FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DAB2-ARSB (FusionGDB2 ID:21224)

Fusion Gene Summary for DAB2-ARSB

check button Fusion gene summary
Fusion gene informationFusion gene name: DAB2-ARSB
Fusion gene ID: 21224
HgeneTgene
Gene symbol

DAB2

ARSB

Gene ID

1601

411

Gene nameDAB adaptor protein 2arylsulfatase B
SynonymsDOC-2|DOC2ASB|G4S|MPS6
Cytomap

5p13.1

5q14.1

Type of geneprotein-codingprotein-coding
Descriptiondisabled homolog 2DAB2, clathrin adaptor proteinDab, mitogen-responsive phosphoprotein, homolog 2adaptor molecule disabled-2differentially expressed in ovarian carcinoma 2differentially-expressed protein 2disabled homolog 2, mitogen-responsive phosparylsulfatase BN-acetylgalactosamine-4-sulfatase
Modification date2020031320200313
UniProtAcc

P98082

P15848

Ensembl transtripts involved in fusion geneENST00000320816, ENST00000339788, 
ENST00000509337, ENST00000545653, 
ENST00000512525, 		ENST00000521800, 
ENST00000264914, ENST00000396151, 
ENST00000565165, 
Fusion gene scores* DoF score10 X 9 X 5=45010 X 8 X 5=400
# samples 1111
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAB2 [Title/Abstract] AND ARSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAB2(39392467)-ARSB(78265015), # samples:3
Anticipated loss of major functional domain due to fusion event.DAB2-ARSB seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DAB2-ARSB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAB2

GO:0010718

positive regulation of epithelial to mesenchymal transition

15734730

HgeneDAB2

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

11387212

HgeneDAB2

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

11387212

HgeneDAB2

GO:0043066

negative regulation of apoptotic process

15734730

HgeneDAB2

GO:0060391

positive regulation of SMAD protein signal transduction

11387212


check buttonFusion gene breakpoints across DAB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J1-01ADAB2chr5

39392467

-ARSBchr5

78265015

-
ChimerDB4ACCTCGA-OR-A5J1DAB2chr5

39392466

-ARSBchr5

78265015

-


Top

Fusion Gene ORF analysis for DAB2-ARSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000320816ENST00000521800DAB2chr5

39392467

-ARSBchr5

78265015

-
5CDS-intronENST00000320816ENST00000521800DAB2chr5

39392466

-ARSBchr5

78265015

-
5CDS-intronENST00000339788ENST00000521800DAB2chr5

39392467

-ARSBchr5

78265015

-
5CDS-intronENST00000339788ENST00000521800DAB2chr5

39392466

-ARSBchr5

78265015

-
5CDS-intronENST00000509337ENST00000521800DAB2chr5

39392467

-ARSBchr5

78265015

-
5CDS-intronENST00000509337ENST00000521800DAB2chr5

39392466

-ARSBchr5

78265015

-
5CDS-intronENST00000545653ENST00000521800DAB2chr5

39392467

-ARSBchr5

78265015

-
5CDS-intronENST00000545653ENST00000521800DAB2chr5

39392466

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000264914DAB2chr5

39392467

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000264914DAB2chr5

39392466

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000396151DAB2chr5

39392467

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000396151DAB2chr5

39392466

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000565165DAB2chr5

39392467

-ARSBchr5

78265015

-
5UTR-3CDSENST00000512525ENST00000565165DAB2chr5

39392466

-ARSBchr5

78265015

-
5UTR-intronENST00000512525ENST00000521800DAB2chr5

39392467

-ARSBchr5

78265015

-
5UTR-intronENST00000512525ENST00000521800DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000264914DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000264914DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000396151DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000396151DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000565165DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000320816ENST00000565165DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000264914DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000264914DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000396151DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000396151DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000565165DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000339788ENST00000565165DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000264914DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000264914DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000396151DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000396151DAB2chr5

39392466

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000565165DAB2chr5

39392467

-ARSBchr5

78265015

-
Frame-shiftENST00000545653ENST00000565165DAB2chr5

39392466

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000264914DAB2chr5

39392467

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000264914DAB2chr5

39392466

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000396151DAB2chr5

39392467

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000396151DAB2chr5

39392466

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000565165DAB2chr5

39392467

-ARSBchr5

78265015

-
In-frameENST00000509337ENST00000565165DAB2chr5

39392466

-ARSBchr5

78265015

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509337DAB2chr539392467-ENST00000264914ARSBchr578265015-4888410471699550
ENST00000509337DAB2chr539392467-ENST00000396151ARSBchr578265015-1915410471339430
ENST00000509337DAB2chr539392467-ENST00000565165ARSBchr578265015-1371410471339430
ENST00000509337DAB2chr539392466-ENST00000264914ARSBchr578265015-4888410471699550
ENST00000509337DAB2chr539392466-ENST00000396151ARSBchr578265015-1915410471339430
ENST00000509337DAB2chr539392466-ENST00000565165ARSBchr578265015-1371410471339430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509337ENST00000264914DAB2chr539392467-ARSBchr578265015-0.0004576340.99954236
ENST00000509337ENST00000396151DAB2chr539392467-ARSBchr578265015-0.001188010.99881196
ENST00000509337ENST00000565165DAB2chr539392467-ARSBchr578265015-0.0021893270.99781066
ENST00000509337ENST00000264914DAB2chr539392466-ARSBchr578265015-0.0004576340.99954236
ENST00000509337ENST00000396151DAB2chr539392466-ARSBchr578265015-0.001188010.99881196
ENST00000509337ENST00000565165DAB2chr539392466-ARSBchr578265015-0.0021893270.99781066

Top

Fusion Genomic Features for DAB2-ARSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DAB2-ARSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:39392467/chr5:78265015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAB2

P98082

ARSB

P15848

FUNCTION: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.FUNCTION: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAB2chr5:39392466chr5:78265015ENST00000320816-41545_1961101191.0DomainPID
HgeneDAB2chr5:39392466chr5:78265015ENST00000339788-41445_1961101036.3333333333333DomainPID
HgeneDAB2chr5:39392466chr5:78265015ENST00000509337-31345_196110805.0DomainPID
HgeneDAB2chr5:39392466chr5:78265015ENST00000545653-41445_1961101149.0DomainPID
HgeneDAB2chr5:39392467chr5:78265015ENST00000320816-41545_1961101191.0DomainPID
HgeneDAB2chr5:39392467chr5:78265015ENST00000339788-41445_1961101036.3333333333333DomainPID
HgeneDAB2chr5:39392467chr5:78265015ENST00000509337-31345_196110805.0DomainPID
HgeneDAB2chr5:39392467chr5:78265015ENST00000545653-41445_1961101149.0DomainPID
HgeneDAB2chr5:39392466chr5:78265015ENST00000320816-415293_2951101191.0MotifNote=DPF 1
HgeneDAB2chr5:39392466chr5:78265015ENST00000320816-415298_3001101191.0MotifNote=DPF 2
HgeneDAB2chr5:39392466chr5:78265015ENST00000339788-414293_2951101036.3333333333333MotifNote=DPF 1
HgeneDAB2chr5:39392466chr5:78265015ENST00000339788-414298_3001101036.3333333333333MotifNote=DPF 2
HgeneDAB2chr5:39392466chr5:78265015ENST00000509337-313293_295110805.0MotifNote=DPF 1
HgeneDAB2chr5:39392466chr5:78265015ENST00000509337-313298_300110805.0MotifNote=DPF 2
HgeneDAB2chr5:39392466chr5:78265015ENST00000545653-414293_2951101149.0MotifNote=DPF 1
HgeneDAB2chr5:39392466chr5:78265015ENST00000545653-414298_3001101149.0MotifNote=DPF 2
HgeneDAB2chr5:39392467chr5:78265015ENST00000320816-415293_2951101191.0MotifNote=DPF 1
HgeneDAB2chr5:39392467chr5:78265015ENST00000320816-415298_3001101191.0MotifNote=DPF 2
HgeneDAB2chr5:39392467chr5:78265015ENST00000339788-414293_2951101036.3333333333333MotifNote=DPF 1
HgeneDAB2chr5:39392467chr5:78265015ENST00000339788-414298_3001101036.3333333333333MotifNote=DPF 2
HgeneDAB2chr5:39392467chr5:78265015ENST00000509337-313293_295110805.0MotifNote=DPF 1
HgeneDAB2chr5:39392467chr5:78265015ENST00000509337-313298_300110805.0MotifNote=DPF 2
HgeneDAB2chr5:39392467chr5:78265015ENST00000545653-414293_2951101149.0MotifNote=DPF 1
HgeneDAB2chr5:39392467chr5:78265015ENST00000545653-414298_3001101149.0MotifNote=DPF 2


Top

Fusion Gene Sequence for DAB2-ARSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21224_21224_1_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000264914_length(transcript)=4888nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTT
CTCTTCCAGAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTCCTCACGGGCTACCCAGGCTGTG
GTTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCTGAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTG
ATCGGGACCCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCCCGCCTACAGTTCTACCATAAAC
ACTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGCTGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAGGATTTCAGGG
AGGCTAGAAAACCTTTCAATTGGAAGTTGGACCTCAGGCCTTTTCTCACGACTCTTGTCTCATTTGTTATCCCAACCTGGGTTCACTTGG
CCCTTCTCTTGCTCTTAAACCACACCGAGGTGTCTAATTTCAACCCCTAATGCATTTAAGAAGCTGATAAAATCTGCAACACTCCTGCTG
TTGGCTGGAGCATGTGTCTAGAGGTGGGGGTGGCTGGGTTTATCCCCCTTTCCTAAGCCTTGGGACAGCTGGGAACTTAACTTGAAATAG
GAAGTTCTCACTGAATCCTGGAGGCTGGAACAGCTGGCTCTTTTAGACTCACAAGTCAGACGTTCGATTCCCCTCTGCCAATAGCCAGTT
TTATTGGAGTGAATCACATTTCTTACGCAAATGAAGGGAGCAGACAGTGATTAATGGTTCTGTTGGCCAAGGCTTCTCCCTGTCGGTGAA
GGATCATGTTCAGGCACTCCAAGTGAACCACCCCTCTTGGTTCACCCCTTACTCACTTATCTCATCACAGAGCATAAGGCCCATTTTGTT
GTTCAGGTCAACAGCAAAATGCCTGCACCATGACTGTGGCTTTTAAAATAAAGAAATGTGTTTTTATCGTAATTTATTTCCCCCCAGCCA
TTGCTCACTCTGTCTAGACTTCCTGCCACTTCCAATTCTTCTGTGGCTTTTCCTGCCTTTCCTTTTGACCTCAGTAGTCCTATCCCTGGG
AAGGCCACTTTGCTTCTCTACCTGAGCACCCCTGATTTCTGGAACGCTGCTGAGCCCTGCCTTACTTTTGCCCCTAGGGCTGAAGCTAGA
GGCCTCCCCGTAATAGGCGGTGGAGTTGCTCTGTGAGGATGTTCATGGTAGACACTAAGAGGGCTGGGTGGGAGATGCTTGGCTCTGTGG
CATCTGTTCAGCGAGGCTTTTCCTATATTGCATGGAGTTAGTCATTGTGATTGTAGCTTTATTTCATAATATATTAAGACTTGCACTGCT
ATTTACTAGCAGTGAGAAGAAACCTCAGGAAAGGATATGAAAAAGCAAGTGGCCAGTGTCTGGGATACTGGGCCTTGGTAAAGCAGAGGA
GGGCACACCCACAGTCCTCTTATTCTCTGTTTTACTGCTTGTTTTGAGGTTCTGGGGTCTGGCAAAGAGGATGCAGTTTGACACCTGCAG
CCCTTTCTCAATCCCACTAATGTCTTACTAATGTGGAACAGTCCATATTAGCTCCAGAGAGTGTCAAACCCAGAGAAATGTGTGCAAAAA
TGATACTCTTTTCTGCATTAGCCCCACCATTGTGTTCACCAATGCTTGGAACACTGCCTGAAGGCACTCATTTTTTAATTTTTATTTTAT
TTTTAATTTTTTATATCTTTATGAGACGATCTCACTCTGTCACCAGGTTGGAGTACAGTGGTACAATCACAACTCACCGTAGCCTCAAAC
TCCTGGGCTCAAGTGATTCTCCCACCTCAGGCACCCAAATAGCTGGAACTACAGGCATATACCGCCACACCCAGCTAATTTTATTTTTTG
AAAAGACAAGGTTCCCTATGTTGCCCAGCTGGTCTTAAACTCCTGGGCTCCAGCAATTATCCCAGCTTGGGCTCCAAAAGTGCTGGGATT
ACAGGCATGAGTCACCATGCCTGGCCTCATTTTTTAAAACAAATGAATAAATGGACAAATGAGTAAATGAGAAAGTCTCACACCATGAAA
GATGCTAGTCCAATGAGCTGAATACAGAGGTAATATAAATGTCTTCCAGCTGTTGCTTTTCTGTTCTCAAGCTGCCCCTCCTGGGGTAGG
AGCATAATCTACATCACTGGGCAGTCACAGGACACTCTATAGCAAGGTTGTAGCGTCCTCTCCAGTGGGGGGAGAAAAGGAACTGTGCCT
ACCAAAGGTACTCTCTTGTCAGCAATTTCCATTTCTATACTTTATGGGACACTAGAAACTAAAAGCAACAAATAATCTGATATAAGTCCT
TGTATAGTCATCCTTCAATTCAGTAGCAATATTTTCTGGTCACTACTAACCTGTATTGTATTAAAATGAGACTATTGGAAGGAAATGGTG
CTAAAACTAATAACATCTCTTACCAACCTTTACCCAACTCCTGGGTTGGCAAACAGCTGACCAAACTGCCATCACCTCCCACTTGGAAGT
GTATGGCCGACAGCATGAAATAGCTGAGCCCAGATGTTCCTTCTGCATCCTCCGAATCCCAGGGCTGGGTGTAGGTAGCCGTTGGAGGCC
ATCGCTACAGGGCACCTATCTGTTATCGCTGCTGTCCTCCCAACAGCTGTCTCCAGTTCTAGTTCCTTGGTTTTCAGGCACAGTGGGGGA
TGTTCTGCACCCAGTGGACTTCAAAAGAGTTTTGAAGACTTAATTTTTTGTAAAACAAGTACTTGAGATTTTGGTTTATCCATAATAGAA
TGTATTTCATTAGATTCTCTGATTCTATATAAGAATGTGAAAAGATTGATATATTGTTGTTAGAAATAATGTTATTTCTTTCCAATTTTT
TTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAGCCTCTAACTCCC
AGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGATTACAGGCATACACCACCACGCCTGGCTATGTTTTGTATTTTTCGTA
GAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCACTTCAGCTTCCCAAAGCACTGGGATT
ACAGGTGTGAGCCACTGTGCCCGGCAAATTTTTTTACCTTTACAGAAGGTTTTGCTTATTTAATTGTGAGCTCATTTTTCTTTGTTACTT
TTGTCCCCCCAGATTTGGGGGACAAAATAAAATTAATCTTTTAAAATGTGTCAGCCATATGTATGGGGCTTCCATTTGGGGTGAGGAGAA
AGTTCTGGAACTAGATAGTGGTCATGGTTATACAACATCATAAATGCAATTACTGCCACTGAATTGTATGTTTTAAAGTGGTTAAAATGT
TAAGTTTTATGTTTTATTACAATTTTTAAATGTGTCAACCAACTTTATAGTACATAAATTATATCTCAGTAAAGCTGTTAAATAAATAAA

>21224_21224_1_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000264914_length(amino acids)=550AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK
NRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAI
RHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDP

--------------------------------------------------------------
>21224_21224_2_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000396151_length(transcript)=1915nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAA
CTTTCTACTGAAGATGATAACCCAGGGCATAAGAAATGACTTCAGACCCAAGGTTCTGAAAGGGCCCCTCAAGGCCTCGGGTGGCTCCTG
CAGAAGTGGCAGAAGAGGCGGGAACTAGGAACCTGGCATCATAGGAAAAGTGCCTTCTCCAAGAAAGAAGGGGCCCCAGGAGGCTGTCTT
ACTTAGATCAACCATAAACTACCACAGATGGGTCATTTCTTATATTATTTCAAAATATCTTTGAAGATGAGAATTCATTTGTGTCCTTCA
TAGACCAAAGTTCTTTGTGTTACCTTTTCCCAAAAGTAAATTCCTTTCCCTTTATTCATTCCTTGTGGAAATAAAATGCAAGCCCTTTAT
ACTTGTCTTACAGTAATATGGCACATGTAGCTTACTTTTGAGCATCCCAGTGAATAATGTTTGGAACTTTTCTTATTACCTAATAGCATA
TAGAGAAGAGTGAAGTCAGCTAAAAACAGAAATTTTGAAAAGCCATCTTCAGGAAAATGTAGGCCCAGATGCTTTCCTCCACCTTTTTTG

>21224_21224_2_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000396151_length(amino acids)=430AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK

--------------------------------------------------------------
>21224_21224_3_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000565165_length(transcript)=1371nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAA

>21224_21224_3_DAB2-ARSB_DAB2_chr5_39392466_ENST00000509337_ARSB_chr5_78265015_ENST00000565165_length(amino acids)=430AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK

--------------------------------------------------------------
>21224_21224_4_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000264914_length(transcript)=4888nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTT
CTCTTCCAGAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTCCTCACGGGCTACCCAGGCTGTG
GTTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCTGAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTG
ATCGGGACCCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCCCGCCTACAGTTCTACCATAAAC
ACTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGCTGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAGGATTTCAGGG
AGGCTAGAAAACCTTTCAATTGGAAGTTGGACCTCAGGCCTTTTCTCACGACTCTTGTCTCATTTGTTATCCCAACCTGGGTTCACTTGG
CCCTTCTCTTGCTCTTAAACCACACCGAGGTGTCTAATTTCAACCCCTAATGCATTTAAGAAGCTGATAAAATCTGCAACACTCCTGCTG
TTGGCTGGAGCATGTGTCTAGAGGTGGGGGTGGCTGGGTTTATCCCCCTTTCCTAAGCCTTGGGACAGCTGGGAACTTAACTTGAAATAG
GAAGTTCTCACTGAATCCTGGAGGCTGGAACAGCTGGCTCTTTTAGACTCACAAGTCAGACGTTCGATTCCCCTCTGCCAATAGCCAGTT
TTATTGGAGTGAATCACATTTCTTACGCAAATGAAGGGAGCAGACAGTGATTAATGGTTCTGTTGGCCAAGGCTTCTCCCTGTCGGTGAA
GGATCATGTTCAGGCACTCCAAGTGAACCACCCCTCTTGGTTCACCCCTTACTCACTTATCTCATCACAGAGCATAAGGCCCATTTTGTT
GTTCAGGTCAACAGCAAAATGCCTGCACCATGACTGTGGCTTTTAAAATAAAGAAATGTGTTTTTATCGTAATTTATTTCCCCCCAGCCA
TTGCTCACTCTGTCTAGACTTCCTGCCACTTCCAATTCTTCTGTGGCTTTTCCTGCCTTTCCTTTTGACCTCAGTAGTCCTATCCCTGGG
AAGGCCACTTTGCTTCTCTACCTGAGCACCCCTGATTTCTGGAACGCTGCTGAGCCCTGCCTTACTTTTGCCCCTAGGGCTGAAGCTAGA
GGCCTCCCCGTAATAGGCGGTGGAGTTGCTCTGTGAGGATGTTCATGGTAGACACTAAGAGGGCTGGGTGGGAGATGCTTGGCTCTGTGG
CATCTGTTCAGCGAGGCTTTTCCTATATTGCATGGAGTTAGTCATTGTGATTGTAGCTTTATTTCATAATATATTAAGACTTGCACTGCT
ATTTACTAGCAGTGAGAAGAAACCTCAGGAAAGGATATGAAAAAGCAAGTGGCCAGTGTCTGGGATACTGGGCCTTGGTAAAGCAGAGGA
GGGCACACCCACAGTCCTCTTATTCTCTGTTTTACTGCTTGTTTTGAGGTTCTGGGGTCTGGCAAAGAGGATGCAGTTTGACACCTGCAG
CCCTTTCTCAATCCCACTAATGTCTTACTAATGTGGAACAGTCCATATTAGCTCCAGAGAGTGTCAAACCCAGAGAAATGTGTGCAAAAA
TGATACTCTTTTCTGCATTAGCCCCACCATTGTGTTCACCAATGCTTGGAACACTGCCTGAAGGCACTCATTTTTTAATTTTTATTTTAT
TTTTAATTTTTTATATCTTTATGAGACGATCTCACTCTGTCACCAGGTTGGAGTACAGTGGTACAATCACAACTCACCGTAGCCTCAAAC
TCCTGGGCTCAAGTGATTCTCCCACCTCAGGCACCCAAATAGCTGGAACTACAGGCATATACCGCCACACCCAGCTAATTTTATTTTTTG
AAAAGACAAGGTTCCCTATGTTGCCCAGCTGGTCTTAAACTCCTGGGCTCCAGCAATTATCCCAGCTTGGGCTCCAAAAGTGCTGGGATT
ACAGGCATGAGTCACCATGCCTGGCCTCATTTTTTAAAACAAATGAATAAATGGACAAATGAGTAAATGAGAAAGTCTCACACCATGAAA
GATGCTAGTCCAATGAGCTGAATACAGAGGTAATATAAATGTCTTCCAGCTGTTGCTTTTCTGTTCTCAAGCTGCCCCTCCTGGGGTAGG
AGCATAATCTACATCACTGGGCAGTCACAGGACACTCTATAGCAAGGTTGTAGCGTCCTCTCCAGTGGGGGGAGAAAAGGAACTGTGCCT
ACCAAAGGTACTCTCTTGTCAGCAATTTCCATTTCTATACTTTATGGGACACTAGAAACTAAAAGCAACAAATAATCTGATATAAGTCCT
TGTATAGTCATCCTTCAATTCAGTAGCAATATTTTCTGGTCACTACTAACCTGTATTGTATTAAAATGAGACTATTGGAAGGAAATGGTG
CTAAAACTAATAACATCTCTTACCAACCTTTACCCAACTCCTGGGTTGGCAAACAGCTGACCAAACTGCCATCACCTCCCACTTGGAAGT
GTATGGCCGACAGCATGAAATAGCTGAGCCCAGATGTTCCTTCTGCATCCTCCGAATCCCAGGGCTGGGTGTAGGTAGCCGTTGGAGGCC
ATCGCTACAGGGCACCTATCTGTTATCGCTGCTGTCCTCCCAACAGCTGTCTCCAGTTCTAGTTCCTTGGTTTTCAGGCACAGTGGGGGA
TGTTCTGCACCCAGTGGACTTCAAAAGAGTTTTGAAGACTTAATTTTTTGTAAAACAAGTACTTGAGATTTTGGTTTATCCATAATAGAA
TGTATTTCATTAGATTCTCTGATTCTATATAAGAATGTGAAAAGATTGATATATTGTTGTTAGAAATAATGTTATTTCTTTCCAATTTTT
TTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAGCCTCTAACTCCC
AGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGATTACAGGCATACACCACCACGCCTGGCTATGTTTTGTATTTTTCGTA
GAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCACTTCAGCTTCCCAAAGCACTGGGATT
ACAGGTGTGAGCCACTGTGCCCGGCAAATTTTTTTACCTTTACAGAAGGTTTTGCTTATTTAATTGTGAGCTCATTTTTCTTTGTTACTT
TTGTCCCCCCAGATTTGGGGGACAAAATAAAATTAATCTTTTAAAATGTGTCAGCCATATGTATGGGGCTTCCATTTGGGGTGAGGAGAA
AGTTCTGGAACTAGATAGTGGTCATGGTTATACAACATCATAAATGCAATTACTGCCACTGAATTGTATGTTTTAAAGTGGTTAAAATGT
TAAGTTTTATGTTTTATTACAATTTTTAAATGTGTCAACCAACTTTATAGTACATAAATTATATCTCAGTAAAGCTGTTAAATAAATAAA

>21224_21224_4_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000264914_length(amino acids)=550AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK
NRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAI
RHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDP

--------------------------------------------------------------
>21224_21224_5_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000396151_length(transcript)=1915nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAA
CTTTCTACTGAAGATGATAACCCAGGGCATAAGAAATGACTTCAGACCCAAGGTTCTGAAAGGGCCCCTCAAGGCCTCGGGTGGCTCCTG
CAGAAGTGGCAGAAGAGGCGGGAACTAGGAACCTGGCATCATAGGAAAAGTGCCTTCTCCAAGAAAGAAGGGGCCCCAGGAGGCTGTCTT
ACTTAGATCAACCATAAACTACCACAGATGGGTCATTTCTTATATTATTTCAAAATATCTTTGAAGATGAGAATTCATTTGTGTCCTTCA
TAGACCAAAGTTCTTTGTGTTACCTTTTCCCAAAAGTAAATTCCTTTCCCTTTATTCATTCCTTGTGGAAATAAAATGCAAGCCCTTTAT
ACTTGTCTTACAGTAATATGGCACATGTAGCTTACTTTTGAGCATCCCAGTGAATAATGTTTGGAACTTTTCTTATTACCTAATAGCATA
TAGAGAAGAGTGAAGTCAGCTAAAAACAGAAATTTTGAAAAGCCATCTTCAGGAAAATGTAGGCCCAGATGCTTTCCTCCACCTTTTTTG

>21224_21224_5_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000396151_length(amino acids)=430AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK

--------------------------------------------------------------
>21224_21224_6_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000565165_length(transcript)=1371nt_BP=410nt
TATTTGAGACTTCTCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCTTCTTGCCATGTCTAACG
AAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAA
AGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAA
GAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCT
GGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTC
AGCCCAGCTGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACCCATATGGTCGGAAAATGGCACC
TGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGAGGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCC
ATGAACGCTGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAAGAAGTTGCAACAGGATATAAAA
ATATGTATTCAACAAACATATTCACCAAAAGGGCTATAGCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTC
TCCAGTCTGTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGACAAGAACAGGCATCACTATGCAG
GAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTCACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTT
CTACAGATAACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGCCTGTGGGAAGGAGGCGTCCGAG
GGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAGGGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCG
TGAAGCTGGCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATCAGTGAAGGAAGCCCATCCCCCA
GAATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAA

>21224_21224_6_DAB2-ARSB_DAB2_chr5_39392467_ENST00000509337_ARSB_chr5_78265015_ENST00000565165_length(amino acids)=430AA_BP=121
MVLRFAACLLAMSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGM
AAAGRSQGQHKQRIWVNISLSGIKIIDEKTGIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFD
TYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK
PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DAB2-ARSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DAB2-ARSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DAB2-ARSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource