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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYYR1-APP (FusionGDB2 ID:21174)

Fusion Gene Summary for CYYR1-APP

check button Fusion gene summary
Fusion gene informationFusion gene name: CYYR1-APP
Fusion gene ID: 21174
HgeneTgene
Gene symbol

CYYR1

APP

Gene ID

116159

351

Gene namecysteine and tyrosine rich 1amyloid beta precursor protein
SynonymsC21orf95AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

21q21.3

21q21.3

Type of geneprotein-codingprotein-coding
Descriptioncysteine and tyrosine-rich protein 1cysteine and tyrosine-rich protein 1 isoform 1,2,2bis,3,4cysteine and tyrosine-rich protein 1 isoform 1,2,3,4bcysteine and tyrosine-rich protein 1 isoform 1,2,3bcysteine and tyrosine-rich protein 1 isoform 1,2,4cysamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020031320200329
UniProtAcc

Q96J86

Q8NEU8

Ensembl transtripts involved in fusion geneENST00000299340, ENST00000400043, 
ENST00000435845, 		ENST00000440126, 
ENST00000448388, ENST00000474136, 
ENST00000348990, ENST00000354192, 
ENST00000357903, ENST00000358918, 
ENST00000359726, ENST00000439274, 
ENST00000346798, 
Fusion gene scores* DoF score2 X 2 X 2=825 X 18 X 10=4500
# samples 227
** MAII scorelog2(2/8*10)=1.32192809488736log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYYR1 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPP(27462259)-CYYR1(27938687), # samples:1
APP(27484296)-CYYR1(27852748), # samples:1
CYYR1(27938585)-APP(27484463), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across CYYR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-RW-A68C-01ACYYR1chr21

27938585

-APPchr21

27484463

-


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Fusion Gene ORF analysis for CYYR1-APP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000299340ENST00000440126CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000299340ENST00000448388CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000299340ENST00000474136CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000400043ENST00000440126CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000400043ENST00000448388CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000400043ENST00000474136CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000435845ENST00000440126CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000435845ENST00000448388CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-5UTRENST00000435845ENST00000474136CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000348990CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000354192CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000357903CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000358918CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000359726CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000299340ENST00000439274CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000348990CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000354192CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000357903CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000358918CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000359726CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000400043ENST00000439274CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000348990CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000354192CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000357903CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000358918CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000359726CYYR1chr21

27938585

-APPchr21

27484463

-
5CDS-intronENST00000435845ENST00000439274CYYR1chr21

27938585

-APPchr21

27484463

-
Frame-shiftENST00000299340ENST00000346798CYYR1chr21

27938585

-APPchr21

27484463

-
Frame-shiftENST00000400043ENST00000346798CYYR1chr21

27938585

-APPchr21

27484463

-
In-frameENST00000435845ENST00000346798CYYR1chr21

27938585

-APPchr21

27484463

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435845CYYR1chr2127938585-ENST00000346798APPchr2127484463-38965204812775764

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435845ENST00000346798CYYR1chr2127938585-APPchr2127484463-0.0021078730.9978922

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Fusion Genomic Features for CYYR1-APP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CYYR1-APP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27462259/chr21:27938687)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYYR1

Q96J86

APP

Q8NEU8

FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYYR1chr21:27938585chr21:27484463ENST00000299340-2430_6158155.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018230_26019771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018274_28019771.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016230_26019696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016274_28019696.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017230_26019752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017274_28019752.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017230_26019753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017274_28019753.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017230_26019715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017274_28019715.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017230_26014747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017274_28014747.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:27938585chr21:27484463ENST0000034679801828_18919771.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018374_56519771.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000034899001628_18919696.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016374_56519696.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000035790301728_18919752.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017374_56519752.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000035891801728_18919753.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017374_56519753.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000035972601728_18919715.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017374_56519715.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST0000044012601728_18914747.0DomainE1
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017374_56514747.0DomainE2
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018344_36519771.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018724_73419771.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016344_36519696.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016724_73419696.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017344_36519752.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017724_73419752.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017344_36519753.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017724_73419753.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017344_36519715.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017724_73419715.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017344_36514747.0MotifOX-2
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017724_73414747.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018131_18919771.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018181_18819771.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000034679801828_12319771.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018391_42319771.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018491_52219771.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018523_54019771.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000034679801896_11019771.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016131_18919696.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016181_18819696.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000034899001628_12319696.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016391_42319696.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016491_52219696.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016523_54019696.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000034899001696_11019696.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017131_18919752.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017181_18819752.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035790301728_12319752.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017391_42319752.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017491_52219752.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017523_54019752.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035790301796_11019752.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017131_18919753.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017181_18819753.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035891801728_12319753.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017391_42319753.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017491_52219753.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017523_54019753.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035891801796_11019753.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017131_18919715.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017181_18819715.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035972601728_12319715.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017391_42319715.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017491_52219715.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017523_54019715.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000035972601796_11019715.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017131_18914747.0RegionCuBD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017181_18814747.0RegionNote=Zinc-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000044012601728_12314747.0RegionGFLD subdomain
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017391_42314747.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017491_52214747.0RegionNote=Heparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017523_54014747.0RegionCollagen-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000044012601796_11014747.0RegionHeparin-binding
TgeneAPPchr21:27938585chr21:27484463ENST0000034679801818_70119771.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018723_77019771.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000034899001618_70119696.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016723_77019696.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000035790301718_70119752.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017723_77019752.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000035891801718_70119753.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017723_77019753.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000035972601718_70119715.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017723_77019715.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST0000044012601718_70114747.0Topological domainExtracellular
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017723_77014747.0Topological domainCytoplasmic
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018702_72219771.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016702_72219696.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017702_72219752.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017702_72219753.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017702_72219715.0TransmembraneHelical
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017702_72214747.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYYR1chr21:27938585chr21:27484463ENST00000299340-24144_14958155.0Compositional biasNote=Poly-Pro
HgeneCYYR1chr21:27938585chr21:27484463ENST00000299340-2483_15458155.0Topological domainCytoplasmic
HgeneCYYR1chr21:27938585chr21:27484463ENST00000299340-2462_8258155.0TransmembraneHelical


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Fusion Gene Sequence for CYYR1-APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21174_21174_1_CYYR1-APP_CYYR1_chr21_27938585_ENST00000435845_APP_chr21_27484463_ENST00000346798_length(transcript)=3896nt_BP=520nt
AGTCGTTGCCACCCGCGGAGATGAAATGTGAGCCTGGGTGGCCAAGGACGCCGGAGTGGCCGCCTTCCCCGCGCCTGAGCGCAGTGGGGC
GAGACAAAGAGACCTGGGCCCCCAGCGCAGCCCGTCTCGGGCCACGGGCGCCCCAGCTCCGCGGAGTCCCGCAGTCGCTGGCCCGGGACG
CGCCCGGCCCGGGCTCCCTTGGAAGGCTCCCTAGGCAATGGCCGGGTCTCTGCTCCACCCGGCTCTCAGGAGCGCTGCTCTCTCCATCTG
ATCGCCCTCCATCCTCCCCATTCCCTCCGGTTCCGGGCTCTCCCTTCGCTCCAAGCCTCAGGCCACCGGCTTGGATGGACGCTCCGAGGC
TACCCGTGCGTCCAGGGGTCTTGCTTCCGAAGTTGGTCCTGCTCTTTGTCTACGCAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCA
AATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGTACCCACTGATGGTAATGC
TGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCC
ATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGT
AGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCG
CTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAAC
TCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAAT
TGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTC
GGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGA
GGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCAC
AGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGA
GACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGG
CAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACC
TCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAA
TGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGC
AGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGC
AGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTA
CATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACA
GCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGT
GATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCT
TCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATC
TTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGC
TGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTC
TGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCA
AAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGAT
CGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGA
GCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGC
AGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTAT
GATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTA
TCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATA
GATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATA
TGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCA
TTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTG
CTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAG
CTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAG
GGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCG
CTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCG
AAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGA
AGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATG

>21174_21174_1_CYYR1-APP_CYYR1_chr21_27938585_ENST00000435845_APP_chr21_27484463_ENST00000346798_length(amino acids)=764AA_BP=13
MLLLLRLYWEYPLVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQN
WCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVC
CPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTT
TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPT
TAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVET
HMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLS
LLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE
VEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYYR1-APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018732_75119.0771.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016732_75119.0696.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015732_7510640.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017732_75119.0752.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017732_75119.0753.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017732_75119.0715.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017732_75114.0747.0G(o)-alpha
TgeneAPPchr21:27938585chr21:27484463ENST00000346798018695_72219.0771.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000348990016695_72219.0696.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000354192015695_7220640.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000357903017695_72219.0752.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000358918017695_72219.0753.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000359726017695_72219.0715.0PSEN1
TgeneAPPchr21:27938585chr21:27484463ENST00000440126017695_72214.0747.0PSEN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYYR1-APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYYR1-APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource