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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAZAP2-DPP10 (FusionGDB2 ID:21414)

Fusion Gene Summary for DAZAP2-DPP10

check button Fusion gene summary
Fusion gene informationFusion gene name: DAZAP2-DPP10
Fusion gene ID: 21414
HgeneTgene
Gene symbol

DAZAP2

DPP10

Gene ID

9802

57628

Gene nameDAZ associated protein 2dipeptidyl peptidase like 10
SynonymsPRTBDPL2|DPPY|DPRP-3|DPRP3
Cytomap

12q13.13

2q14.1

Type of geneprotein-codingprotein-coding
DescriptionDAZ-associated protein 2deleted in azoospermia associated protein 2proline-rich transcript in brainproline-rich transcript, brain-expressed proteininactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional)
Modification date2020031320200313
UniProtAcc

Q15038

Q8N608

Ensembl transtripts involved in fusion geneENST00000412716, ENST00000449723, 
ENST00000425012, ENST00000439799, 
ENST00000549555, ENST00000549732, 
ENST00000551313, ENST00000551534, 
ENST00000604900, 		ENST00000310323, 
ENST00000393147, ENST00000409163, 
ENST00000410059, ENST00000488208, 
Fusion gene scores* DoF score8 X 9 X 2=14412 X 13 X 3=468
# samples 913
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAZAP2 [Title/Abstract] AND DPP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAZAP2(51636750)-DPP10(115271193), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP10

GO:1903078

positive regulation of protein localization to plasma membrane

15671030


check buttonFusion gene breakpoints across DAZAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DPP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW904644DAZAP2chr12

51636750

-DPP10chr2

115271193

+


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Fusion Gene ORF analysis for DAZAP2-DPP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000412716ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000412716ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000412716ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000412716ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000412716ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000449723ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000449723ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000449723ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000449723ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
3UTR-intronENST00000449723ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000425012ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000425012ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000425012ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000425012ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000425012ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000439799ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000439799ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000439799ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000439799ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000439799ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549555ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549555ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549555ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549555ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549555ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549732ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549732ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549732ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549732ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000549732ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551313ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551313ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551313ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551313ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551313ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551534ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551534ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551534ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551534ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000551534ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000604900ENST00000310323DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000604900ENST00000393147DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000604900ENST00000409163DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000604900ENST00000410059DAZAP2chr12

51636750

-DPP10chr2

115271193

+
intron-intronENST00000604900ENST00000488208DAZAP2chr12

51636750

-DPP10chr2

115271193

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAZAP2-DPP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAZAP2-DPP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:51636750/:115271193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAZAP2

Q15038

DPP10

Q8N608

FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:15671030}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DAZAP2-DPP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAZAP2-DPP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAZAP2-DPP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DAZAP2-DPP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource