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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAAM1-MEF2A (FusionGDB2 ID:21192)

Fusion Gene Summary for DAAM1-MEF2A

check button Fusion gene summary
Fusion gene informationFusion gene name: DAAM1-MEF2A
Fusion gene ID: 21192
HgeneTgene
Gene symbol

DAAM1

MEF2A

Gene ID

23002

4205

Gene namedishevelled associated activator of morphogenesis 1myocyte enhancer factor 2A
Synonyms-ADCAD1|RSRFC4|RSRFC9|mef2
Cytomap

14q23.1

15q26.3

Type of geneprotein-codingprotein-coding
Descriptiondisheveled-associated activator of morphogenesis 1myocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1
Modification date2020031320200313
UniProtAcc

Q9Y4D1

Q02078

Ensembl transtripts involved in fusion geneENST00000351081, ENST00000360909, 
ENST00000395125, ENST00000553966, 
ENST00000556135, 		ENST00000338042, 
ENST00000354410, ENST00000449277, 
ENST00000453228, ENST00000557785, 
ENST00000557942, ENST00000558812, 
ENST00000558856, 
Fusion gene scores* DoF score11 X 11 X 7=84711 X 10 X 5=550
# samples 1411
** MAII scorelog2(14/847*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAAM1 [Title/Abstract] AND MEF2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAAM1(59799381)-MEF2A(100209160), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEF2A

GO:0000122

negative regulation of transcription by RNA polymerase II

16484498

TgeneMEF2A

GO:0000165

MAPK cascade

9858528

TgeneMEF2A

GO:0006351

transcription, DNA-templated

16043483

TgeneMEF2A

GO:0010613

positive regulation of cardiac muscle hypertrophy

24161931

TgeneMEF2A

GO:0045944

positive regulation of transcription by RNA polymerase II

7760790|9858528|10748098|15466416|20590529|21468593

TgeneMEF2A

GO:0071277

cellular response to calcium ion

16484498


check buttonFusion gene breakpoints across DAAM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MEF2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEI708470DAAM1chr14

59799381

+MEF2Achr15

100209160

+


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Fusion Gene ORF analysis for DAAM1-MEF2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000351081ENST00000338042DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000354410DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000449277DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000453228DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000557785DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000557942DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000558812DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000351081ENST00000558856DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000338042DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000354410DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000449277DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000453228DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000557785DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000557942DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000558812DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000360909ENST00000558856DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000338042DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000354410DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000449277DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000453228DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000557785DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000557942DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000558812DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000395125ENST00000558856DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000338042DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000354410DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000449277DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000453228DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000557785DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000557942DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000558812DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000553966ENST00000558856DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000338042DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000354410DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000449277DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000453228DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000557785DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000557942DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000558812DAAM1chr14

59799381

+MEF2Achr15

100209160

+
intron-intronENST00000556135ENST00000558856DAAM1chr14

59799381

+MEF2Achr15

100209160

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAAM1-MEF2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAAM1-MEF2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:59799381/:100209160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAAM1

Q9Y4D1

MEF2A

Q02078

FUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DAAM1-MEF2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAAM1-MEF2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAAM1-MEF2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAAM1-MEF2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource