTGCTT

>20992_20992_4_CYLD-HAGH_CYLD_chr16_50788335_ENST00000540145_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_5_CYLD-HAGH_CYLD_chr16_50788335_ENST00000564326_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1698nt_BP=1107nt
GGCCCAGGTAGCAGGTTTGGCTGCGCGGGGGCCGCGCGTCGGAGGCATTTTGATTTCCTTTCTTTTTACAGCATGGACACCACGTTGCTG
AAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTG
AAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATTTTTTACTTGCTTCTTC
AAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGG
GGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCAGTTCTCTTTGTTGATG
AAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACA
GAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATTTCCTGGAGTTG
TACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTT
TCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCTAGAACTCATAG
AAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAG
TTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGGATATTTTGTTG
GTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTC
TATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACCTACAAC
CCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAG
GACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGGTAACTGGCTTTCCTGCT
GGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTAATGCATATTTATAAGAG
AAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTGTCCCCTCGGGCCTCCTT
CCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGCCTTGGCTGGGTGCTGAT

>20992_20992_5_CYLD-HAGH_CYLD_chr16_50788335_ENST00000564326_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_6_CYLD-HAGH_CYLD_chr16_50788335_ENST00000566206_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1754nt_BP=1163nt
AGGTAGCAGGTTTGGCTGCGCGGGGGCCGCGCGTCGGAGTTTCCCCCTTTCTAGGGTGAGGATGGTTCTACACAGCCACCCGGAGTTCCT
TAGTTGAAAGGCATTTTGATTTCCTTTCTTTTTACAGCATGGACACCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCT
TTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAG
CCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATTTTTTACTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAA
GCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAA
AAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCAGTTCTCTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCAC
AGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGT
GGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATTTCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGAC
AGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTT
TCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCTAGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGC
AGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGG
AACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGA
TGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGT
ACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGC
AGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCC
CTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGGTAACTGGCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCT
TAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTAATGCATATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCC
TTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTGTCCCCTCGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCA
CGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGCCTTGGCTGGGTGCTGATGGGACTGTCAGGCCCACTGCTGCGGTCGGTACCT

>20992_20992_6_CYLD-HAGH_CYLD_chr16_50788335_ENST00000566206_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_7_CYLD-HAGH_CYLD_chr16_50788335_ENST00000568704_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1654nt_BP=1063nt
GCATTTTGATTTCCTTTCTTTTTACAGCATGGACACCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTT
TATGACAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTGAAGTTAATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAA
GTCACTTCACCCTACTGGGAAGAGCGGATTTTTTACTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAA
GTACCGAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATT
GGATTAAAAATTCTAGAGCAACCTCATGCAGTTCTCTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTT
TTGGCAATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCT
GTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATTTCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGA
ATATTCTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGAT
GAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCTAGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGG
GACACAATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATA
TTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTT
GATGGAGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTCTATTGCACATCAATGATATCATCCCAGGAGAAGTACAGCATCGG
GGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGG
TGAGACGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTC
AGCGGATTTGGGGATTAGGCTCTTTTAGGTAACTGGCTTTCCTGCTGGTCCGTGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACA
GCCCTTGGCTTGTGTTATCGGACATTCTAATGCATATTTATAAGAGAAGTTTAACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTG
TTTTCTTCTGGCCTTTAGGCCTCTGCTTGTCCCCTCGGGCCTCCTTCCTCCTCCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGT
CAGGCGTGAGCCGGTGCCTTTGCTGTGGCCTTGGCTGGGTGCTGATGGGACTGTCAGGCCCACTGCTGCGGTCGGTACCTTTGCAGCCTG

>20992_20992_7_CYLD-HAGH_CYLD_chr16_50788335_ENST00000568704_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------
>20992_20992_8_CYLD-HAGH_CYLD_chr16_50788335_ENST00000569418_HAGH_chr16_1859834_ENST00000455446_length(transcript)=1782nt_BP=1191nt
GTGCGGTTCGGAGGCGGGGCAGGTGGGGGCGGGCCCAGGTAGCAGGTTTGGCTGCGCGGGGGCCGCGCGTCGGAGTTTCCCCCTTTCTAG
GGTGAGGATGGTTCTACACAGCCACCCGGAGTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGCATGGACACCACGTTGCTGAAAACA
TGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGACAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTGAAGTTA
ATATCACAATGAGTTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATTTTTTACTTGCTTCTTCAAGAAT
GCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACCGAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGGGGCATT
CAAGGATTCCTTCTGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCAGTTCTCTTTGTTGATGAAAAGG
ATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGCAATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACAGAAACA
GACTAAGTAAAGGCCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATTTCCTGGAGTTGTACGCT
TCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATTCTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTTTCACTG
ACGGGGTGTACCAAGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCTAGAACTCATAGAAGATG
ATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACACAATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAGTTTCTT
TGAAGGTTGGAGAAACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGGATATTTTGTTGGTGTGG
ACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGGAGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTCTATTGC
ACATCAATGATATCATCCCAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACCTACAACCCCTTC
ATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAG
TTCAAGATGCCCCGGGACTGAGGCCGCCCTGCACCTTCAGCGGATTTGGGGATTAGGCTCTTTTAGGTAACTGGCTTTCCTGCTGGTCCG
TGCGGGAAATTCAGTCTTGATTTAACCTTAATTTTACAGCCCTTGGCTTGTGTTATCGGACATTCTAATGCATATTTATAAGAGAAGTTT
AACAAGTATTTATTCCCATAACTTCCCCTTGCAGACTGTTTTCTTCTGGCCTTTAGGCCTCTGCTTGTCCCCTCGGGCCTCCTTCCTCCT
CCGTGAGCCACTGCAGTCCCCCCACCCACGCTTCAGGTCAGGCGTGAGCCGGTGCCTTTGCTGTGGCCTTGGCTGGGTGCTGATGGGACT

>20992_20992_8_CYLD-HAGH_CYLD_chr16_50788335_ENST00000569418_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CYLD-HAGH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620470_554304.3333333333333957.0IKBKG/NEMO
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518470_554304.3333333333333954.0IKBKG/NEMO
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418470_554304.3333333333333957.0IKBKG/NEMO
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417470_554304.3333333333333954.0IKBKG/NEMO
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518470_554304.3333333333333954.0IKBKG/NEMO
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620394_469304.3333333333333957.0TRAF2
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518394_469304.3333333333333954.0TRAF2
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418394_469304.3333333333333957.0TRAF2
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417394_469304.3333333333333954.0TRAF2
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518394_469304.3333333333333954.0TRAF2
HgeneCYLDchr16:50788335chr16:1859834ENST00000311559+620106_593304.3333333333333957.0TRIP
HgeneCYLDchr16:50788335chr16:1859834ENST00000398568+518106_593304.3333333333333954.0TRIP
HgeneCYLDchr16:50788335chr16:1859834ENST00000427738+418106_593304.3333333333333957.0TRIP
HgeneCYLDchr16:50788335chr16:1859834ENST00000564326+417106_593304.3333333333333954.0TRIP
HgeneCYLDchr16:50788335chr16:1859834ENST00000569418+518106_593304.3333333333333954.0TRIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYLD-HAGH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYLD-HAGH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource