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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAZAP2-CDIPT (FusionGDB2 ID:21412)

Fusion Gene Summary for DAZAP2-CDIPT

check button Fusion gene summary
Fusion gene informationFusion gene name: DAZAP2-CDIPT
Fusion gene ID: 21412
HgeneTgene
Gene symbol

DAZAP2

CDIPT

Gene ID

9802

10423

Gene nameDAZ associated protein 2CDP-diacylglycerol--inositol 3-phosphatidyltransferase
SynonymsPRTBPIS|PIS1
Cytomap

12q13.13

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionDAZ-associated protein 2deleted in azoospermia associated protein 2proline-rich transcript in brainproline-rich transcript, brain-expressed proteinCDP-diacylglycerol--inositol 3-phosphatidyltransferasePI synthasePtdIns synthasephosphatidylinositol synthase
Modification date2020031320200313
UniProtAcc

Q15038

O14735

Ensembl transtripts involved in fusion geneENST00000551534, ENST00000412716, 
ENST00000425012, ENST00000449723, 
ENST00000549732, ENST00000551313, 
ENST00000604900, ENST00000439799, 
ENST00000549555, 		ENST00000219789, 
ENST00000566113, ENST00000561555, 
ENST00000563415, ENST00000567459, 
ENST00000569956, ENST00000570016, 
Fusion gene scores* DoF score8 X 9 X 2=1446 X 5 X 1=30
# samples 96
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DAZAP2 [Title/Abstract] AND CDIPT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAZAP2(51634881)-CDIPT(29874290), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDIPT

GO:0006661

phosphatidylinositol biosynthetic process

8110188|9407135


check buttonFusion gene breakpoints across DAZAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDIPT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA014768DAZAP2chr12

51634881

+CDIPTchr16

29874290

-


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Fusion Gene ORF analysis for DAZAP2-CDIPT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000551534ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-5UTRENST00000551534ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-intronENST00000551534ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-intronENST00000551534ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-intronENST00000551534ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-intronENST00000551534ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
3UTR-intronENST00000551534ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000412716ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000412716ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000425012ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000425012ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000449723ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000449723ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000549732ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000549732ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000551313ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000551313ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000604900ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-5UTRENST00000604900ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000412716ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000412716ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000412716ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000412716ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000412716ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000425012ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000425012ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000425012ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000425012ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000425012ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000449723ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000449723ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000449723ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000449723ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000449723ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000549732ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000549732ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000549732ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000549732ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000549732ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000551313ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000551313ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000551313ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000551313ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000551313ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000604900ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000604900ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000604900ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000604900ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
5CDS-intronENST00000604900ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-5UTRENST00000439799ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-5UTRENST00000439799ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-5UTRENST00000549555ENST00000219789DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-5UTRENST00000549555ENST00000566113DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000439799ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000439799ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000439799ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000439799ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000439799ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000549555ENST00000561555DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000549555ENST00000563415DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000549555ENST00000567459DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000549555ENST00000569956DAZAP2chr12

51634881

+CDIPTchr16

29874290

-
intron-intronENST00000549555ENST00000570016DAZAP2chr12

51634881

+CDIPTchr16

29874290

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAZAP2-CDIPT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAZAP2-CDIPT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:51634881/:29874290)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAZAP2

Q15038

CDIPT

O14735

FUNCTION: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188, ECO:0000269|PubMed:9407135}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DAZAP2-CDIPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAZAP2-CDIPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAZAP2-CDIPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAZAP2-CDIPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource