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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAAM1-DAAM1 (FusionGDB2 ID:21187)

Fusion Gene Summary for DAAM1-DAAM1

check button Fusion gene summary
Fusion gene informationFusion gene name: DAAM1-DAAM1
Fusion gene ID: 21187
HgeneTgene
Gene symbol

DAAM1

DAAM1

Gene ID

23002

23002

Gene namedishevelled associated activator of morphogenesis 1dishevelled associated activator of morphogenesis 1
Synonyms--
Cytomap

14q23.1

14q23.1

Type of geneprotein-codingprotein-coding
Descriptiondisheveled-associated activator of morphogenesis 1disheveled-associated activator of morphogenesis 1
Modification date2020031320200313
UniProtAcc

Q9Y4D1

Q9Y4D1

Ensembl transtripts involved in fusion geneENST00000553966, ENST00000395125, 
ENST00000351081, ENST00000360909, 
ENST00000556135, 		ENST00000351081, 
ENST00000360909, ENST00000395125, 
ENST00000553966, ENST00000556135, 
Fusion gene scores* DoF score11 X 11 X 7=8476 X 9 X 3=162
# samples 149
** MAII scorelog2(14/847*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAAM1 [Title/Abstract] AND DAAM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAAM1(59757410)-DAAM1(59757434), # samples:1
DAAM1(59656778)-DAAM1(59656419), # samples:1
DAAM1(59835533)-DAAM1(59834192), # samples:1
DAAM1(59837471)-DAAM1(59836506), # samples:1
Anticipated loss of major functional domain due to fusion event.DAAM1-DAAM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DAAM1-DAAM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DAAM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DAAM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF748744DAAM1chr14

59757410

+DAAM1chr14

59757434

-
ChiTaRS5.0N/ABF762998DAAM1chr14

59656778

-DAAM1chr14

59656419

+
ChiTaRS5.0N/ABG944832DAAM1chr14

59835533

+DAAM1chr14

59834192

+
ChiTaRS5.0N/ACF137708DAAM1chr14

59837471

-DAAM1chr14

59836506

+


Top

Fusion Gene ORF analysis for DAAM1-DAAM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000553966ENST00000351081DAAM1chr14

59835533

+DAAM1chr14

59834192

+
3UTR-3CDSENST00000553966ENST00000360909DAAM1chr14

59835533

+DAAM1chr14

59834192

+
3UTR-3CDSENST00000553966ENST00000395125DAAM1chr14

59835533

+DAAM1chr14

59834192

+
3UTR-3UTRENST00000395125ENST00000395125DAAM1chr14

59837471

-DAAM1chr14

59836506

+
3UTR-3UTRENST00000553966ENST00000553966DAAM1chr14

59835533

+DAAM1chr14

59834192

+
3UTR-intronENST00000395125ENST00000351081DAAM1chr14

59837471

-DAAM1chr14

59836506

+
3UTR-intronENST00000395125ENST00000360909DAAM1chr14

59837471

-DAAM1chr14

59836506

+
3UTR-intronENST00000395125ENST00000553966DAAM1chr14

59837471

-DAAM1chr14

59836506

+
3UTR-intronENST00000395125ENST00000556135DAAM1chr14

59837471

-DAAM1chr14

59836506

+
3UTR-intronENST00000553966ENST00000556135DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-3UTRENST00000351081ENST00000553966DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-3UTRENST00000360909ENST00000553966DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-3UTRENST00000395125ENST00000553966DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-intronENST00000351081ENST00000556135DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-intronENST00000360909ENST00000556135DAAM1chr14

59835533

+DAAM1chr14

59834192

+
5CDS-intronENST00000395125ENST00000556135DAAM1chr14

59835533

+DAAM1chr14

59834192

+
Frame-shiftENST00000395125ENST00000351081DAAM1chr14

59835533

+DAAM1chr14

59834192

+
Frame-shiftENST00000395125ENST00000360909DAAM1chr14

59835533

+DAAM1chr14

59834192

+
Frame-shiftENST00000395125ENST00000395125DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000351081ENST00000351081DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000351081ENST00000360909DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000351081ENST00000395125DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000360909ENST00000351081DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000360909ENST00000360909DAAM1chr14

59835533

+DAAM1chr14

59834192

+
In-frameENST00000360909ENST00000395125DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-3CDSENST00000556135ENST00000351081DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-3CDSENST00000556135ENST00000360909DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-3CDSENST00000556135ENST00000395125DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-3UTRENST00000351081ENST00000395125DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-3UTRENST00000360909ENST00000395125DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-3UTRENST00000553966ENST00000395125DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-3UTRENST00000556135ENST00000395125DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-3UTRENST00000556135ENST00000553966DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-intronENST00000351081ENST00000351081DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000351081ENST00000351081DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000351081ENST00000351081DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000351081ENST00000360909DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000351081ENST00000360909DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000351081ENST00000360909DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000351081ENST00000395125DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000351081ENST00000395125DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000351081ENST00000553966DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000351081ENST00000553966DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000351081ENST00000553966DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000351081ENST00000556135DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000351081ENST00000556135DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000351081ENST00000556135DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000360909ENST00000351081DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000360909ENST00000351081DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000360909ENST00000351081DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000360909ENST00000360909DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000360909ENST00000360909DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000360909ENST00000360909DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000360909ENST00000395125DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000360909ENST00000395125DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000360909ENST00000553966DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000360909ENST00000553966DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000360909ENST00000553966DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000360909ENST00000556135DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000360909ENST00000556135DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000360909ENST00000556135DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000395125ENST00000351081DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000395125ENST00000351081DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000395125ENST00000360909DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000395125ENST00000360909DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000395125ENST00000395125DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000395125ENST00000395125DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000395125ENST00000553966DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000395125ENST00000553966DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000395125ENST00000556135DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000395125ENST00000556135DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000351081DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000553966ENST00000351081DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000351081DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000553966ENST00000360909DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000553966ENST00000360909DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000360909DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000553966ENST00000395125DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000553966ENST00000395125DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000553966DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000553966ENST00000553966DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000553966DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000553966ENST00000556135DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000553966ENST00000556135DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000553966ENST00000556135DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000556135ENST00000351081DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000556135ENST00000351081DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000556135ENST00000351081DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000556135ENST00000360909DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000556135ENST00000360909DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000556135ENST00000360909DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000556135ENST00000395125DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000556135ENST00000395125DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000556135ENST00000553966DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000556135ENST00000553966DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000556135ENST00000553966DAAM1chr14

59837471

-DAAM1chr14

59836506

+
intron-intronENST00000556135ENST00000556135DAAM1chr14

59757410

+DAAM1chr14

59757434

-
intron-intronENST00000556135ENST00000556135DAAM1chr14

59656778

-DAAM1chr14

59656419

+
intron-intronENST00000556135ENST00000556135DAAM1chr14

59835533

+DAAM1chr14

59834192

+
intron-intronENST00000556135ENST00000556135DAAM1chr14

59837471

-DAAM1chr14

59836506

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAAM1-DAAM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAAM1-DAAM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:59757410/chr14:59757434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAAM1

Q9Y4D1

DAAM1

Q9Y4D1

FUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.FUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDAAM1chr14:59835533chr14:59834192ENST00000351081026437_52601079.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM1chr14:59835533chr14:59834192ENST00000360909025437_52601069.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM1chr14:59835533chr14:59834192ENST00000395125025437_52601079.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM1chr14:59835533chr14:59834192ENST00000351081026528_59301079.0Compositional biasNote=Pro-rich
TgeneDAAM1chr14:59835533chr14:59834192ENST00000360909025528_59301069.0Compositional biasNote=Pro-rich
TgeneDAAM1chr14:59835533chr14:59834192ENST00000395125025528_59301079.0Compositional biasNote=Pro-rich
TgeneDAAM1chr14:59835533chr14:59834192ENST000003510810261027_105801079.0DomainDAD
TgeneDAAM1chr14:59835533chr14:59834192ENST0000035108102645_42001079.0DomainGBD/FH3
TgeneDAAM1chr14:59835533chr14:59834192ENST00000351081026528_59901079.0DomainNote=FH1
TgeneDAAM1chr14:59835533chr14:59834192ENST00000351081026600_100901079.0DomainFH2
TgeneDAAM1chr14:59835533chr14:59834192ENST000003609090251027_105801069.0DomainDAD
TgeneDAAM1chr14:59835533chr14:59834192ENST0000036090902545_42001069.0DomainGBD/FH3
TgeneDAAM1chr14:59835533chr14:59834192ENST00000360909025528_59901069.0DomainNote=FH1
TgeneDAAM1chr14:59835533chr14:59834192ENST00000360909025600_100901069.0DomainFH2
TgeneDAAM1chr14:59835533chr14:59834192ENST000003951250251027_105801079.0DomainDAD
TgeneDAAM1chr14:59835533chr14:59834192ENST0000039512502545_42001079.0DomainGBD/FH3
TgeneDAAM1chr14:59835533chr14:59834192ENST00000395125025528_59901079.0DomainNote=FH1
TgeneDAAM1chr14:59835533chr14:59834192ENST00000395125025600_100901079.0DomainFH2
TgeneDAAM1chr14:59835533chr14:59834192ENST00000351081026693_70201079.0RegionNote=Actin-binding
TgeneDAAM1chr14:59835533chr14:59834192ENST00000360909025693_70201069.0RegionNote=Actin-binding
TgeneDAAM1chr14:59835533chr14:59834192ENST00000395125025693_70201079.0RegionNote=Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+126437_52601079.0Coiled coilOntology_term=ECO:0000255
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+125437_52601069.0Coiled coilOntology_term=ECO:0000255
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+125437_52601079.0Coiled coilOntology_term=ECO:0000255
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+126528_59301079.0Compositional biasNote=Pro-rich
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+125528_59301069.0Compositional biasNote=Pro-rich
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+125528_59301079.0Compositional biasNote=Pro-rich
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+1261027_105801079.0DomainDAD
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+12645_42001079.0DomainGBD/FH3
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+126528_59901079.0DomainNote=FH1
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+126600_100901079.0DomainFH2
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+1251027_105801069.0DomainDAD
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+12545_42001069.0DomainGBD/FH3
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+125528_59901069.0DomainNote=FH1
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+125600_100901069.0DomainFH2
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+1251027_105801079.0DomainDAD
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+12545_42001079.0DomainGBD/FH3
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+125528_59901079.0DomainNote=FH1
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+125600_100901079.0DomainFH2
HgeneDAAM1chr14:59835533chr14:59834192ENST00000351081+126693_70201079.0RegionNote=Actin-binding
HgeneDAAM1chr14:59835533chr14:59834192ENST00000360909+125693_70201069.0RegionNote=Actin-binding
HgeneDAAM1chr14:59835533chr14:59834192ENST00000395125+125693_70201079.0RegionNote=Actin-binding


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Fusion Gene Sequence for DAAM1-DAAM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAAM1-DAAM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAAM1-DAAM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAAM1-DAAM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource