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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAPK2-FAM96A (FusionGDB2 ID:21359)

Fusion Gene Summary for DAPK2-FAM96A

check button Fusion gene summary
Fusion gene informationFusion gene name: DAPK2-FAM96A
Fusion gene ID: 21359
HgeneTgene
Gene symbol

DAPK2

FAM96A

Gene ID

23604

84191

Gene namedeath associated protein kinase 2cytosolic iron-sulfur assembly component 2A
SynonymsDRP-1|DRP1CIA2A|FAM96A
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptiondeath-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoformcytosolic iron-sulfur assembly component 2AMIP18 family protein FAM96Afamily with sequence similarity 96 member A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261891, ENST00000457488, 
ENST00000558069, ENST00000558482, 
ENST00000380290, ENST00000557835, 
ENST00000558779, ENST00000559950, 
ENST00000300030, 
Fusion gene scores* DoF score9 X 9 X 5=4059 X 8 X 7=504
# samples 1012
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAPK2 [Title/Abstract] AND FAM96A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAPK2(64332369)-FAM96A(64381050), # samples:2
DAPK2(64332369)-FAM96A(64367736), # samples:2
Anticipated loss of major functional domain due to fusion event.DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DAPK2-FAM96A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAPK2

GO:0006468

protein phosphorylation

10376525

HgeneDAPK2

GO:0035556

intracellular signal transduction

10376525


check buttonFusion gene breakpoints across DAPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM96A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A495-01ADAPK2chr15

64332369

-FAM96Achr15

64373350

-
ChimerDB4LIHCTCGA-FV-A495-01ADAPK2chr15

64332369

-FAM96Achr15

64381050

-
ChimerDB4PAADTCGA-IB-A5ST-01ADAPK2chr15

64332369

-FAM96Achr15

64367736

-
ChimerDB4PAADTCGA-IB-A5STDAPK2chr15

64332369

-FAM96Achr15

64367736

-


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Fusion Gene ORF analysis for DAPK2-FAM96A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261891ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000261891ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000261891ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000261891ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000261891ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000261891ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000261891ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000261891ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000261891ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000261891ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000261891ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000261891ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000457488ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000457488ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000457488ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000457488ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000457488ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000457488ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000457488ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000457488ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000457488ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000457488ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000457488ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000457488ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000558069ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000558069ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000558069ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000558069ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000558069ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000558069ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000558069ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000558069ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000558069ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5CDS-intronENST00000558069ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5CDS-intronENST00000558069ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5CDS-intronENST00000558069ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5UTR-3CDSENST00000558482ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5UTR-3CDSENST00000558482ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5UTR-3CDSENST00000558482ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5UTR-intronENST00000558482ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5UTR-intronENST00000558482ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5UTR-intronENST00000558482ENST00000380290DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5UTR-intronENST00000558482ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5UTR-intronENST00000558482ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5UTR-intronENST00000558482ENST00000557835DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5UTR-intronENST00000558482ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5UTR-intronENST00000558482ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5UTR-intronENST00000558482ENST00000558779DAPK2chr15

64332369

-FAM96Achr15

64367736

-
5UTR-intronENST00000558482ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64373350

-
5UTR-intronENST00000558482ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64381050

-
5UTR-intronENST00000558482ENST00000559950DAPK2chr15

64332369

-FAM96Achr15

64367736

-
Frame-shiftENST00000261891ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64373350

-
Frame-shiftENST00000261891ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64381050

-
Frame-shiftENST00000457488ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64373350

-
Frame-shiftENST00000457488ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64381050

-
Frame-shiftENST00000457488ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64367736

-
Frame-shiftENST00000558069ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64373350

-
Frame-shiftENST00000558069ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64381050

-
Frame-shiftENST00000558069ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64367736

-
In-frameENST00000261891ENST00000300030DAPK2chr15

64332369

-FAM96Achr15

64367736

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAPK2-FAM96A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAPK2-FAM96A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:64332369/chr15:64381050)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAPK2chr15:64332369chr15:64367736ENST00000261891-11123_28530371.0DomainProtein kinase
HgeneDAPK2chr15:64332369chr15:64367736ENST00000457488-21223_28530371.0DomainProtein kinase
HgeneDAPK2chr15:64332369chr15:64367736ENST00000558069-21023_28530489.0DomainProtein kinase
HgeneDAPK2chr15:64332369chr15:64367736ENST00000261891-11129_3730371.0Nucleotide bindingATP
HgeneDAPK2chr15:64332369chr15:64367736ENST00000457488-21229_3730371.0Nucleotide bindingATP
HgeneDAPK2chr15:64332369chr15:64367736ENST00000558069-21029_3730489.0Nucleotide bindingATP
HgeneDAPK2chr15:64332369chr15:64367736ENST00000261891-111277_34430371.0RegionNote=Calmodulin-binding
HgeneDAPK2chr15:64332369chr15:64367736ENST00000261891-111292_30130371.0RegionAutoinhibitory domain
HgeneDAPK2chr15:64332369chr15:64367736ENST00000457488-212277_34430371.0RegionNote=Calmodulin-binding
HgeneDAPK2chr15:64332369chr15:64367736ENST00000457488-212292_30130371.0RegionAutoinhibitory domain
HgeneDAPK2chr15:64332369chr15:64367736ENST00000558069-210277_34430489.0RegionNote=Calmodulin-binding
HgeneDAPK2chr15:64332369chr15:64367736ENST00000558069-210292_30130489.0RegionAutoinhibitory domain


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Fusion Gene Sequence for DAPK2-FAM96A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAPK2-FAM96A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAPK2-FAM96A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAPK2-FAM96A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource