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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYP3A4-ITGAV (FusionGDB2 ID:21072)

Fusion Gene Summary for CYP3A4-ITGAV

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP3A4-ITGAV
Fusion gene ID: 21072
HgeneTgene
Gene symbol

CYP3A4

ITGAV

Gene ID

1576

3685

Gene namecytochrome P450 family 3 subfamily A member 4integrin subunit alpha V
SynonymsCP33|CP34|CYP3A|CYP3A3|CYPIIIA3|CYPIIIA4|HLP|NF-25|P450C3|P450PCN1CD51|MSK8|VNRA|VTNR
Cytomap

7q22.1

2q32.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 3A41,4-cineole 2-exo-monooxygenase1,8-cineole 2-exo-monooxygenaseP450-III, steroid induciblealbendazole monooxygenasealbendazole monooxygenase (sulfoxide-forming)albendazole sulfoxidasecholesterol 25-hydroxylasecytochrome P450 3A3integrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alpha
Modification date2020032720200313
UniProtAcc

P08684

P06756

Ensembl transtripts involved in fusion geneENST00000336411, ENST00000354593, 
ENST00000474571, ENST00000261023, 
ENST00000374907, ENST00000433736, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 8 X 6=432
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP3A4 [Title/Abstract] AND ITGAV [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYP3A4(99381634)-ITGAV(187540331), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP3A4

GO:0002933

lipid hydroxylation

14559847

HgeneCYP3A4

GO:0008202

steroid metabolic process

14559847

HgeneCYP3A4

GO:0008210

estrogen metabolic process

11555828|12865317|14559847

HgeneCYP3A4

GO:0009822

alkaloid catabolic process

15039299

HgeneCYP3A4

GO:0016098

monoterpenoid metabolic process

16401082

HgeneCYP3A4

GO:0017144

drug metabolic process

15327587|19219744

HgeneCYP3A4

GO:0042572

retinol metabolic process

10681376

HgeneCYP3A4

GO:0042573

retinoic acid metabolic process

11093772

HgeneCYP3A4

GO:0042737

drug catabolic process

15039299

HgeneCYP3A4

GO:0042738

exogenous drug catabolic process

18619574

HgeneCYP3A4

GO:0046483

heterocycle metabolic process

15327587

HgeneCYP3A4

GO:0055114

oxidation-reduction process

16401082|19219744

HgeneCYP3A4

GO:0070989

oxidative demethylation

15039299|18619574

TgeneITGAV

GO:0007155

cell adhesion

10218736

TgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

TgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

TgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

TgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

TgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

TgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

TgeneITGAV

GO:1901388

regulation of transforming growth factor beta activation

22278742

TgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297


check buttonFusion gene breakpoints across CYP3A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGAV (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315457CYP3A4chr7

99381634

-ITGAVchr2

187540331

+


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Fusion Gene ORF analysis for CYP3A4-ITGAV

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336411ENST00000474571CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
5CDS-intronENST00000354593ENST00000474571CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000336411ENST00000261023CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000336411ENST00000374907CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000336411ENST00000433736CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000354593ENST00000261023CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000354593ENST00000374907CYP3A4chr7

99381634

-ITGAVchr2

187540331

+
In-frameENST00000354593ENST00000433736CYP3A4chr7

99381634

-ITGAVchr2

187540331

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354593CYP3A4chr799381634-ENST00000261023ITGAVchr2187540331+4225175136615159
ENST00000354593CYP3A4chr799381634-ENST00000374907ITGAVchr2187540331+4221175136615159
ENST00000354593CYP3A4chr799381634-ENST00000433736ITGAVchr2187540331+765175136615159
ENST00000336411CYP3A4chr799381634-ENST00000261023ITGAVchr2187540331+4305255216695159
ENST00000336411CYP3A4chr799381634-ENST00000374907ITGAVchr2187540331+4301255216695159
ENST00000336411CYP3A4chr799381634-ENST00000433736ITGAVchr2187540331+845255216695159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354593ENST00000261023CYP3A4chr799381634-ITGAVchr2187540331+0.098548770.9014513
ENST00000354593ENST00000374907CYP3A4chr799381634-ITGAVchr2187540331+0.0305976330.9694024
ENST00000354593ENST00000433736CYP3A4chr799381634-ITGAVchr2187540331+0.0592445170.94075555
ENST00000336411ENST00000261023CYP3A4chr799381634-ITGAVchr2187540331+0.095205350.90479463
ENST00000336411ENST00000374907CYP3A4chr799381634-ITGAVchr2187540331+0.0295335910.97046643
ENST00000336411ENST00000433736CYP3A4chr799381634-ITGAVchr2187540331+0.0469076150.95309234

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Fusion Genomic Features for CYP3A4-ITGAV


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CYP3A4chr799381633-ITGAVchr2187540330+0.99999752.44E-06
CYP3A4chr799381633-ITGAVchr2187540330+0.99999752.44E-06

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CYP3A4-ITGAV


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:99381634/chr2:187540331)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP3A4

P08684

ITGAV

P06756

FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:20702771, PubMed:19965576, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:2732228, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:21576599, PubMed:21490593). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:14559847, PubMed:12865317). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:2732228, PubMed:15373842, PubMed:15764715, PubMed:22773874). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:2732228, PubMed:15373842, PubMed:15764715). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}.FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYP3A4chr7:99381634chr2:187540331ENST00000336411-1132_2223504.0TransmembraneHelical
TgeneITGAVchr7:99381634chr2:187540331ENST0000026102325301019_10239021049.0MotifNote=GFFKR motif
TgeneITGAVchr7:99381634chr2:187540331ENST0000037490723281019_10238661013.0MotifNote=GFFKR motif
TgeneITGAVchr7:99381634chr2:187540331ENST0000043373625301019_10238561003.0MotifNote=GFFKR motif
TgeneITGAVchr7:99381634chr2:187540331ENST0000026102325301017_10489021049.0Topological domainCytoplasmic
TgeneITGAVchr7:99381634chr2:187540331ENST0000037490723281017_10488661013.0Topological domainCytoplasmic
TgeneITGAVchr7:99381634chr2:187540331ENST0000043373625301017_10488561003.0Topological domainCytoplasmic
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530993_10169021049.0TransmembraneHelical
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328993_10168661013.0TransmembraneHelical
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530993_10168561003.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530260_2689021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530314_3229021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530379_3879021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530443_4519021049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328260_2688661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328314_3228661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328379_3878661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328443_4518661013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530260_2688561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530314_3228561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530379_3878561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530443_4518561003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530109_1709021049.0RepeatFG-GAP 2
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530173_2259021049.0RepeatFG-GAP 3
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530237_2919021049.0RepeatFG-GAP 4
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530292_3579021049.0RepeatFG-GAP 5
TgeneITGAVchr7:99381634chr2:187540331ENST00000261023253032_989021049.0RepeatFG-GAP 1
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530358_4159021049.0RepeatFG-GAP 6
TgeneITGAVchr7:99381634chr2:187540331ENST000002610232530419_4829021049.0RepeatFG-GAP 7
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328109_1708661013.0RepeatFG-GAP 2
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328173_2258661013.0RepeatFG-GAP 3
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328237_2918661013.0RepeatFG-GAP 4
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328292_3578661013.0RepeatFG-GAP 5
TgeneITGAVchr7:99381634chr2:187540331ENST00000374907232832_988661013.0RepeatFG-GAP 1
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328358_4158661013.0RepeatFG-GAP 6
TgeneITGAVchr7:99381634chr2:187540331ENST000003749072328419_4828661013.0RepeatFG-GAP 7
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530109_1708561003.0RepeatFG-GAP 2
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530173_2258561003.0RepeatFG-GAP 3
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530237_2918561003.0RepeatFG-GAP 4
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530292_3578561003.0RepeatFG-GAP 5
TgeneITGAVchr7:99381634chr2:187540331ENST00000433736253032_988561003.0RepeatFG-GAP 1
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530358_4158561003.0RepeatFG-GAP 6
TgeneITGAVchr7:99381634chr2:187540331ENST000004337362530419_4828561003.0RepeatFG-GAP 7
TgeneITGAVchr7:99381634chr2:187540331ENST00000261023253031_9929021049.0Topological domainExtracellular
TgeneITGAVchr7:99381634chr2:187540331ENST00000374907232831_9928661013.0Topological domainExtracellular
TgeneITGAVchr7:99381634chr2:187540331ENST00000433736253031_9928561003.0Topological domainExtracellular


