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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DAXX-DGKB (FusionGDB2 ID:21385)

Fusion Gene Summary for DAXX-DGKB

Fusion gene summary

Fusion gene information	Fusion gene name: DAXX-DGKB
	Fusion gene ID: 21385
		Hgene	Tgene
	Gene symbol	DAXX	DGKB
	Gene ID	1616	1607
	Gene name	death domain associated protein	diacylglycerol kinase beta
	Synonyms	BING2\|DAP6\|EAP1\|SMIM40	DAGK2\|DGK\|DGK-BETA
	Cytomap	6p21.32	7p21.2
	Type of gene	protein-coding	protein-coding
	Description	death domain-associated protein 6CENP-C binding proteinETS1-associated protein 1Fas-binding proteindeath-associated protein 6fas death domain-associated protein	diacylglycerol kinase beta90 kDa diacylglycerol kinaseDAG kinase betadiacylglycerol kinase, beta 90kDadiglyceride kinase beta
	Modification date	20200313	20200313
	UniProtAcc	Q9UER7	Q9Y6T7
	Ensembl transtripts involved in fusion gene	ENST00000266000, ENST00000374542, ENST00000383062, ENST00000383194, ENST00000399060, ENST00000399344, ENST00000414083, ENST00000414388, ENST00000433482, ENST00000436311, ENST00000445009, ENST00000455860, ENST00000461796, ENST00000469277, ENST00000472399, ENST00000477162, ENST00000494562,	ENST00000258767, ENST00000399322, ENST00000402815, ENST00000403951, ENST00000403963, ENST00000406247, ENST00000407950, ENST00000444700,
Fusion gene scores	* DoF score	2 X 2 X 1=4	19 X 16 X 9=2736
	# samples	2	19
	** MAII score	log2(2/4*10)=2.32192809488736	log2(19/2736*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DAXX [Title/Abstract] AND DGKB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DAXX(33286335)-DGKB(14327932), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DAXX	GO:0006334	nucleosome assembly	20504901\|20651253
Hgene	DAXX	GO:0006338	chromatin remodeling	20651253
Hgene	DAXX	GO:0006355	regulation of transcription, DNA-templated	15878163
Hgene	DAXX	GO:0030521	androgen receptor signaling pathway	15572661
Hgene	DAXX	GO:0031396	regulation of protein ubiquitination	18566590
Hgene	DAXX	GO:0034605	cellular response to heat	15016915
Hgene	DAXX	GO:0034620	cellular response to unfolded protein	15016915
Hgene	DAXX	GO:0045892	negative regulation of transcription, DNA-templated	12140263\|15572661
Hgene	DAXX	GO:0071276	cellular response to cadmium ion	15016915
Hgene	DAXX	GO:0071280	cellular response to copper ion	15016915
Hgene	DAXX	GO:0072738	cellular response to diamide	15016915
Hgene	DAXX	GO:1903936	cellular response to sodium arsenite	15016915
Tgene	DGKB	GO:0046486	glycerolipid metabolic process	22627129
Tgene	DGKB	GO:0046834	lipid phosphorylation	22627129

Fusion gene breakpoints across DAXX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DGKB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BP429489	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-

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Fusion Gene ORF analysis for DAXX-DGKB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000266000	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000266000	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
5CDS-intron	ENST00000374542	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383062	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000383194	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399060	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000399344	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414083	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000414388	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000433482	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000436311	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000445009	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000455860	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000461796	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000469277	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000472399	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000477162	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000258767	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000399322	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000402815	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000403951	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000403963	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000406247	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000407950	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-
intron-intron	ENST00000494562	ENST00000444700	DAXX	chr6	33286335	-	DGKB	chr7	14327932	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DAXX-DGKB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAXX-DGKB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33286335/:14327932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DAXX Q9UER7	DGKB Q9Y6T7
FUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:15364927, ECO:0000269\|PubMed:16845383, ECO:0000269\|PubMed:17081986, ECO:0000269\|PubMed:17942542, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:23222847, ECO:0000269\|PubMed:24200965, ECO:0000269\|PubMed:24530302}.	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250\|UniProtKB:P49621, ECO:0000250\|UniProtKB:Q6NS52, ECO:0000269\|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269\|PubMed:11719522}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DAXX-DGKB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAXX-DGKB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DAXX-DGKB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DAXX-DGKB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source