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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ADAMTS9-CHL1 (FusionGDB2 ID:2112) |
Fusion Gene Summary for ADAMTS9-CHL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS9-CHL1 | Fusion gene ID: 2112 | Hgene | Tgene | Gene symbol | ADAMTS9 | CHL1 | Gene ID | 56999 | 10752 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 9 | cell adhesion molecule L1 like | |
| Synonyms | - | CALL|L1CAM2 | |
| Cytomap | 3p14.1 | 3p26.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 9a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 | neural cell adhesion molecule L1-like proteinL1 cell adhesion molecule 2cell adhesion molecule with homology to L1CAM (close homolog of L1)cell adhesion molecule with homology to L1CAM (close homologue of L1)close homolog of L1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9P2N4 | O00533 | |
| Ensembl transtripts involved in fusion gene | ENST00000295903, ENST00000498707, ENST00000459780, ENST00000467257, | ENST00000489224, ENST00000256509, ENST00000397491, | |
| Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 5 X 7 X 4=140 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS9 [Title/Abstract] AND CHL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADAMTS9(64619374)-CHL1(447178), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ADAMTS9-CHL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. ADAMTS9-CHL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADAMTS9 | GO:0006508 | proteolysis | 12514189 |
| Fusion gene breakpoints across ADAMTS9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CHL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-62-8395-01A | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
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Fusion Gene ORF analysis for ADAMTS9-CHL1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000295903 | ENST00000489224 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| 5CDS-intron | ENST00000498707 | ENST00000489224 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| Frame-shift | ENST00000295903 | ENST00000256509 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| Frame-shift | ENST00000498707 | ENST00000256509 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| In-frame | ENST00000295903 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| In-frame | ENST00000498707 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-3CDS | ENST00000459780 | ENST00000256509 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-3CDS | ENST00000459780 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-3CDS | ENST00000467257 | ENST00000256509 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-3CDS | ENST00000467257 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-intron | ENST00000459780 | ENST00000489224 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| intron-intron | ENST00000467257 | ENST00000489224 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000295903 | ADAMTS9 | chr3 | 64619374 | - | ENST00000397491 | CHL1 | chr3 | 447178 | + | 3334 | 1976 | 22 | 2058 | 678 |
| ENST00000498707 | ADAMTS9 | chr3 | 64619374 | - | ENST00000397491 | CHL1 | chr3 | 447178 | + | 3739 | 2381 | 343 | 2463 | 706 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000295903 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + | 0.001506127 | 0.9984939 |
| ENST00000498707 | ENST00000397491 | ADAMTS9 | chr3 | 64619374 | - | CHL1 | chr3 | 447178 | + | 0.001506383 | 0.99849355 |
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Fusion Genomic Features for ADAMTS9-CHL1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ADAMTS9 | chr3 | 64619373 | - | CHL1 | chr3 | 447177 | + | 0.01713641 | 0.9828636 |
| ADAMTS9 | chr3 | 64619373 | - | CHL1 | chr3 | 447177 | + | 0.01713641 | 0.9828636 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ADAMTS9-CHL1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:64619374/chr3:447178) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS9 | CHL1 |
| FUNCTION: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:22419820}. | FUNCTION: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 88_96 | 651 | 2196.6666666666665 | Compositional bias | Note=Poly-Ser |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 88_96 | 679 | 2117.3333333333335 | Compositional bias | Note=Poly-Ser |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 293_499 | 651 | 2196.6666666666665 | Domain | Peptidase M12B |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 509_587 | 651 | 2196.6666666666665 | Domain | Note=Disintegrin |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 588_643 | 651 | 2196.6666666666665 | Domain | TSP type-1 1 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 293_499 | 679 | 2117.3333333333335 | Domain | Peptidase M12B |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 509_587 | 679 | 2117.3333333333335 | Domain | Note=Disintegrin |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 588_643 | 679 | 2117.3333333333335 | Domain | TSP type-1 1 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 221_228 | 651 | 2196.6666666666665 | Motif | Cysteine switch |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 221_228 | 679 | 2117.3333333333335 | Motif | Cysteine switch |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 1181_1185 | 1152 | 1225.0 | Motif | Note=FIG[AQ]Y | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 1181_1185 | 1136 | 1209.0 | Motif | Note=FIG[AQ]Y |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 644_752 | 651 | 2196.6666666666665 | Compositional bias | Note=Cys-rich |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 644_752 | 679 | 2117.3333333333335 | Compositional bias | Note=Cys-rich |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1052_1109 | 651 | 2196.6666666666665 | Domain | TSP type-1 5 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1110_1166 | 651 | 2196.6666666666665 | Domain | TSP type-1 6 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1182_1240 | 651 | 2196.6666666666665 | Domain | TSP type-1 7 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1241_1296 | 651 | 2196.6666666666665 | Domain | TSP type-1 8 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1328_1379 | 651 | 2196.6666666666665 | Domain | TSP type-1 9 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1382_1440 | 651 | 2196.6666666666665 | Domain | TSP type-1 10 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1441_1494 | 651 | 2196.6666666666665 | Domain | TSP type-1 11 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1497_1555 | 651 | 2196.6666666666665 | Domain | TSP type-1 12 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1556_1611 | 651 | 2196.6666666666665 | Domain | TSP type-1 13 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1612_1676 | 651 | 2196.6666666666665 | Domain | TSP type-1 14 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1677_1734 | 651 | 2196.6666666666665 | Domain | TSP type-1 15 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 1735_1935 | 651 | 2196.6666666666665 | Domain | GON |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 878_936 | 651 | 2196.6666666666665 | Domain | TSP type-1 2 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 939_997 | 651 | 2196.6666666666665 | Domain | TSP type-1 3 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 998_1049 | 651 | 2196.6666666666665 | Domain | TSP type-1 4 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1052_1109 | 679 | 2117.3333333333335 | Domain | TSP type-1 5 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1110_1166 | 679 | 2117.3333333333335 | Domain | TSP type-1 6 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1182_1240 | 679 | 2117.3333333333335 | Domain | TSP type-1 7 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1241_1296 | 679 | 2117.3333333333335 | Domain | TSP type-1 8 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1328_1379 | 679 | 2117.3333333333335 | Domain | TSP type-1 9 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1382_1440 | 679 | 2117.3333333333335 | Domain | TSP type-1 10 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1441_1494 | 679 | 2117.3333333333335 | Domain | TSP type-1 11 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1497_1555 | 679 | 2117.3333333333335 | Domain | TSP type-1 12 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1556_1611 | 679 | 2117.3333333333335 | Domain | TSP type-1 13 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1612_1676 | 679 | 2117.3333333333335 | Domain | TSP type-1 14 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1677_1734 | 679 | 2117.3333333333335 | Domain | TSP type-1 15 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 1735_1935 | 679 | 2117.3333333333335 | Domain | GON |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 878_936 | 679 | 2117.3333333333335 | Domain | TSP type-1 2 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 939_997 | 679 | 2117.3333333333335 | Domain | TSP type-1 3 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 998_1049 | 679 | 2117.3333333333335 | Domain | TSP type-1 4 |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000295903 | - | 12 | 39 | 753_877 | 651 | 2196.6666666666665 | Region | Note=Spacer |
| Hgene | ADAMTS9 | chr3:64619374 | chr3:447178 | ENST00000498707 | - | 13 | 40 | 753_877 | 679 | 2117.3333333333335 | Region | Note=Spacer |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 128_223 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 235_328 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 331_417 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 35_124 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 423_510 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 515_607 | 1152 | 1225.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 614_709 | 1152 | 1225.0 | Domain | Fibronectin type-III 1 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 714_807 | 1152 | 1225.0 | Domain | Fibronectin type-III 2 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 809_914 | 1152 | 1225.0 | Domain | Fibronectin type-III 3 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 918_1015 | 1152 | 1225.0 | Domain | Fibronectin type-III 4 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 128_223 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 235_328 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 331_417 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 35_124 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 423_510 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 515_607 | 1136 | 1209.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 614_709 | 1136 | 1209.0 | Domain | Fibronectin type-III 1 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 714_807 | 1136 | 1209.0 | Domain | Fibronectin type-III 2 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 809_914 | 1136 | 1209.0 | Domain | Fibronectin type-III 3 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 918_1015 | 1136 | 1209.0 | Domain | Fibronectin type-III 4 | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 555_558 | 1152 | 1225.0 | Motif | Note=DGEA | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 555_558 | 1136 | 1209.0 | Motif | Note=DGEA | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 1104_1208 | 1152 | 1225.0 | Topological domain | Cytoplasmic | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 25_1082 | 1152 | 1225.0 | Topological domain | Extracellular | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 1104_1208 | 1136 | 1209.0 | Topological domain | Cytoplasmic | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 25_1082 | 1136 | 1209.0 | Topological domain | Extracellular | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000256509 | 26 | 28 | 1083_1103 | 1152 | 1225.0 | Transmembrane | Helical | |
| Tgene | CHL1 | chr3:64619374 | chr3:447178 | ENST00000397491 | 25 | 27 | 1083_1103 | 1136 | 1209.0 | Transmembrane | Helical |
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Fusion Gene Sequence for ADAMTS9-CHL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >2112_2112_1_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000295903_CHL1_chr3_447178_ENST00000397491_length(transcript)=3334nt_BP=1976nt GGAGGGAGGGGTGGGAAGCACCATGCAGTTTGTATCCTGGGCCACACTGCTAACGCTCCTGGTGCGGGACCTGGCCGAGATGGGGAGCCC AGACGCCGCGGCGGCCGTGCGCAAGGACAGGCTGCACCCGAGGCAAGTGAAATTATTAGAGACCCTGAGCGAATACGAAATCGTGTCTCC CATCCGAGTGAACGCTCTCGGAGAACCCTTTCCCACGAACGTCCACTTCAAAAGAACGCGACGGAGCATTAACTCTGCCACTGACCCCTG GCCTGCCTTCGCCTCCTCCTCTTCCTCCTCTACCTCCTCCCAGGCGCATTACCGCCTCTCTGCCTTCGGCCAGCAGTTTCTATTTAATCT CACCGCCAATGCCGGATTTATCGCTCCACTGTTCACTGTCACCCTCCTCGGGACGCCCGGGGTGAATCAGACCAAGTTTTATTCCGAAGA GGAAGCGGAACTCAAGCACTGTTTCTACAAAGGCTATGTCAATACCAACTCCGAGCACACGGCCGTCATCAGCCTCTGCTCAGGAATGCT GGGCACATTCCGGTCTCATGATGGGGATTATTTTATTGAACCACTACAGTCTATGGATGAACAAGAAGATGAAGAGGAACAAAACAAACC CCACATCATTTATAGGCGCAGCGCCCCCCAGAGAGAGCCCTCAACAGGAAGGCATGCATGTGACACCTCAGAACACAAAAATAGGCACAG TAAAGACAAGAAGAAAACCAGAGCAAGAAAATGGGGAGAAAGGATTAACCTGGCTGGTGACGTAGCAGCATTAAACAGCGGCTTAGCAAC AGAGGCATTTTCTGCTTATGGTAATAAGACGGACAACACAAGAGAAAAGAGGACCCACAGAAGGACAAAACGTTTTTTATCCTATCCACG GTTTGTAGAAGTCTTGGTGGTGGCAGACAACAGAATGGTTTCATACCATGGAGAAAACCTTCAACACTATATTTTAACTTTAATGTCAAT TGATGGGCCTTCCATATCTTTTAATGCTCAGACAACATTAAAAAACTTTTGCCAGTGGCAGCATTCGAAGAACAGTCCAGGTGGAATCCA TCATGATACTGCTGTTCTCTTAACAAGACAGGATATCTGCAGAGCTCACGACAAATGTGATACCTTAGGCCTGGCTGAACTGGGAACCAT TTGTGATCCCTATAGAAGCTGTTCTATTAGTGAAGATAGTGGATTGAGTACAGCTTTTACGATCGCCCATGAGCTGGGCCATGTGTTTAA CATGCCTCATGATGACAACAACAAATGTAAAGAAGAAGGAGTTAAGAGTCCCCAGCATGTCATGGCTCCAACACTGAACTTCTACACCAA CCCCTGGATGTGGTCAAAGTGTAGTCGAAAATATATCACTGAGTTTTTAGACACTGGTTATGGCGAGTGTTTGCTTAACGAACCTGAATC CAGACCCTACCCTTTGCCTGTCCAACTGCCAGGCATCCTTTACAACGTGAATAAACAATGTGAATTGATTTTTGGACCAGGTTCTCAGGT GTGCCCATATATGATGCAGTGCAGACGGCTCTGGTGCAATAACGTCAATGGAGTACACAAAGGCTGCCGGACTCAGCACACACCCTGGGC CGATGGGACGGAGTGCGAGCCTGGAAAGCACTGCAAGTATGGATTTTGTGTTCCCAAAGAAATGGATGTCCCCGTGACAGATGGATCCTG GGGAAGTTGGAGTCCCTTTGGAACCTGCTCCAGAACATGTGGAGGGGGCATCAAAACAGCCATTCGAGAGTGCAACAGACCAGAACCAAA AAATGGTGGAAAATACTGTGTAGGACGTAGAATGAAATTTAAGTCCTGCAACACGGAGCCATGTCTCAAGCAGAAGCGAGACTTCCGAGA TGAACAGTGTGCTCACTTTGACGGGAAGCATTTTAACATCAACGGTCTGCTTCCCAATGTGCGCTGGGTCCCTAAATACAGTGGAATGAC AGTGATGAAAAGCCTCTCAAAGGAAGCCTTCGGTCCCTTAATAGGGATATGCAGCCTACTGAAAGTGCTGACAGCTTAGTCGAATACGGA GAGGGAGACCATGGTCTCTTCAGTGAAGATGGATCATTTATTGGTGCCTACGCTGGATCTAAGGAGAAGGGATCTGTTGAAAGCAATGGA AGTTCTACAGCAACTTTTCCCCTTCGGGCATAAACACAACATATGTAAGCAACGCTACTGGTTCACCCCAACCTTCCATATTTATCTGTT CAAAGGAGCAAGAACTTTCATATAGGAATAGAAACATGCTGGCCGAAGATTTCATCCAGAAGTCAACATCCTGCAATTATGTTGAAAAGA GTAGTACTTTCTTCAAAATATAAAATGCCAAGCACTTCAGGCCTATGTTTTGCTTATATTGTTTTCAGGTGCTCAAAATGCAAAACACAA AACAAATCCTGCATTTAGATACACCTCAACTAAATCCAAAGTCCCCATTCAGTATATTCCATATTTGCCTGATTTTACTATTCGGTGTGT TTGCATAGATGTTGCTACTTGGTGGGTTTTTCTCCGTATGCACATTGGTATACAGTCTCTGAGAACTGGCTTGGTGACTTTGCTTCACTA CAGGTTAAAAGACCATAAGCAAACTGGTTATTTAAAATGTAAAAAGGAATATGAAAGTCTTATTAAAACACTTCATTGAAAATATACAGT CTAAATTTATTATTTAAATTTTACTAGCAAAAGTCTTAGGTGAACAATCAACTAGTATTTGTTGAGCTCCTATTTGCCCAGAGATGGTCA TATTTAAACAGAAGTATACGTTTTTCAGTTTCAACATGAATTTTTTTATTTCTGTCAGTTATGACATCCACAAGCATCACTTTTTGTGTC TGTTTTTTTTTTTTTTCTTGGACTAAATTCAACTGCATGGAAGCGGTGGTCAGAAGGTTGTTTTATACGAGAACAGGCAGAAAGTGCCCA TTGTTCAGGATTCTAATAGCTACATCTACTTAATATCTTCATTTCTAAATTGACTGCTTTTACCTTTTTCTCATGTTTATATAATGGTAT GCTTGCATATATTTCATGAATACATTGTACATATTATGTTAATATTTACACAATTTAAAATATAGATGTGTTTTATTTTGAAGTGAGAAA ATGAACATTAACAGGCATGTTTGTACAGCTAGAATATATTAGTAAGATACTGTTTTTCGTCATTCCAGAGCTACAACTAATAACACGAGG TTCCAAAGCTGAAGACTTTGTATAAAGTATTTGGGTTTTGTTCTTGTATTGCTTTCTTTCAACAGTTTCAAAATAAAATATCATATAAAT >2112_2112_1_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000295903_CHL1_chr3_447178_ENST00000397491_length(amino acids)=678AA_BP=652 MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSS SSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYG NKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLL TRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKC SRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEP GKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFD -------------------------------------------------------------- >2112_2112_2_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000498707_CHL1_chr3_447178_ENST00000397491_length(transcript)=3739nt_BP=2381nt ACAGGGCGCCCGGCGCGCCTCGGAGCGCAAGTTCCTCGCCTTCTCCTGCCCGCTCGCTGGGCATTATGCGGCCAAGCAGCCGAGCCCCAG TCCTCCTCCTCCTCCTGCTCCTCCGGCTCCTCCTGCGGCCCGAGCGGCTCAGCTCTCGGCAGGCGGCGGCGTTGCTCAGCCGAGCGCAGA CGGGACCCTCGCAGCGAGACCTCAGCGACTCCTAAAGTCAAAAGTTGGCGGCGGGCGCCGGGCTCCGCGCGCTCTCCACGGCCGCTGCCT CGCGTCGCCGCCGCAGCCAAGGAGGGCAGGAGGGAGGGGGGTGGGGGCAGCGGAGGGAGGGGTGGGAAGCACCATGCAGTTTGTATCCTG GGCCACACTGCTAACGCTCCTGGTGCGGGACCTGGCCGAGATGGGGAGCCCAGACGCCGCGGCGGCCGTGCGCAAGGACAGGCTGCACCC GAGGCAAGTGAAATTATTAGAGACCCTGAGCGAATACGAAATCGTGTCTCCCATCCGAGTGAACGCTCTCGGAGAACCCTTTCCCACGAA CGTCCACTTCAAAAGAACGCGACGGAGCATTAACTCTGCCACTGACCCCTGGCCTGCCTTCGCCTCCTCCTCTTCCTCCTCTACCTCCTC CCAGGCGCATTACCGCCTCTCTGCCTTCGGCCAGCAGTTTCTATTTAATCTCACCGCCAATGCCGGATTTATCGCTCCACTGTTCACTGT CACCCTCCTCGGGACGCCCGGGGTGAATCAGACCAAGTTTTATTCCGAAGAGGAAGCGGAACTCAAGCACTGTTTCTACAAAGGCTATGT CAATACCAACTCCGAGCACACGGCCGTCATCAGCCTCTGCTCAGGAATGCTGGGCACATTCCGGTCTCATGATGGGGATTATTTTATTGA ACCACTACAGTCTATGGATGAACAAGAAGATGAAGAGGAACAAAACAAACCCCACATCATTTATAGGCGCAGCGCCCCCCAGAGAGAGCC CTCAACAGGAAGGCATGCATGTGACACCTCAGAACACAAAAATAGGCACAGTAAAGACAAGAAGAAAACCAGAGCAAGAAAATGGGGAGA AAGGATTAACCTGGCTGGTGACGTAGCAGCATTAAACAGCGGCTTAGCAACAGAGGCATTTTCTGCTTATGGTAATAAGACGGACAACAC AAGAGAAAAGAGGACCCACAGAAGGACAAAACGTTTTTTATCCTATCCACGGTTTGTAGAAGTCTTGGTGGTGGCAGACAACAGAATGGT TTCATACCATGGAGAAAACCTTCAACACTATATTTTAACTTTAATGTCAATTGTAGCCTCTATCTATAAAGACCCAAGTATTGGAAATTT AATTAATATTGTTATTGTGAACTTAATTGTGATTCATAATGAACAGGATGGGCCTTCCATATCTTTTAATGCTCAGACAACATTAAAAAA CTTTTGCCAGTGGCAGCATTCGAAGAACAGTCCAGGTGGAATCCATCATGATACTGCTGTTCTCTTAACAAGACAGGATATCTGCAGAGC TCACGACAAATGTGATACCTTAGGCCTGGCTGAACTGGGAACCATTTGTGATCCCTATAGAAGCTGTTCTATTAGTGAAGATAGTGGATT GAGTACAGCTTTTACGATCGCCCATGAGCTGGGCCATGTGTTTAACATGCCTCATGATGACAACAACAAATGTAAAGAAGAAGGAGTTAA GAGTCCCCAGCATGTCATGGCTCCAACACTGAACTTCTACACCAACCCCTGGATGTGGTCAAAGTGTAGTCGAAAATATATCACTGAGTT TTTAGACACTGGTTATGGCGAGTGTTTGCTTAACGAACCTGAATCCAGACCCTACCCTTTGCCTGTCCAACTGCCAGGCATCCTTTACAA CGTGAATAAACAATGTGAATTGATTTTTGGACCAGGTTCTCAGGTGTGCCCATATATGATGCAGTGCAGACGGCTCTGGTGCAATAACGT CAATGGAGTACACAAAGGCTGCCGGACTCAGCACACACCCTGGGCCGATGGGACGGAGTGCGAGCCTGGAAAGCACTGCAAGTATGGATT TTGTGTTCCCAAAGAAATGGATGTCCCCGTGACAGATGGATCCTGGGGAAGTTGGAGTCCCTTTGGAACCTGCTCCAGAACATGTGGAGG GGGCATCAAAACAGCCATTCGAGAGTGCAACAGACCAGAACCAAAAAATGGTGGAAAATACTGTGTAGGACGTAGAATGAAATTTAAGTC CTGCAACACGGAGCCATGTCTCAAGCAGAAGCGAGACTTCCGAGATGAACAGTGTGCTCACTTTGACGGGAAGCATTTTAACATCAACGG TCTGCTTCCCAATGTGCGCTGGGTCCCTAAATACAGTGGAATGACAGTGATGAAAAGCCTCTCAAAGGAAGCCTTCGGTCCCTTAATAGG GATATGCAGCCTACTGAAAGTGCTGACAGCTTAGTCGAATACGGAGAGGGAGACCATGGTCTCTTCAGTGAAGATGGATCATTTATTGGT GCCTACGCTGGATCTAAGGAGAAGGGATCTGTTGAAAGCAATGGAAGTTCTACAGCAACTTTTCCCCTTCGGGCATAAACACAACATATG TAAGCAACGCTACTGGTTCACCCCAACCTTCCATATTTATCTGTTCAAAGGAGCAAGAACTTTCATATAGGAATAGAAACATGCTGGCCG AAGATTTCATCCAGAAGTCAACATCCTGCAATTATGTTGAAAAGAGTAGTACTTTCTTCAAAATATAAAATGCCAAGCACTTCAGGCCTA TGTTTTGCTTATATTGTTTTCAGGTGCTCAAAATGCAAAACACAAAACAAATCCTGCATTTAGATACACCTCAACTAAATCCAAAGTCCC CATTCAGTATATTCCATATTTGCCTGATTTTACTATTCGGTGTGTTTGCATAGATGTTGCTACTTGGTGGGTTTTTCTCCGTATGCACAT TGGTATACAGTCTCTGAGAACTGGCTTGGTGACTTTGCTTCACTACAGGTTAAAAGACCATAAGCAAACTGGTTATTTAAAATGTAAAAA GGAATATGAAAGTCTTATTAAAACACTTCATTGAAAATATACAGTCTAAATTTATTATTTAAATTTTACTAGCAAAAGTCTTAGGTGAAC AATCAACTAGTATTTGTTGAGCTCCTATTTGCCCAGAGATGGTCATATTTAAACAGAAGTATACGTTTTTCAGTTTCAACATGAATTTTT TTATTTCTGTCAGTTATGACATCCACAAGCATCACTTTTTGTGTCTGTTTTTTTTTTTTTTCTTGGACTAAATTCAACTGCATGGAAGCG GTGGTCAGAAGGTTGTTTTATACGAGAACAGGCAGAAAGTGCCCATTGTTCAGGATTCTAATAGCTACATCTACTTAATATCTTCATTTC TAAATTGACTGCTTTTACCTTTTTCTCATGTTTATATAATGGTATGCTTGCATATATTTCATGAATACATTGTACATATTATGTTAATAT TTACACAATTTAAAATATAGATGTGTTTTATTTTGAAGTGAGAAAATGAACATTAACAGGCATGTTTGTACAGCTAGAATATATTAGTAA GATACTGTTTTTCGTCATTCCAGAGCTACAACTAATAACACGAGGTTCCAAAGCTGAAGACTTTGTATAAAGTATTTGGGTTTTGTTCTT >2112_2112_2_ADAMTS9-CHL1_ADAMTS9_chr3_64619374_ENST00000498707_CHL1_chr3_447178_ENST00000397491_length(amino acids)=706AA_BP=680 MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSS SSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYG NKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADAMTS9-CHL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAMTS9-CHL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAMTS9-CHL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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