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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DARS-R3HDM1 (FusionGDB2 ID:21381)

Fusion Gene Summary for DARS-R3HDM1

check button Fusion gene summary
Fusion gene informationFusion gene name: DARS-R3HDM1
Fusion gene ID: 21381
HgeneTgene
Gene symbol

DARS

R3HDM1

Gene ID

1615

23518

Gene nameaspartyl-tRNA synthetase 1R3H domain containing 1
SynonymsDARS|HBSL|aspRSR3HDM
Cytomap

2q21.3

2q21.3

Type of geneprotein-codingprotein-coding
Descriptionaspartate--tRNA ligase, cytoplasmicaspartate tRNA ligase 1, cytoplasmicaspartyl-tRNA synthetase, cytoplasmiccell proliferation-inducing gene 40 proteintesticular tissue protein Li 192R3H domain-containing protein 1R3H domain (binds single-stranded nucleic acids) containing
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264161, ENST00000537273, 
ENST00000463008, 		ENST00000443537, 
ENST00000264160, ENST00000409606, 
ENST00000410054, ENST00000329971, 
ENST00000409478, 
Fusion gene scores* DoF score6 X 7 X 3=12610 X 12 X 10=1200
# samples 716
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1200*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DARS [Title/Abstract] AND R3HDM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDARS(136668708)-R3HDM1(136481506), # samples:1
DARS(136668709)-R3HDM1(136481507), # samples:1
Anticipated loss of major functional domain due to fusion event.DARS-R3HDM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across R3HDM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1728-01ADARSchr2

136668709

-R3HDM1chr2

136481507

+
ChimerDB4OVTCGA-61-1728DARSchr2

136668708

-R3HDM1chr2

136481506

+


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Fusion Gene ORF analysis for DARS-R3HDM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264161ENST00000443537DARSchr2

136668709

-R3HDM1chr2

136481507

+
5CDS-intronENST00000264161ENST00000443537DARSchr2

136668708

-R3HDM1chr2

136481506

+
5CDS-intronENST00000537273ENST00000443537DARSchr2

136668709

-R3HDM1chr2

136481507

+
5CDS-intronENST00000537273ENST00000443537DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000264161ENST00000264160DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000264161ENST00000264160DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000264161ENST00000409606DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000264161ENST00000409606DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000264161ENST00000410054DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000264161ENST00000410054DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000537273ENST00000264160DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000537273ENST00000264160DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000537273ENST00000409606DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000537273ENST00000409606DARSchr2

136668708

-R3HDM1chr2

136481506

+
Frame-shiftENST00000537273ENST00000410054DARSchr2

136668709

-R3HDM1chr2

136481507

+
Frame-shiftENST00000537273ENST00000410054DARSchr2

136668708

-R3HDM1chr2

136481506

+
In-frameENST00000264161ENST00000329971DARSchr2

136668709

-R3HDM1chr2

136481507

+
In-frameENST00000264161ENST00000329971DARSchr2

136668708

-R3HDM1chr2

136481506

+
In-frameENST00000264161ENST00000409478DARSchr2

136668709

-R3HDM1chr2

136481507

+
In-frameENST00000264161ENST00000409478DARSchr2

136668708

-R3HDM1chr2

136481506

+
In-frameENST00000537273ENST00000329971DARSchr2

136668709

-R3HDM1chr2

136481507

+
In-frameENST00000537273ENST00000329971DARSchr2

136668708

-R3HDM1chr2

136481506

+
In-frameENST00000537273ENST00000409478DARSchr2

136668709

-R3HDM1chr2

136481507

+
In-frameENST00000537273ENST00000409478DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-3CDSENST00000463008ENST00000264160DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-3CDSENST00000463008ENST00000264160DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-3CDSENST00000463008ENST00000329971DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-3CDSENST00000463008ENST00000329971DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-3CDSENST00000463008ENST00000409478DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-3CDSENST00000463008ENST00000409478DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-3CDSENST00000463008ENST00000409606DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-3CDSENST00000463008ENST00000409606DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-3CDSENST00000463008ENST00000410054DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-3CDSENST00000463008ENST00000410054DARSchr2

136668708

-R3HDM1chr2

136481506

+
intron-intronENST00000463008ENST00000443537DARSchr2

136668709

-R3HDM1chr2

136481507

+
intron-intronENST00000463008ENST00000443537DARSchr2

136668708

-R3HDM1chr2

136481506

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264161DARSchr2136668708-ENST00000409478R3HDM1chr2136481506+2960163061985659
ENST00000264161DARSchr2136668708-ENST00000329971R3HDM1chr2136481506+2960163061985659
ENST00000537273DARSchr2136668708-ENST00000409478R3HDM1chr2136481506+27101380981735545
ENST00000537273DARSchr2136668708-ENST00000329971R3HDM1chr2136481506+27101380981735545
ENST00000264161DARSchr2136668709-ENST00000409478R3HDM1chr2136481507+2960163061985659
ENST00000264161DARSchr2136668709-ENST00000329971R3HDM1chr2136481507+2960163061985659
ENST00000537273DARSchr2136668709-ENST00000409478R3HDM1chr2136481507+27101380981735545
ENST00000537273DARSchr2136668709-ENST00000329971R3HDM1chr2136481507+27101380981735545

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264161ENST00000409478DARSchr2136668708-R3HDM1chr2136481506+0.0003715370.9996284
ENST00000264161ENST00000329971DARSchr2136668708-R3HDM1chr2136481506+0.0003715370.9996284
ENST00000537273ENST00000409478DARSchr2136668708-R3HDM1chr2136481506+0.0008177780.99918216
ENST00000537273ENST00000329971DARSchr2136668708-R3HDM1chr2136481506+0.0008177780.99918216
ENST00000264161ENST00000409478DARSchr2136668709-R3HDM1chr2136481507+0.0003715370.9996284
ENST00000264161ENST00000329971DARSchr2136668709-R3HDM1chr2136481507+0.0003715370.9996284
ENST00000537273ENST00000409478DARSchr2136668709-R3HDM1chr2136481507+0.0008177780.99918216
ENST00000537273ENST00000329971DARSchr2136668709-R3HDM1chr2136481507+0.0008177780.99918216

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Fusion Genomic Features for DARS-R3HDM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DARSchr2136668708-R3HDM1chr2136481506+1.31E-070.9999999
DARSchr2136668708-R3HDM1chr2136481506+1.31E-070.9999999
DARSchr2136668708-R3HDM1chr2136481506+1.31E-070.9999999
DARSchr2136668708-R3HDM1chr2136481506+1.31E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DARS-R3HDM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:136668708/chr2:136481506)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDARSchr2:136668708chr2:136481506ENST00000264161-1516273_275471502.0Nucleotide bindingATP
HgeneDARSchr2:136668708chr2:136481506ENST00000264161-1516281_283471502.0Nucleotide bindingATP
HgeneDARSchr2:136668709chr2:136481507ENST00000264161-1516273_275471502.0Nucleotide bindingATP
HgeneDARSchr2:136668709chr2:136481507ENST00000264161-1516281_283471502.0Nucleotide bindingATP
HgeneDARSchr2:136668708chr2:136481506ENST00000264161-1516251_254471502.0RegionAspartate
HgeneDARSchr2:136668708chr2:136481506ENST00000264161-1516411_415471502.0RegionBinding site for the 3'-end of tRNA
HgeneDARSchr2:136668709chr2:136481507ENST00000264161-1516251_254471502.0RegionAspartate
HgeneDARSchr2:136668709chr2:136481507ENST00000264161-1516411_415471502.0RegionBinding site for the 3'-end of tRNA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDARSchr2:136668708chr2:136481506ENST00000264161-1516472_475471502.0Nucleotide bindingATP
HgeneDARSchr2:136668709chr2:136481507ENST00000264161-1516472_475471502.0Nucleotide bindingATP
TgeneR3HDM1chr2:136668708chr2:136481506ENST000002641602426589_6089811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST000002641602426822_8269811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST00000264160242689_949811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST000003299712123589_608852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST000003299712123822_826852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST00000329971212389_94852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST000002641602426589_6089811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST000002641602426822_8269811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST00000264160242689_949811100.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST000003299712123589_608852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST000003299712123822_826852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668709chr2:136481507ENST00000329971212389_94852971.0Compositional biasNote=Poly-Pro
TgeneR3HDM1chr2:136668708chr2:136481506ENST000002641602426168_2319811100.0DomainR3H
TgeneR3HDM1chr2:136668708chr2:136481506ENST000002641602426232_3029811100.0DomainSUZ
TgeneR3HDM1chr2:136668708chr2:136481506ENST000003299712123168_231852971.0DomainR3H
TgeneR3HDM1chr2:136668708chr2:136481506ENST000003299712123232_302852971.0DomainSUZ
TgeneR3HDM1chr2:136668709chr2:136481507ENST000002641602426168_2319811100.0DomainR3H
TgeneR3HDM1chr2:136668709chr2:136481507ENST000002641602426232_3029811100.0DomainSUZ
TgeneR3HDM1chr2:136668709chr2:136481507ENST000003299712123168_231852971.0DomainR3H
TgeneR3HDM1chr2:136668709chr2:136481507ENST000003299712123232_302852971.0DomainSUZ


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Fusion Gene Sequence for DARS-R3HDM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21381_21381_1_DARS-R3HDM1_DARS_chr2_136668708_ENST00000264161_R3HDM1_chr2_136481506_ENST00000329971_length(transcript)=2960nt_BP=1630nt
GAGACCCTGCGCGCGGCCGCCAGCGCTCCGGGATCTCGAGATAGCCGCAGCTCTCGCGATCTTTCTGGAGCCGCACCTCCACGCGGAGTC
CGAGCGCGTGTGCTGAGACCCCAGGGTCGGGAGGGCGGAGACTGGGAGGGAGGGAGAAGCCCCTTTGGCCTGCCTTACGGAAGCCTGCGA
GGGAGGGTGGTGTCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATG
GACGCGGCGGAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCAGATCGAGTTTTGGTTCGGGTT
AGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTA
GTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGGTTAAATTTGCTGCCAACATC
AACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACAT
GTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGCCTGAGGCAGAAGGAGAAGAG
GAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTC
CAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTAAAATTATTTCAGCTGCCAGT
GAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATT
TGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGACATCTAACTGAGTTTGTTGGT
TTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAA
GAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGCCAACTCTAAGACTAGAATAT
TGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCAT
TTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCTATACCATGCCTGACCCAAGA
AATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTA
ACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTGGAGCCCCTCCTCATGCTGGT
GGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTGAAAAGCTTTTTGGGGAACTC
TTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCTGTGGCAGTGGGGACAACACT
GCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCATTTCAGCTGCACAGAATGCA
CTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACATTTTGGAAAGGGCAAGTTCT
CAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGGTATTTGGAGCTTCTGTTAAC
ATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAAGGGGGAAAAATATGCATTTC
ACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTCAAATGCCTCCTAACTTTTAT
AGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTTCAAAATGATTATAACCAGTT
GCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAGGAGTGAAATAACCAAGTCAA
AACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCCTGAATCTCTAAACTCAGAAA
CAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATTAAGTATAAAATAAATTATGT
TCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCACTTTTTTTTTTTCAAGTATC
TCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTTGATGAGTGCTGGAAACTTCT
TAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATGAACAAGGAACCTTCTTTTCA

>21381_21381_1_DARS-R3HDM1_DARS_chr2_136668708_ENST00000264161_R3HDM1_chr2_136481506_ENST00000329971_length(amino acids)=659AA_BP=541
MRAAASAPGSRDSRSSRDLSGAAPPRGVRARVLRPQGREGGDWEGGRSPFGLPYGSLRGRVVSTAQFRVPMPSASASRKSQEKPREIMDA
AEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK
ESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQS
GICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD
IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLV
KEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGG
IVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALK

--------------------------------------------------------------
>21381_21381_2_DARS-R3HDM1_DARS_chr2_136668708_ENST00000264161_R3HDM1_chr2_136481506_ENST00000409478_length(transcript)=2960nt_BP=1630nt
GAGACCCTGCGCGCGGCCGCCAGCGCTCCGGGATCTCGAGATAGCCGCAGCTCTCGCGATCTTTCTGGAGCCGCACCTCCACGCGGAGTC
CGAGCGCGTGTGCTGAGACCCCAGGGTCGGGAGGGCGGAGACTGGGAGGGAGGGAGAAGCCCCTTTGGCCTGCCTTACGGAAGCCTGCGA
GGGAGGGTGGTGTCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATG
GACGCGGCGGAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCAGATCGAGTTTTGGTTCGGGTT
AGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTA
GTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGGTTAAATTTGCTGCCAACATC
AACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACAT
GTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGCCTGAGGCAGAAGGAGAAGAG
GAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTC
CAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTAAAATTATTTCAGCTGCCAGT
GAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATT
TGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGACATCTAACTGAGTTTGTTGGT
TTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAA
GAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGCCAACTCTAAGACTAGAATAT
TGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCAT
TTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCTATACCATGCCTGACCCAAGA
AATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTA
ACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTGGAGCCCCTCCTCATGCTGGT
GGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTGAAAAGCTTTTTGGGGAACTC
TTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCTGTGGCAGTGGGGACAACACT
GCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCATTTCAGCTGCACAGAATGCA
CTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACATTTTGGAAAGGGCAAGTTCT
CAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGGTATTTGGAGCTTCTGTTAAC
ATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAAGGGGGAAAAATATGCATTTC
ACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTCAAATGCCTCCTAACTTTTAT
AGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTTCAAAATGATTATAACCAGTT
GCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAGGAGTGAAATAACCAAGTCAA
AACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCCTGAATCTCTAAACTCAGAAA
CAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATTAAGTATAAAATAAATTATGT
TCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCACTTTTTTTTTTTCAAGTATC
TCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTTGATGAGTGCTGGAAACTTCT
TAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATGAACAAGGAACCTTCTTTTCA

>21381_21381_2_DARS-R3HDM1_DARS_chr2_136668708_ENST00000264161_R3HDM1_chr2_136481506_ENST00000409478_length(amino acids)=659AA_BP=541
MRAAASAPGSRDSRSSRDLSGAAPPRGVRARVLRPQGREGGDWEGGRSPFGLPYGSLRGRVVSTAQFRVPMPSASASRKSQEKPREIMDA
AEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK
ESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQS
GICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD
IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLV
KEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGG
IVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALK

--------------------------------------------------------------
>21381_21381_3_DARS-R3HDM1_DARS_chr2_136668708_ENST00000537273_R3HDM1_chr2_136481506_ENST00000329971_length(transcript)=2710nt_BP=1380nt
TCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCGGAA
ATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTA
AAGGGAAACAGTGCTTCTTAGTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGG
TTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACAC
AGCAAGACGTTGAGTTACATGTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGC
CTGAGGCAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTA
GTCAGGCAGTCTTCCGTCTCCAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTA
AAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGC
TATATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGAC
ATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTAC
AAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGC
CAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAA
ATGAAAAGCTGTTGGGTCATTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCT
ATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAA
TACATGATCCTCAACTGCTAACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTG
GAGCCCCTCCTCATGCTGGTGGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTG
AAAAGCTTTTTGGGGAACTCTTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCT
GTGGCAGTGGGGACAACACTGCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCA
TTTCAGCTGCACAGAATGCACTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACA
TTTTGGAAAGGGCAAGTTCTCAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGG
TATTTGGAGCTTCTGTTAACATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAA
GGGGGAAAAATATGCATTTCACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTC
AAATGCCTCCTAACTTTTATAGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTT
CAAAATGATTATAACCAGTTGCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAG
GAGTGAAATAACCAAGTCAAAACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCC
TGAATCTCTAAACTCAGAAACAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATT
AAGTATAAAATAAATTATGTTCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCA
CTTTTTTTTTTTCAAGTATCTCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTT
GATGAGTGCTGGAAACTTCTTAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATG
AACAAGGAACCTTCTTTTCAATTTCTGTGTAATTTGCAAGGCTGTACAATGTGTGCTGATGCAAGCCTTTTTCAGTTCAAGAGAATAAAT

>21381_21381_3_DARS-R3HDM1_DARS_chr2_136668708_ENST00000537273_R3HDM1_chr2_136481506_ENST00000329971_length(amino acids)=545AA_BP=427
MVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQD
VELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII
SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF
KGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM
PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIVVGKVLEITELPDGITRMEAEKL
FGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFKLRTSKKHYDFHILE

--------------------------------------------------------------
>21381_21381_4_DARS-R3HDM1_DARS_chr2_136668708_ENST00000537273_R3HDM1_chr2_136481506_ENST00000409478_length(transcript)=2710nt_BP=1380nt
TCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCGGAA
ATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTA
AAGGGAAACAGTGCTTCTTAGTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGG
TTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACAC
AGCAAGACGTTGAGTTACATGTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGC
CTGAGGCAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTA
GTCAGGCAGTCTTCCGTCTCCAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTA
AAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGC
TATATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGAC
ATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTAC
AAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGC
CAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAA
ATGAAAAGCTGTTGGGTCATTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCT
ATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAA
TACATGATCCTCAACTGCTAACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTG
GAGCCCCTCCTCATGCTGGTGGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTG
AAAAGCTTTTTGGGGAACTCTTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCT
GTGGCAGTGGGGACAACACTGCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCA
TTTCAGCTGCACAGAATGCACTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACA
TTTTGGAAAGGGCAAGTTCTCAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGG
TATTTGGAGCTTCTGTTAACATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAA
GGGGGAAAAATATGCATTTCACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTC
AAATGCCTCCTAACTTTTATAGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTT
CAAAATGATTATAACCAGTTGCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAG
GAGTGAAATAACCAAGTCAAAACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCC
TGAATCTCTAAACTCAGAAACAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATT
AAGTATAAAATAAATTATGTTCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCA
CTTTTTTTTTTTCAAGTATCTCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTT
GATGAGTGCTGGAAACTTCTTAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATG
AACAAGGAACCTTCTTTTCAATTTCTGTGTAATTTGCAAGGCTGTACAATGTGTGCTGATGCAAGCCTTTTTCAGTTCAAGAGAATAAAT

>21381_21381_4_DARS-R3HDM1_DARS_chr2_136668708_ENST00000537273_R3HDM1_chr2_136481506_ENST00000409478_length(amino acids)=545AA_BP=427
MVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQD
VELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII
SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF
KGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM
PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIVVGKVLEITELPDGITRMEAEKL
FGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFKLRTSKKHYDFHILE

--------------------------------------------------------------
>21381_21381_5_DARS-R3HDM1_DARS_chr2_136668709_ENST00000264161_R3HDM1_chr2_136481507_ENST00000329971_length(transcript)=2960nt_BP=1630nt
GAGACCCTGCGCGCGGCCGCCAGCGCTCCGGGATCTCGAGATAGCCGCAGCTCTCGCGATCTTTCTGGAGCCGCACCTCCACGCGGAGTC
CGAGCGCGTGTGCTGAGACCCCAGGGTCGGGAGGGCGGAGACTGGGAGGGAGGGAGAAGCCCCTTTGGCCTGCCTTACGGAAGCCTGCGA
GGGAGGGTGGTGTCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATG
GACGCGGCGGAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCAGATCGAGTTTTGGTTCGGGTT
AGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTA
GTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGGTTAAATTTGCTGCCAACATC
AACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACAT
GTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGCCTGAGGCAGAAGGAGAAGAG
GAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTC
CAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTAAAATTATTTCAGCTGCCAGT
GAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATT
TGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGACATCTAACTGAGTTTGTTGGT
TTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAA
GAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGCCAACTCTAAGACTAGAATAT
TGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCAT
TTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCTATACCATGCCTGACCCAAGA
AATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTA
ACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTGGAGCCCCTCCTCATGCTGGT
GGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTGAAAAGCTTTTTGGGGAACTC
TTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCTGTGGCAGTGGGGACAACACT
GCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCATTTCAGCTGCACAGAATGCA
CTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACATTTTGGAAAGGGCAAGTTCT
CAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGGTATTTGGAGCTTCTGTTAAC
ATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAAGGGGGAAAAATATGCATTTC
ACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTCAAATGCCTCCTAACTTTTAT
AGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTTCAAAATGATTATAACCAGTT
GCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAGGAGTGAAATAACCAAGTCAA
AACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCCTGAATCTCTAAACTCAGAAA
CAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATTAAGTATAAAATAAATTATGT
TCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCACTTTTTTTTTTTCAAGTATC
TCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTTGATGAGTGCTGGAAACTTCT
TAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATGAACAAGGAACCTTCTTTTCA

>21381_21381_5_DARS-R3HDM1_DARS_chr2_136668709_ENST00000264161_R3HDM1_chr2_136481507_ENST00000329971_length(amino acids)=659AA_BP=541
MRAAASAPGSRDSRSSRDLSGAAPPRGVRARVLRPQGREGGDWEGGRSPFGLPYGSLRGRVVSTAQFRVPMPSASASRKSQEKPREIMDA
AEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK
ESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQS
GICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD
IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLV
KEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGG
IVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALK

--------------------------------------------------------------
>21381_21381_6_DARS-R3HDM1_DARS_chr2_136668709_ENST00000264161_R3HDM1_chr2_136481507_ENST00000409478_length(transcript)=2960nt_BP=1630nt
GAGACCCTGCGCGCGGCCGCCAGCGCTCCGGGATCTCGAGATAGCCGCAGCTCTCGCGATCTTTCTGGAGCCGCACCTCCACGCGGAGTC
CGAGCGCGTGTGCTGAGACCCCAGGGTCGGGAGGGCGGAGACTGGGAGGGAGGGAGAAGCCCCTTTGGCCTGCCTTACGGAAGCCTGCGA
GGGAGGGTGGTGTCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATG
GACGCGGCGGAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCAGATCGAGTTTTGGTTCGGGTT
AGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTA
GTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGGTTAAATTTGCTGCCAACATC
AACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACAT
GTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGCCTGAGGCAGAAGGAGAAGAG
GAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTC
CAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTAAAATTATTTCAGCTGCCAGT
GAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATT
TGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGACATCTAACTGAGTTTGTTGGT
TTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAA
GAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGCCAACTCTAAGACTAGAATAT
TGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCAT
TTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCTATACCATGCCTGACCCAAGA
AATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTA
ACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTGGAGCCCCTCCTCATGCTGGT
GGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTGAAAAGCTTTTTGGGGAACTC
TTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCTGTGGCAGTGGGGACAACACT
GCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCATTTCAGCTGCACAGAATGCA
CTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACATTTTGGAAAGGGCAAGTTCT
CAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGGTATTTGGAGCTTCTGTTAAC
ATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAAGGGGGAAAAATATGCATTTC
ACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTCAAATGCCTCCTAACTTTTAT
AGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTTCAAAATGATTATAACCAGTT
GCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAGGAGTGAAATAACCAAGTCAA
AACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCCTGAATCTCTAAACTCAGAAA
CAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATTAAGTATAAAATAAATTATGT
TCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCACTTTTTTTTTTTCAAGTATC
TCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTTGATGAGTGCTGGAAACTTCT
TAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATGAACAAGGAACCTTCTTTTCA

>21381_21381_6_DARS-R3HDM1_DARS_chr2_136668709_ENST00000264161_R3HDM1_chr2_136481507_ENST00000409478_length(amino acids)=659AA_BP=541
MRAAASAPGSRDSRSSRDLSGAAPPRGVRARVLRPQGREGGDWEGGRSPFGLPYGSLRGRVVSTAQFRVPMPSASASRKSQEKPREIMDA
AEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK
ESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQS
GICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD
IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLV
KEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGG
IVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALK

--------------------------------------------------------------
>21381_21381_7_DARS-R3HDM1_DARS_chr2_136668709_ENST00000537273_R3HDM1_chr2_136481507_ENST00000329971_length(transcript)=2710nt_BP=1380nt
TCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCGGAA
ATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTA
AAGGGAAACAGTGCTTCTTAGTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGG
TTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACAC
AGCAAGACGTTGAGTTACATGTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGC
CTGAGGCAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTA
GTCAGGCAGTCTTCCGTCTCCAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTA
AAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGC
TATATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGAC
ATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTAC
AAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGC
CAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAA
ATGAAAAGCTGTTGGGTCATTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCT
ATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAA
TACATGATCCTCAACTGCTAACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTG
GAGCCCCTCCTCATGCTGGTGGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTG
AAAAGCTTTTTGGGGAACTCTTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCT
GTGGCAGTGGGGACAACACTGCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCA
TTTCAGCTGCACAGAATGCACTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACA
TTTTGGAAAGGGCAAGTTCTCAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGG
TATTTGGAGCTTCTGTTAACATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAA
GGGGGAAAAATATGCATTTCACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTC
AAATGCCTCCTAACTTTTATAGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTT
CAAAATGATTATAACCAGTTGCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAG
GAGTGAAATAACCAAGTCAAAACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCC
TGAATCTCTAAACTCAGAAACAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATT
AAGTATAAAATAAATTATGTTCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCA
CTTTTTTTTTTTCAAGTATCTCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTT
GATGAGTGCTGGAAACTTCTTAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATG
AACAAGGAACCTTCTTTTCAATTTCTGTGTAATTTGCAAGGCTGTACAATGTGTGCTGATGCAAGCCTTTTTCAGTTCAAGAGAATAAAT

>21381_21381_7_DARS-R3HDM1_DARS_chr2_136668709_ENST00000537273_R3HDM1_chr2_136481507_ENST00000329971_length(amino acids)=545AA_BP=427
MVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQD
VELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII
SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF
KGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM
PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIVVGKVLEITELPDGITRMEAEKL
FGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFKLRTSKKHYDFHILE

--------------------------------------------------------------
>21381_21381_8_DARS-R3HDM1_DARS_chr2_136668709_ENST00000537273_R3HDM1_chr2_136481507_ENST00000409478_length(transcript)=2710nt_BP=1380nt
TCCACTGCCCAGTTCCGTGTCCCGATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCGGAA
ATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGGGTACGTGCAAGAGTTCATACAAGCAGAGCTA
AAGGGAAACAGTGCTTCTTAGTCCTACGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATGG
TTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGAAAAGTGAATCAGAAAATTGGAAGCTGTACAC
AGCAAGACGTTGAGTTACATGTTCAGAAGATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGGC
CTGAGGCAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGACAACAGAGTCATTGATCTTAGGACATCAACTA
GTCAGGCAGTCTTCCGTCTCCAGTCTGGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCTA
AAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAAAATAATGCATACCTGGCTCAGTCCCCACAGC
TATATAAGCAAATGTGCATTTGTGCTGATTTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGAC
ATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAAGTTATGGAAGAAATTGCTGACACCATGGTAC
AAATATTCAAAGGACTTCAAGAAAGGTTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAGC
CAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAAATGGGAGATGAAGACGATCTGAGCACACCAA
ATGAAAAGCTGTTGGGTCATTTGGTAAAGGAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTCT
ATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAACTCTTACGATATGTTCATGAGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAA
TACATGATCCTCAACTGCTAACAGAGAGAGCTTTACATCATGGAATTGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTTG
GAGCCCCTCCTCATGCTGGTGGAGGCATTGTTGTTGGGAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTG
AAAAGCTTTTTGGGGAACTCTTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCT
GTGGCAGTGGGGACAACACTGCCAACCCTGAACGCTCTAAACCCAGTGACTTGGCCTCCACCTACACCGTCTTAGCCACATTCCCCTCCA
TTTCAGCTGCACAGAATGCACTGAAGAAACAAATTAACTCAGTTAACAAGTTTAAGCTGAGAACAAGCAAGAAGCACTATGACTTTCACA
TTTTGGAAAGGGCAAGTTCTCAGTAACAGCCACCTTTGGACCCTTCGCCTTTATGGTTCCCCTGCCCTCTCCCATCTTTGATTGGCTTGG
TATTTGGAGCTTCTGTTAACATTATAGAGACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAA
GGGGGAAAAATATGCATTTCACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTC
AAATGCCTCCTAACTTTTATAGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTT
CAAAATGATTATAACCAGTTGCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAG
GAGTGAAATAACCAAGTCAAAACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCC
TGAATCTCTAAACTCAGAAACAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATT
AAGTATAAAATAAATTATGTTCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCA
CTTTTTTTTTTTCAAGTATCTCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTT
GATGAGTGCTGGAAACTTCTTAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATG
AACAAGGAACCTTCTTTTCAATTTCTGTGTAATTTGCAAGGCTGTACAATGTGTGCTGATGCAAGCCTTTTTCAGTTCAAGAGAATAAAT

>21381_21381_8_DARS-R3HDM1_DARS_chr2_136668709_ENST00000537273_R3HDM1_chr2_136481507_ENST00000409478_length(amino acids)=545AA_BP=427
MVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQD
VELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII
SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF
KGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM
PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIVVGKVLEITELPDGITRMEAEKL
FGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFKLRTSKKHYDFHILE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DARS-R3HDM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DARS-R3HDM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DARS-R3HDM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource