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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CYTH3-FBXW7 (FusionGDB2 ID:21158) |
Fusion Gene Summary for CYTH3-FBXW7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYTH3-FBXW7 | Fusion gene ID: 21158 | Hgene | Tgene | Gene symbol | CYTH3 | FBXW7 | Gene ID | 9265 | 55294 |
| Gene name | cytohesin 3 | F-box and WD repeat domain containing 7 | |
| Synonyms | ARNO3|GRP1|PSCD3|cytohesin-3 | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | |
| Cytomap | 7p22.1 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3 | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | O43739 | Q969H0 | |
| Ensembl transtripts involved in fusion gene | ENST00000350796, ENST00000396741, ENST00000488964, | ENST00000263981, ENST00000281708, ENST00000296555, ENST00000393956, ENST00000603548, ENST00000603841, ENST00000604095, ENST00000604872, | |
| Fusion gene scores | * DoF score | 12 X 10 X 8=960 | 6 X 6 X 4=144 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/960*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYTH3 [Title/Abstract] AND FBXW7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CYTH3(6237403)-FBXW7(153242410), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
| Tgene | FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
| Tgene | FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
| Tgene | FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
| Tgene | FBXW7 | GO:0050821 | protein stabilization | 20208556 |
| Tgene | FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
| Tgene | FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
| Tgene | FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
| Tgene | FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
| Fusion gene breakpoints across CYTH3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across FBXW7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BI496455 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
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Fusion Gene ORF analysis for CYTH3-FBXW7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000350796 | ENST00000263981 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000281708 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000296555 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000393956 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000603548 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000603841 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000604095 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000350796 | ENST00000604872 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000263981 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000281708 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000296555 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000393956 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000603548 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000603841 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000604095 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000396741 | ENST00000604872 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000263981 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000281708 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000296555 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000393956 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000603548 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000603841 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000604095 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| intron-intron | ENST00000488964 | ENST00000604872 | CYTH3 | chr7 | 6237403 | - | FBXW7 | chr4 | 153242410 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CYTH3-FBXW7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CYTH3-FBXW7 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6237403/:153242410) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYTH3 | FBXW7 |
| FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}. | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CYTH3-FBXW7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CYTH3-FBXW7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CYTH3-FBXW7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CYTH3-FBXW7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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