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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DACH1-NFYC (FusionGDB2 ID:21252)

Fusion Gene Summary for DACH1-NFYC

check button Fusion gene summary
Fusion gene informationFusion gene name: DACH1-NFYC
Fusion gene ID: 21252
HgeneTgene
Gene symbol

DACH1

NFYC

Gene ID

1602

4802

Gene namedachshund family transcription factor 1nuclear transcription factor Y subunit gamma
SynonymsDACHCBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YC
Cytomap

13q21.33

1p34.2

Type of geneprotein-codingprotein-coding
Descriptiondachshund homolog 1dac homolognuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
Modification date2020032820200313
UniProtAcc

Q9UI36

Q13952

Ensembl transtripts involved in fusion geneENST00000305425, ENST00000313174, 
ENST00000354591, ENST00000359684, 
ENST00000308733, ENST00000372652, 
ENST00000425457, ENST00000427410, 
ENST00000447388, ENST00000456393, 
ENST00000372651, ENST00000372653, 
ENST00000372654, ENST00000440226, 
ENST00000483091, 
Fusion gene scores* DoF score8 X 7 X 4=22416 X 10 X 7=1120
# samples 818
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1120*10)=-2.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DACH1 [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDACH1(72357977)-NFYC(41236781), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDACH1

GO:0000122

negative regulation of transcription by RNA polymerase II

20956529

HgeneDACH1

GO:0030336

negative regulation of cell migration

20956529

HgeneDACH1

GO:2000279

negative regulation of DNA biosynthetic process

16980615

TgeneNFYC

GO:0006355

regulation of transcription, DNA-templated

15243141


check buttonFusion gene breakpoints across DACH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NFYC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABQ012815DACH1chr13

72357977

-NFYCchr1

41236781

-


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Fusion Gene ORF analysis for DACH1-NFYC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000305425ENST00000308733DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000305425ENST00000372652DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000305425ENST00000425457DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000305425ENST00000427410DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000305425ENST00000447388DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000305425ENST00000456393DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000308733DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000372652DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000425457DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000427410DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000447388DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000313174ENST00000456393DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000308733DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000372652DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000425457DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000427410DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000447388DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000354591ENST00000456393DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000308733DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000372652DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000425457DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000427410DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000447388DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-3UTRENST00000359684ENST00000456393DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000305425ENST00000372651DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000305425ENST00000372653DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000305425ENST00000372654DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000305425ENST00000440226DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000305425ENST00000483091DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000313174ENST00000372651DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000313174ENST00000372653DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000313174ENST00000372654DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000313174ENST00000440226DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000313174ENST00000483091DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000354591ENST00000372651DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000354591ENST00000372653DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000354591ENST00000372654DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000354591ENST00000440226DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000354591ENST00000483091DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000359684ENST00000372651DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000359684ENST00000372653DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000359684ENST00000372654DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000359684ENST00000440226DACH1chr13

72357977

-NFYCchr1

41236781

-
intron-intronENST00000359684ENST00000483091DACH1chr13

72357977

-NFYCchr1

41236781

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DACH1-NFYC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DACH1-NFYC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:72357977/:41236781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DACH1

Q9UI36

NFYC

Q13952

FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}.FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DACH1-NFYC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DACH1-NFYC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DACH1-NFYC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DACH1-NFYC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource