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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CYP2E1-AMACR (FusionGDB2 ID:21055) |
Fusion Gene Summary for CYP2E1-AMACR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP2E1-AMACR | Fusion gene ID: 21055 | Hgene | Tgene | Gene symbol | CYP2E1 | AMACR | Gene ID | 1571 | 23600 |
| Gene name | cytochrome P450 family 2 subfamily E member 1 | alpha-methylacyl-CoA racemase | |
| Synonyms | CPE1|CYP2E|P450-J|P450C2E | AMACRD|CBAS4|P504S|RACE|RM | |
| Cytomap | 10q26.3 | 5p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome P450 2E14-nitrophenol 2-hydroxylaseCYPIIE1cytochrome P450, family 2, subfamily E, polypeptide 1cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1cytochrome P450-Jflavoprotein-linked monooxygenasemicrosomal monooxygenasexe | alpha-methylacyl-CoA racemase2-methylacyl-CoA racemase | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | P05181 | Q9UHK6 | |
| Ensembl transtripts involved in fusion gene | ENST00000480558, ENST00000252945, ENST00000463117, | ENST00000335606, ENST00000382072, ENST00000382068, ENST00000382085, ENST00000426255, ENST00000441713, ENST00000502637, ENST00000512079, ENST00000514195, | |
| Fusion gene scores | * DoF score | 8 X 5 X 3=120 | 28 X 3 X 4=336 |
| # samples | 8 | 23 | |
| ** MAII score | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/336*10)=-0.546827371834385 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYP2E1 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CYP2E1(135342144)-AMACR(34006004), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CYP2E1 | GO:0002933 | lipid hydroxylation | 10553002 |
| Hgene | CYP2E1 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
| Hgene | CYP2E1 | GO:0017144 | drug metabolic process | 19219744 |
| Hgene | CYP2E1 | GO:0018960 | 4-nitrophenol metabolic process | 9348445 |
| Hgene | CYP2E1 | GO:0046483 | heterocycle metabolic process | 19651758 |
| Hgene | CYP2E1 | GO:0055114 | oxidation-reduction process | 16401082|19219744 |
| Tgene | AMACR | GO:0008206 | bile acid metabolic process | 10655068 |
| Fusion gene breakpoints across CYP2E1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across AMACR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-DD-A39W-01A | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
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Fusion Gene ORF analysis for CYP2E1-AMACR |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000480558 | ENST00000335606 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-3CDS | ENST00000480558 | ENST00000382072 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000382068 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000382085 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000426255 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000441713 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000502637 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000512079 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 3UTR-5UTR | ENST00000480558 | ENST00000514195 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000382068 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000382085 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000426255 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000441713 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000502637 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000512079 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000252945 | ENST00000514195 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000382068 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000382085 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000426255 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000441713 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000502637 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000512079 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| 5CDS-5UTR | ENST00000463117 | ENST00000514195 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| In-frame | ENST00000252945 | ENST00000335606 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| In-frame | ENST00000252945 | ENST00000382072 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| In-frame | ENST00000463117 | ENST00000335606 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| In-frame | ENST00000463117 | ENST00000382072 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000463117 | CYP2E1 | chr10 | 135342144 | + | ENST00000335606 | AMACR | chr5 | 34006004 | - | 4426 | 609 | 200 | 1510 | 436 |
| ENST00000463117 | CYP2E1 | chr10 | 135342144 | + | ENST00000382072 | AMACR | chr5 | 34006004 | - | 3269 | 609 | 200 | 958 | 252 |
| ENST00000252945 | CYP2E1 | chr10 | 135342144 | + | ENST00000335606 | AMACR | chr5 | 34006004 | - | 4187 | 370 | 33 | 1271 | 412 |
| ENST00000252945 | CYP2E1 | chr10 | 135342144 | + | ENST00000382072 | AMACR | chr5 | 34006004 | - | 3030 | 370 | 33 | 719 | 228 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000463117 | ENST00000335606 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - | 0.000288096 | 0.99971193 |
| ENST00000463117 | ENST00000382072 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - | 0.039836638 | 0.9601633 |
| ENST00000252945 | ENST00000335606 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - | 8.25E-05 | 0.9999175 |
| ENST00000252945 | ENST00000382072 | CYP2E1 | chr10 | 135342144 | + | AMACR | chr5 | 34006004 | - | 0.004744016 | 0.995256 |
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Fusion Genomic Features for CYP2E1-AMACR |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CYP2E1-AMACR |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:135342144/chr5:34006004) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP2E1 | AMACR |
| FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. | FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000335606 | 0 | 5 | 380_382 | 82 | 383.0 | Motif | Microbody targeting signal | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382072 | 0 | 4 | 380_382 | 82 | 199.0 | Motif | Microbody targeting signal | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382085 | 0 | 6 | 380_382 | 82 | 395.0 | Motif | Microbody targeting signal | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000441713 | 0 | 4 | 380_382 | 82 | 230.0 | Motif | Microbody targeting signal | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000335606 | 0 | 5 | 121_126 | 82 | 383.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382072 | 0 | 4 | 121_126 | 82 | 199.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382085 | 0 | 6 | 121_126 | 82 | 395.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000441713 | 0 | 4 | 121_126 | 82 | 230.0 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CYP2E1 | chr10:135342144 | chr5:34006004 | ENST00000252945 | + | 2 | 9 | 298_303 | 112 | 494.0 | Region | Substrate binding |
| Hgene | CYP2E1 | chr10:135342144 | chr5:34006004 | ENST00000463117 | + | 4 | 11 | 298_303 | 112 | 494.0 | Region | Substrate binding |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000335606 | 0 | 5 | 55_58 | 82 | 383.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382072 | 0 | 4 | 55_58 | 82 | 199.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000382085 | 0 | 6 | 55_58 | 82 | 395.0 | Region | Substrate binding | |
| Tgene | AMACR | chr10:135342144 | chr5:34006004 | ENST00000441713 | 0 | 4 | 55_58 | 82 | 230.0 | Region | Substrate binding |
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Fusion Gene Sequence for CYP2E1-AMACR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >21055_21055_1_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000335606_length(transcript)=4187nt_BP=370nt CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA TTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTG ATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCAC AGGGACAGGGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGA TTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGT GGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTT GACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAG AAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAA TTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATG AGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGC ACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAG GAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACAC ACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAA GCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAA ACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAA ATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATA TTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTA TTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGC ATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGA AAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGT CCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCT CCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACC CCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTT TACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGG TGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAA TCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCG CCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATT ATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAA CTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCT CCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTAT AGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTC AAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATAT TTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAG GAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGG ACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAG GATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCT AAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATAT AACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGG CAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCC AAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTT CCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTA GCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATT CCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCT CCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAA ATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGT >21055_21055_1_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=412AA_BP=112 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL LDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLL ADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPL -------------------------------------------------------------- >21055_21055_2_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3030nt_BP=370nt CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA TTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTG ATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCAC AGGGACAGGGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGA TTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTC TTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTA CAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGA TGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTG GTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGG CTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGA TCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCAT TGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACA TAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAG TGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCC TTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGA AGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTG AAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCAC ACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTG TTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGG GCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAG AAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACA AAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGA TTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTAT CTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTA GTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGT CCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCT ATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACT GCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATG AAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTT TCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAG AAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTT GTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCA >21055_21055_2_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=228AA_BP=112 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL LDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGGRNSIFKFFSVENSEIESV -------------------------------------------------------------- >21055_21055_3_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000335606_length(transcript)=4426nt_BP=609nt ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGT TGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGC TGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGTGTCATGGAGAAACTCCAGC TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCC TGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCA TTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGAC AGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGT TCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGA AGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTT TTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTC TGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCA GCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCA AGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACC ACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAA ACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATT TTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAAT GAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATC TCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCT TCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTG TATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAG CAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGAC TGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCC CTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGA TGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCA TCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCC AAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAA ATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTG GACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTT TTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTAC CTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTG AGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCA GAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCC CAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAA ATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACA GTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAA AAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAA TTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCA AGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGA CACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAG TGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAAT AGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTA GGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAG GATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATT TGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGTGTGTGGAAAACTTGTAGTAAAAAATAGAATG >21055_21055_3_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=436AA_BP=136 MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGP VFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINY LALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGG APFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHH -------------------------------------------------------------- >21055_21055_4_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3269nt_BP=609nt ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGT TGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGC TGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGTGTCATGGAGAAACTCCAGC TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTG TGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTT GGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGAT TGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGT GTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTG AGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATA CTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAA CTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAAC AGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATT AGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATT AAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTG ATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTT TGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCT GTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAG TCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGA TTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTC GTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCA GCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGT AGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAA GGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTT TTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAA CTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAG GAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGT CCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTA TGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAAT ATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAAT ATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCAT AAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCT >21055_21055_4_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=252AA_BP=136 MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGP VFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CYP2E1-AMACR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CYP2E1-AMACR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CYP2E1-AMACR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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