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Fusion Gene Sequence for CYP3A4-ITGAV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21072_21072_1_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000261023_length(transcript)=4305nt_BP=255nt
ACAGGTGGCCCTGCTACTGGCTGCAGCTCCAGCCCTGCCTCCTTCTCTAGCATATAAACAATCCAACAGCCTCACTGAATCACTGCTGTG
CAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAGTAAGGAAAGT
AGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTGTGGAGTTGCT
CAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTGGACTGAGACT
TTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAAGAATCTTCCA
ATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGTGTGGGTGATC
ATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGTCCGGCCACCT
CAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAGTTATGCTACA
TCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCTGATAGTGCTA
ATTGGCATTAACCACAAAATGAGAATTATATTTGTCAACCTTCTCCTTATAAATAAGTTCAGACATACATTTAATAACATAGGGTGACTT
GTGTTTTTAGGTATTTAAATAATAAAATTTCAAGGGATAGTTTTTATTCAATGTATATAAGACAGGTAGTGCCTGATTTACTACTTTATA
TAAAATAGTACCTCCTTCAGTTACTGTTTCTGATTTAATGTACGGAACTTTATTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTAAA
GCAGTCCAAATTTGGACCTTAGCAATCATGTCTTTTGTATAGGTACTTAATGTTAATACATATTACACTACAGTTTACTTTTCAGAATAC
TAAAGACTTTATAACTGCATGAACTTGGATTTTTTTAATCACTCATATGGTAGAATTTTATAAACACATACATGATACCATCCAAATTCT
TGCTTTTAATAACAAAGGTACAATATTTTGTTTTAGTATGAAAATCTGGTAGATCCTATTACACTTCTGTTTATATTAAATCCACAATAT
TTTATTACATTTTTAACTTGTATAAATTTTAGGTCAAATCCTTCAAGCCAACCTATACTAAAAATTAGTTCCATAATCACAAATGGCTCT
TTTGTGTAATTGTTTAATTTCACCTGAATATCATAATGCTTAAAGCCATATGGAGTTGGAAATTATTTCCAAAGCATATTTATTCCATTG
TTTTAGTCTGGCTATTTACAGTATAAAAAAAGCATTTTTATTAAAATACTGTGTAGTTCTTTGAGATAGTTGCTTATGCATATAGTAAGT
ATTACATTCTTAGAGTAGAGCAGAGTTTTTAGTTAGTATTAATTTATTTTCCTCCATTCATGTACTTTTCCTTATATTTCCAAAACTGTT
ACTGAGAATGGGTCAAGATCAGTGAGAAATCTTTACAGTTGACAGGAACCTGGACCCCTTACCCCAACTTTATGAGTAATGCTTGGAATA
AAAACTCTTAAGGCAACTCACTGATTTACTTCTAGCAATAGCATGATGTTACAGGAATATTACCTCTGTTTAAGCAAGGTAATGTGTAAA
ATCAGTCTCGGCTGTCAGAATAACTTCTAAAAGGTATTTTTATAAGCAGTTCAAGTTACTGAAAACCTTTTAAACCTTTCTGAAGTTCGT
TAGTATAAATTACTTTTCTAGGATTATTAATAAAAGCCACATAGGTGGCAAGTTGTAGTTTTATATGGCTCTGTAGAGTGGTGAACCTTC
TAGAGGAATATATGATTTATTCACAGTTCCTCAAGGCCTGGGGATGATGATCAGTTATACCTATTTTTGTGCAATTACATCATGTTGTAC
ATTAGAAATGGAGAGTTTAATAGCTCTTTAACTGCTGTCCTCATTAGGTAATGATAAATATTTCCCTTAAATAATTGACTATTTTGCTGT
GTTTTAAAAATGATTGAAATTTATCTTGCCATATCTCATAATTTCATGCACAAGTTGACTGAGCTAATCTTGAGAATATATTCGTAAAAT
AGGAGCACATTTAGTTGAGGTATACAAGGTAGGACTCTAGACAAAACCTTCTATTTTAGCTTTAGTGAATTTCAAAAGTAATGGGTCTTG
GAGTATAGATTTTTATTAGTAGCTTGAAAGAGCTTAATCATATGCAGTAAGTATTTTTATTACCAATAAATTTAAAATTTTTTAAGAAAA
ATATTTTTATCCTAGGGCCAAGTGTTGCCTGCCACCAATCAGTAAGTTAGTCTATAACAAATTTTACCCTAACAGTTTTACCACCTAGTA
ACAGTCATTTCTGAAAATATGTTGGATAGAAAGTCACTCTTTGGCAAAAGTGTTAGAATTTGCTTTTGTGCCATCTATTCCTTTTATGGC
ATCTATCTTGAAAGTAATCTTGTATTGGAGATTGAAAGATGCTGTAATTTAGAAATTAACATGATATCTTAAATTACCTTTATGAAATAT
AGTTTTGTATAATAGCATAGATTTTCCTTCAAAAAATGAACATTTATATATCTACAAAAATATGGAGAAGAGTAATTTGAAAGCCTACTT
TCTGAAGAAAATGGTGGGATTTTTTTTTATCATGATTAAATATCAAAAAATTGCCCTATGAAAACTTTAAATCTCTAAAACATTTGAAAT
ACTACCATATTTGTGATTTATTGAGAATAAAAATCCATTTTGAAATGTAAAATTTTTATGATCTGATTCAGTTTTAAGAAAACATGAATG
AACTAGAAGATATTAAAAACATTTGACATTGGTAAGAAATATTGATACTGATATTGATTTTTATATAGGTATTTATTTCAGAATTGATAT
TTTGAGAAAAATACATGTGAGTCATTTTTTCTGTTTCTCTTTTCTCTTAACGATTATCACTGTAATTCTGAATCTGAAAGGTAAAACAAT
TAGTCAAAATATTATTGCCATCATTCTACCTGTGTTATGAAACTACTTATTCATAGTTAATTCTCATTAACACTTACATTTCCATAAAGA
AAACTCAAGTATTAATAAAAGAGACTTTACTGGCTTAAGAGGGCTGTGAAAGATTTTTGATAGTGAATCATGACCCTAAGGGAGAGATTT
GTGTGATAAAAGTATTGTATATAATAGATCAGCGATTTTTGTAAGGCAAACAGAATTTGTAAGTTGGCAGATCTTCCTAAGTTGCAAAAT
GTAATGATGAGCTTGGTGGAGAAGAATGAGTCGTTCTTGGAATACCTATGTGCAGCCACTACCCATCTCAATGTCACCTTGTTTGCATTC
TTGGATAGCTTGTATATGTAGTAGTTTGATGAATAATTTAAAGAAAAACACCTAAAATTTGAAAAATGATTGTAGGATCAAAAAAGGCAG
ATGAAATTACTTAATACTCAGTGTTTTGGAGAGTATTCCTTTTAGTTTGTTGGTTGGCTGGTTTGAACGATAGAAATATGCAGCATGCAA
TATATGCTTATATTTCATTTTAATTTCTGATATATAATGAACTTCTTGGGAGAGGTACTGAATCTTTGATGTTTTTTGTCATTGTTCTCA
AGTGCAATATAACAATGTAACCAAATCTAGATAATTTCAAAGTTGTCATTAATTTAGTAAGCCTAATATAAACAAATATTTGTATTATTT
TTGTTAGCAGGAAAGAGTGATTAAGTGAGGTTATTTACCCCTAAATGGTCCATTCTGCATTGTATTTCAGGCTGGAAATGAATTATTCTT
TACCAGTTTTGAAACACTTTGAAATATCCTAAGGTAACTTGGAAGCTGTGTAGTATATCAAATTAATTTGCTACCTAATAACATAGAAAG
TAAATATCTTTGTGGTCACCCACATTGGGTGAGACAGAAAATGAATCTGTTCTAAAATTTGTAATTTGCTAACTTGATTTGAGTTAGTGA

>21072_21072_1_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000261023_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------
>21072_21072_2_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000374907_length(transcript)=4301nt_BP=255nt
ACAGGTGGCCCTGCTACTGGCTGCAGCTCCAGCCCTGCCTCCTTCTCTAGCATATAAACAATCCAACAGCCTCACTGAATCACTGCTGTG
CAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAGTAAGGAAAGT
AGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTGTGGAGTTGCT
CAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTGGACTGAGACT
TTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAAGAATCTTCCA
ATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGTGTGGGTGATC
ATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGTCCGGCCACCT
CAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAGTTATGCTACA
TCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCTGATAGTGCTA
ATTGGCATTAACCACAAAATGAGAATTATATTTGTCAACCTTCTCCTTATAAATAAGTTCAGACATACATTTAATAACATAGGGTGACTT
GTGTTTTTAGGTATTTAAATAATAAAATTTCAAGGGATAGTTTTTATTCAATGTATATAAGACAGGTAGTGCCTGATTTACTACTTTATA
TAAAATAGTACCTCCTTCAGTTACTGTTTCTGATTTAATGTACGGAACTTTATTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTAAA
GCAGTCCAAATTTGGACCTTAGCAATCATGTCTTTTGTATAGGTACTTAATGTTAATACATATTACACTACAGTTTACTTTTCAGAATAC
TAAAGACTTTATAACTGCATGAACTTGGATTTTTTTAATCACTCATATGGTAGAATTTTATAAACACATACATGATACCATCCAAATTCT
TGCTTTTAATAACAAAGGTACAATATTTTGTTTTAGTATGAAAATCTGGTAGATCCTATTACACTTCTGTTTATATTAAATCCACAATAT
TTTATTACATTTTTAACTTGTATAAATTTTAGGTCAAATCCTTCAAGCCAACCTATACTAAAAATTAGTTCCATAATCACAAATGGCTCT
TTTGTGTAATTGTTTAATTTCACCTGAATATCATAATGCTTAAAGCCATATGGAGTTGGAAATTATTTCCAAAGCATATTTATTCCATTG
TTTTAGTCTGGCTATTTACAGTATAAAAAAAGCATTTTTATTAAAATACTGTGTAGTTCTTTGAGATAGTTGCTTATGCATATAGTAAGT
ATTACATTCTTAGAGTAGAGCAGAGTTTTTAGTTAGTATTAATTTATTTTCCTCCATTCATGTACTTTTCCTTATATTTCCAAAACTGTT
ACTGAGAATGGGTCAAGATCAGTGAGAAATCTTTACAGTTGACAGGAACCTGGACCCCTTACCCCAACTTTATGAGTAATGCTTGGAATA
AAAACTCTTAAGGCAACTCACTGATTTACTTCTAGCAATAGCATGATGTTACAGGAATATTACCTCTGTTTAAGCAAGGTAATGTGTAAA
ATCAGTCTCGGCTGTCAGAATAACTTCTAAAAGGTATTTTTATAAGCAGTTCAAGTTACTGAAAACCTTTTAAACCTTTCTGAAGTTCGT
TAGTATAAATTACTTTTCTAGGATTATTAATAAAAGCCACATAGGTGGCAAGTTGTAGTTTTATATGGCTCTGTAGAGTGGTGAACCTTC
TAGAGGAATATATGATTTATTCACAGTTCCTCAAGGCCTGGGGATGATGATCAGTTATACCTATTTTTGTGCAATTACATCATGTTGTAC
ATTAGAAATGGAGAGTTTAATAGCTCTTTAACTGCTGTCCTCATTAGGTAATGATAAATATTTCCCTTAAATAATTGACTATTTTGCTGT
GTTTTAAAAATGATTGAAATTTATCTTGCCATATCTCATAATTTCATGCACAAGTTGACTGAGCTAATCTTGAGAATATATTCGTAAAAT
AGGAGCACATTTAGTTGAGGTATACAAGGTAGGACTCTAGACAAAACCTTCTATTTTAGCTTTAGTGAATTTCAAAAGTAATGGGTCTTG
GAGTATAGATTTTTATTAGTAGCTTGAAAGAGCTTAATCATATGCAGTAAGTATTTTTATTACCAATAAATTTAAAATTTTTTAAGAAAA
ATATTTTTATCCTAGGGCCAAGTGTTGCCTGCCACCAATCAGTAAGTTAGTCTATAACAAATTTTACCCTAACAGTTTTACCACCTAGTA
ACAGTCATTTCTGAAAATATGTTGGATAGAAAGTCACTCTTTGGCAAAAGTGTTAGAATTTGCTTTTGTGCCATCTATTCCTTTTATGGC
ATCTATCTTGAAAGTAATCTTGTATTGGAGATTGAAAGATGCTGTAATTTAGAAATTAACATGATATCTTAAATTACCTTTATGAAATAT
AGTTTTGTATAATAGCATAGATTTTCCTTCAAAAAATGAACATTTATATATCTACAAAAATATGGAGAAGAGTAATTTGAAAGCCTACTT
TCTGAAGAAAATGGTGGGATTTTTTTTTATCATGATTAAATATCAAAAAATTGCCCTATGAAAACTTTAAATCTCTAAAACATTTGAAAT
ACTACCATATTTGTGATTTATTGAGAATAAAAATCCATTTTGAAATGTAAAATTTTTATGATCTGATTCAGTTTTAAGAAAACATGAATG
AACTAGAAGATATTAAAAACATTTGACATTGGTAAGAAATATTGATACTGATATTGATTTTTATATAGGTATTTATTTCAGAATTGATAT
TTTGAGAAAAATACATGTGAGTCATTTTTTCTGTTTCTCTTTTCTCTTAACGATTATCACTGTAATTCTGAATCTGAAAGGTAAAACAAT
TAGTCAAAATATTATTGCCATCATTCTACCTGTGTTATGAAACTACTTATTCATAGTTAATTCTCATTAACACTTACATTTCCATAAAGA
AAACTCAAGTATTAATAAAAGAGACTTTACTGGCTTAAGAGGGCTGTGAAAGATTTTTGATAGTGAATCATGACCCTAAGGGAGAGATTT
GTGTGATAAAAGTATTGTATATAATAGATCAGCGATTTTTGTAAGGCAAACAGAATTTGTAAGTTGGCAGATCTTCCTAAGTTGCAAAAT
GTAATGATGAGCTTGGTGGAGAAGAATGAGTCGTTCTTGGAATACCTATGTGCAGCCACTACCCATCTCAATGTCACCTTGTTTGCATTC
TTGGATAGCTTGTATATGTAGTAGTTTGATGAATAATTTAAAGAAAAACACCTAAAATTTGAAAAATGATTGTAGGATCAAAAAAGGCAG
ATGAAATTACTTAATACTCAGTGTTTTGGAGAGTATTCCTTTTAGTTTGTTGGTTGGCTGGTTTGAACGATAGAAATATGCAGCATGCAA
TATATGCTTATATTTCATTTTAATTTCTGATATATAATGAACTTCTTGGGAGAGGTACTGAATCTTTGATGTTTTTTGTCATTGTTCTCA
AGTGCAATATAACAATGTAACCAAATCTAGATAATTTCAAAGTTGTCATTAATTTAGTAAGCCTAATATAAACAAATATTTGTATTATTT
TTGTTAGCAGGAAAGAGTGATTAAGTGAGGTTATTTACCCCTAAATGGTCCATTCTGCATTGTATTTCAGGCTGGAAATGAATTATTCTT
TACCAGTTTTGAAACACTTTGAAATATCCTAAGGTAACTTGGAAGCTGTGTAGTATATCAAATTAATTTGCTACCTAATAACATAGAAAG
TAAATATCTTTGTGGTCACCCACATTGGGTGAGACAGAAAATGAATCTGTTCTAAAATTTGTAATTTGCTAACTTGATTTGAGTTAGTGA

>21072_21072_2_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000374907_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------
>21072_21072_3_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000433736_length(transcript)=845nt_BP=255nt
ACAGGTGGCCCTGCTACTGGCTGCAGCTCCAGCCCTGCCTCCTTCTCTAGCATATAAACAATCCAACAGCCTCACTGAATCACTGCTGTG
CAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAGTAAGGAAAGT
AGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTGTGGAGTTGCT
CAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTGGACTGAGACT
TTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAAGAATCTTCCA
ATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGTGTGGGTGATC
ATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGTCCGGCCACCT
CAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAGTTATGCTACA
TCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCTGATAGTGCTA

>21072_21072_3_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000336411_ITGAV_chr2_187540331_ENST00000433736_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------
>21072_21072_4_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000261023_length(transcript)=4225nt_BP=175nt
CACTGCTGTGCAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAG
TAAGGAAAGTAGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTG
TGGAGTTGCTCAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTG
GACTGAGACTTTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAA
GAATCTTCCAATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGT
GTGGGTGATCATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGT
CCGGCCACCTCAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAG
TTATGCTACATCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCT
GATAGTGCTAATTGGCATTAACCACAAAATGAGAATTATATTTGTCAACCTTCTCCTTATAAATAAGTTCAGACATACATTTAATAACAT
AGGGTGACTTGTGTTTTTAGGTATTTAAATAATAAAATTTCAAGGGATAGTTTTTATTCAATGTATATAAGACAGGTAGTGCCTGATTTA
CTACTTTATATAAAATAGTACCTCCTTCAGTTACTGTTTCTGATTTAATGTACGGAACTTTATTTGTTGTTGTTGTTGTTGTTGTTGTTG
TTGTTTTAAAGCAGTCCAAATTTGGACCTTAGCAATCATGTCTTTTGTATAGGTACTTAATGTTAATACATATTACACTACAGTTTACTT
TTCAGAATACTAAAGACTTTATAACTGCATGAACTTGGATTTTTTTAATCACTCATATGGTAGAATTTTATAAACACATACATGATACCA
TCCAAATTCTTGCTTTTAATAACAAAGGTACAATATTTTGTTTTAGTATGAAAATCTGGTAGATCCTATTACACTTCTGTTTATATTAAA
TCCACAATATTTTATTACATTTTTAACTTGTATAAATTTTAGGTCAAATCCTTCAAGCCAACCTATACTAAAAATTAGTTCCATAATCAC
AAATGGCTCTTTTGTGTAATTGTTTAATTTCACCTGAATATCATAATGCTTAAAGCCATATGGAGTTGGAAATTATTTCCAAAGCATATT
TATTCCATTGTTTTAGTCTGGCTATTTACAGTATAAAAAAAGCATTTTTATTAAAATACTGTGTAGTTCTTTGAGATAGTTGCTTATGCA
TATAGTAAGTATTACATTCTTAGAGTAGAGCAGAGTTTTTAGTTAGTATTAATTTATTTTCCTCCATTCATGTACTTTTCCTTATATTTC
CAAAACTGTTACTGAGAATGGGTCAAGATCAGTGAGAAATCTTTACAGTTGACAGGAACCTGGACCCCTTACCCCAACTTTATGAGTAAT
GCTTGGAATAAAAACTCTTAAGGCAACTCACTGATTTACTTCTAGCAATAGCATGATGTTACAGGAATATTACCTCTGTTTAAGCAAGGT
AATGTGTAAAATCAGTCTCGGCTGTCAGAATAACTTCTAAAAGGTATTTTTATAAGCAGTTCAAGTTACTGAAAACCTTTTAAACCTTTC
TGAAGTTCGTTAGTATAAATTACTTTTCTAGGATTATTAATAAAAGCCACATAGGTGGCAAGTTGTAGTTTTATATGGCTCTGTAGAGTG
GTGAACCTTCTAGAGGAATATATGATTTATTCACAGTTCCTCAAGGCCTGGGGATGATGATCAGTTATACCTATTTTTGTGCAATTACAT
CATGTTGTACATTAGAAATGGAGAGTTTAATAGCTCTTTAACTGCTGTCCTCATTAGGTAATGATAAATATTTCCCTTAAATAATTGACT
ATTTTGCTGTGTTTTAAAAATGATTGAAATTTATCTTGCCATATCTCATAATTTCATGCACAAGTTGACTGAGCTAATCTTGAGAATATA
TTCGTAAAATAGGAGCACATTTAGTTGAGGTATACAAGGTAGGACTCTAGACAAAACCTTCTATTTTAGCTTTAGTGAATTTCAAAAGTA
ATGGGTCTTGGAGTATAGATTTTTATTAGTAGCTTGAAAGAGCTTAATCATATGCAGTAAGTATTTTTATTACCAATAAATTTAAAATTT
TTTAAGAAAAATATTTTTATCCTAGGGCCAAGTGTTGCCTGCCACCAATCAGTAAGTTAGTCTATAACAAATTTTACCCTAACAGTTTTA
CCACCTAGTAACAGTCATTTCTGAAAATATGTTGGATAGAAAGTCACTCTTTGGCAAAAGTGTTAGAATTTGCTTTTGTGCCATCTATTC
CTTTTATGGCATCTATCTTGAAAGTAATCTTGTATTGGAGATTGAAAGATGCTGTAATTTAGAAATTAACATGATATCTTAAATTACCTT
TATGAAATATAGTTTTGTATAATAGCATAGATTTTCCTTCAAAAAATGAACATTTATATATCTACAAAAATATGGAGAAGAGTAATTTGA
AAGCCTACTTTCTGAAGAAAATGGTGGGATTTTTTTTTATCATGATTAAATATCAAAAAATTGCCCTATGAAAACTTTAAATCTCTAAAA
CATTTGAAATACTACCATATTTGTGATTTATTGAGAATAAAAATCCATTTTGAAATGTAAAATTTTTATGATCTGATTCAGTTTTAAGAA
AACATGAATGAACTAGAAGATATTAAAAACATTTGACATTGGTAAGAAATATTGATACTGATATTGATTTTTATATAGGTATTTATTTCA
GAATTGATATTTTGAGAAAAATACATGTGAGTCATTTTTTCTGTTTCTCTTTTCTCTTAACGATTATCACTGTAATTCTGAATCTGAAAG
GTAAAACAATTAGTCAAAATATTATTGCCATCATTCTACCTGTGTTATGAAACTACTTATTCATAGTTAATTCTCATTAACACTTACATT
TCCATAAAGAAAACTCAAGTATTAATAAAAGAGACTTTACTGGCTTAAGAGGGCTGTGAAAGATTTTTGATAGTGAATCATGACCCTAAG
GGAGAGATTTGTGTGATAAAAGTATTGTATATAATAGATCAGCGATTTTTGTAAGGCAAACAGAATTTGTAAGTTGGCAGATCTTCCTAA
GTTGCAAAATGTAATGATGAGCTTGGTGGAGAAGAATGAGTCGTTCTTGGAATACCTATGTGCAGCCACTACCCATCTCAATGTCACCTT
GTTTGCATTCTTGGATAGCTTGTATATGTAGTAGTTTGATGAATAATTTAAAGAAAAACACCTAAAATTTGAAAAATGATTGTAGGATCA
AAAAAGGCAGATGAAATTACTTAATACTCAGTGTTTTGGAGAGTATTCCTTTTAGTTTGTTGGTTGGCTGGTTTGAACGATAGAAATATG
CAGCATGCAATATATGCTTATATTTCATTTTAATTTCTGATATATAATGAACTTCTTGGGAGAGGTACTGAATCTTTGATGTTTTTTGTC
ATTGTTCTCAAGTGCAATATAACAATGTAACCAAATCTAGATAATTTCAAAGTTGTCATTAATTTAGTAAGCCTAATATAAACAAATATT
TGTATTATTTTTGTTAGCAGGAAAGAGTGATTAAGTGAGGTTATTTACCCCTAAATGGTCCATTCTGCATTGTATTTCAGGCTGGAAATG
AATTATTCTTTACCAGTTTTGAAACACTTTGAAATATCCTAAGGTAACTTGGAAGCTGTGTAGTATATCAAATTAATTTGCTACCTAATA
ACATAGAAAGTAAATATCTTTGTGGTCACCCACATTGGGTGAGACAGAAAATGAATCTGTTCTAAAATTTGTAATTTGCTAACTTGATTT

>21072_21072_4_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000261023_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------
>21072_21072_5_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000374907_length(transcript)=4221nt_BP=175nt
CACTGCTGTGCAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAG
TAAGGAAAGTAGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTG
TGGAGTTGCTCAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTG
GACTGAGACTTTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAA
GAATCTTCCAATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGT
GTGGGTGATCATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGT
CCGGCCACCTCAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAG
TTATGCTACATCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCT
GATAGTGCTAATTGGCATTAACCACAAAATGAGAATTATATTTGTCAACCTTCTCCTTATAAATAAGTTCAGACATACATTTAATAACAT
AGGGTGACTTGTGTTTTTAGGTATTTAAATAATAAAATTTCAAGGGATAGTTTTTATTCAATGTATATAAGACAGGTAGTGCCTGATTTA
CTACTTTATATAAAATAGTACCTCCTTCAGTTACTGTTTCTGATTTAATGTACGGAACTTTATTTGTTGTTGTTGTTGTTGTTGTTGTTG
TTGTTTTAAAGCAGTCCAAATTTGGACCTTAGCAATCATGTCTTTTGTATAGGTACTTAATGTTAATACATATTACACTACAGTTTACTT
TTCAGAATACTAAAGACTTTATAACTGCATGAACTTGGATTTTTTTAATCACTCATATGGTAGAATTTTATAAACACATACATGATACCA
TCCAAATTCTTGCTTTTAATAACAAAGGTACAATATTTTGTTTTAGTATGAAAATCTGGTAGATCCTATTACACTTCTGTTTATATTAAA
TCCACAATATTTTATTACATTTTTAACTTGTATAAATTTTAGGTCAAATCCTTCAAGCCAACCTATACTAAAAATTAGTTCCATAATCAC
AAATGGCTCTTTTGTGTAATTGTTTAATTTCACCTGAATATCATAATGCTTAAAGCCATATGGAGTTGGAAATTATTTCCAAAGCATATT
TATTCCATTGTTTTAGTCTGGCTATTTACAGTATAAAAAAAGCATTTTTATTAAAATACTGTGTAGTTCTTTGAGATAGTTGCTTATGCA
TATAGTAAGTATTACATTCTTAGAGTAGAGCAGAGTTTTTAGTTAGTATTAATTTATTTTCCTCCATTCATGTACTTTTCCTTATATTTC
CAAAACTGTTACTGAGAATGGGTCAAGATCAGTGAGAAATCTTTACAGTTGACAGGAACCTGGACCCCTTACCCCAACTTTATGAGTAAT
GCTTGGAATAAAAACTCTTAAGGCAACTCACTGATTTACTTCTAGCAATAGCATGATGTTACAGGAATATTACCTCTGTTTAAGCAAGGT
AATGTGTAAAATCAGTCTCGGCTGTCAGAATAACTTCTAAAAGGTATTTTTATAAGCAGTTCAAGTTACTGAAAACCTTTTAAACCTTTC
TGAAGTTCGTTAGTATAAATTACTTTTCTAGGATTATTAATAAAAGCCACATAGGTGGCAAGTTGTAGTTTTATATGGCTCTGTAGAGTG
GTGAACCTTCTAGAGGAATATATGATTTATTCACAGTTCCTCAAGGCCTGGGGATGATGATCAGTTATACCTATTTTTGTGCAATTACAT
CATGTTGTACATTAGAAATGGAGAGTTTAATAGCTCTTTAACTGCTGTCCTCATTAGGTAATGATAAATATTTCCCTTAAATAATTGACT
ATTTTGCTGTGTTTTAAAAATGATTGAAATTTATCTTGCCATATCTCATAATTTCATGCACAAGTTGACTGAGCTAATCTTGAGAATATA
TTCGTAAAATAGGAGCACATTTAGTTGAGGTATACAAGGTAGGACTCTAGACAAAACCTTCTATTTTAGCTTTAGTGAATTTCAAAAGTA
ATGGGTCTTGGAGTATAGATTTTTATTAGTAGCTTGAAAGAGCTTAATCATATGCAGTAAGTATTTTTATTACCAATAAATTTAAAATTT
TTTAAGAAAAATATTTTTATCCTAGGGCCAAGTGTTGCCTGCCACCAATCAGTAAGTTAGTCTATAACAAATTTTACCCTAACAGTTTTA
CCACCTAGTAACAGTCATTTCTGAAAATATGTTGGATAGAAAGTCACTCTTTGGCAAAAGTGTTAGAATTTGCTTTTGTGCCATCTATTC
CTTTTATGGCATCTATCTTGAAAGTAATCTTGTATTGGAGATTGAAAGATGCTGTAATTTAGAAATTAACATGATATCTTAAATTACCTT
TATGAAATATAGTTTTGTATAATAGCATAGATTTTCCTTCAAAAAATGAACATTTATATATCTACAAAAATATGGAGAAGAGTAATTTGA
AAGCCTACTTTCTGAAGAAAATGGTGGGATTTTTTTTTATCATGATTAAATATCAAAAAATTGCCCTATGAAAACTTTAAATCTCTAAAA
CATTTGAAATACTACCATATTTGTGATTTATTGAGAATAAAAATCCATTTTGAAATGTAAAATTTTTATGATCTGATTCAGTTTTAAGAA
AACATGAATGAACTAGAAGATATTAAAAACATTTGACATTGGTAAGAAATATTGATACTGATATTGATTTTTATATAGGTATTTATTTCA
GAATTGATATTTTGAGAAAAATACATGTGAGTCATTTTTTCTGTTTCTCTTTTCTCTTAACGATTATCACTGTAATTCTGAATCTGAAAG
GTAAAACAATTAGTCAAAATATTATTGCCATCATTCTACCTGTGTTATGAAACTACTTATTCATAGTTAATTCTCATTAACACTTACATT
TCCATAAAGAAAACTCAAGTATTAATAAAAGAGACTTTACTGGCTTAAGAGGGCTGTGAAAGATTTTTGATAGTGAATCATGACCCTAAG
GGAGAGATTTGTGTGATAAAAGTATTGTATATAATAGATCAGCGATTTTTGTAAGGCAAACAGAATTTGTAAGTTGGCAGATCTTCCTAA
GTTGCAAAATGTAATGATGAGCTTGGTGGAGAAGAATGAGTCGTTCTTGGAATACCTATGTGCAGCCACTACCCATCTCAATGTCACCTT
GTTTGCATTCTTGGATAGCTTGTATATGTAGTAGTTTGATGAATAATTTAAAGAAAAACACCTAAAATTTGAAAAATGATTGTAGGATCA
AAAAAGGCAGATGAAATTACTTAATACTCAGTGTTTTGGAGAGTATTCCTTTTAGTTTGTTGGTTGGCTGGTTTGAACGATAGAAATATG
CAGCATGCAATATATGCTTATATTTCATTTTAATTTCTGATATATAATGAACTTCTTGGGAGAGGTACTGAATCTTTGATGTTTTTTGTC
ATTGTTCTCAAGTGCAATATAACAATGTAACCAAATCTAGATAATTTCAAAGTTGTCATTAATTTAGTAAGCCTAATATAAACAAATATT
TGTATTATTTTTGTTAGCAGGAAAGAGTGATTAAGTGAGGTTATTTACCCCTAAATGGTCCATTCTGCATTGTATTTCAGGCTGGAAATG
AATTATTCTTTACCAGTTTTGAAACACTTTGAAATATCCTAAGGTAACTTGGAAGCTGTGTAGTATATCAAATTAATTTGCTACCTAATA
ACATAGAAAGTAAATATCTTTGTGGTCACCCACATTGGGTGAGACAGAAAATGAATCTGTTCTAAAATTTGTAATTTGCTAACTTGATTT

>21072_21072_5_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000374907_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------
>21072_21072_6_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000433736_length(transcript)=765nt_BP=175nt
CACTGCTGTGCAGGGCAGGAAAGCTCCATGCACATAGCCCAGCAAAGAGCAACACAGAGCTGAAAGGAAGACTCAGAGGAGAGAGATAAG
TAAGGAAAGTAGTGATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTGGTTG
TGGAGTTGCTCAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATCTTGTACGTAAAGTCATTACTGTG
GACTGAGACTTTTATGAATAAAGAAAATCAGAATCATTCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAA
GAATCTTCCAATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAGCCAGCGCCCATGCCTGTGCCTGT
GTGGGTGATCATTTTAGCAGTTCTAGCAGGATTGTTGCTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGT
CCGGCCACCTCAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCAGAAACTTAACTGCAGTTTTTAAG
TTATGCTACATCTTGACCCACTAGAATTAGCAACTTTATTATAGATTTAAACTTTCTTCATGAGGAGTAAAAATCCAAGGCTTTACTGCT

>21072_21072_6_CYP3A4-ITGAV_CYP3A4_chr7_99381634_ENST00000354593_ITGAV_chr2_187540331_ENST00000433736_length(amino acids)=159AA_BP=13
MASPGCQPGAPLSGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYP3A4-ITGAV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYP3A4-ITGAV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYP3A4-ITGAV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource