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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYP4A11-SLC4A7 (FusionGDB2 ID:21081)

Fusion Gene Summary for CYP4A11-SLC4A7

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP4A11-SLC4A7
Fusion gene ID: 21081
HgeneTgene
Gene symbol

CYP4A11

SLC4A7

Gene ID

1579

9497

Gene namecytochrome P450 family 4 subfamily A member 11solute carrier family 4 member 7
SynonymsCP4Y|CYP4A2|CYP4AII|CYPIVA11NBC2|NBC3|NBCN1|SBC2|SLC4A6
Cytomap

1p33

3p24.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 4A1120-HETE synthase20-hydroxyeicosatetraenoic acid synthaseP450HL-omegaalkane-1 monooxygenasecytochrome P-450HK-omegacytochrome P450, family 4, subfamily A, polypeptide 11cytochrome P450, subfamily IVA, polypeptide 11cytochrome P4sodium bicarbonate cotransporter 3bicarbonate transporterelectroneutral Na/HCO(3) cotransportersodium bicarbonate cotransporter 2sodium bicarbonate cotransporter 2bsolute carrier family 4, sodium bicarbonate cotransporter, member 7
Modification date2020031320200313
UniProtAcc

Q02928

.
Ensembl transtripts involved in fusion geneENST00000310638, ENST00000371904, 
ENST00000371905, ENST00000457840, 
ENST00000462347, ENST00000496519, 
ENST00000295736, ENST00000388777, 
ENST00000425128, ENST00000428386, 
ENST00000435667, ENST00000437179, 
ENST00000440156, ENST00000445684, 
ENST00000446700, ENST00000454389, 
ENST00000455077, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYP4A11 [Title/Abstract] AND SLC4A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYP4A11(47395580)-SLC4A7(27523259), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP4A11

GO:0001676

long-chain fatty acid metabolic process

18433732

HgeneCYP4A11

GO:0006691

leukotriene metabolic process

9799565

HgeneCYP4A11

GO:0019369

arachidonic acid metabolic process

10660572

HgeneCYP4A11

GO:0019373

epoxygenase P450 pathway

9618440

HgeneCYP4A11

GO:0055114

oxidation-reduction process

9618440|9799565|18433732


check buttonFusion gene breakpoints across CYP4A11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC4A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AW84867CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-


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Fusion Gene ORF analysis for CYP4A11-SLC4A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000310638ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CYP4A11-SLC4A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CYP4A11-SLC4A7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47395580/:27523259)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4A11

Q02928

.
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:7679927, ECO:0000269|PubMed:8914854}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CYP4A11-SLC4A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CYP4A11-SLC4A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYP4A11-SLC4A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYP4A11-SLC4A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource